Abstract:
:Adrenal involvement in the course of a non-Hodgkin's lymphoma (NHL) appears to occur relatively often, but only seven cases of NHL-induced adrenal insufficiency were found in a recent review of the literature. The authors report four cases of hypoadrenalism in 127 patients treated for NHL; the cases were staged and classified according to the Working Formulation and were investigated for endocrine function by the cosyntropin stimulation test. The involvement was bilateral in four patients; all of the patients had high grade, mostly widespread NHL. These observations suggest that adrenal insufficiency may be underestimated in NHL. Basal hormonal serum levels may be borderline; consequently, only stimulation tests can prove the hormonal failure. The authors suggest that such tests are essential if the staging of the NHL shows bilateral adrenal enlargement, and that the tests should be performed before chemotherapy begins because of the risk of acute adrenal insufficiency.
journal_name
Cancerjournal_title
Cancerauthors
Gamelin E,Beldent V,Rousselet MC,Rieux D,Rohmer V,Ifrah N,Boasson M,Bigorgne JCdoi
10.1002/1097-0142(19920501)69:9<2333::aid-cncr2820subject
Has Abstractpub_date
1992-05-01 00:00:00pages
2333-6issue
9eissn
0008-543Xissn
1097-0142journal_volume
69pub_type
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