HL-A in cancer family "N".

abstract：BACKGROUND:Patients' estimates of their chances of therapeutic benefit from participation in early phase trials greatly exceed historical data. Ethicists worry that this therapeutic misestimation undermines the validity of informed consent. METHODS:The authors interviewed 45 patients enrolled in phase 1 or 2 oncology ...

journal_title：Cancer

authors： Sulmasy DP,Astrow AB,He MK,Seils DM,Meropol NJ,Micco E,Weinfurt KP

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:The phosphatidylinositol-3 kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is dysregulated in patients with metastatic renal cell carcinoma (mRCC). Buparlisib is a pan-PI3K inhibitor with activity in advanced solid tumors. The primary objective of the current study was to determine the maximum...

journal_title：Cancer

authors： McKay RR,De Velasco G,Werner L,Bellmunt J,Harshman L,Sweeney C,Rosenberg JE,Hirsch M,Signoretti S,Van Allen EM,Walsh M,Vaishampayan U,McDermott DF,Choueiri TK

更新日期：2016-08-01 00:00:00

abstract：:A panel of Japanese and American pathologists reviewed existing histologic material used to study breast cancer risk among the A-bomb survivors in Hiroshima and Nagasaki, a population in which incidence studies have found a strong relationship between breast cancer risk and radiation dose. The primary charge to the pa...

journal_title：Cancer

authors： Tokuoka S,Asano M,Yamamoto T,Tokunaga M,Sakamoto G,Hartmann WH,Hutter RV,Land CE,Henson DE

更新日期：1984-09-01 00:00:00

abstract：:Adenoid cystic carcinoma (ACC) of the breast is a rare histologic type of breast cancer associated with a good prognosis. A woman who earlier had a pulmonary metastasis surgically resected 6 years postmastectomy developed clinically symptomatic bleeding from a renal metastasis 12 years postmastectomy. An atypical angi...

journal_title：Cancer

authors： Herzberg AJ,Bossen EH,Walther PJ

更新日期：1991-09-01 00:00:00

abstract：:In 230 cases of chronic lymphocytic leukemia (CLL), marker analysis was performed with rosette techniques and a panel of xeno-antisera. A monoclonal B-cell proliferation was found in the majority of cases (94%). In most cases, the B-cells carried IgM, with or without IgD. Cytoplasmic immunoglobulin-inclusion bodies we...

journal_title：Cancer

authors： van der Reijden HJ,van der Gaag R,Pinkster J,Rümke HC,van't Veer MB,Melief CJ,von dem Borne AE

更新日期：1982-12-15 00:00:00

abstract：BACKGROUND:Trimetrexate is an antifol that differs from methotrexate in ways that may be clinically important. Because methotrexate has activity in advanced bladder cancer, this trial was initiated. METHODS:Ambulatory patients with advanced urothelial carcinoma were treated with the nonclassic antifol trimetrexate at ...

journal_title：Cancer

authors： Witte RS,Elson P,Khandakar J,Trump DL

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:To determine whether high-risk patients with hematuria receive evaluation according to guideline recommendations. METHODS:We recently performed a screening study for bladder cancer using a urine-based tumor marker in 1502 subjects at high risk based on aged > or = 50 years, > or = 10-year smoking history, a...

journal_title：Cancer

authors： Elias K,Svatek RS,Gupta S,Ho R,Lotan Y

更新日期：2010-06-15 00:00:00

abstract：:To assess the efficacy of performing both computed tomography (CT) of the thorax and upper abdomen and whole-body gallium scintigraphy for staging lung cancer, the results of each test were compared with those obtained by chest radiography and clinical examination in 100 patients. Clinical efficacy was defined in term...

journal_title：Cancer

authors： MacMahon H,Scott W,Ryan JW,Montner SM,Little AG,Hoffman PC,Ferguson MK,Golomb HM

更新日期：1989-10-01 00:00:00

abstract：:From February 1972 to July 1975, 200 lung cancer patients were seen at the University of Rochester Cancer Center's Division of Radiation Oncology; 40% had squamous cell tumors and 87.5% had advanced disease localized to the thorax. Of the 160 patients who completed treatment, 101 were treated with continuous therapy s...

journal_title：Cancer

authors： Salazar OM,Rubin P,Brown JC,Feldstein ML,Keller BE

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) is the leading cause of death among patients with early-stage breast cancer (BC), but adherence to cardiovascular disease risk factor (CVD-RF) medications is reported to be poor in BC survivors. The objective of the current study was to determine the association between nonadhere...

