Abstract:
BACKGROUND:Leptomeningeal disease (LMD) involves the spread of malignant cells from solid tumors to the cerebrospinal fluid or to the leptomeninges. LMD has a very poor prognosis and it is difficult to diagnose and follow with traditional diagnostic tools. The purposes of this study were to characterize cognitive functioning of LMD patients before treatment and to determine if measurement of cognitive functioning could be used to predict survival time. METHODS:Thirty-seven subjects with LMD were administered the Mattis Dementia Rating Scale (DRS) before they received treatment and statistical analyses were performed. RESULTS:The Conceptualization subtest of the DRS was the most sensitive to disease course. It was the only individual subtest to predict survival and it was the most impaired subtest across individual subjects. These results support earlier findings of a frontal-subcortical pattern of dysfunction in LMD patients. Cognitive performance at time of LMD diagnosis predicts survival time. Age and clinical status, two factors often correlated with survival in the cancer literature, did not predict survival time for our LMD population. In addition, there were no correlations between survival time and previous medical history or demographic factors. CONCLUSIONS:Neuropsychological assessment appears to be a valuable tool both for tracking disease course over time and for predicting survival of patients.
journal_name
Cancerjournal_title
Cancerauthors
Sherman AM,Jaeckle K,Meyers CAdoi
10.1002/cncr.10816subject
Has Abstractpub_date
2002-09-15 00:00:00pages
1311-6issue
6eissn
0008-543Xissn
1097-0142journal_volume
95pub_type
杂志文章相关文献
CANCER文献大全abstract::The effectiveness of combined modality therapy was studied in 29 patients with metastatic extradural spinal tumor who had had a previous diagnosis of malignancy. Dexamethasone was begun upon suspicion of the diagnosis in a dose of 40 mg daily. Following emergency myelography, in all patients without rapid progression,...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(197711)40:5<2067::aid-cncr282040
更新日期:1977-11-01 00:00:00
abstract::This study is based on 38 patients, each of whom had a malignant lymphoma in which the gonad was the site of the main tumor mass at the time of diagnosis. Histiocytic lymphoma was the predominant type in the 27 male patients; in the 11 female patients, poorly differentiated lymphocytic lymphoma was the most frequent t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800201)45:3<561::aid-cncr28204
更新日期:1980-02-01 00:00:00
abstract::While using the natural killer (NK) cell-associated HNK-1 antibody in a panel of hematopoietic cell markers, the authors found that metastatic tumor cells in the bone marrow of a patient with disseminated prostatic carcinoma stained strongly with this antibody using an indirect immunofluorescence technique. More than ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850715)56:2<289::aid-cncr28205
更新日期:1985-07-15 00:00:00
abstract:BACKGROUND:The experience of one institution in treating soft tissue sarcomas of the head and neck in a pediatric population is presented. METHODS:Case materials of 134 patients younger than 20 years who were referred to the University of Texas M. D. Anderson Cancer Center between 1970 and 1989 for treatment of sarcom...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960101)77:1<193::AID-CNC
更新日期:1996-01-01 00:00:00
abstract::Serum trace elements (STE) were measured in 50 patients with chronic lymphocytic leukemia (CLL) and 100 normal subjects. Copper was higher in patients than in controls (1.50 +/- 0.06 versus 1.10 +/- 0.02 micrograms/ml, P less than 0.001), increased steadily from Stage 0 to Stage 4 (P = 0.002), and correlated with the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19871015)60:8<1842::aid-cncr2820
更新日期:1987-10-15 00:00:00
abstract:BACKGROUND:Filanesib (ARRY-520) is a highly selective inhibitor of kinesin spindle protein, which has demonstrated preclinical antimyeloma activity. METHODS:This open-label Phase 1/2 study determined the maximum tolerated dose of Filanesib administered on Days 1 and 2 of 14-Day Cycles in patients with multiple myeloma...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30892
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Childhood cancer is a highly curable disease when timely diagnosis and appropriate therapy are provided. A negative impact of the coronavirus disease 2019 (COVID-19) pandemic on access to care for children with cancer is likely but has not been evaluated. METHODS:A 34-item survey focusing on barriers to ped...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33075
更新日期:2020-09-15 00:00:00
