Abstract:
BACKGROUND:The authors tested a biotherapy regimen involving recombinant interferon-alpha-2a (rIFN-alpha-2a) and recombinant human interleukin-2 (rhIL-2), given in a "decrescendo" schedule over 5 days, for its activity and toxicity in 21 patients who previously had received chemotherapy for advanced melanoma. METHODS:Patients (15 men and 6 women) were given intravenous rhIL-2 at a dose of 18 MIU/m(2) over 6 hours, followed by 18 MIU/m(2) over 12 hours, then 18 MIU/m(2) over 24 hours, and finally 4.5 MIU/m(2)/day for 3 consecutive days. rIFN-alpha-2a (10 MIU/m(2)) was given subcutaneously on Days 1-5. Courses were repeated every 4 weeks. Tumor sites were measured every 8 weeks. Toxicity was recorded using National Cancer Institute Common Toxicity Criteria. RESULTS:No major objective responses were noted. The median number of courses given was two. The median time to progression was 2 months and the median survival was 6 months (range, 2-25 months). However, 2 patients with melanoma involving >/= 2 visceral organs (1 with a high baseline serum lactate dehydrogenase level) and a third with soft tissue metastases achieved durable control of disease and were alive a median of 30+ months later. A fourth patient had a palliative response with reversal of melanosis and a survival of 7 months. This regimen was well tolerated and resulted in no serious long term adverse effects. CONCLUSIONS:The response rate for this regimen was no greater than 10% with Type I and II errors each not exceeding 10%. Nevertheless, occasional durable control of disease and the nonoverlapping toxicity profile with prior chemotherapy support consideration of this regimen in these patients who have limited second-line treatment options.
journal_name
Cancerjournal_title
Cancerauthors
Eton O,Buzaid AC,Bedikian AY,Smith TM,Papadopoulos NE,Ellerhorst JA,Hibberts JL,Legha SS,Benjamin RSsubject
Has Abstractpub_date
2000-04-01 00:00:00pages
1703-9issue
7eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(20000401)88:7<1703::AID-CNjournal_volume
88pub_type
临床试验,杂志文章相关文献
CANCER文献大全abstract::Apart from choriocarcinoma, involvement of the central nervous system (CNS) by gynecologic malignancy is rare. A 10-year retrospective review at the University of Washington Medical Center (Seattle, WA) and Swedish Hospital and Medical Center Tumor Registry (Seattle, WA) identified 14 patients with cerebral metastases...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910415)67:8<2194::aid-cncr2820
更新日期:1991-04-15 00:00:00
abstract:BACKGROUND:Poor prognosis of Stage IV breast cancer patients have at best a 10% 3-year survival rate with conventional chemotherapy. Dose-intensive chemotherapy improved survival rates for some of these patients. METHODS:All patients were Stage IV estrogen receptor-negative or estrogen receptor-positive hormonal refra...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19940415)73:8<2157::aid-cncr2820
更新日期:1994-04-15 00:00:00
abstract:BACKGROUND:Patients with basal cell carcinoma (BCC) demonstrate marked variation in clinical phenotype, suggesting the presence of distinct subgroups. Patients with truncal lesions comprise an interesting subgroup, because, although the pathogenesis of these tumors is unclear, there is evidence to suggest that their de...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010715)92:2<354::aid-cncr1330>
更新日期:2001-07-15 00:00:00
abstract::Neuroblastoma is the most common neoplasm in children less than 1 year of age and has one of the earliest incidence peaks of all childhood cancers. Using birth registration data, a matched case-control study was undertaken to investigate potential prenatal and perinatal risk factors. Ninety-seven neuroblastoma patient...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880601)61:11<2202::aid-cncr282
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND:Seminal vesicle (SV) invasion at the time of radical prostatectomy (RP) generally is considered to be indicative of poor outcome. The authors examined whether there was a subset of men with SV invasion who had long-term prostate-specific antigen (PSA) progression-free survival. METHODS:Data were examined fr...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.20122
更新日期:2004-04-15 00:00:00
abstract:BACKGROUND:Patient navigation may reduce cancer disparities associated with socioeconomic status (SES) and household factors. This study examined whether these factors were associated with delays in diagnostic resolution among patients with cancer screening abnormalities and whether patient navigation ameliorated these...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29612
更新日期:2015-11-15 00:00:00
abstract::A retrospective study of all cases of seminoma treated at Roswell Park Memorial Institute from 1970 through 1979 was conducted. Fifty-six evaluable patients treated initially with radiation therapy were seen during this period, and the overall survival rate at an average follow-up period of 52 months was 82%. The surv...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840401)53:7<1451::aid-cncr2820
更新日期:1984-04-01 00:00:00
abstract::Fourteen patients with advanced salivary gland malignancies were treated with combination chemotherapy. Five of 13 patients responded to cyclophosphamide and adriamycin and two patients in the responding groups underwent further potentially curable treatment, rendering them disease-free. Three patients with mucoepider...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19821201)50:11<2261::aid-cncr282
