Pretreatment cognitive performance predicts survival in patients with leptomeningeal disease.

Abstract:

BACKGROUND:Leptomeningeal disease (LMD) involves the spread of malignant cells from solid tumors to the cerebrospinal fluid or to the leptomeninges. LMD has a very poor prognosis and it is difficult to diagnose and follow with traditional diagnostic tools. The purposes of this study were to characterize cognitive functioning of LMD patients before treatment and to determine if measurement of cognitive functioning could be used to predict survival time. METHODS:Thirty-seven subjects with LMD were administered the Mattis Dementia Rating Scale (DRS) before they received treatment and statistical analyses were performed. RESULTS:The Conceptualization subtest of the DRS was the most sensitive to disease course. It was the only individual subtest to predict survival and it was the most impaired subtest across individual subjects. These results support earlier findings of a frontal-subcortical pattern of dysfunction in LMD patients. Cognitive performance at time of LMD diagnosis predicts survival time. Age and clinical status, two factors often correlated with survival in the cancer literature, did not predict survival time for our LMD population. In addition, there were no correlations between survival time and previous medical history or demographic factors. CONCLUSIONS:Neuropsychological assessment appears to be a valuable tool both for tracking disease course over time and for predicting survival of patients.

journal_name

Cancer

journal_title

Cancer

authors

Sherman AM,Jaeckle K,Meyers CA

doi

10.1002/cncr.10816

subject

Has Abstract

pub_date

2002-09-15 00:00:00

pages

1311-6

issue

6

eissn

0008-543X

issn

1097-0142

journal_volume

95

pub_type

杂志文章

相关文献

CANCER文献大全
  • Combined therapy for metastatic extradural tumors of the spine.

    abstract::The effectiveness of combined modality therapy was studied in 29 patients with metastatic extradural spinal tumor who had had a previous diagnosis of malignancy. Dexamethasone was begun upon suspicion of the diagnosis in a dose of 40 mg daily. Following emergency myelography, in all patients without rapid progression,...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(197711)40:5<2067::aid-cncr282040

    authors: Marshall LF,Langfitt TW

    更新日期:1977-11-01 00:00:00

  • Malignant lymphoma with primary manifestation in the gonad: a clinicopathologic study of 38 patients.

    abstract::This study is based on 38 patients, each of whom had a malignant lymphoma in which the gonad was the site of the main tumor mass at the time of diagnosis. Histiocytic lymphoma was the predominant type in the 27 male patients; in the 11 female patients, poorly differentiated lymphocytic lymphoma was the most frequent t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800201)45:3<561::aid-cncr28204

    authors: Paladugu RR,Bearman RM,Rappaport H

    更新日期:1980-02-01 00:00:00

  • The natural-killer-cell-associated HNK-1 (Leu-7) antibody reacts with hypertrophic and malignant prostatic epithelium.

    abstract::While using the natural killer (NK) cell-associated HNK-1 antibody in a panel of hematopoietic cell markers, the authors found that metastatic tumor cells in the bone marrow of a patient with disseminated prostatic carcinoma stained strongly with this antibody using an indirect immunofluorescence technique. More than ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850715)56:2<289::aid-cncr28205

    authors: Rusthoven JJ,Robinson JB,Kolin A,Pinkerton PH

    更新日期:1985-07-15 00:00:00

  • Soft tissue sarcoma of the head and neck in children and adolescents.

    abstract:BACKGROUND:The experience of one institution in treating soft tissue sarcomas of the head and neck in a pediatric population is presented. METHODS:Case materials of 134 patients younger than 20 years who were referred to the University of Texas M. D. Anderson Cancer Center between 1970 and 1989 for treatment of sarcom...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960101)77:1<193::AID-CNC

    authors: Lyos AT,Goepfert H,Luna MA,Jaffe N,Malpica A

    更新日期:1996-01-01 00:00:00

  • Observations of serum trace elements in chronic lymphocytic leukemia.

