Abstract:
BACKGROUND:Although the biologic characteristics of papillary cystic tumors (PCT) generally indicate a good prognosis, a malignant form has been reported. METHODS:Twenty-two examples of PCT were examined to assess their malignant potential by histologic, flow cytometric, and immunohistochemical studies. RESULTS:Three had hepatic, peritoneal, and/or lymph node metastases (metastasizing tumors [MT]); the other 19 PCT had no such metastatic features (nonmetastasizing tumors [NMT]). Venous invasion was detected in all three MT and two NMT. Compared with the 19 NMT, the MT had a higher nuclear grade and more prominent necrobiotic nests characterized by aggregates of cells with pyknotic nuclei and eosinophilic cytoplasm. In the flow cytometric analysis of cellular DNA content, one MT was aneuploid, and eight NMT were diploid. Immunohistochemically, there was no difference between the MT and NMT. CONCLUSIONS:These results support the assumption that venous invasion, nuclear grade, and prominent necrobiotic nests are useful as histologic parameters to detect the malignant potential of PCT.
journal_name
Cancerjournal_title
Cancerauthors
Nishihara K,Nagoshi M,Tsuneyoshi M,Yamaguchi K,Hayashi Idoi
10.1002/1097-0142(19930101)71:1<82::aid-cncr282071subject
Has Abstractpub_date
1993-01-01 00:00:00pages
82-92issue
1eissn
0008-543Xissn
1097-0142journal_volume
71pub_type
杂志文章,评审相关文献
CANCER文献大全abstract:BACKGROUND:Children with diffuse brainstem glioma (BSG) commonly undergo novel therapies because their outcome is poor with radiation therapy (RT). Although recent clinical trials using new biologic agents documented intratumoral hemorrhage (IH) among several children with BSG, to the authors' knowledge little is known...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21749
更新日期:2006-03-15 00:00:00
abstract::Blood was obtained on 36 occasions from 12 healthy adult volunteers and the polymorphonuclear leukocytes (PMNL) were separated. PMNL hexose monophosphate shunt activity of whole blood and ability of separated cells to phagocytize and kill E. coli were evaluated when the PMNL were incubated with normal pooled sera and ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197810)42:4<1741::aid-cncr282042
更新日期:1978-10-01 00:00:00
abstract:BACKGROUND:For this report, the authors comprehensively summarized the existing literature on patients with pineoblastoma and identified the variables and treatments that had an impact patient on outcomes. METHODS:A comprehensive search identified 109 studies that collectively described the outcomes of patients with p...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.26300
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:To the authors' knowledge, relatively little is known regarding the interaction of risk factors for hepatocellular carcinoma (HCC) with age, sex, and liver disorder status. METHODS:The authors followed 504,646 Korean patients aged 40 to 80 years who underwent routine health checkups between 2002 and 2003 un...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31406
更新日期:2018-07-01 00:00:00
abstract::Treatment with BCG (Bacillus Calmette-Guérin) followed by irradiation was attempted to improve response to therapy by cutaneous metastases from malignant skin melanomas. Both agents were applied in low doses, known to cause minimal side effects. Nineteen patients, divided into three groups, entered the clinical trial....