abstract:BACKGROUND:Evidence of racial disparities in the receipt of postmastectomy breast reconstruction is well documented. The objective of this study was to describe trends in racial disparities overall and by reconstructive technique. METHODS:The American College of Surgeons National Surgical Quality Improvement Program d...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31395
更新日期:2018-07-01 00:00:00
abstract::Adrenal involvement in the course of a non-Hodgkin's lymphoma (NHL) appears to occur relatively often, but only seven cases of NHL-induced adrenal insufficiency were found in a recent review of the literature. The authors report four cases of hypoadrenalism in 127 patients treated for NHL; the cases were staged and cl...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920501)69:9<2333::aid-cncr2820
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:There is an increasing number of articles regarding the long term follow-up of Papanicolaou (Pap) smears with the diagnosis of atypical squamous cells of undetermined significance (ASCUS). Much controversy exists regarding the management of patients with this diagnosis. In a prior study in 1992, the authors ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19971225)81:6<348::aid-cnc
更新日期:1997-12-25 00:00:00
abstract:BACKGROUND:Sixty percent of patients with stage IV melanoma may develop brain metastases, which result in significantly increased morbidity and a poor overall prognosis. Phase 3 studies of melanoma usually exclude patients with untreated brain metastases; therefore, clinical data for intracranial responses to treatment...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32547
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Although cervical carcinoma incidence and mortality rates have declined in the U.S. greatly since the introduction of the Papanicolaou smear, this decline has not been uniform for all histologic subtypes. Therefore, the authors assessed the differential incidence rates of squamous cell carcinoma (SCC) and ad...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20064
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Splenic and nodal marginal zone lymphomas (MZL) are subtypes of marginal zone-derived neoplasms. Due to their rarity, little is known concerning their relation, pattern of dissemination, and treatment outcome. METHODS:The authors analyzed the clinicopathologic features and outcome of 43 patients (34 patient...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11893
更新日期:2004-01-01 00:00:00
abstract::The presentation, growth patterns, and response to therapy of 11 consecutive children with choroid plexus carcinomas were analyzed, and the results were compared with the outcome reported in other series. Patients were a median of 26 months of age at diagnosis. Two patients had thalamic tumors, one had a posterior fos...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19920115)69:2<580::aid-cncr28206
更新日期:1992-01-15 00:00:00
abstract::Elevated circulating CEA levels occur in patients with benign gastrointestinal and hepatic disorders. These are usually less than 10 ng/ml. Of clinical importance is the influence of liver disease on the interpretation of CEA. At least 50% of patients with severe benign hepatic disease have elevated CEA levels, most o...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197809)42:3+<1412::aid-cncr28204
更新日期:1978-09-01 00:00:00
abstract:BACKGROUND:In the United States, detection of squamous carcinoma in situ (CIS) by screening has led to reduced rates for invasive squamous carcinoma and lower mortality. Adenocarcinoma in situ (AIS) rates also have increased, but invasive cervical adenocarcinoma rates have not declined similarly. To make inferences abo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20877
更新日期:2005-03-15 00:00:00
abstract:BACKGROUND:It is unclear whether palliative endourologic or percutaneous urinary diversion in the treatment of advanced cancer provides significant improvement in quality or duration of life. The purpose of this study was to evaluate survival and performance status after endourologic palliative urinary diversion in pat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990215)85:4<998::aid-cnc
更新日期:1999-02-15 00:00:00
abstract::The Gastrointestinal Tumor Study Group performed a two-stage trial of alpha-2B interferon in 30 hepatocellular carcinoma patients. Two patients did not receive the treatment and are not considered in the analysis. Only two (7%) short-lived objective responses were observed and the median survival time was 22 weeks. To...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19900701)66:1<135::aid-cncr28206
更新日期:1990-07-01 00:00:00