更新日期:1982-12-01 00:00:00
abstract:BACKGROUND:Biological aging pathways accelerated by cancer treatments may be a mechanism for cognitive impairment in cancer survivors. The goal of the current study was to examine whether indicators of biological aging, namely elevated levels of DNA damage, reduced telomerase enzymatic activity, and shorter peripheral ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31777
更新日期:2019-01-15 00:00:00
abstract::A randomized study was designed to determine the effect of intermittent oral cyclophosphamide on the rate of metastases in children with localized and regional neuroblastoma. Secondary objectives of the study were to determine the value of the proposed staging system, to measure the influence of the peripheral lymphoc...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(197608)38:2<661::aid-cncr2820380
更新日期:1976-08-01 00:00:00
abstract::Myelofibrosis occurs in various hematologic neoplasias, including myelodysplastic syndrome (MDS), with a relatively low incidence. To gain insight into the clinical and cytogenetic implications of MDS patients in whom myelofibrosis develops, statistical analysis was done on 82 primary MDS patients with successful cyto...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910701)68:1<178::aid-cncr28206
更新日期:1991-07-01 00:00:00
abstract::Measurement of the alpha 1 (fast liver) fraction of alkaline phosphatases in the serum for 217 cancer patients, 92 patients with nonmalignant hepatic affections and 131 controls, revealed that the alpha 1 fraction offers better global value (94%), sensitivity (96%), and specificity (93%) than gamma GT or total alkalin...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830701)52:1<140::aid-cncr28205
更新日期:1983-07-01 00:00:00
abstract::The 136 patients who underwent total laryngectomy as the primary treatment for squamous cell carcinoma of the glottis at the Mayo Clinic in 1970 through 1981 were followed by retrospective record review for at least 4 years or until death, local recurrence, neck recurrence, or delayed neck metastasis. Cancer recurred ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890701)64:1<143::aid-cncr28206
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:There is no consistent definition at what age patients with non-Hodgkin lymphoma (NHL) are considered "elderly." This might hamper well balanced decisions with respect to treatment. METHODS:From a population-based NHL registry the age groups younger than 60 years, 60-64 years, 65-69 years, 70-74 years, and ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20001215)89:12<2667::aid-cncr21>
更新日期:2000-12-15 00:00:00
abstract:BACKGROUND:Age-related disparities in colon cancer treatment exist, with older patients being less likely to receive recommended therapy. However, to the authors' knowledge, few studies to date have focused on receipt of surgery. The objective of the current study was to describe patterns of surgery in patients aged ≥ ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27765
更新日期:2013-02-01 00:00:00
abstract::Carcinoembryonic antigen is only a tumor assoicated antigen and is less clinically useful than the original report suggested. However, the CEA assays in clinical use utilize reagents operationally defined by old criteria. There is now abundant evidence that "CEA" consists of a heterogenous family of related glycoprote...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197809)42:3+<1585::aid-cncr28204
更新日期:1978-09-01 00:00:00
abstract:BACKGROUND:The demonstration of the monoclonality of immunoglobulin heavy chain (IgH) gene rearrangement is an indispensable method for the diagnosis of B-cell lymphoma as well as histocytochemical analysis. For the detection of IgH gene rearrangement, the extraction of DNA from a homogenous cell population is necessar...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.11331
更新日期:2003-08-25 00:00:00
abstract:BACKGROUND:African-American (AA) and white patients with early-stage disease who were treated with breast conservation therapy (BCT) were examined to detect differences in clinicopathologic features and outcomes as a function of race. METHODS:Clinical data from the charts of 2164 white and 207 AA patients treated with...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23881
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:Portal vein thrombosis (PVT) is a common complication in patients with advanced-stage hepatocellular carcinoma (HCC). The authors evaluated the impact of radiotherapy (RT) for PVT of HCC and analyzed the dose-response relation between RT and PVT. METHODS:Between March 1995 and December 2003, 59 patients dia...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21043
更新日期:2005-06-01 00:00:00
abstract::Fiberoptic endoscopic examination and biopsy of the nasopharynx was done in 130 patients as a prospective study. They all had elevated titers of antibodies against the viral capsid antigen of Epstein-Barr virus but no symptoms or signs of nasopharyngeal carcinoma. Each underwent a biopsy from six fixed sites in the na...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910615)67:12<3127::aid-cncr282
更新日期:1991-06-15 00:00:00
abstract:BACKGROUND:The current study was conducted to expedite international standardized reporting of bone marrow disease in children with neuroblastoma and to improve equivalence of care. METHODS:A multidisciplinary International Neuroblastoma Response Criteria Bone Marrow Working Group was convened by the US National Cance...
