Abstract:
:Twelve cases of ovarian adenocarcinoma were studied for alterations in proto-oncogenes, and a unique pattern of altered ras proto-oncogenes was observed. Amplification of ras-Ki was found in three of seven ovarian tumors and amplification of ras-Ha in one of 12. In contrast, ras-Ha amplification was not found in any of the 334 other tumors and ras-Ki amplification was only seen in breast cancer at a frequency of 3%. Other proto-oncogenes altered in ovarian adenocarcinomas included c-myc and c-erbb-2. Proto-oncogene abnormalities were more frequent in aggressive tumors of high histologic grade.
journal_name
Cancerjournal_title
Cancerauthors
Zhou DJ,Gonzalez-Cadavid N,Ahuja H,Battifora H,Moore GE,Cline MJdoi
10.1002/1097-0142(19881015)62:8<1573::aid-cncr2820subject
Has Abstractpub_date
1988-10-15 00:00:00pages
1573-6issue
8eissn
0008-543Xissn
1097-0142journal_volume
62pub_type
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