journal_title：Cancer

authors： Hershman DL,Accordino MK,Shen S,Buono D,Crew KD,Kalinsky K,Trivedi MS,Hur C,Hu J,Unger JM,Wright JD

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:The stabilization and nuclear translocation of beta-catenin are early events in the majority of sporadic colorectal carcinomas (CRC). beta-catenin up-regulates c-Myc and cyclin D1, which antagonize the association of the cyclin-dependent kinase (Cdk) inhibitor, p27(kip1), with Cdk2, thus allowing cell cycle ...

journal_title：Cancer

authors： Cheah PY,Choo PH,Yao J,Eu KW,Seow-Choen F

更新日期：2002-12-15 00:00:00

abstract：:Five cases of squamous cell carcinoma of the cervix associated with widespread squamous cell carcinoma in situ of the endometrial surface are reported. In one case, carcinoma in situ was also found in one fallopian tube in continuity with the cervicoendometrial lesion. A survey of the literature reveals only 20 cases ...

journal_title：Cancer

authors： Kanbour AI,Stock RJ

更新日期：1978-08-01 00:00:00

abstract：BACKGROUND:The current study analyzed the feasibility and outcome of stereotactic radiosurgery (SRS) for treatment of brain metastases from breast carcinoma. METHODS:During an 8-year period, 151 patients with a combined total of 620 brain metastases from breast carcinoma underwent 197 outpatient SRS procedures. Sixty-...

journal_title：Cancer

authors： Muacevic A,Kreth FW,Tonn JC,Wowra B

更新日期：2004-04-15 00:00:00

abstract：:Since single drug therapy of chronic lymphocytic leukemia (CLL) has not resulted in prolonged remissions of advanced disease, we initiated a program of combination chemotherapy, COP (cycloposphamide, vincristine sulfate, prednisone) for CLL patients with increasing adenopathy, spenomegaly, and/or signs of marrow failu...

journal_title：Cancer

authors： Liepman M,Votaw ML

更新日期：1978-05-01 00:00:00

abstract：BACKGROUND:Recent clinical trials have documented activity for combinations of chemotherapeutic agents that target the microtubular apparatus in patients with hormone-refractory prostate cancer. Taxol has a novel antimicrotubular mechanism, acting by stabilizing polymerized tubulin. METHODS:Twenty-three patients with ...

journal_title：Cancer

authors： Roth BJ,Yeap BY,Wilding G,Kasimis B,McLeod D,Loehrer PJ

更新日期：1993-10-15 00:00:00

abstract：BACKGROUND:The current study was conducted to investigate the diagnostic value of neurologic evaluation for the prediction of intracranial metastases in cancer patients with new or changed headache. METHODS:Between February 1997 and February 2000, general practitioners and specialists referred cancer patients with new...

journal_title：Cancer

authors： Christiaans MH,Kelder JC,Arnoldus EP,Tijssen CC

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:For patients who have chondrosarcoma with unresectable disease, because of tumor location, tumor size, or extensive metastatic disease, treatment options are very limited because of their relative resistance to radiotherapy and chemotherapy. The overall survival of this patient population is poor; however, s...

journal_title：Cancer

authors： van Maldegem AM,Gelderblom H,Palmerini E,Dijkstra SD,Gambarotti M,Ruggieri P,Nout RA,van de Sande MA,Ferrari C,Ferrari S,Bovée JV,Picci P

更新日期：2014-10-15 00:00:00

abstract：:During 6375 patient-years of observation, 136 new cancers developed in 117 of 1429 patients with squamous cell carcinoma of the oral cavity. The risk of multiple cancers was excessive in the upper digestive or respiratory tract in patients with squamous cell carcinoma of the oral cavity, accounting for 87 (64%) of the...

journal_title：Cancer

authors： Shibuya H,Hisamitsu S,Shioiri S,Horiuchi J,Suzuki S

更新日期：1987-12-15 00:00:00

abstract：:The National Wilms' Tumor Study (NWTS) was initiated in 1969. One of its objectives was to modulate treatments according to risk factors to minimize the number and severity of treatment-related short-term and long-term iatrogenic complications. The NWTS has therefore incorporated a Long Term Follow-up Study (LTFS) wit...

journal_title：Cancer

authors： Evans AE,Norkool P,Evans I,Breslow N,D'Angio GJ

更新日期：1991-01-15 00:00:00

abstract：BACKGROUND:Hemangiopericytomas and malignant solitary fibrous tumors (HPC/SFT) are rare, closely related sarcomas with unpredictable behavior that respond infrequently to chemotherapy. An optimal systemic treatment strategy for advanced HPC/SFT has not yet been identified. METHODS:We retrospectively analyzed the recor...

