Spinal cord sparing reirradiation with helical tomotherapy.

Abstract:

BACKGROUND:The purpose of this study was to present planning, feasibility, toxicity, and outcome of helical tomotherapy for spinal cord-sparing reirradiation of spinal metastases and tumors. METHODS:Thirty-six patients with spinal metastases and tumors who had undergone previous radiotherapy were reirradiated with helical tomotherapy because of tumor progression, pain, or compromised stability. Mean spinal cord dose of previous radiotherapy was 36.3 grays (Gy) after a median time interval of 17.5 months. Mean prescribed dose of reirradiation was 34.8 Gy. Daily megavoltage computed tomography (CT) image guidance was performed to assure precise dose application. RESULTS:Mean beam time was 8.4 minutes; the dose maximum to the spinal cord at reirradiation could be limited to a 9.8-Gy median dose (minimum, 5.2 Gy; maximum, 21.8 Gy). Significant pain relief from a median value of 7 on the visual analogue scale before therapy to a median value of 3 at 6 weeks after radiotherapy was achieved. One- and 2-year local control was 76% and 63%; overall survival was 67% after 1 year and 58% after 2 years. One grade 2 skin toxicity and no grade 3 or higher toxicities were observed. CONCLUSIONS:Helical tomotherapy makes reirradiation of spinal metastases and excellent avoidance of the spinal cord possible and achieves good pain relief and local control. With a minimal distance of several millimeters between target volume and spinal cord, tailor-made dose distributions with steep dose gradients around previously irradiated tissue are obtained and precisely applied with daily megavoltage CT-based image guidance.

journal_name

Cancer

journal_title

Cancer

authors

Sterzing F,Hauswald H,Uhl M,Herm H,Wiener A,Herfarth K,Debus J,Krempien R

doi

10.1002/cncr.25187

subject

Has Abstract

pub_date

2010-08-15 00:00:00

pages

3961-8

issue

16

eissn

0008-543X

issn

1097-0142

journal_volume

116

pub_type

杂志文章

相关文献

CANCER文献大全
  • Biomarker-based phase I dose-escalation, pharmacokinetic, and pharmacodynamic study of oral apricoxib in combination with erlotinib in advanced nonsmall cell lung cancer.

    abstract:BACKGROUND:Apricoxib, a novel once-daily selective cyclooxygenase-2 inhibitor, was investigated in combination with erlotinib for recurrent stage IIIB/IV nonsmall cell lung cancer to determine the maximum tolerated dose, dose-limiting toxicity, and recommended phase II dose (RP2D) based on changes in urinary prostaglan...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.25473

    authors: Reckamp K,Gitlitz B,Chen LC,Patel R,Milne G,Syto M,Jezior D,Zaknoen S

    更新日期:2011-02-15 00:00:00

  • Cisplatin neuropathy. Risk factors, prognosis, and protection by WR-2721.

    abstract::A prospective study of patients receiving cis-diaminedichloroplatin II (DDP) was carried out to determine if risk factors could be identified related to the patient's living habits or past medical history that would predict in which patients DDP neuropathy might develop. Sixty-nine patients receiving six different com...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880601)61:11<2192::aid-cncr282

    authors: Mollman JE,Glover DJ,Hogan WM,Furman RE

    更新日期:1988-06-01 00:00:00

  • The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS.

    abstract:BACKGROUND:The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene resulting from the chromosome inversion inv(2)(p21;p23) recently was identified in nonsmall cell lung cancer (NSCLC). The authors of this study investigated the frequency, genetic and clinicopathologic prof...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24181

    authors: Wong DW,Leung EL,So KK,Tam IY,Sihoe AD,Cheng LC,Ho KK,Au JS,Chung LP,Pik Wong M,University of Hong Kong Lung Cancer Study Group.

