Abstract:
:Previous studies and those of the authors have reported about raised levels of lipid-bound sialic acid (LSA) in sera of patients with various neoplasms. Most authors have used the method of Katopodis and Stock for isolating serum LSA. Because of the discrepancy of the amount of extracted LSA with the content of pure gangliosides in sera reported by other groups the authors analyzed the composition of the extracted LSA by immunochemical approaches. They were able to isolate considerable amounts of glycoproteins containing sialic acid as acid alpha-1-glycoprotein, antitrypsin, haptoglobin, antichymotrypsin, and immunoglobulins from the so-called "LSA" fraction. There is a very strong correlation between the raised LSA levels and the content of acid-alpha-1-glycoprotein in the sera of patients with malignancy. Therefore the term lipid-bound sialic acid applied to this test is misleading, since glycoproteins containing sialic acid are mostly responsible for the high "LSA" levels.
journal_name
Cancerjournal_title
Cancerauthors
Voigtmann R,Pokorny J,Meinshausen Adoi
10.1002/1097-0142(19891201)64:11<2279::aid-cncr282subject
Has Abstractpub_date
1989-12-01 00:00:00pages
2279-83issue
11eissn
0008-543Xissn
1097-0142journal_volume
64pub_type
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