Prediction of malignant transformation in oral epithelial lesions by image cytometry.

abstract：BACKGROUND:Electrochemotherapy (ECT) is a new antitumor approach that combines systemic bleomycin (BLM) with electric pulses (EP) delivered locally at the tumor site. These EP permeabilize the cells in the tissue, allow BLM delivery inside the cells, and increase BLM cytotoxicity. As an extension of our initial Phase I...

journal_title：Cancer

authors： Domenge C,Orlowski S,Luboinski B,De Baere T,Schwaab G,Belehradek J Jr,Mir LM

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Aggressive treatment of early stage prostate carcinoma (PC) is limited primarily to two modalities: radical prostatectomy (RP) and external beam radiation therapy (RT). The authors conducted a population-based study of Detroit area men with localized PC to determine the outcome of bowel, urinary, and sexual ...

journal_title：Cancer

authors： Schwartz K,Bunner S,Bearer R,Severson RK

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Recently, the authors identified molecular signatures and pathways associated with nonsmall cell lung carcinoma histology and lung development. They hypothesized that genetic classifiers of histology would provide insight into lung tumorigenesis and would be associated with clinical outcome when evaluated in...

journal_title：Cancer

authors： Shah L,Walter KL,Borczuk AC,Kawut SM,Sonett JR,Gorenstein LA,Ginsburg ME,Steinglass KM,Powell CA

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:DFP-10917, a deoxycytidine nucleoside analogue, has a unique mechanism of action resulting in leukemic cell death when administered for prolonged periods at low doses. The current phase 1/2 study investigated the safety, maximum tolerated dose, and evidence of antileukemic activity for DFP-10917 administered...

journal_title：Cancer

authors： Kantarjian HM,Jabbour EJ,Garcia-Manero G,Kadia TM,DiNardo CD,Daver NG,Borthakur G,Jain N,Waukau JB,Kwari MI,Ravandi F,Anderson BD,Iizuka K,Jin C,Zhang C,Plunkett WK

更新日期：2019-05-15 00:00:00

abstract：BACKGROUND:Recent clinical trials have documented activity for combinations of chemotherapeutic agents that target the microtubular apparatus in patients with hormone-refractory prostate cancer. Taxol has a novel antimicrotubular mechanism, acting by stabilizing polymerized tubulin. METHODS:Twenty-three patients with ...

journal_title：Cancer

authors： Roth BJ,Yeap BY,Wilding G,Kasimis B,McLeod D,Loehrer PJ

更新日期：1993-10-15 00:00:00

abstract：BACKGROUND:The objective of this study was to investigate the patterns of recurrence, various prognostic factors, and the role of radioiodine in the treatment of patients with follicular thyroid carcinoma (FTC). METHODS:The clinical outcomes of 215 patients with FTC who were treated at a single institution were analyz...

journal_title：Cancer

authors： Chow SM,Law SC,Mendenhall WM,Au SK,Yau S,Yuen KT,Law CC,Lau WH

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Occult hepatitis B virus (HBV) infection frequently occurs in patients with HBV surface antigen (HBsAg)-negative chronic liver disease, and much evidence suggests that it is a risk factor for hepatocellular carcinoma (HCC) development. However, to the authors' knowledge, no follow-up study has been performed...

journal_title：Cancer

authors： Squadrito G,Pollicino T,Cacciola I,Caccamo G,Villari D,La Masa T,Restuccia T,Cucinotta E,Scisca C,Magazzu D,Raimondo G

更新日期：2006-03-15 00:00:00

abstract：BACKGROUND:Many trials submitted to scientific meetings are not reported in peer-reviewed journals. Results may vary substantially and the lack of final publication constitutes a form of reporting bias. The authors sought to determine the presentation and publication rates of Phase I trials submitted to a major oncolog...

journal_title：Cancer

authors： Camacho LH,Bacik J,Cheung A,Spriggs DR

更新日期：2005-10-01 00:00:00

abstract：:The descriptive epidemiologic features of bladder cancer and lung cancer in Los Angeles County were studied for the period 1972-1976, using data from the Los Angeles County/University of Southern California Cancer Surveillance Program. The incidence pattern for bladder cancer was found to differ markedly from the patt...

journal_title：Cancer

authors： Weinberg DM,Ross RK,Mack TM,Paganini-Hill A,Henderson BE

更新日期：1983-02-15 00:00:00

abstract：BACKGROUND:Seminal vesicle (SV) invasion at the time of radical prostatectomy (RP) generally is considered to be indicative of poor outcome. The authors examined whether there was a subset of men with SV invasion who had long-term prostate-specific antigen (PSA) progression-free survival. METHODS:Data were examined fr...