    更新日期:2009-04-15 00:00:00

  • Chromosome abnormalities in bilateral breast carcinomas. Cytogenetic evaluation of the clonal origin of multiple primary tumors.

    abstract:BACKGROUND:Although acquired somatic mutations presumably are crucial in carcinogenesis, nothing is known about the chromosome aberrations of bilateral breast carcinomas. METHODS:Eighteen specimens from 16 bilateral carcinomas were analyzed cytogenetically. The banding analysis was supplemented with fluorescence in si...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950715)76:2<250::aid-cncr28207

    authors: Pandis N,Teixeira MR,Gerdes AM,Limon J,Bardi G,Andersen JA,Idvall I,Mandahl N,Mitelman F,Heim S

    更新日期:1995-07-15 00:00:00

  • New diagnostic, staging, and therapeutic aspects of early breast cancer.

    abstract::Many advances have occurred in breast cancer through research and clinical trials. More confidence in new biological consumptions about invasive breast cancer indicate that: (1) details of the primary breast cancer do not control survival; (2) breast-only failures after local excision do not bias against survival; and...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19900201)65:3+<634::aid-cncr2820

    authors: Cady B

    更新日期:1990-02-01 00:00:00

  • Chemotherapy for advanced or recurrent gynecologic cancer.

    abstract::Studies of chemotherapy in advanced or recurrent gynecologic cancer have focussed on ovarian, cervical, and endometrial carcinoma. For celomic epithelial carcinomas of the ovary, a large number of cytotoxic agents have been shown to be active. Dramatic improvement in frequency of response with lesser improvement in su...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19901015)60:8+<2104::aid-cncr282

    authors: Thigpen T,Vance R,Lambuth B,Balducci L,Khansur T,Blessing J,McGehee R

    更新日期:1987-10-15 00:00:00

  • The United States experience with oral controlled-release morphine (MS Contin tablets). Parts I and II. Review of nine dose titration studies and clinical pharmacology of 15-mg, 30-mg, 60-mg, and 100-mg tablet strengths in normal subjects.

    abstract::The results of nine US multicenter, sequential crossover, dose titration studies of controlled-release oral morphine (MS Contin 30 mg tablets [MSC], Purdue Frederick, Norwalk, CT) are reviewed in Part I. The studies demonstrated the prolonged analgesic efficacy of the preparation in the treatment of patients with mode...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890601)63:11<2348::aid-cncr282

    authors: Kaiko RF,Grandy RP,Oshlack B,Pav J,Horodniak J,Thomas G,Ingber E,Goldenheim PD

    更新日期:1989-06-01 00:00:00

  • Primary lymphoma of the central nervous system. Computerized tomography scan characteristics and treatment results for 12 cases.

    abstract::A retrospective analysis of 12 patients with primary central nervous system non-Hodgkin's lymphoma seen from 1958 to 1980 was carried out with emphasis on diagnostic evaluation and treatment results. Computerized tomography (CT) scans were found to be the most valuable diagnostic tool both for initial evaluation as we...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19831201)52:11<1993::aid-cncr282

    authors: Mendenhall NP,Thar TL,Agee OF,Harty-Golder B,Ballinger WE Jr,Million RR

    更新日期:1983-12-01 00:00:00

  • Gangliosides of human melanoma.

    abstract::Human melanoma synthesizes a large quantity of gangliosides, glycosphingolipids containing sialic acid. The authors previously have demonstrated that the ganglioside profile differs among individual melanomas and is widely heterogeneous. In the current study, a retrospective study was performed to compare the relation...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890315)63:6<1166::aid-cncr2820

    authors: Tsuchida T,Saxton RE,Morton DL,Irie RF

    更新日期:1989-03-15 00:00:00

  • Phase II trial of prednimustine, L-1031, (NSC-134087) in advanced breast cancer.

    abstract::The therapeutic effect of prednimustine was studied in 35 patients with advanced breast cancer resistant to previous cytotoxic and/or endocrine therapy. Response (PR + CR) was obtained in 14 patients (40%) of a median duration of five months. Among the 14 responding patients, 10 were resistant to previous endocrine th...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800715)46:2<253::aid-cncr28204

    authors: Mouridsen HT,Kristensen D,Nielsen JH,Dombernowsky P

    更新日期:1980-07-15 00:00:00

  • Angiosarcoma of skin and soft tissue: a study of forty-four cases.