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820915)50:6<1100::aid-cncr2820
更新日期:1982-09-15 00:00:00
abstract:BACKGROUND:Elderly people constitute a heterogeneous group and are at an increased risk for the development of cancer. It is not clear whether comorbid conditions and functional status influence clinical decisions and the pattern of referral in elderly cancer patients. The current study investigated functional status m...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-02-15 00:00:00
abstract::The histories of 121 Stage II melanoma patients were reviewed to determine the value of monitoring serum LDH in postoperative follow-up examinations. Charts of 58 Stage III patients who had autopsies at UCLA also were reviewed to define the relationship between an elevated LDH and liver metastases. The sensitivity and...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830301)51:5<840::aid-cncr28205
更新日期:1983-03-01 00:00:00
abstract::Carboplatin (diammine [1,1-cyclobutanedicarboxylate(2-)-O,o']platinum) is a second generation platinum coordination complex. It has a spectrum of activity that is similar to that of cisplatin and is less nephrotoxic and emetogenic in experimental animals. Fifty-two 30-minute infusions of carboplatin were given to 20 e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860115)57:2<222::aid-cncr28205
更新日期:1986-01-15 00:00:00
abstract::A 44-year-old patient with histologically proven bilateral ulcerated lymph node metastases from a carcinoma of the penis was treated by sequenced combined chemotherapy and radical irradiation. Methotrexate and bleomycin were administered at weekly intervals for 5 weeks, followed by radiation with a split-course coning...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841015)54:8<1720::aid-cncr2820
更新日期:1984-10-15 00:00:00
abstract:BACKGROUND:Survivors of head and neck squamous cell carcinoma (HNSCC) face excess mortality from multiple causes. METHODS:We used the population-based Surveillance, Epidemiology, and End Results (SEER) cancer registry data to evaluate the causes of death in patients with nonmetastatic HNSCC diagnosed between 1992 and ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28588
更新日期:2014-05-15 00:00:00
abstract:BACKGROUND:During hospitalization for hematopoietic stem cell transplantation (HCT), patients experience a steep deterioration in quality of life (QOL) and mood. To our knowledge, the impact of this deterioration on patients' QOL and posttraumatic stress disorder (PTSD) symptoms after HCT is unknown. METHODS:We conduc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29818
更新日期:2016-03-01 00:00:00
abstract::In a study conducted by the Eastern Cooperative Oncology Group, 51 evaluable women with advanced ovarian carcinoma were randomized to either abdominal radiation therapy alone, chlorambucil alone, or to a combination of radiation therapy and chlorambucil by members of the Eastern Cooperative Oncology Group. Provision w...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(197511)36:5<1625::aid-cncr282036
更新日期:1975-11-01 00:00:00
abstract:BACKGROUND:The bone destruction in myeloma patients is largely responsible for the clinical features of the disease. However, only recently has attention focused on identifying and developing drugs targeted specifically at the osteolysis. Receptor activator of NF-kappaB ligand (RANKL), macrophage inflammatory protein (...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11133
更新日期:2003-02-01 00:00:00
abstract::Associations were sought between specific histocompatibility antigens (HLA) of the human major histocompatibility complex and the incidence of head and neck squamous cell carcinoma (SqCC). Seventy sequential patients with SqCC and 217 control subjects from the same geographic region were typed for HLA-A, HLA-B, and HL...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920501)69:9<2327::aid-cncr2820
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:We investigated p16(INK4A) expression in branchial cleft cysts and its utility in distinguishing branchial cleft cysts from metastatic head and neck squamous cell carcinomas (SCCs) in fine-needle aspiration biopsies (FNABs). METHODS:A study set comprising 41 resections (15 SCC and 26 branchial cleft cysts) ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncy.20001
更新日期:2009-04-25 00:00:00
abstract:BACKGROUND:The purpose of this article was to evaluate the utility of a pharmacokinetically modeled measure of regional contrast access, based on dynamic contrast-enhanced magnetic resonance imaging (MRI) studies after preoperative chemotherapy, as a predictor of disease free survival in osteosarcoma. METHODS:The kine...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2001-06-15 00:00:00
abstract:BACKGROUND:The objective of this article was to report the results from a randomized clinical trial comparing intensity-modulated radiotherapy (IMRT) with 3-dimensonal conformal radiotherapy (3DCRT) for the treatment of prostate cancer on a hypofractionated schedule. METHODS:The authors randomly assigned 215 men who h...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.29983
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:The combination of a platinating agent and etoposide has induced responses in various pediatric tumors. The study estimated the maximum tolerated dose (MTD) of an oxaliplatin and etoposide regimen in children with recurrent solid tumors. METHODS:Oxaliplatin was administered on Day 1 and etoposide on Days 1 ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24054
更新日期:2009-02-01 00:00:00
abstract::Between February 1983 and February 1986, 132 patients with advanced urothelial tract tumors were treated with methotrexate, vinblastine, Adriamycin (doxorubicin), and cisplatin (M-VAC) chemotherapy. Analysis of prognostic factors for survival of the first 92 patients was undertaken using the Cox proportional hazards m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910315)67:6<1525::aid-cncr2820
更新日期:1991-03-15 00:00:00
abstract:BACKGROUND:The quality of randomized radiotherapy studies investigating the palliation of painful bone metastases has been questioned, with some authors recognizing the potential impact of bias on result interpretation. However, there has been no published comprehensive evaluation of quality assessment. The goals of th...
