Abstract:
BACKGROUND:The experience of one institution in treating soft tissue sarcomas of the head and neck in a pediatric population is presented. METHODS:Case materials of 134 patients younger than 20 years who were referred to the University of Texas M. D. Anderson Cancer Center between 1970 and 1989 for treatment of sarcoma of the head and neck were retrospectively reviewed. Patients with rhabdomyosarcoma underwent multimodality treatment consisting of surgery, irradiation, and chemotherapy. Wide resection was the treatment used for patients with nonrhabdomyosarcomatous soft tissue sarcomas (NRSTS). Adjuvant chemotherapy and irradiation were used to treat high grade neoplasms and residual disease. The clinical response to therapy was measured in terms of the disease-specific survival rate. RESULTS:Seventy-nine of 134 patients presented with untreated or biopsy-proven disease. Fifty-six had rhabdomyosarcoma and 23 had NRSTS:At 2 and 5 years, the disease-specific survival rates for patients with rhabdomyosarcoma were 74% and 63%, respectively, and patients with NRSTS had 80% and 75% disease-specific survival rates at 2 and 5 years, respectively. CONCLUSIONS:Rhabdomyosarcoma of the head and neck in children is effectively treated with multimodality therapy. Prognostic indicators for rhabdomyosarcoma include completeness of tumor resection and the development of recurrent disease. Aggressive surgical resection is the treatment of choice for patients with NRSTS:Prognostic indicators for NRSTS include completeness of tumor resection and the development of recurrent disease.
journal_name
Cancerjournal_title
Cancerauthors
Lyos AT,Goepfert H,Luna MA,Jaffe N,Malpica Adoi
10.1002/(SICI)1097-0142(19960101)77:1<193::AID-CNCsubject
Has Abstractpub_date
1996-01-01 00:00:00pages
193-200issue
1eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(19960101)77:1<193::AID-CNCjournal_volume
77pub_type
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