A study of 15 cases of primary mediastinal lymphoma of B-cell type.

Abstract:

:Fifteen cases of pure supradiapragmatic lymphoma with initial prominent antero-superior mediastinal involvement displaying a B-cell pattern of reactivity were studied. These cases occurred in six men and nine women with a median age of 33 years at diagnosis (range, 23 to 75 years). Supradiapragmatic peripheral lymphadenopathies were present in three cases, and intrathoracic extension to the lung, pericardium, or pleura was possible. In five cases a thymic origin was obvious. All cases exhibited a B-cell pattern of differentiation, with a great variety of histopathologic aspects associated with a high frequency of fibrosis and/or necrosis. Hodgkin's disease was initially misdiagnosed in four cases. The evolution was purely local, with extrathoracic extension in five cases, at the ultimate phase of the disease. The prognosis appeared to be poor with only five patients still alive at a median survival time of 16 months. A complete chemoresistance and radio-resistance was observed in seven cases; only two complete remissions were achieved with aggressive chemotherapy. Prolonged remission could be achieved after surgical reduction of the mass. Primary B-cell mediastinal lymphoma appears to be a distinct clinical entity with local evolution and resistance to therapy. A new therapeutic regimen, which could include surgery in some cases, should be found for this disease.

journal_name

Cancer

journal_title

Cancer

authors

Lavabre-Bertrand T,Donadio D,Fegueux N,Jessueld D,Taib J,Charlier D,Rousset T,Emberger JM,Baldet P,Navarro M

doi

10.1002/1097-0142(19920515)69:10<2561::aid-cncr282

subject

Has Abstract

pub_date

1992-05-15 00:00:00

pages

2561-6

issue

10

eissn

0008-543X

issn

1097-0142

journal_volume

69

pub_type

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