journal_title：Cancer

authors： Freedland SJ,Aronson WJ,Presti JC Jr,Amling CL,Terris MK,Trock B,Kane CJ

更新日期：2004-04-15 00:00:00

abstract：:This report describes 11 adults with non-Hodgkin's lymphoma who presented with symptoms caused by large mediastinal masses. Patients with lymphoblastic lymphoma were excluded from this analysis. Most of the patients were young women with localized disease at presentation. Ten tumors were diffuse large cell ("histiocyt...

journal_title：Cancer

authors： Trump DL,Mann RB

更新日期：1982-07-15 00:00:00

abstract：BACKGROUND:Surveillance, Epidemiology, and End Results (SEER) data for the years 1973-1992 documented that patients age < 50 years presented with more advanced disease. Because of the increase in the incidence rate of lung adenocarcinoma in the past few decades and the presentation of more advanced disease in young pat...

journal_title：Cancer

authors： Liu NS,Spitz MR,Kemp BL,Cooksley C,Fossella FV,Lee JS,Hong WK,Khuri FR

更新日期：2000-04-15 00:00:00

abstract：BACKGROUND:Sunitinib malate is an orally bioavailable tyrosine kinase inhibitor that is active against many tyrosine kinase receptors involving crucial pathways in both healthy tissues and malignant tissues. Because its use in clinical practice is quite recent, many of its possible side effects remain unknown. In this ...

journal_title：Cancer

authors： Baldazzi V,Tassi R,Lapini A,Lunghi A,Garofoli E,Caruso S,Carini M,Mazzanti R

更新日期：2012-06-15 00:00:00

abstract：BACKGROUND:The purpose of the current analysis was to evaluate the impact of local recurrence (LR) on the development of distant metastases (DM), overall survival (OS), and cause specific survival (CSS) in patients with early-stage breast carcinoma who underwent conservative surgery (CS) and received postoperative radi...

journal_title：Cancer

authors： Vicini FA,Kestin L,Huang R,Martinez A

更新日期：2003-02-15 00:00:00

abstract：BACKGROUND:There is little information on the function of dendritic cells in women with human papillomavirus (HPV)-related cervical squamous intraepithelial lesions (SILs). In the current study the functions of dendritic cells in the development of T-cell immunity in women with cervical SILs were assessed. METHODS:The...

journal_title：Cancer

authors： Lee BN,Follen M,Rodriquez G,Shen DY,Malpica A,Shearer WT,Reuben JM

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:The objective of this study was to characterize chronic disease, health-related quality of life (HRQOL), emotional distress, and social attainment among long-term survivors of neuroblastoma. METHODS:Chronic health conditions among 136 ≥10-year neuroblastoma survivors (median age, 31.9 years; range, 20.2-54....

journal_title：Cancer

authors： Wilson CL,Brinkman TM,Cook C,Huang S,Hyun G,Green DM,Furman WL,Bhakta N,Ehrhardt MJ,Krasin MJ,Robison LL,Ness KK,Hudson MM

更新日期：2020-03-15 00:00:00

abstract：:We examined resected specimens from 40 cases of advanced rectal cancer to determine the extent of microtubular cancer nests and undifferentiated cancer cells (budding). We investigated the relationship between this budding and lymphatic invasion (ly), venous invasion (v), and lymph node metastasis (n), respectively. M...

journal_title：Cancer

authors： Morodomi T,Isomoto H,Shirouzu K,Kakegawa K,Irie K,Morimatsu M

更新日期：1989-02-01 00:00:00

abstract：:The National Wilms' Tumor Study (NWTS) was initiated in 1969. One of its objectives was to modulate treatments according to risk factors to minimize the number and severity of treatment-related short-term and long-term iatrogenic complications. The NWTS has therefore incorporated a Long Term Follow-up Study (LTFS) wit...

journal_title：Cancer

authors： Evans AE,Norkool P,Evans I,Breslow N,D'Angio GJ

更新日期：1991-01-15 00:00:00

abstract：BACKGROUND:Molecular genetic studies of ovarian cancer have been limited by the inaccessible location of the ovary, the advanced stage of tumors available for analysis, and the lack of a well-defined precursor lesion. However, genetic alterations important in ovarian tumorigenesis have been identified recently. METHOD...

journal_title：Cancer

authors： Gallion HH,Pieretti M,DePriest PD,van Nagell JR Jr

更新日期：1995-11-15 00:00:00

abstract：:Regressing atypical histiocytosis (RAH) of skin is a cutaneous noduloulcerative proliferation of atypical neoplastic histiocytes with concomitant polymorphous inflammation, frequently pronounced epidermal hyperplasia, and an unexpectedly indolent biologic course. Spontaneous regression and recurrence without systemic ...