    abstract::Serum trace elements (STE) were measured in 50 patients with chronic lymphocytic leukemia (CLL) and 100 normal subjects. Copper was higher in patients than in controls (1.50 +/- 0.06 versus 1.10 +/- 0.02 micrograms/ml, P less than 0.001), increased steadily from Stage 0 to Stage 4 (P = 0.002), and correlated with the ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19871015)60:8<1842::aid-cncr2820

    authors: Beguin Y,Brasseur F,Weber G,Bury J,Delbrouck JM,Roelandts I,Robaye G,Fillet G

    更新日期:1987-10-15 00:00:00

  • A Phase 1 and 2 study of Filanesib alone and in combination with low-dose dexamethasone in relapsed/refractory multiple myeloma.

    abstract:BACKGROUND:Filanesib (ARRY-520) is a highly selective inhibitor of kinesin spindle protein, which has demonstrated preclinical antimyeloma activity. METHODS:This open-label Phase 1/2 study determined the maximum tolerated dose of Filanesib administered on Days 1 and 2 of 14-Day Cycles in patients with multiple myeloma...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30892

    authors: Shah JJ,Kaufman JL,Zonder JA,Cohen AD,Bensinger WI,Hilder BW,Rush SA,Walker DH,Tunquist BJ,Litwiler KS,Ptaszynski M,Orlowski RZ,Lonial S

    更新日期:2017-12-01 00:00:00

  • Impact of the coronavirus disease 2019 (COVID-19) pandemic on pediatric oncology care in the Middle East, North Africa, and West Asia region: A report from the Pediatric Oncology East and Mediterranean (POEM) group.

    abstract:BACKGROUND:Childhood cancer is a highly curable disease when timely diagnosis and appropriate therapy are provided. A negative impact of the coronavirus disease 2019 (COVID-19) pandemic on access to care for children with cancer is likely but has not been evaluated. METHODS:A 34-item survey focusing on barriers to ped...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33075

    authors: Saab R,Obeid A,Gachi F,Boudiaf H,Sargsyan L,Al-Saad K,Javakhadze T,Mehrvar A,Abbas SS,Abed Al-Agele YS,Al-Haddad S,Al Ani MH,Al-Sweedan S,Al Kofide A,Jastaniah W,Khalifa N,Bechara E,Baassiri M,Noun P,El-Houdzi J,K

    更新日期:2020-09-15 00:00:00

  • Racial disparities in postmastectomy breast reconstruction: National trends in utilization from 2005 to 2014.

    abstract:BACKGROUND:Evidence of racial disparities in the receipt of postmastectomy breast reconstruction is well documented. The objective of this study was to describe trends in racial disparities overall and by reconstructive technique. METHODS:The American College of Surgeons National Surgical Quality Improvement Program d...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31395

    authors: Epstein S,Tran BN,Cohen JB,Lin SJ,Singhal D,Lee BT

    更新日期:2018-07-01 00:00:00

  • Non-Hodgkin's lymphoma presenting with primary adrenal insufficiency. A disease with an underestimated frequency?

    abstract::Adrenal involvement in the course of a non-Hodgkin's lymphoma (NHL) appears to occur relatively often, but only seven cases of NHL-induced adrenal insufficiency were found in a recent review of the literature. The authors report four cases of hypoadrenalism in 127 patients treated for NHL; the cases were staged and cl...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920501)69:9<2333::aid-cncr2820

    authors: Gamelin E,Beldent V,Rousselet MC,Rieux D,Rohmer V,Ifrah N,Boasson M,Bigorgne JC

    更新日期:1992-05-01 00:00:00

  • Atypical squamous cells of undetermined significance: a comparative review of original and automated rescreen diagnosis of cervicovaginal smears with long term follow-up.

