Abstract:
:This trial determines the feasibility for patients with resectable Stages III/IV head and neck cancer who achieved a complete response to induction chemotherapy of eliminating surgery from their treatment program. Thirty patients were treated with three cycles of cisplatin and 5-fluorouracil (5-FU), followed by reendoscopy and biopsy. Twelve patients achieved a complete pathologic response at the primary and received radiation (interstitial and/or external beam) only. The remainder underwent surgical resection and postoperative radiation. At 2 years, the relapse-free survival was 52%, and the survival was 53% for the entire group. For the 12 complete responders who had surgery eliminated, the relapse-free survival was 60%, and the survival was 70%. This pilot study suggests that for patients with resectable disease who achieve a complete pathologic response to induction chemotherapy at their primary, it is feasible to omit surgery and treat with primary radiation without compromise in survival. This approach warrants further study in a randomized trial.
journal_name
Cancerjournal_title
Cancerauthors
Jacobs C,Goffinet DR,Goffinet L,Kohler M,Fee WEdoi
10.1002/1097-0142(19870915)60:6<1178::aid-cncr2820subject
Has Abstractpub_date
1987-09-15 00:00:00pages
1178-83issue
6eissn
0008-543Xissn
1097-0142journal_volume
60pub_type
临床试验,杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:The objective of this study was to investigate whether polymorphisms in DNA repair genes affect clinical outcome of never-smokers with lung adenocarcinoma (NSLA). METHOD:Common polymorphisms in the DNA repair genes ribonucleotide reductase M1 (RRM1), excision repair cross-complementation group 1 (ERCC1), an...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25863
更新日期:2011-07-15 00:00:00
abstract::One hundred twenty-seven white European patients with differentiated thyroid cancer were typed for human lymphocyte antigen (HLA) DR specificities. There was no significant deviation from the HLA-DR distribution observed in 160 normal patient controls, neither in the entire group nor in the patient groups with nonmedu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19881215)62:12<2486::aid-cncr282
更新日期:1988-12-15 00:00:00
abstract::Adrenal cortical carcinoma is an uncommon neoplasm in children. Only a handful of congenital adrenal cortical carcinoma cases have been described. A newborn who had metastatic adrenal cortical carcinoma (skin metastases and cerebral lesions) is described. This patient underwent surgical resection of the right adrenal ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880801)62:3<507::aid-cncr28206
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND:Molecular genetic studies of ovarian cancer have been limited by the inaccessible location of the ovary, the advanced stage of tumors available for analysis, and the lack of a well-defined precursor lesion. However, genetic alterations important in ovarian tumorigenesis have been identified recently. METHOD...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19951115)76:10+<1992::aid-cncr28
更新日期:1995-11-15 00:00:00
abstract::The accumulation of large amounts of fluid in the pleural space is a common sequela of disseminated carcinomatosis. Traditional management has included therapeutic thoracentesis or the placement of a large bore chest tube for drainage with the subsequent installation of a sclerosing agent in an attempt to achieve pleu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890915)64:6<1218::aid-cncr2820
更新日期:1989-09-15 00:00:00
abstract::Kaposi's sarcoma developed in two lymphoma patients previously treated by chemotherapy and chemoirradiation. The histologic picture in the two cases showed a non-Hodgkin's lymphoma with multifocal epithelioid histiocytic reaction. Both patients had Hepatitis-B surface antigen and other infections due to herpes and str...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(1984)54:4<773::aid-cncr282054043
更新日期:1984-08-15 00:00:00
abstract::Seventeen cases of pulmonary scar carcinomas were found in 112 surgically resected pulmonary carcinomas from 1985 through 1988 in a hospital situated in a histoplasmosis endemic area. These carcinomas can be divided into two types: Type I, mucinous; and Type II, non-mucinous (Clara cell). Each type of carcinoma consti...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900101)65:1<164::aid-cncr28206
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:A subset of patients with diffuse gastric cancer harbor deleterious cancer-causing germline mutations in the type 1 E-cadherin (epithelial) gene (CDH1), which predisposes to the autosomal dominantly inherited hereditary diffuse gastric cancer (HDGC) syndrome. These mutations are associated with a 70% life-ti...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23501