journal_title:Cancer
pub_type: 共识发展会议,杂志文章,评审
doi:10.1002/cncr.30380
更新日期:2017-04-01 00:00:00
abstract::The records of 52 patients younger than 40 years of age who had bronchogenic carcinoma diagnosed between 1965 and 1985 were reviewed. The preponderance of adenocarcinoma (54%), the lower male-female ratio in this age group compared with patients age 40 or older (2:1), the importance of cigarette smoking as a causative...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910301)67:5<1436::aid-cncr2820
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Onycholysis has been reported in association with the use of several noncytotoxic drugs and with chemotherapy in 135 patients. Onycholysis may be precipitated by exposure to ultraviolet radiation. METHODS:The authors studied 91 patients who received paclitaxel and 187 patients who received doxorubicin. RES...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(20000515)88:10<2367::aid-c
更新日期:2000-05-15 00:00:00
abstract:BACKGROUND:Questions have existed as to whether residential segregation is a mediator of racial/ethnic disparities in breast cancer care and breast cancer mortality, or has a differential effect by race/ethnicity. METHODS:Data from the Surveillance, Epidemiology, and End Results-Medicare database on white, black, and ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23828
更新日期:2008-10-15 00:00:00
abstract::Nine years after biopsy and radiation therapy for an extramedullary plasmacytoma of the nasal cavity, a 64-year-old man developed locally recurrent tumor. Repeat biopsy revealed tumor identical in hematoxylin and eosin stain (H & E) appearance to that found originally, leading to the diagnosis of recurrent extramedull...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870701)60:1<88::aid-cncr282060
更新日期:1987-07-01 00:00:00
abstract:BACKGROUND:Squamous cell carcinoma of the esophagus is endemic in parts of South Africa. Previous case-control studies have shown many associations but no clear etiologic pathway has been established. METHODS:A case-control study of dietary and social factors was performed for 130 patient/control pairs matched for age...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract::Racial differences in the risk of cancer of the urinary bladder associated with cigarette smoking and alcohol consumption were examined in a study of 1663 cases (1534 whites and 129 blacks) and 4930 controls matched 3:1 by sex, race, and age to the cases. Significant increases in cancer risk associated with cigarette ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19901215)66:12<2673::aid-cncr282
更新日期:1990-12-15 00:00:00
abstract:BACKGROUND:More cases of bronchogenic carcinoma have been reported in recent years, and these patients are more prone to secondary aspergillosis. However, the frequency of secondary aspergillosis in bronchogenic carcinoma still has not been defined clearly in the literature. METHODS:The current study population was co...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23570
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:The authors undertook a prospective evaluation of the clinical value of 2-fluoro [18-]-2-deoxyglucose positron emission tomography (FDG-PET) in the detection and staging of malignant lymphoma compared with computed tomography (CT) and bone marrow biopsy (BMB). METHODS:Fifty-two consecutive patients with unt...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:2001-03-01 00:00:00
abstract::The potential of using a blood test enumerating oncofetal ferritin-bearing lymphocytes (FBL) as a biomarker for early breast cancer was further explored. Nine hundred women attending a high-risk breast cancer clinic and 2500 normal-risk women were physically examined and their blood drawn for FBL determination using a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890801)64:3<691::aid-cncr28206
更新日期:1989-08-01 00:00:00