    abstract:BACKGROUND:There is an increasing number of articles regarding the long term follow-up of Papanicolaou (Pap) smears with the diagnosis of atypical squamous cells of undetermined significance (ASCUS). Much controversy exists regarding the management of patients with this diagnosis. In a prior study in 1992, the authors ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19971225)81:6<348::aid-cnc

    authors: Stastny JF,Remmers RE,London WB,Pedigo MA,Cahill LA,Ryan M,Frable WJ

    更新日期:1997-12-25 00:00:00

  • Intracranial antitumor activity with encorafenib plus binimetinib in patients with melanoma brain metastases: A case series.

    abstract:BACKGROUND:Sixty percent of patients with stage IV melanoma may develop brain metastases, which result in significantly increased morbidity and a poor overall prognosis. Phase 3 studies of melanoma usually exclude patients with untreated brain metastases; therefore, clinical data for intracranial responses to treatment...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32547

    authors: Holbrook K,Lutzky J,Davies MA,Davis JM,Glitza IC,Amaria RN,Diab A,Patel SP,Amin A,Tawbi H

    更新日期:2020-02-01 00:00:00

  • Cervical adenocarcinoma and squamous cell carcinoma incidence trends among white women and black women in the United States for 1976-2000.

    abstract:BACKGROUND:Although cervical carcinoma incidence and mortality rates have declined in the U.S. greatly since the introduction of the Papanicolaou smear, this decline has not been uniform for all histologic subtypes. Therefore, the authors assessed the differential incidence rates of squamous cell carcinoma (SCC) and ad...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20064

    authors: Wang SS,Sherman ME,Hildesheim A,Lacey JV Jr,Devesa S

    更新日期:2004-03-01 00:00:00

  • Splenic and nodal marginal zone lymphomas are indolent disorders at high hepatitis C virus seroprevalence with distinct presenting features but similar morphologic and phenotypic profiles.

    abstract:BACKGROUND:Splenic and nodal marginal zone lymphomas (MZL) are subtypes of marginal zone-derived neoplasms. Due to their rarity, little is known concerning their relation, pattern of dissemination, and treatment outcome. METHODS:The authors analyzed the clinicopathologic features and outcome of 43 patients (34 patient...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11893

    authors: Arcaini L,Paulli M,Boveri E,Vallisa D,Bernuzzi P,Orlandi E,Incardona P,Brusamolino E,Passamonti F,Burcheri S,Schena C,Pascutto C,Cavanna L,Magrini U,Lazzarino M

    更新日期:2004-01-01 00:00:00

  • Choroid plexus carcinoma of childhood.

    abstract::The presentation, growth patterns, and response to therapy of 11 consecutive children with choroid plexus carcinomas were analyzed, and the results were compared with the outcome reported in other series. Patients were a median of 26 months of age at diagnosis. Two patients had thalamic tumors, one had a posterior fos...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19920115)69:2<580::aid-cncr28206

    authors: Packer RJ,Perilongo G,Johnson D,Sutton LN,Vezina G,Zimmerman RA,Ryan J,Reaman G,Schut L

    更新日期:1992-01-15 00:00:00

  • Carcinoembryonic antigen (CEA) levels in benign gastrointestinal disease states.

    abstract::Elevated circulating CEA levels occur in patients with benign gastrointestinal and hepatic disorders. These are usually less than 10 ng/ml. Of clinical importance is the influence of liver disease on the interpretation of CEA. At least 50% of patients with severe benign hepatic disease have elevated CEA levels, most o...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197809)42:3+<1412::aid-cncr28204

    authors: Loewenstein MS,Zamcheck N

    更新日期:1978-09-01 00:00:00

  • Mortality trends for cervical squamous and adenocarcinoma in the United States. Relation to incidence and survival.

    abstract:BACKGROUND:In the United States, detection of squamous carcinoma in situ (CIS) by screening has led to reduced rates for invasive squamous carcinoma and lower mortality. Adenocarcinoma in situ (AIS) rates also have increased, but invasive cervical adenocarcinoma rates have not declined similarly. To make inferences abo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20877

    authors: Sherman ME,Wang SS,Carreon J,Devesa SS

    更新日期:2005-03-15 00:00:00

  • Outcome of palliative urinary diversion in the treatment of advanced malignancies.

