Abstract:
BACKGROUND:Children with diffuse brainstem glioma (BSG) commonly undergo novel therapies because their outcome is poor with radiation therapy (RT). Although recent clinical trials using new biologic agents documented intratumoral hemorrhage (IH) among several children with BSG, to the authors' knowledge little is known regarding this phenomenon. In the current study, the authors assessed the characteristics and estimated the cumulative incidence of IH among children with BSG. METHODS:All available brain imaging studies and medical records of 48 consecutive patients with newly diagnosed BSG treated at the study institution over a 10-year interval (1992-2002) were reviewed. Treatment was comprised of RT and various regimens of conventional chemotherapy; none of these patients received biologic agents. At the time of last follow-up, all patients had died of tumor progression. RESULTS:The authors reviewed 319 imaging studies (251 magnetic resonance imaging scans and 68 computed tomography scans). IH was present in 6.25% of patients at the time of diagnosis. The 6-month and 12-month cumulative incidence estimates of IH regardless of the associated symptoms were 15.5% +/- 5.5% and 24.4% +/- 6.5%, respectively. The same estimates for symptomatic cases were 8.9% +/- 4% and 17.8% +/- 6%, respectively. All cases of IH at the time of diagnosis and 78% of symptomatic cases that developed after diagnosis were located in necrotic areas. CONCLUSIONS:Although IH is uncommon at the time of diagnosis, symptomatic IH may occur among nearly 20% of children after the diagnosis of BSG. The uniform occurrence of IH among patients treated with various chemotherapeutic regimens and its association with necrotic areas suggests that tumor biology plays a significant role in this event.
journal_name
Cancerjournal_title
Cancerauthors
Broniscer A,Laningham FH,Kocak M,Krasin MJ,Fouladi M,Merchant TE,Kun LE,Boyett JM,Gajjar Adoi
10.1002/cncr.21749subject
Has Abstractpub_date
2006-03-15 00:00:00pages
1364-71issue
6eissn
0008-543Xissn
1097-0142journal_volume
106pub_type
杂志文章相关文献
CANCER文献大全abstract::A case of squamous cell carcinoma of the tongue in a 26-year-old man developing nine years after renal transplantation is presented. This is the first such case to be reported. Within seven months, widespread tumor metastases resulted in death. Pathologic examination of the transplanted kidney demonstrated neither re-...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197801)41:1<1::aid-cncr282041010
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:Typhlitis is increasingly recognized in children undergoing chemotherapy but is poorly characterized. The authors investigated the demographic, clinical, and imaging (ultrasonography and computed tomography [CT] scans) variables related to the diagnosis, risk, and outcome of typhlitis. METHODS:The authors r...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21134
更新日期:2005-07-15 00:00:00
abstract:BACKGROUND:Ultrasonography has a limited value in endometrial assessment for identification of endometrial pathologies in postmenopausal tamoxifen-treated patients. METHODS:We compared the rate of endometrial pathologies and the mean +/- SD of endometrial thickness diagnosed after the first and second transvaginal ult...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10587
更新日期:2002-06-15 00:00:00
abstract::With increasing numbers of survivors from cancer at a young age, the issue of fertility preservation has assumed greater importance. This review describes normal ovarian and testicular function and summarizes what is known about the effect of chemotherapy and radiotherapy on the gonads and uterus. All young patients w...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.26045
更新日期:2011-05-15 00:00:00
abstract::Plasma levels of cyclic AMP and cyclic GMP were determined in 35 guinea pigs for up to 9 days following subcutaneous passage of L2C leukemia cells. Twenty guinea pigs into which normal syngeneic guinea pig thymocytes were passaged served as controls. Cyclic AMP levels in plasma showed little change and were only eleva...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840101)53:1<79::aid-cncr282053
更新日期:1984-01-01 00:00:00
abstract::Adenoid cystic carcinoma (ACC) of the breast is a rare histologic type of breast cancer associated with a good prognosis. A woman who earlier had a pulmonary metastasis surgically resected 6 years postmastectomy developed clinically symptomatic bleeding from a renal metastasis 12 years postmastectomy. An atypical angi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910901)68:5<1015::aid-cncr2820
更新日期:1991-09-01 00:00:00
abstract::The reactivity of serum alpha-fetoprotein (AFP) from 20 patients with hepatocellular carcinoma (HCC) with immobilized lentil lectin was examined and found to be significantly greater (39% +/- 18%) than that of the same protein from seven patients with chronic liver disease (CLD, 11.2% +/- 3.3%), seven with fulminant h...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910115)67:2<476::aid-cncr28206