journal_title：Cancer

authors： Flynn KJ,Dehner LP,Gajl-Peczalska KJ,Dahl MV,Ramsay N,Wang N

更新日期：1982-03-01 00:00:00

abstract：BACKGROUND:Thymic malignancies are rare tumors. The insulin-like growth factor-1 (IGF-1)/IGF-1 receptor (IGF-1R) system is involved in the development of the thymus. IGF-1R expression in thymic epithelial malignancies is unknown. METHODS:The authors investigated the expression of IGF-1R and phosphorylated AKT serine 4...

journal_title：Cancer

authors： Zucali PA,Petrini I,Lorenzi E,Merino M,Cao L,Di Tommaso L,Lee HS,Incarbone M,Walter BA,Simonelli M,Roncalli M,Santoro A,Giaccone G

更新日期：2010-10-15 00:00:00

abstract：:Twenty-one cases of clear cell adenocarcinoma of the cervix and vagina have been reviewed. Fifteen cases occurred in females under 25 years of age and four in women over 45 years. In seven cases, a positive history of maternal ingestion of diethylstilbestrol (DES) was obtained. One mother gave a history of medication ...

journal_title：Cancer

authors： Nordqvist SR,Fidler WJ Jr,Woodruff JM,Lewis JL Jr

更新日期：1976-02-01 00:00:00

abstract：:In this report, the authors describe an innovative antitobacco advertising campaign in Arizona that was aimed at youth. The campaign utilizes traditional as well as non-traditional methods of research to determine the attitudes, behavior and values of today's adolescents. These creative methodologies led to rigorously...

journal_title：Cancer

authors： Riester T,Linton M

更新日期：1998-12-15 00:00:00

abstract：BACKGROUND:Because of the small number of cases (five) reported between 1929 and 1969 and a significant increase reported in the decade of the 1970s, the Familial Ovarian Cancer Registry was established in 1981 to study the occurrence of familial ovarian cancer in the United States. METHODS:Any woman (with or without ...

journal_title：Cancer

authors： Piver MS,Baker TR,Jishi MF,Sandecki AM,Tsukada Y,Natarajan N,Mettlin CJ,Blake CA

更新日期：1993-01-15 00:00:00

abstract：:The woman treated for gynecologic cancer must contend with a challenging group of issues in her efforts to recover psychologically in the months and years after treatment: chance of dying, changed self-perception, treatment-related menopause, impaired or lost fertility, sexual dysfunction, and relationship problems mu...

journal_title：Cancer

authors： Auchincloss SS

更新日期：1995-11-15 00:00:00

abstract：:Many cancer patients have elevated serum protein and sialic acid (N-acetyl neuraminic acid, NANA) levels. Serial determinations were performed, using serum treated with perchloric acid from 34 patients with widespread metastatic disease. Six of six patients who underwent debulking surgery had a drop in their serum NAN...

journal_title：Cancer

authors： Harvey HA,Lipton A,White D,Davidson E

更新日期：1981-01-15 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) occurs more frequently in patients with hepatitis C virus (HCV)-related chronic liver disease than those with hepatitis B virus-related disease. It is important to assess the factors affecting the development of HCC. METHODS:A long term follow-up study involving patients with ...

journal_title：Cancer

authors： Aizawa Y,Shibamoto Y,Takagi I,Zeniya M,Toda G

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:The development of novel therapeutic approaches for cancer therapy is important, especially for tumors that have poor response or develop resistance to standard chemotherapy and radiation. We discovered that noninvasive radiofrequency (RF) fields can affect cancer cells but not normal cells, inhibit progress...

journal_title：Cancer

authors： Curley SA,Palalon F,Lu X,Koshkina NV

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:In regional lymph node metastasis of cutaneous melanoma, the number and volume of involved lymph nodes are the most important prognostic factors. Several studies have revealed that palpation of the lymphatic drainage area(s) and regional lymph nodes has a high rate of false-negative results during follow-up....

journal_title：Cancer

authors： Blum A,Schlagenhauff B,Stroebel W,Breuninger H,Rassner G,Garbe C

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Women treated with tamoxifen for breast cancer are at increased risk of endometrial cancer. This study examines the experience at Roswell Park Cancer Institute (RPCI) with women diagnosed with both endometrial carcinoma (EC) and breast carcinoma (BC) to determine the risk and stage of endometrial carcinoma a...

journal_title：Cancer

authors： Cuenca RE,Giachino J,Arredondo MA,Hempling R,Edge SB

更新日期：1996-05-15 00:00:00