    abstract:BACKGROUND:It is unclear whether palliative endourologic or percutaneous urinary diversion in the treatment of advanced cancer provides significant improvement in quality or duration of life. The purpose of this study was to evaluate survival and performance status after endourologic palliative urinary diversion in pat...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19990215)85:4<998::aid-cnc

    authors: Shekarriz B,Shekarriz H,Upadhyay J,Banerjee M,Becker H,Pontes JE,Wood DP Jr

    更新日期:1999-02-15 00:00:00

  • A prospective trial of recombinant human interferon alpha 2B in previously untreated patients with hepatocellular carcinoma. The Gastrointestinal Tumor Study Group.

    abstract::The Gastrointestinal Tumor Study Group performed a two-stage trial of alpha-2B interferon in 30 hepatocellular carcinoma patients. Two patients did not receive the treatment and are not considered in the analysis. Only two (7%) short-lived objective responses were observed and the median survival time was 22 weeks. To...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19900701)66:1<135::aid-cncr28206

    authors:

    更新日期:1990-07-01 00:00:00

  • Autologous bone marrow rescue in the treatment of advanced tumors of childhood.

    abstract::High-dose multiagent chemotherapy followed by autologous marrow rescue was used in the treatment of 13 patients with Stage III or IV childhood tumors. Encouraging results are being obtained in abdominal lymphoma (1/3 complete remissions (CR); rhabdomyosarcoma (2/4 CR); and retinoblastoma (1/2 CR). In neuroblastoma, th...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820201)49:3<603::aid-cncr28204

    authors: Ekert H,Ellis WM,Waters KD,Tauro GP

    更新日期:1982-02-01 00:00:00

  • A phase I report of paclitaxel dose escalation combined with a fixed dose of carboplatin in the treatment of head and neck carcinoma.

    abstract:BACKGROUND:Standard therapy for advanced head and neck carcinoma is surgery and radiation, and the subsequent 5-year survival with this treatment has been less than 50%. New combined modality treatment strategies are being tested to improve survival. New chemotherapy combinations are being developed and administered si...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:

    authors: Dunphy FR,Boyd JH,Kim HJ,Dunphy CH,Harrison BR,Dunleavy TL,Rodriguez JJ,McDonough EM,Minster JR,Hilton JG

    更新日期:1997-05-15 00:00:00

  • Biology of the human malignant lymphomas. IV. Functional characterization of ten diffuse histiocytic lymphoma cell lines.

    abstract::Ten consecutive diffuse histiocytic lymphoma (DHL) cell lines established in our laboratory were studied for the presence of Epstein-Barr virus (EBV) genomes, lysozyme, nonspecific esterase and other cytochemical reactions, phagocytic activity, cytoplasmic immunoglobulin light and heavy chains, and surface receptors t...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197811)42:5<2379::aid-cncr282042

    authors: Epstein AL,Levy R,Kim H,Henle W,Henle G,Kaplan HS

    更新日期:1978-11-01 00:00:00

  • Quality of life of nasopharyngeal carcinoma patients.

    abstract:BACKGROUND:Quality of life (QOL) issues in patients with head and neck carcinoma are of importance beyond the incidence of these tumors because of the impact of the disease and its treatment on external appearance and function of the upper aerodigestive tract. Nasopharyngeal carcinoma (NPC) patients comprise a unique s...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Talmi YP,Horowitz Z,Bedrin L,Wolf M,Chaushu G,Kronenberg J,Pfeffer MR

    更新日期:2002-02-15 00:00:00

  • Racial disparities in urologist visits among elderly men with prostate cancer: a cohort analysis of patient-related and county of residence-related factors.

    abstract:BACKGROUND:Factors contributing to the lower likelihood of urologist follow-up among African American (AA) men diagnosed with prostate cancer may not be strictly related to patient factors. The authors investigated the relationship between crime, poverty, and poor housing, among others, and postdiagnosis urologist visi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28894

    authors: Onukwugha E,Osteen P,Jayasekera J,Mullins CD,Mair CA,Hussain A

    更新日期:2014-11-01 00:00:00

  • Expression of carbohydrate antigens in human pulmonary adenocarcinoma.

