Significance of secondary ultrasonographic endometrial thickening in postmenopausal tamoxifen-treated women.

Abstract:

BACKGROUND:Ultrasonography has a limited value in endometrial assessment for identification of endometrial pathologies in postmenopausal tamoxifen-treated patients. METHODS:We compared the rate of endometrial pathologies and the mean +/- SD of endometrial thickness diagnosed after the first and second transvaginal ultrasonographic studies performed on 55 postmenopausal tamoxifen-treated patients with secondary endometrial thickening (Group I). This rate was also compared with 46 similar patients without secondary thickening (Group II). We also compared the mean +/- SD of endometrial thickness detected in various ultrasonographic studies, as well as various clinical features. RESULTS:A significantly higher rate of endometrial pathologies, including two cases of endometrial cancer identified in gynecologically asymptomatic patients (3.6%), was diagnosed in Group I after the second study compared with the first study (52.7% and 9.1%, respectively; P = 0.001) and compared with those diagnosed after the second study in Group II (30.4%; P = 0.03). There was a significant increase (74.7 +/- 115%) in endometrial thickness after the second study compared with the first study performed on Group I (10.7 +/- 5.53 mm and 16.59 +/- 5.53 mm, respectively; P = 0.0001) and a significant difference in endometrial thickness demonstrated in the second study performed on Groups I and II (16.59 +/- 5.53 mm and 11.4 +/- 3.91 mm, respectively; P = 0.001). There were no significant differences in the time elapsed since the diagnosis of breast carcinoma and from the beginning of tamoxifen treatment to the performance of the first ultrasonographic study as well as the time elapsed between the first and second studies performed. CONCLUSIONS:A significant increase (> 50%) in secondary endometrial thickening, measured ultrasonographically, in postmenopausal tamoxifen-treated patients, is associated with a high rate of endometrial pathologies, including endometrial cancer.

journal_name

Cancer

journal_title

Cancer

authors

Cohen I,Azaria R,Shapira J,Yigael D,Tepper R

doi

10.1002/cncr.10587

subject

Has Abstract

pub_date

2002-06-15 00:00:00

pages

3101-6

issue

12

eissn

0008-543X

issn

1097-0142

journal_volume

94

pub_type

杂志文章

相关文献

CANCER文献大全
  • Phase II randomized study of daily gefitinib treatment alone or with vinorelbine every 2 weeks in patients with adenocarcinoma of the lung who failed at least 2 regimens of chemotherapy.

    abstract:BACKGROUND:The objective of this study was to assess the efficacy of adding chronic, intermittent, low-dose vinorelbine to gefitinib treatment for patients who had adenocarcinoma of the lung who failed>or=2 regimens of chemotherapy. METHODS:Patients were randomized into 2 arms: Oral gefitinib 250 mg daily (the G arm) ...

    journal_title:Cancer

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/cncr.22616

    authors: Chen YM,Liu JM,Chou TY,Perng RP,Tsai CM,Whang-Peng J

    更新日期:2007-05-01 00:00:00

  • Review of four cases of childhood hepatic angiosarcoma--elevated environmental arsenic exposure in one case.

    abstract::Four cases of childhood hepatic angiosarcoma (HAS), representing the malignant form of infantile hemangioendothelioma, are described. The morphologic appearance of childhood HAS differs from the adult form in the following features: the associated presence of benign infantile hemangioendothelioma; the presence of dyso...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810115)47:2<382::aid-cncr28204

    authors: Falk H,Herbert JT,Edmonds L,Heath CW Jr,Thomas LB,Popper H

    更新日期:1981-01-15 00:00:00

  • Meningeal hematopoiesis causing exophthalmus and hemiparesis in myelofibrosis: effect of radiotherapy. A case report.

    abstract::Meningeal myeloid metaplasia (MM) is very rarely observed in patients with myelofibrosis. We report the occurrence of meningeal MM causing exophthalmus and fever in a patient with myelofibrosis secondary to polycythemia vera. A computerized tomography (CT) scan showed multiple intracranial and intraorbital enhancing m...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19881201)62:11<2346::aid-cncr282

    authors: Landolfi R,Colosimo C Jr,De Candia E,Castellana MA,De Cristofaro R,Trodella L,Leone G

    更新日期:1988-12-01 00:00:00

  • Environmental factors in cancer of the larynx: a second look.