更新日期:1991-01-15 00:00:00
abstract:BACKGROUND:Patient navigation may reduce cancer disparities associated with socioeconomic status (SES) and household factors. This study examined whether these factors were associated with delays in diagnostic resolution among patients with cancer screening abnormalities and whether patient navigation ameliorated these...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29612
更新日期:2015-11-15 00:00:00
abstract:BACKGROUND:Cancer costs should be discussed by patients and providers, but information is not readily available. Results from recently published studies (in the last 5 years) on direct and indirect cancer costs may help guide these discussions. METHODS:The authors reviewed studies published between 2013 and 2017 that ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.31643
更新日期:2018-11-01 00:00:00
abstract::Twenty-five patients with advanced measurable adenocarcinoma of the lung were treated with combination chemotherapy consisting of 5-fluorouracil, adriamycin, and mitomycin-C (FAM). Objective response (1CR, 8PR) was obtained in 36% of patients. The median duration of response was 7.0 months and the median survival for ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197904)43:4<1183::aid-cncr282043
更新日期:1979-04-01 00:00:00
abstract:BACKGROUND:Chemotherapy improves survival for patients with stage III colon cancer, but some older patients with lymph node-positive colon cancer do not see a medical oncologist and, thus, do not receive adjuvant chemotherapy. METHODS:To evaluate the role of the surgeon in determining referrals to medical oncology amo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22462
更新日期:2007-03-01 00:00:00
abstract::The various radiologic methods used in the detection of hepatic lesions in the oncologic patient are discussed. The advantages and disadvantages of each imaging technique as well as a new diagnostic approach are also discussed. With the rapid technological advances made in cross-sectional imaging, the authors believe ...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1982-12-01 00:00:00
abstract::Using a silver staining technique, nucleolar organizer region-associated proteins (Ag-NOR) were studied in paraffin sections of five specimens of normal bronchial epithelium, eight of atypical squamous metaplasia, five of carcinoma in situ, and seven of microinvasive squamous cell carcinoma. The mean number of Ag-NOR ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910115)67:2<472::aid-cncr28206
更新日期:1991-01-15 00:00:00
abstract:BACKGROUND:Lung carcinoma remains the major cause of cancer death in North America and is even more common among military veterans. The objective of this study was to determine whether there were differences in the characteristics and survival of Pennsylvania patients with lung carcinoma in the Veterans Administration ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21228
更新日期:2005-08-15 00:00:00
abstract::The clinical course of 29 patients with idiopathic refractory sideroblastic anemia studied by us was reviewed. Four patients developed acute leukemia. We were able to find 27 out of 268 cases of idiopathic refractory sideroblastic anemia reported in the literature which terminated in acute leukemia. Nine of these were...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197908)44:2<724::aid-cncr2820440
更新日期:1979-08-01 00:00:00
abstract:BACKGROUND:The optimal weekly oral dose of sirolimus and intravenous nanoparticle albumin-bound paclitaxel (nab-paclitaxel) were evaluated. METHODS:A phase 1b study was performed to evaluate escalating doses of oral sirolimus (5-60 mg) on days 2, 9, and 16 with intravenous nab-paclitaxel (100 mg/m(2) ) on days 1, 8, a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29254
更新日期:2015-06-01 00:00:00
abstract::The National Wilms' Tumor Study (NWTS) was initiated in 1969. One of its objectives was to modulate treatments according to risk factors to minimize the number and severity of treatment-related short-term and long-term iatrogenic complications. The NWTS has therefore incorporated a Long Term Follow-up Study (LTFS) wit...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910115)67:2<331::aid-cncr28206
更新日期:1991-01-15 00:00:00
abstract::The most important area in which cancer care and bioethics intersect is in the care of the dying. It is in the shift toward according more control to patients, more choice in the setting in which death will come, and in the willingness to take palliative care and comfort care seriously that bioethics has most usefully...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23647
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:The identification of high risk patients with endometrial carcinoma is considered essential for individualized therapy to improve prognosis and avoid overtreatment. The goal of the current study was to investigate the prognostic value of nuclear morphometry, particularly for patients with localized endometri...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