abstract::High-dose multiagent chemotherapy followed by autologous marrow rescue was used in the treatment of 13 patients with Stage III or IV childhood tumors. Encouraging results are being obtained in abdominal lymphoma (1/3 complete remissions (CR); rhabdomyosarcoma (2/4 CR); and retinoblastoma (1/2 CR). In neuroblastoma, th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820201)49:3<603::aid-cncr28204
更新日期:1982-02-01 00:00:00
abstract:BACKGROUND:Standard therapy for advanced head and neck carcinoma is surgery and radiation, and the subsequent 5-year survival with this treatment has been less than 50%. New combined modality treatment strategies are being tested to improve survival. New chemotherapy combinations are being developed and administered si...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1997-05-15 00:00:00
abstract::Ten consecutive diffuse histiocytic lymphoma (DHL) cell lines established in our laboratory were studied for the presence of Epstein-Barr virus (EBV) genomes, lysozyme, nonspecific esterase and other cytochemical reactions, phagocytic activity, cytoplasmic immunoglobulin light and heavy chains, and surface receptors t...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197811)42:5<2379::aid-cncr282042
更新日期:1978-11-01 00:00:00
abstract:BACKGROUND:Quality of life (QOL) issues in patients with head and neck carcinoma are of importance beyond the incidence of these tumors because of the impact of the disease and its treatment on external appearance and function of the upper aerodigestive tract. Nasopharyngeal carcinoma (NPC) patients comprise a unique s...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2002-02-15 00:00:00
abstract:BACKGROUND:Factors contributing to the lower likelihood of urologist follow-up among African American (AA) men diagnosed with prostate cancer may not be strictly related to patient factors. The authors investigated the relationship between crime, poverty, and poor housing, among others, and postdiagnosis urologist visi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28894
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:The altered and anomalous expression of carbohydrate antigens (CA) occur in patients with lung carcinomas. METHODS:To investigate the relationship between prognosis and immunohistochemical findings of CA in serum and pulmonary adenocarcinomas (PA), PA specimens surgically resected from 102 patients were stu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930901)72:5<1581::aid-cncr2820
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:The objective of this study was to compare findings after a cytologic report of low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion (LSIL-H) with findings after a report of low-grade squamous intraepithelial lesion (LSIL). METHODS:A review of patient records ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23984
更新日期:2008-12-25 00:00:00
abstract:BACKGROUND:Initial clinic studies revealed that the overexpression of proline-directed protein kinase F(A) (PDPK F(A)) is associated conversely with various stages of tumor tissue differentiation. However, the role of overexpressed PDPK F(A) in tumor cell differentiation remains unknown and needs to be established. In ...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND:The objectives of this study were to investigate outcome prediction by measuring absolute tumor volume and regression ratios using serial magnetic resonance imaging (MRI) during radiation therapy (RT) for cervical cancer and to develop algorithms capable of identifying patients at risk of a poor therapeutic ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25260
更新日期:2010-11-01 00:00:00
abstract::A previous study evaluated two types of endometrial carcinoma: one with, the other without, associated adenomatous hyperplasia (Groups 1 and 2, respectively). On the basis of histologic observations, the study concluded that Group 1 tumors were likely to be estrogen-dependent, whereas Group 2 tumors appeared to repres...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860401)57:7<1385::aid-cncr2820
更新日期:1986-04-01 00:00:00
abstract:BACKGROUND:Children receiving immunosuppressive treatment for cancer are at high risk for invasive pneumococcal disease. The 13-valent pneumococcal conjugate vaccine (PCV13) can prevent pneumococcal disease in healthy children; however, there is an absence of literature regarding the benefit of PCV13 in immunocompromis...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30764
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Questions have existed as to whether residential segregation is a mediator of racial/ethnic disparities in breast cancer care and breast cancer mortality, or has a differential effect by race/ethnicity. METHODS:Data from the Surveillance, Epidemiology, and End Results-Medicare database on white, black, and ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23828
更新日期:2008-10-15 00:00:00