    abstract::During a retrospective case-control study of recent laryngeal cancer patients, several associated factors were studied to determine possible changes in the epidemiology of laryngeal cancer between 1956 and 1974. The large sex difference noted in the early survey (male: female ratio of 14.9:1) diminished considerably i...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197610)38:4<1591::aid-cncr282038

    authors: Wynder EL,Covey LS,Mabuchi K,Mushinski M

    更新日期:1976-10-01 00:00:00

  • Follicular thyroid carcinoma: prognostic factors and the role of radioiodine.

    abstract:BACKGROUND:The objective of this study was to investigate the patterns of recurrence, various prognostic factors, and the role of radioiodine in the treatment of patients with follicular thyroid carcinoma (FTC). METHODS:The clinical outcomes of 215 patients with FTC who were treated at a single institution were analyz...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10683

    authors: Chow SM,Law SC,Mendenhall WM,Au SK,Yau S,Yuen KT,Law CC,Lau WH

    更新日期:2002-08-01 00:00:00

  • Carcinoma of the endometrium: I. A clinicopathologic study of clear-cell carcinoma and secretory carcinoma.

    abstract::In a pathologic review of 1224 cases of endometrial carcinoma, 1023 were confirmed cases of endometrial carcinoma. Fifty-six (5.5%) were clear-cell adenocarcinoma (CCE). Fifteen cases of "secretory carcinoma" (SCE) were examined for comparison. Fifty-five patients with CCE and all with SCE were followed for at least f...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820415)49:8<1511::aid-cncr2820

    authors: Christopherson WM,Alberhasky RC,Connelly PJ

    更新日期:1982-04-15 00:00:00

  • Factors predicting prostate cancer upgrading on magnetic resonance imaging-targeted biopsy in an active surveillance population.

    abstract:BACKGROUND:The objective of this study was to create a nomogram model integrating clinical and multiparametric magnetic resonance imaging (MP-MRI)-based variables to predict prostate cancer upgrading in a population of active surveillance (AS) patients. METHODS:Prostate cancer patients on AS who underwent MP-MRI with ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30548

    authors: Lai WS,Gordetsky JB,Thomas JV,Nix JW,Rais-Bahrami S

    更新日期:2017-06-01 00:00:00

  • The relationship of depth of penetration and tumor size to the number of positive nodes in Dukes C colorectal cancer.

    abstract::This study examines the interrelationships of depth of penetration, tumor size, and the number of positive nodes in Dukes C colorectal cancer. The results indicated that depth of tumor penetration was related to both tumor size and the number of positive regional lymph nodes. Tumors with positive nodes which failed to...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840615)53:12<2707::aid-cncr282

    authors: Wolmark N,Fisher ER,Wieand HS,Fisher B

    更新日期:1984-06-15 00:00:00

  • Impact of patient navigation in eliminating economic disparities in cancer care.

    abstract:BACKGROUND:Patient navigation may reduce cancer disparities associated with socioeconomic status (SES) and household factors. This study examined whether these factors were associated with delays in diagnostic resolution among patients with cancer screening abnormalities and whether patient navigation ameliorated these...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29612

    authors: Rodday AM,Parsons SK,Snyder F,Simon MA,Llanos AA,Warren-Mears V,Dudley D,Lee JH,Patierno SR,Markossian TW,Sanders M,Whitley EM,Freund KM

    更新日期:2015-11-15 00:00:00

  • Helicobacter pylori and primary gastric lymphoma. A histopathologic and immunohistochemical analysis of 237 patients.

    abstract:BACKGROUND:Few previous articles have analyzed the relation between infection with Helicobacter pylori (H. pylori) and primary gastric lymphoma in a large number of patients. METHODS:Resected and biopsied specimens from 237 patients with primary gastric lymphoma were investigated for H. pylori using hematoxylin and eo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Nakamura S,Yao T,Aoyagi K,Iida M,Fujishima M,Tsuneyoshi M

    更新日期:1997-01-01 00:00:00

  • In sickness and in health: transition of cancer-related care for older adolescents and young adults.

    abstract::With nearly 80% of childhood cancer patients achieving cure, there are more adult survivors living now than at any other time in history. Because they are at risk for developing complications of treatment years later, it is recommended that survivors undergo systematic, regular monitoring into young adulthood and beyo...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.22109

    authors: Freyer DR,Kibrick-Lazear R

    更新日期:2006-10-01 00:00:00

  • Chinese expert consensus on the clinical diagnosis and treatment of advanced breast cancer (2018).