    abstract::Forty-four cases of skin and soft tissue angiosarcoma seen at M. D. Anderson Hospital before 1976 were reviewed. The cases fell into six different clinical groups: scalp-face, 17 cases; postmastectomy, 14 cases; postradiation, 5 cases; leg with vascular stasis, 2 cases; breast, 2 cases; and miscellaneous, 4 cases. In ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19811015)48:8<1907::aid-cncr2820

    authors: Maddox JC,Evans HL

    更新日期:1981-10-15 00:00:00

  • Prolonged survival with a longer duration of maintenance lenalidomide after autologous hematopoietic stem cell transplantation for multiple myeloma.

    abstract:BACKGROUND:Although lenalidomide maintenance therapy has demonstrated improved outcomes after autologous hematopoietic stem cell transplantation (auto-HCT) for patients with multiple myeloma (MM), the impact of the duration of this therapy is not clearly known. METHODS:This study retrospectively analyzed all MM patien...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30366

    authors: Mian I,Milton DR,Shah N,Nieto Y,Popat UR,Kebriaei P,Parmar S,Oran B,Shah JJ,Manasanch EE,Orlowski RZ,Shpall EJ,Champlin RE,Qazilbash MH,Bashir Q

    更新日期:2016-12-15 00:00:00

  • Flow cytometric DNA analysis of hepatocellular carcinoma.

    abstract::The prognostic value of nuclear DNA content was studied retrospectively using flow cytometry in 203 cases of resected hepatocellular carcinoma. The occurrence of DNA aneuploidy, which was detected in 50% of patients, correlated significantly with tumor size and the presence of vascular invasion or intrahepatic metasta...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910215)67:4<939::aid-cncr28206

    authors: Fujimoto J,Okamoto E,Yamanaka N,Toyosaka A,Mitsunobu M

    更新日期:1991-02-15 00:00:00

  • Neutropenic enterocolitis. Clinical diagnosis and treatment.

    abstract::Review of the consultation records of the Gastrointestinal Surgical Oncology service at Roswell Park Memorial Institute from 1982 to 1987 revealed 22 patients with a clinical diagnosis of neutropenic enterocolitis. Ninety-one percent of the patients had hematologic malignancies, and 95% were receiving cytotoxic chemot...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920101)69:1<17::aid-cncr282069

    authors: Wade DS,Nava HR,Douglass HO Jr

    更新日期:1992-01-01 00:00:00

  • Paclitaxel-based second-line therapy for patients with advanced chemotherapy-resistant bladder carcinoma (M1): a clinical Phase II study.

    abstract:BACKGROUND:In a previous clinical trial, the authors disclosed that the expression of tumor cell motility factor gp78hAMFR correlates with tumor progression in patients with bladder carcinoma. This study was initiated to evaluate whether the combination of cytostatic drugs with an antimotility factor has an effect on c...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1097-0142(19970801)80:3<465::aid-cnc

    authors: Otto T,Bex A,Krege S,Walz PH,Rübben H

    更新日期:1997-08-01 00:00:00

  • Prognostic value of p53 and MIB-1 in transitional cell carcinoma of the urinary bladder with regional lymph node involvement.

    abstract:BACKGROUND:The effect of p53 protein expression and MIB-1 proliferative activity on survival and chemotherapeutic response in patients with lymph node (LN)-positive transitional cell carcinoma (TCC) of the urinary bladder remains unclear. The objective of this study was to assess the ability of these markers to predict...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20567

    authors: Frank I,Cheville JC,Blute ML,Lohse CM,Karnes RJ,Weaver AL,Sebo TJ,Nehra A,Zincke H

    更新日期:2004-10-15 00:00:00

  • Cancer prevention and detection. An overview of variables influencing adoption and practice.

    abstract::This paper presents an overview of factors, attitudes, and beliefs that may influence the adoption of cancer prevention and detection strategies by health-care providers and the public. Health-care practitioners require education about prevention and detection approaches to health care and the social variations in the...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19880601)61:11+<2391::aid-cncr28

    authors: Fink DJ,Sheehan HE

    更新日期:1988-06-01 00:00:00

  • Primary extramedullary esophageal plasmacytoma: First case report.

