Abstract:
BACKGROUND:Patient navigation may reduce cancer disparities associated with socioeconomic status (SES) and household factors. This study examined whether these factors were associated with delays in diagnostic resolution among patients with cancer screening abnormalities and whether patient navigation ameliorated these delays. METHODS:This study analyzed data from 5 of 10 centers of the National Cancer Institute's Patient Navigation Research Program, which collected SES and household data on employment, income, education, housing, marital status, and household composition. The primary outcome was the time to diagnostic resolution after a cancer screening abnormality. Separate adjusted Cox proportional hazard models were fit for each SES and household factor, and an interaction between that factor and the intervention status was included. RESULTS:Among the 3777 participants (1968 in the control arm and 1809 in the navigation intervention arm), 91% were women, and the mean age was 44 years; 43% were Hispanic, 28% were white, and 27% were African American. Within the control arm, the unemployed experienced a longer time to resolution than those employed full-time (hazard ratio [HR], 0.85; P = .02). Renters (HR, 0.81; P = .02) and those with other (ie, unstable) housing (HR, 0.60; P < .001) had delays in comparison with homeowners. Never married (HR, 0.70; P < .001) and previously married participants (HR, 0.85; P = .03) had a longer time to care than married participants. There were no differences in the time to diagnostic resolution with any of these variables within the navigation intervention arm. CONCLUSIONS:Delays in diagnostic resolution exist by employment, housing type, and marital status. Patient navigation eliminated these disparities in the study sample. These findings demonstrate the value of providing patient navigation to patients at high risk for delays in cancer care.
journal_name
Cancerjournal_title
Cancerauthors
Rodday AM,Parsons SK,Snyder F,Simon MA,Llanos AA,Warren-Mears V,Dudley D,Lee JH,Patierno SR,Markossian TW,Sanders M,Whitley EM,Freund KMdoi
10.1002/cncr.29612subject
Has Abstractpub_date
2015-11-15 00:00:00pages
4025-34issue
22eissn
0008-543Xissn
1097-0142journal_volume
121pub_type
杂志文章相关文献
CANCER文献大全abstract::This trial determines the feasibility for patients with resectable Stages III/IV head and neck cancer who achieved a complete response to induction chemotherapy of eliminating surgery from their treatment program. Thirty patients were treated with three cycles of cisplatin and 5-fluorouracil (5-FU), followed by reendo...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19870915)60:6<1178::aid-cncr2820
更新日期:1987-09-15 00:00:00
abstract::The value of image analysis in predicting the malignant potential of oral epithelial lesions showing either hyperplasia or dysplasia was investigated; 5-micron formalin-fixed sections of 16 oral epithelial lesions, of which eight had later transformed to carcinoma and eight had not transformed during a follow-up of 10...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19881101)62:9<1981::aid-cncr2820
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:The aim of the current study was to assess circulating levels of endogenous endostatin in patients with renal carcinoma and to determine the relationship of these levels to circulating levels of vascular endothelial growth factor (VEGF) and prognosis. METHODS:The authors prospectively studied 66 patients (4...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10845
更新日期:2002-10-15 00:00:00
abstract::Seventeen patients were given DTIC, 200 mg/m2/day in five-day courses every four to six weeks. In four patients (stage II) treated on an adjuvant basis, tumor recurrence has been verified in three. Four of the palliatively treated patients were also given DTIC by regional intra-arterial infusion with minimal positive ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800115)45:2<245::aid-cncr28204
更新日期:1980-01-15 00:00:00
abstract::Two published cases of medulloepithelioma, a rare malignant pediatric brain tumor composed of a mixture of primitive neuroepithelium and its differentiated neuronal and glial descendants, were examined by immunohistochemical staining for the presence of growth factors. From a panel of antibodies, those identifying bas...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19910815)68:4<798::aid-cncr28206
更新日期:1991-08-15 00:00:00
abstract:BACKGROUND:Interferon is approved for adjuvant treatment of patients with stage IIB/III melanoma. The identification of predictive markers that would permit selection of patients would be beneficial. Specific human leukocyte antigen (HLA) class I and II antigens have previously shown an association with response to the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25211
更新日期:2010-09-15 00:00:00