更新日期:2008-06-15 00:00:00
abstract:BACKGROUND:Many experienced oncologists have encountered patients with proven non-small cell lung cancer (NCLC) who received modest doses of palliative radiotherapy (RT) and who unexpectedly survived for > 5 years; some were apparently cured. We used a very large prospective database to estimate the frequency of this p...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21704
更新日期:2006-03-01 00:00:00
abstract::Six patients with breast cancer developed pulmonary toxicity following mitomycin therapy. The presenting symptoms were shortness of breath and a dry cough. The radiological pictures varied from a normal chest x-ray to extensive bilateral pneumonitis. The histological findings consisted of diffuse alveolar damage progr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800115)45:2<236::aid-cncr28204
更新日期:1980-01-15 00:00:00
abstract::The poor postsurgical prognosis in patients with colorectal cancer of the Dukes' C classification has prompted a clinical trial of adjuvant immunotherapy versus chemoimmunotherapy intended to prolong either the disease-free interval or the overall survival or both. One hundred and twenty-one patients have been entered...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197711)40:5+<2726::aid-cncr28204
更新日期:1977-11-01 00:00:00
abstract::Two cases are reported of patients who developed a hematologic malignancy several years after intravesical chemotherapy of superficial bladder cancer with etoglucid, doxorubicin, and mitomycin C. In one patient, karyotypic abnormalities (-5, 7q-) typical of a therapy induced malignancy were associated with rapid progr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900101)65:1<23::aid-cncr282065
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:We have often encountered difficulties in identifying small liver cancers during surgery. Fluorescent imaging using indocyanine green (ICG) has the potential to detect liver cancers through the visualization of the disordered biliary excretion of ICG in cancer tissues and noncancerous liver tissues compresse...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24291
更新日期:2009-06-01 00:00:00
abstract::Clinical and laboratory data, histologic, electron microscopic and immunocytochemical findings of the tumors of eight patients suffering from Cushing's syndrome and of one patient with hypercalcemia are described. The unlabeled antibody enzyme method was used for the detection of insulin, glucagon, somatostatin, pancr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19811101)48:9<2029::aid-cncr2820
更新日期:1981-11-01 00:00:00
abstract::Twelve cases of ovarian adenocarcinoma were studied for alterations in proto-oncogenes, and a unique pattern of altered ras proto-oncogenes was observed. Amplification of ras-Ki was found in three of seven ovarian tumors and amplification of ras-Ha in one of 12. In contrast, ras-Ha amplification was not found in any o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19881015)62:8<1573::aid-cncr2820
更新日期:1988-10-15 00:00:00
abstract::Neuroendocrine small cell carcinoma is a lethal, but rare, tumor that arises most frequently in the lung. Small cell cancer also rarely may occur in the female genital tract, usually in the cervix. This article concerns the fourth reported case of neuroendocrine small cell carcinoma of the vulva. Previously, small cel...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19910501)67:9<2415::aid-cncr2820
更新日期:1991-05-01 00:00:00
abstract::A randomized study was designed to determine the effect of intermittent oral cyclophosphamide on the rate of metastases in children with localized and regional neuroblastoma. Secondary objectives of the study were to determine the value of the proposed staging system, to measure the influence of the peripheral lymphoc...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(197608)38:2<661::aid-cncr2820380
更新日期:1976-08-01 00:00:00
abstract::Seven children with advanced nasopharyngeal carcinoma younger than 20 years of age diagnosed between 1975 and 1986 (inclusive) were treated with a uniform adjuvant chemotherapy regimen, which consisted of vincristine (1.5 mg/m2; day 1), doxorubicin (45 mg/m2; day 1), 5-fluorouracil (8 mg/kg; days 1 through 5), and cyc...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19890515)63:10<1922::aid-cncr282
更新日期:1989-05-15 00:00:00
abstract::In estrogen target tissues and hormone-dependent tumors, the steroid enters the cells and binds to a cytoplasmic protein called the estrogen receptor (ER). The steroid-receptor complex then migrates to the nuclei, where it initiates the biochemicial events characteristic of estrogen stimulation. Since ER is absent in ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197508)36:2+<638::aid-cncr282036