    abstract::Solitary extramedullary plasmacytomas are rare tumors, reported to occur most commonly in the upper respiratory passages, but which also are rarely seen in the middle and lower gastrointestinal system. This report documents the first primary plasmacytoma of the esophagus. A 67-year-old Caucasian man complained of dysp...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197608)38:2<943::aid-cncr2820380

    authors: Ahmed N,Ramos S,Sika J,LeVeen HH,Piccone VA

    更新日期:1976-08-01 00:00:00

  • Thin-needle aspiration biopsy: the diagnosis of head and neck tumors revisited.

    abstract::Results of 567 thin-needle aspiration biopsies of head and neck lesions are reviewed. Cases included lymph nodes, salivary glands, thyroid, soft tissue and bone lesions. For the entire series, 17 patients had unsatisfactory aspirations. There were 12 false negative reports and 4 false positive reports, rates of 2.1% a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197904)43:4<1541::aid-cncr282043

    authors: Frable WJ,Frable MA

    更新日期:1979-04-01 00:00:00

  • A phase 2 trial of lenvatinib (E7080) in advanced, progressive, radioiodine-refractory, differentiated thyroid cancer: A clinical outcomes and biomarker assessment.

    abstract:BACKGROUND:Lenvatinib is an oral, multitargeted tyrosine kinase inhibitor of the vascular endothelial growth factor receptors 1 through 3 (VEGFR1-VEGFR3), fibroblast growth factor receptors 1 through 4 (FGFR1-FGFR4), platelet-derived growth factor receptor α (PDGFRα), ret proto-oncogene (RET), and v-kit Hardy-Zuckerman...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29395

    authors: Cabanillas ME,Schlumberger M,Jarzab B,Martins RG,Pacini F,Robinson B,McCaffrey JC,Shah MH,Bodenner DL,Topliss D,Andresen C,O'Brien JP,Ren M,Funahashi Y,Allison R,Elisei R,Newbold K,Licitra LF,Sherman SI,Ball DW

    更新日期:2015-08-15 00:00:00

  • Potentially avoidable hospitalizations after chemotherapy: Differences across medicare and the Veterans Health Administration.

    abstract:BACKGROUND:The Centers for Medicare and Medicaid Services (CMS) has released quality measures regarding potentially avoidable hospitalizations visits in the 30 days after receipt of outpatient chemotherapy. This study evaluated the proportions of patients treated by Medicare-reimbursed clinicians and Veterans Health Ad...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32896

    authors: Gidwani-Marszowski R,Faricy-Anderson K,Asch SM,Illarmo S,Ananth L,Patel MI

    更新日期:2020-07-15 00:00:00

  • Gender representation of cancer patients in medical treatment and psychosocial survivorship research: changes over three decades.

    abstract:BACKGROUND:Prior studies raise concern about gender bias in cancer research, including insufficient inclusion of women or men, or studying women and men differently. The 1993 National Institutes of Health Revitalization Act aimed to eliminate gender bias in medicine. To examine changes in medical and psychological lite...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27432

    authors: Hoyt MA,Rubin LR

    更新日期:2012-10-01 00:00:00

  • Salvage combination chemotherapy with 5-fluorouracil and actinomycin D for patients with refractory, high-risk gestational trophoblastic tumors.

    abstract:BACKGROUND:The objective of this study was to evaluate the efficacy and toxicity of a high-dose 5-fluorouracil and actinomycin D regimen (the FA regimen) as salvage chemotherapy for patients with high-risk gestational trophoblastic tumors (GTTs). METHODS:From 1985 to 1997, 10 patients with refractory, high-risk GTTs w...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10790

    authors: Matsui H,Suzuka K,Iitsuka Y,Yamazawa K,Tanaka N,Mitsuhashi A,Seki K,Sekiya S

    更新日期:2002-09-01 00:00:00

  • The elderly population. Opportunities for cancer prevention and detection.

