Non-Hodgkin's lymphoma presenting with primary adrenal insufficiency. A disease with an underestimated frequency?

Abstract:

:Adrenal involvement in the course of a non-Hodgkin's lymphoma (NHL) appears to occur relatively often, but only seven cases of NHL-induced adrenal insufficiency were found in a recent review of the literature. The authors report four cases of hypoadrenalism in 127 patients treated for NHL; the cases were staged and classified according to the Working Formulation and were investigated for endocrine function by the cosyntropin stimulation test. The involvement was bilateral in four patients; all of the patients had high grade, mostly widespread NHL. These observations suggest that adrenal insufficiency may be underestimated in NHL. Basal hormonal serum levels may be borderline; consequently, only stimulation tests can prove the hormonal failure. The authors suggest that such tests are essential if the staging of the NHL shows bilateral adrenal enlargement, and that the tests should be performed before chemotherapy begins because of the risk of acute adrenal insufficiency.

journal_name

Cancer

journal_title

Cancer

authors

Gamelin E,Beldent V,Rousselet MC,Rieux D,Rohmer V,Ifrah N,Boasson M,Bigorgne JC

doi

10.1002/1097-0142(19920501)69:9<2333::aid-cncr2820

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

2333-6

issue

9

eissn

0008-543X

issn

1097-0142

journal_volume

69

pub_type

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