abstract:BACKGROUND:Discrimination and trust are known barriers to accessing health care. Despite well-documented racial disparities in the ovarian cancer care continuum, the role of these barriers has not been examined. This study evaluated the association of everyday discrimination and trust in physicians with a prolonged int...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32451
更新日期:2019-12-15 00:00:00
abstract::In estrogen target tissues and hormone-dependent tumors, the steroid enters the cells and binds to a cytoplasmic protein called the estrogen receptor (ER). The steroid-receptor complex then migrates to the nuclei, where it initiates the biochemicial events characteristic of estrogen stimulation. Since ER is absent in ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197508)36:2+<638::aid-cncr282036
更新日期:1975-08-01 00:00:00
abstract:BACKGROUND:Previous research has demonstrated that many lung cancer survivors report difficulties with symptom control and experience a poor quality of life (QOL). Although recent studies have suggested a relationship of single nucleotide polymorphisms (SNPs) in several cytokine genes with cancer susceptibility and pro...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25255
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:This study aimed to evaluate prevalence and risk factors for emotional and behavioral problems in dependent children of cancer patients using a multinational research design. METHODS:The sample comprised 350 ill parents, 250 healthy partners, and 352 children. Parents assessed the child's psychological func...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.24449
更新日期:2009-09-01 00:00:00
abstract::Fiberoptic endoscopic examination and biopsy of the nasopharynx was done in 130 patients as a prospective study. They all had elevated titers of antibodies against the viral capsid antigen of Epstein-Barr virus but no symptoms or signs of nasopharyngeal carcinoma. Each underwent a biopsy from six fixed sites in the na...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910615)67:12<3127::aid-cncr282
更新日期:1991-06-15 00:00:00
abstract::The authors describe two cases of Fournier's gangrene complicating aggressive therapy for hematologic malignancies. Fournier's gangrene is a fulminant necrotizing fasciitis of the scrotum and penis, often with an infectious etiology. Only one prior case has been reported in a patient receiving aggressive chemotherapy ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860615)57:12<2291::aid-cncr282
更新日期:1986-06-15 00:00:00
abstract:BACKGROUND:Carboplatin-based regimens have demonstrated activity in pediatric patients with low-grade glioma (LGG). However, carboplatin hypersensitivity reaction (Cb HSR) represents a common and limiting factor for the continuation of therapy. METHODS:The objectives of this study were to describe the prevalence, char...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.23249
更新日期:2008-02-15 00:00:00
abstract::A number of cases of sinusoidal hematolymphoid malignancy ("malignant histiocytosis") in which early lymph node biopsies have not allowed clear separation from benign histiocytic disorders have been observed. Nine such cases in which only a follow-up lymph node biopsy documented their malignant nature are reported. Se...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861015)58:8<1681::aid-cncr2820
更新日期:1986-10-15 00:00:00
abstract:BACKGROUND:Gastrin-releasing peptide (GRP) is an autocrine growth factor in patients with small cell lung carcinoma (SCLC). The authors developed a reverse transcriptase-polymerase chain reaction (RT-PCR) assay for the detection of SCLC cells in the peripheral blood and the pleural effusion using preproGRP mRNA as a ta...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11378
更新日期:2003-05-15 00:00:00
abstract:BACKGROUND:Leptomeningeal disease (LMD) involves the spread of malignant cells from solid tumors to the cerebrospinal fluid or to the leptomeninges. LMD has a very poor prognosis and it is difficult to diagnose and follow with traditional diagnostic tools. The purposes of this study were to characterize cognitive funct...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10816
更新日期:2002-09-15 00:00:00
abstract:BACKGROUND:The vast majority of soft tissue sarcomas spread initially to the lungs and then to other sites. The lung has been the most carefully monitored organ system during routine surveillance for a metastasis. Liposarcoma is one of the most common soft tissue sarcomas and has been noted to have extrapulmonary sites...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950301)75:5<1120::aid-cncr2820
更新日期:1995-03-01 00:00:00
abstract::Recombinant human granulocyte colony-stimulating factor (rhG-CSF) was administered intraperitoneally in combination with multidrug chemotherapy using methotrexate (M), vinblastine (V), doxorubicin (A), and cisplatin (C, or for the combination, MVAC) to C3H/He mice (5-week-old females) after experimental carcinoma, MBT...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920215)69:4<997::aid-cncr28206
更新日期:1992-02-15 00:00:00