    abstract::Interest in the elderly population, persons 65 years of age or older, as a target group for cancer control has not been great. Age recommendations rarely are made for prevention and early detection of cancer for elderly persons. However, cancer incidence and mortality rates are known to rise rapidly with increasing ag...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19881015)62:1+<1823::aid-cncr282

    authors: Yancik R,Kessler L,Yates JW

    更新日期:1988-10-15 00:00:00

  • Primary central nervous system T-cell lymphoma with a predominant CD8 immunophenotype.

    abstract:BACKGROUND:Primary T-cell lymphomas of the central nervous system are uncommon neoplasms. METHODS:A case of a primary central nervous system T-cell lymphoma in a 66-year-old female who died 8 months after surgery is described. The biopsy specimen was evaluated by routine histology, immunohistochemistry, flow cytometry...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950415)75:8<2180::aid-cncr2820

    authors: Novak JA,Katzin WE

    更新日期:1995-04-15 00:00:00

  • A multivariate analysis of the survival of patients with aggressive lymphoma: variations in the predictive value of prognostic factors during the course of the disease. Groupe d'Etudes des Lymphomes de l'Adulte.

    abstract:BACKGROUND:Aggressive non-Hodgkin's lymphoma is now often curable with chemotherapy. The International Prognostic Index (IPI) was recently developed to predict patient survival on the basis of pretreatment clinical features. However, classical multivariate regression models such as the IPI fail to detect time-dependent...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:

    authors: Mounier N,Morel P,Haioun C,Coiffier B,Tilly H,Chatelain C,Lederlin P,Thyss A,Herbrecht R,Gisselbrecht C,Lepage E

    更新日期:1998-05-15 00:00:00

  • A phase 1 study of the antibody-drug conjugate brentuximab vedotin with re-induction chemotherapy in patients with CD30-expressing relapsed/refractory acute myeloid leukemia.

    abstract:BACKGROUND:Outcomes for patients with relapsed/refractory acute myeloid leukemia (R/R AML) remain poor. Novel therapies specifically targeting AML are of high interest. Brentuximab vedotin (BV) is an antibody-drug conjugate that is specific for human CD30. In this phase 1 dose escalation study, the authors evaluated th...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32657

    authors: Narayan R,Blonquist TM,Emadi A,Hasserjian RP,Burke M,Lescinskas C,Neuberg DS,Brunner AM,Hobbs G,Hock H,McAfee SL,Chen YB,Attar E,Graubert TA,Bertoli C,Moran JA,Bergeron MK,Foster JE,Ramos AY,Som TT,Vartanian MK,

    更新日期:2020-03-15 00:00:00

  • Metastatic bronchogenic carcinoma to the bones of the hand.

    abstract::A case of bronchogenic carcinoma with polyostotic metastatasis to the phalanges is presented. The literature has also been extensively reviewed. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800215)45:4<824::aid-cncr28204

    authors: Nagendran T,Patel MN,Gaillard WE,Imm F,Walker M

    更新日期:1980-02-15 00:00:00

  • Ultrastructure of 16 cases of clear cell adenocarcinoma of the vagina and cervix in young women.

    abstract::Sixteen cases of clear cell adenocarcinoma of the cervix and vagina in young women were studied by electron microscopy and the observations were compared with the light microscopic appearance. Ultrastructurally, the neoplastic cells were found to be of the same basic type, regardless of whether light microscopy disclo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800401)45:7<1615::aid-cncr2820

    authors: Dickersin GR,Welch WR,Erlandson R,Robboy SJ

    更新日期:1980-04-01 00:00:00

  • Adrenal adenomas and adrenal carcinomas in association with hereditary adenomatosis of the colon and rectum.

    abstract::Hereditary adenomatosis of the colon and rectum (HACR) is associated with a wide variety of extracolonic manifestations. Two cases of neoplasia involving the adrenal gland are reported, one adenoma and one carcinoma. The literature relating these lesions to HACR and other syndromes of malignant and nonmalignant growth...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850501)55:9<2001::aid-cncr2820

    authors: Painter TA,Jagelman DG

    更新日期:1985-05-01 00:00:00