更新日期:1975-08-01 00:00:00
abstract:BACKGROUND:Two-thirds of cancer cases are associated with two lifestyle practices: 35% with the typical American diet, and 30% with tobacco use. In contrast to the field of tobacco control, research and resources dedicated to the field of nutrition have been limited, in part because dietary change has been considered c...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19930801)72:3+<1005::aid-cncr282
更新日期:1993-08-01 00:00:00
abstract::Disulfiram (tetraethylthiuram disulfide, Antabuse) and sodium diethyldithiocarbamate, when added to the diet, inhibit 1,2-dimethylhydrazine (DMH)-induced neoplasia of the large bowel in female CF1 mice. Ethylene bis(dithiocarbamato)manganese (Maneb) and bis(ethylxanthogen), two pesticides with structural similarities ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197711)40:5+<2432::aid-cncr28204
更新日期:1977-11-01 00:00:00
abstract:BACKGROUND:Parathyroid hormone-related peptide (PTHrP) is a tumor-derived circulating factor that has been associated with hypercalcemia of malignancy. The role of PTHrP as a prognostic indicator remains unclear. Studies suggest that it may function as a growth factor; and, recently, the ability of PTHrP to induce cyto...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20972
更新日期:2005-05-01 00:00:00
abstract::Fifteen cases of pure supradiapragmatic lymphoma with initial prominent antero-superior mediastinal involvement displaying a B-cell pattern of reactivity were studied. These cases occurred in six men and nine women with a median age of 33 years at diagnosis (range, 23 to 75 years). Supradiapragmatic peripheral lymphad...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920515)69:10<2561::aid-cncr282
更新日期:1992-05-15 00:00:00
abstract:BACKGROUND:The presence of tumor cells in peritoneal washing cytology specimens taken during surgery affects the staging of many gynecologic malignancies. Peritoneal washings are often collected routinely, even in cases of presumed benign disease. This study was designed to address whether evaluation of these specimens...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19991025)87:5<259::aid-cnc
更新日期:1999-10-25 00:00:00
abstract::Cross-sectional imaging is often a useful complement to clinical examination in patients with gynecologic malignancies. Patients with ovarian cancer will benefit less from the use of computed tomography and magnetic resonance imaging (MRI); however, extensive intraperitoneal disease may be evaluated and followed with ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.2820710431
更新日期:1993-02-15 00:00:00
abstract:BACKGROUND:Validation of the prognostic indices for the recurrence-free interval of patients with parotid carcinoma, the development of which was described in a previous report, is needed to be confident of their generalizability and justified prospective use. METHODS:The Dutch Cooperative Group on Head and Neck Cance...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11254
更新日期:2003-03-15 00:00:00
abstract:BACKGROUND:Patients with prostate cancer receiving androgen deprivation therapy (ADT) are at risk of sleep disturbance; however, to the authors' knowledge, the mechanisms by which ADT may affect sleep are not well understood. The current study compared objective and subjective sleep disturbance in ADT recipients and co...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31024
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:In this report, the authors describe their collective experience with melphalan-based autotransplants since the inception of their program at the University of Arkansas for Medical Sciences in 1989. METHODS:The authors evaluated the clinical outcomes of 3077 successive patients with multiple myeloma (MM) wh...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23327
更新日期:2008-04-15 00:00:00
abstract:BACKGROUND:Chronic myeloid leukemia (CML) can be treated effectively with tyrosine kinase inhibitor therapy directed at BCR-ABL, but access to care, medication cost, and adherence may be barriers to treatment. This study was designed to determine whether the insurance status at diagnosis influences CML patient outcomes...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30639
更新日期:2017-07-01 00:00:00
abstract::Giant cell tumors of synovium (pigmented villonodular synovitis) involving the vertebral column recently have been seen in two women: the third and fourth cases to be reported in the English-language literature. Unlike the previously reported cases, both these tumors grew outside the dura and produced symptoms of spin...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860515)57:10<2030::aid-cncr282
更新日期:1986-05-15 00:00:00