abstract::A clinicopathologic study of 48 cases of pleomorphic lipoma from the files of the Armed Forces Institute of Pathology reveals that this tumor occurs principally in males (83%) in the fifth to seventh decades (mean 57 years) and shows a predilection for the posterior neck, shoulder, and back. Typically, the lesion appe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810101)47:1<126::aid-cncr28204
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Specific kinase activity of the proto-oncogene product pp60(c-src) is reported to be elevated in patients with carcinoma of the colon, and a novel cytoplasmic protein-tyrosine kinase, C-terminal Src kinase (Csk), has been found to inactivate the members of the Src family protein-tyrosine kinase. In this stud...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010701)92:1<61::aid-cncr1292>3
更新日期:2001-07-01 00:00:00
abstract::This report describes a unique palliative approach of radical surgical debridement for uncontrollable, recurrent pelvic tumors ulcerating through the perineum. All conservative treatment attempts with radiotherapy and chemotherapy had failed. Seven patients have been treated with resection of the tumor including a por...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900301)65:5<1111::aid-cncr2820
更新日期:1990-03-01 00:00:00
abstract::In a randomized series of 70 patients with with colo rectal adenocarcinoma, a comparison of systemic 5-fluorouracil chemotherapy administered as a continuous 120-hours infusion vs. intravenous bolus injection daily for 5 days demonstrated superiority of prolonged intravenous infusion. The most striking advantage of pr...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(197507)36:1<123::aid-cncr2820360
更新日期:1975-07-01 00:00:00
abstract:BACKGROUND:The presence of urinary excretion products of human chorionic gonadotropin (hCG) has been proposed as a tumor marker. To ascertain the clinical value in gynecologic cancers, the authors studied 612 nonpregnant women. METHODS:Three different assays in four clinical groups were compared: no disease, benign di...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930615)71:12<4124::aid-cncr282
更新日期:1993-06-15 00:00:00
abstract:BACKGROUND:An open-label Phase II study of oxaliplatin was conducted to evaluate its safety and efficacy in children with recurrent or refractory medulloblastoma (MB), supratentorial primitive neuroectodermal tumors (SPNET), and atypical teratoid rhabdoid tumor (ATRT). METHODS:Patients were stratified as follows: stra...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22241
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:Patients with aggressive non-Hodgkin lymphoma (NHL) require intensive and extensive therapy, which seems impracticable in elderly patients due to hematologic and extrahematologic toxicity. Consequent dose reduction and therapy attenuation can reduce treatment-related toxicity but also decreases therapeutic e...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.11032
更新日期:2003-01-01 00:00:00
abstract::Five cases of squamous cell carcinoma of the cervix associated with widespread squamous cell carcinoma in situ of the endometrial surface are reported. In one case, carcinoma in situ was also found in one fallopian tube in continuity with the cervicoendometrial lesion. A survey of the literature reveals only 20 cases ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197808)42:2<570::aid-cncr2820420
更新日期:1978-08-01 00:00:00
abstract:BACKGROUND:Previous Commission on Cancer studies have examined time trends in stage of disease, treatment patterns, and survival for special populations. Reported herein are the most current National Cancer Data Base data for Hispanics. METHODS:Two Calls for Data have yielded a total of 23,650 cancer reports for Hispa...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19941015)74:8<2386::aid-cncr2820
更新日期:1994-10-15 00:00:00
abstract::The establishment and characterization of 11 human lung cancer cell lines are described in this article. Nine of these cell lines were established over a 5-year period, from 1983 to 1988, from patients treated at the Kingston Regional Cancer Centre. These include eight definite or probable small cell lung cancer (SCLC...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920415)69:8<2064::aid-cncr2820
更新日期:1992-04-15 00:00:00
abstract::Two cases of extraskeletal myxoid chondrosarcoma are reported. The patients presented with metastasis to the lung, 10 years and 2 years, respectively, prior to discovery of the primary neoplasms in the soft tissues of the lower extremities. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860901)58:5<1144::aid-cncr2820
更新日期:1986-09-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to analyze the extent of hypoxia in prostate carcinoma tumors using the Eppendorf pO(2) microelectrode and correlate this with pretreatment characteristics and prognostic factors. METHODS:Custom-made Eppendorf pO(2) microelectrodes were used to obtain pO(2) measurements from th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20001101)89:9<2018::aid-cncr19>3
更新日期:2000-11-01 00:00:00