abstract::Tumor necrosis factor-alpha (TNF-alpha), a product of activated macrophages that is cytotoxic to tumor cells, could be used to purge tumor cells from bone marrow before autologous bone marrow transplantation for hematologic malignancies and/or solid tumors. To determine whether exposure to TNF-alpha would have an inhi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19871215)60:12<2965::aid-cncr282
更新日期:1987-12-15 00:00:00
abstract:BACKGROUND:Previous Commission on Cancer studies have examined time trends in stage of disease, treatment patterns, and survival for special populations. Reported herein are the most current National Cancer Data Base data for Hispanics. METHODS:Two Calls for Data have yielded a total of 23,650 cancer reports for Hispa...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19941015)74:8<2386::aid-cncr2820
更新日期:1994-10-15 00:00:00
abstract::In search of tumor-associated components in human melanomas and gliomas, plasma membranes were isolated from these tumors and compared morphologically, biochemically and immunologically with those from normal human brain. The preparations exhibited a comparable ultrastructure of empty vesicles of various form and size...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19811201)48:11<2399::aid-cncr282
更新日期:1981-12-01 00:00:00
abstract::Seventy three patients with disseminated diffuse non-Hodgkin's lymphomas were treated with combinations of cyclophosphamide, vincristine sulfate, prednisone, and doxorubicin with and without 2 weekly doses of oral methotrexate in "intermediate" doses, followed by calcium leucovorin rescue. The addition of methotrexate...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19870701)60:1<18::aid-cncr282060
更新日期:1987-07-01 00:00:00
abstract::The two cancers specific to women for which substantial research on their relationship to exogenous estrogens has been reported are endometrial cancer and breast cancer. With the former, the link to estrogen use is well established. The estrogen use patterns associated with increased risk of endometrial cancer are cha...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19901015)60:8+<1960::aid-cncr282
更新日期:1987-10-15 00:00:00
abstract:BACKGROUND:It has been postulated that different biologic characteristics of a tumor might account for at least a portion of the disparity in breast cancer survival for patients across racial and ethnic groups. The hormone receptor status of breast tumors is one characteristic with prognostic significance. Results of s...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960415)77:8<1465::AID-CN
更新日期:1996-04-15 00:00:00
abstract::The livers of 345 autopsy cases of chronic liver disease were examined for macroregenerative nodule (MRN), a large nodular lesion more than 10 mm in diameter. A total of 86 lesions of MRN was found in 49 cases (14.2%): 32 were from 191 cases of hepatocellular carcinoma (HCC), 16 were from 148 cases of cirrhosis only, ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880101)61:1<99::aid-cncr282061
更新日期:1988-01-01 00:00:00
abstract::Univariate and multivariate regression methods were used to analyze 17 potential clinical prognostic factors among 138 patients with advanced breast cancer who received Adriamycin-cyclophosphamide combination chemotherapy between 1973 and 1977 at the University of Arizona. Follow-up of patients was through September 1...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801201)46:11<2380::aid-cncr282
更新日期:1980-12-01 00:00:00
abstract:BACKGROUND:The objective of this study was to investigate the potential of virtual microscopy (VM) as an avenue for the delivery of mandatory cytology proficiency tests). METHODS:Three senior cytotechnologists and 2 board-certified cytopathologists participated in 3 virtual proficiency tests. Each set consisted of 10 ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22766
更新日期:2007-08-25 00:00:00
abstract::Alkylating agents form the basis of most combination treatment regimens for low-grade lymphoproliferative disorders. Bendamustine is a unique alkylating agent that has distinctive preclinical activity in cell lines resistant to other alkylators. Furthermore, clinical activity has been demonstrated in patients with alk...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.24057
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Although the anticancer effects of progesterone therapy for patients with endometrial carcinoma are widely acknowledged, a detailed assessment of the resultant morphologic alterations in tumor tissue kinetics has hitherto been lacking. METHODS:Biopsy and hysterectomy specimens of 14 endometrial carcinomas (...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980701)83:1<111::aid-cnc
更新日期:1998-07-01 00:00:00