journal_title:Cancer
pub_type: 杂志文章,meta分析
doi:10.1002/cncr.20993
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Epithelial ovarian cancer continues to challenge clinicians. There is no accepted method of screening for ovarian cancer, and most patients present with advanced disease. In spite of advances in surgery and chemotherapy, survival continues to be poor. METHODS:The data, comprising the ovarian cancer caseload...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19961115)78:10<2236::aid-c
更新日期:1996-11-15 00:00:00
abstract:BACKGROUND:Fine-needle aspiration biopsy (FNAB) has been used with variable success as a diagnostic test for benign and malignant breast lesions. The goal of this study was to examine the effects of training physicians in the fine-needle aspiration sampling-technique on the diagnostic accuracy of FNAB of palpable breas...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.9040
更新日期:2001-08-25 00:00:00
abstract::Estradiol and testosterone levels in the peripheral and ovarian circulation of patients with endometrial cancer and of postmenopausal women were studied. These levels proved to be the same in the two groups. The ovaries of neither group secreted estradiol. The testosterone level in the ovarian circulation of all exami...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197911)44:5<1809::aid-cncr282044
更新日期:1979-11-01 00:00:00
abstract:BACKGROUND:Immediate or early postmastectomy breast reconstruction is performed infrequently. To the authors' knowledge, little is known regarding surgeon or patient perspectives on reconstruction treatment decisions. The purpose of the current study was to identify patient attitudes and preferences associated with bre...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.21444
更新日期:2005-12-01 00:00:00
abstract::Tumor-specific DNA sequences or unique sequences have been found in a number of human cancer cells including gliomas but not in equivalent normal cells. In a continuing effort to further elucidate the nature of these sequences, thermal analysis using the hydroxyapatite technique was carried out on the various grades o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800715)46:2<303::aid-cncr28204
更新日期:1980-07-15 00:00:00
abstract:BACKGROUND:According to the overview of Early Breast Cancer Trialists' Collaborative Group, anthracycline containing regimens are superior to cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) as adjuvant chemotherapy for breast carcinoma, but no comparative information is available in terms of primary chemothera...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/cncr.10678
更新日期:2002-07-15 00:00:00
abstract::Racial differences in the risk of cancer of the urinary bladder associated with cigarette smoking and alcohol consumption were examined in a study of 1663 cases (1534 whites and 129 blacks) and 4930 controls matched 3:1 by sex, race, and age to the cases. Significant increases in cancer risk associated with cigarette ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19901215)66:12<2673::aid-cncr282
更新日期:1990-12-15 00:00:00
abstract::As the toll taken by breast cancer continues unabated, screening programs are widely perceived to play a critical role to improve diagnosis and successful treatment. Breast cancer screening programs are increasingly promoted to women; however, the economic implications of mass screening is a subject of much health pol...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920401)69:7+<1957::aid-cncr282
更新日期:1992-04-01 00:00:00
abstract::Primary lymphomas of the small intestine (PIL) show definite racial and geographic distribution. Clinical and laboratory data on 132 patients with PIL treated and followed up over a 14-year period in Baghdad, Iraq, are presented. Based on the pattern of involvement of the bowel and the histopathologic appearance of th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19831101)52:9<1666::aid-cncr2820
更新日期:1983-11-01 00:00:00
abstract::Compliance in oncology clinic attendance was prospectively evaluated over a 12-month period at Harlem Hospital Center, an inner city municipal facility serving a predominantly black population. One hundred patients were followed (97 blacks, 2 Hispanics, 1 white) with an average age of 60 years. There were 41 men and 5...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860801)58:3<793::aid-cncr28205
更新日期:1986-08-01 00:00:00