journal_title：Cancer

authors： Park MS,Patel SR,Ludwig JA,Trent JC,Conrad CA,Lazar AJ,Wang WL,Boonsirikamchai P,Choi H,Wang X,Benjamin RS,Araujo DM

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Inactivation of the PTEN suppressor gene has been shown to occur in the majority of endometrial cancer cases. Somatic PTEN inactivation by deletion and/or mutation, the first detectible change of endometrial carcinogenesis, has been reported to occur at a high frequency in the endometrium of normal premenopa...

journal_title：Cancer

authors： Lin MC,Burkholder KA,Viswanathan AN,Neuberg D,Mutter GL

更新日期：2009-05-15 00:00:00

abstract：BACKGROUND:The spontaneous formation of neutralizing antibodies (inhibitors) to factor VIII (FVIII) in patients with cancer is a well known phenomenon. However, to the authors' knowledge there is lack of information in the literature with respect to the clinical course of these patients and the nature of the associatio...

journal_title：Cancer

authors： Sallah S,Wan JY

更新日期：2001-03-15 00:00:00

abstract：BACKGROUND:Prostate carcinoma is often associated with perineural (PN) invasion. The common occurrence of this phenomenon has led to speculation regarding the mechanisms of this association, yet to date there have been no studies that clearly define biologic differences between PN and nonperineural (NPN) carcinoma cell...

journal_title：Cancer

authors： Yang G,Wheeler TM,Kattan MW,Scardino PT,Thompson TC

更新日期：1996-09-15 00:00:00

abstract：:In a study conducted by the Eastern Cooperative Oncology Group, 51 evaluable women with advanced ovarian carcinoma were randomized to either abdominal radiation therapy alone, chlorambucil alone, or to a combination of radiation therapy and chlorambucil by members of the Eastern Cooperative Oncology Group. Provision w...

journal_title：Cancer

authors： Miller SP,Brenner S,Horton J,Stolbach L,Shnider BI,Pocock S

更新日期：1975-11-01 00:00:00

abstract：:External-beam irradiation of prostatic cancer was introduced at Stanford in 1956. The program has sought to determine the following: whether prostatic carcinoma can be cured by external beam radiation therapy, with what frequency this can be accomplished, which patients are best suited for irradiation, and what techni...

journal_title：Cancer

authors： Bagshaw MA,Ray GR,Cox RS

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:Low frequency epithelial cells in bone marrow from colorectal carcinoma patients are associated with an increased risk of recurrence and decreased survival. Current immunohistochemical approaches to detect epithelial cells in bone marrow aspirates rely on antibodies against cytokeratin 18 (CK18). The predict...

journal_title：Cancer

authors： Litle VR,Warren RS,Moore D 2nd,Pallavicini MG

更新日期：1997-05-01 00:00:00

abstract：:The clinical, histological, and ultrastructural aspects of a cervical paraganglioma of the vagus nerve, in a 66-year-old white man, have been discussed in detail. Ultrastructurally, the tumor chief cells contained characteristic membrane-bound and dense-cored neurosecretory granules which ranged in size from 85 millim...

journal_title：Cancer

authors： Chaudhry AP,Haar JG,Koul A,Nickerson PA

更新日期：1979-05-01 00:00:00

abstract：:Seventeen cases of pulmonary scar carcinomas were found in 112 surgically resected pulmonary carcinomas from 1985 through 1988 in a hospital situated in a histoplasmosis endemic area. These carcinomas can be divided into two types: Type I, mucinous; and Type II, non-mucinous (Clara cell). Each type of carcinoma consti...

journal_title：Cancer

authors： Yoneda K

更新日期：1990-01-01 00:00:00

abstract：:Ultrastructural examination of an alveolar rhabdomyosarcoma revealed that the bulk of the tumor was composed of small polygonal cells containing polyribosomes, short strands of rough endoplasmic reticulum, and variable amounts of glycogen; the cells were joined by small desmosome-like structures. Similar cells, as wel...

journal_title：Cancer

authors： Churg A,Ringus J

更新日期：1978-04-01 00:00:00

abstract：BACKGROUND:Results from numerous trials have indicated that breast-conserving therapy (BCT) produces outcomes equivalent to those produced by mastectomy in terms of both locoregional control and survival. However, conservative treatment has resulted in the dilemma of how best to address recurrences when they appear in ...

journal_title：Cancer

authors： Vicini FA,Antonucci JV,Goldstein N,Wallace M,Kestin L,Krauss D,Kunzmann J,Gilbert S,Schell S

更新日期：2007-04-01 00:00:00