    abstract:BACKGROUND:The altered and anomalous expression of carbohydrate antigens (CA) occur in patients with lung carcinomas. METHODS:To investigate the relationship between prognosis and immunohistochemical findings of CA in serum and pulmonary adenocarcinomas (PA), PA specimens surgically resected from 102 patients were stu...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930901)72:5<1581::aid-cncr2820

    authors: Kawai T,Suzuki M,Kase K,Ozeki Y

    更新日期:1993-09-01 00:00:00

  • Pathology correlates of a Papanicolaou diagnosis of low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion.

    abstract:BACKGROUND:The objective of this study was to compare findings after a cytologic report of low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion (LSIL-H) with findings after a report of low-grade squamous intraepithelial lesion (LSIL). METHODS:A review of patient records ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23984

    authors: Al-Nourhji O,Beckmann MJ,Markwell SJ,Massad LS

    更新日期:2008-12-25 00:00:00

  • Suppression of proline-directed protein kinase F(A) expression potentiates erythroid differentiation of human myeloid leukemia cells.

    abstract:BACKGROUND:Initial clinic studies revealed that the overexpression of proline-directed protein kinase F(A) (PDPK F(A)) is associated conversely with various stages of tumor tissue differentiation. However, the role of overexpressed PDPK F(A) in tumor cell differentiation remains unknown and needs to be established. In ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Hsu CP,Yang CC,Yang SD

    更新日期:2000-09-01 00:00:00

  • Sequential magnetic resonance imaging of cervical cancer: the predictive value of absolute tumor volume and regression ratio measured before, during, and after radiation therapy.

    abstract:BACKGROUND:The objectives of this study were to investigate outcome prediction by measuring absolute tumor volume and regression ratios using serial magnetic resonance imaging (MRI) during radiation therapy (RT) for cervical cancer and to develop algorithms capable of identifying patients at risk of a poor therapeutic ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25260

    authors: Wang JZ,Mayr NA,Zhang D,Li K,Grecula JC,Montebello JF,Lo SS,Yuh WT

    更新日期:2010-11-01 00:00:00

  • Progesterone receptors in two groups of endometrial carcinoma.

    abstract::A previous study evaluated two types of endometrial carcinoma: one with, the other without, associated adenomatous hyperplasia (Groups 1 and 2, respectively). On the basis of histologic observations, the study concluded that Group 1 tumors were likely to be estrogen-dependent, whereas Group 2 tumors appeared to repres...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860401)57:7<1385::aid-cncr2820

    authors: Deligdisch L,Holinka CF

    更新日期:1986-04-01 00:00:00

  • Immunogenicity and safety of single-dose, 13-valent pneumococcal conjugate vaccine in pediatric and adolescent oncology patients.

    abstract:BACKGROUND:Children receiving immunosuppressive treatment for cancer are at high risk for invasive pneumococcal disease. The 13-valent pneumococcal conjugate vaccine (PCV13) can prevent pneumococcal disease in healthy children; however, there is an absence of literature regarding the benefit of PCV13 in immunocompromis...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30764

    authors: Hung TY,Kotecha RS,Blyth CC,Steed SK,Thornton RB,Ryan AL,Cole CH,Richmond PC

    更新日期:2017-11-01 00:00:00

  • Racial segregation and disparities in breast cancer care and mortality.

    abstract:BACKGROUND:Questions have existed as to whether residential segregation is a mediator of racial/ethnic disparities in breast cancer care and breast cancer mortality, or has a differential effect by race/ethnicity. METHODS:Data from the Surveillance, Epidemiology, and End Results-Medicare database on white, black, and ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23828

    authors: Haas JS,Earle CC,Orav JE,Brawarsky P,Keohane M,Neville BA,Williams DR

    更新日期:2008-10-15 00:00:00