    abstract::Breast cancer is the most common malignant tumor among women in the world. In 2005, there were approximately 272,000 new cases diagnosed and more than 70,000 deaths from breast cancer in China. Of the patients who are newly diagnosed with breast cancer each year, approximately 3% to 10% have distant metastases at the ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32832

    authors: Xu B,Hu X,Feng J,Geng C,Jin F,Li H,Li M,Li Q,Liao N,Liu D,Liu J,Liu Q,Lu J,Liu Z,Ma F,Ouyang Q,Pan Y,Shen K,Sun T,Teng Y,Tong Z,Wang B,Wang H,Wang S,Wang S,Wang T,Wang X,Wang X,Wang Y,Wang Z,Wu

    更新日期:2020-08-15 00:00:00

  • Adjuvant immunotherapy and chemoimmunotherapy in colorectal cancer of the Dukes' C classification. Preliminary clinical results.

    abstract::Fifty-eight patients with Dukes' C classification of carcinoma of the large bowel were placed on adjuvant immuno- or chemoimmunotherapy with Bacillus calmette guerin (BCG) or combination of 5-fluorouracil (5-FU) plus BCG following primary and definitive surgery, and were followed for up to 21 months. Of twenty-six pat...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197512)36:6<2421::aid-cncr282036

    authors: Mavligit GM,Gutterman JU,Burgess MA,Khankhanian N,Seibert GB,Speer JF,Reed RC,Jubert AV,Martin RC,McBride CM,Copeland EM,Gehan EA,Hersh EM

    更新日期:1975-12-01 00:00:00

  • Kaposi's sarcoma in two lymphoma patients with hepatitis B and other infections.

    abstract::Kaposi's sarcoma developed in two lymphoma patients previously treated by chemotherapy and chemoirradiation. The histologic picture in the two cases showed a non-Hodgkin's lymphoma with multifocal epithelioid histiocytic reaction. Both patients had Hepatitis-B surface antigen and other infections due to herpes and str...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(1984)54:4<773::aid-cncr282054043

    authors: Berrebi A,Shtalrid M,Hurwitz N,Frumkin A,Schattner A

    更新日期:1984-08-15 00:00:00

  • A case of spontaneous regression of hepatocellular carcinoma with bone metastasis.

    abstract::A 78-year-old Japanese man with chronic liver disease developed hypervascular liver tumors accompanied by marked elevation of alphafetoprotein value (the highest level; 26200 ng/ml) and pathologic fracture of the femur. After an operation for the fracture followed by gastrointestinal bleeding and repeated transfusions...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850801)56:3<667::aid-cncr28205

    authors: Sato Y,Fujiwara K,Nakagawa S,Kanishima S,Ohta Y,Oka Y,Hayashi S,Oka H

    更新日期:1985-08-01 00:00:00

  • Increasing incidence of rectal cancer in patients aged younger than 40 years: an analysis of the surveillance, epidemiology, and end results database.

    abstract:BACKGROUND:The incidence of rectal cancer in the United States in young patients is considered to be low. Underestimating this incidence may result in a failure to diagnose younger patients with rectal cancer in a timely manner. METHODS:The authors conducted a retrospective cohort study using Surveillance, Epidemiolog...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25432

    authors: Meyer JE,Narang T,Schnoll-Sussman FH,Pochapin MB,Christos PJ,Sherr DL

    更新日期:2010-09-15 00:00:00

  • Steroid receptors in breast angiosarcoma.

    abstract::The presence of receptors for estrogen, glucocorticoid and progesterone was determined in the cytosol of two breast angiosarcomas. Estrogen and glucocorticoid receptors were present in both of them. Progesterone receptors were present in one of the two tumors assayed. Occupied nuclear estrogen receptors have been foun...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830601)51:11<2105::aid-cncr282

    authors: Brentani MM,Pacheco MM,Oshima CT,Nagai MA,Lemos LB,Góes JC

    更新日期:1983-06-01 00:00:00

  • Chondrosarcoma of the foot. A case report and review of the literature.

    abstract::Chondrosarcoma of the foot is a very unusual entity. A case arising from a solitary osteocartilagenous exostosis is presented and the literature is reviewed and discussed. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197508)36:2<586::aid-cncr2820360

    authors: Lewis MM,Marcove RC,Bullough PG

    更新日期:1975-08-01 00:00:00

  • Risk perception and concern among brothers of men with prostate carcinoma.

    abstract:BACKGROUND:It is important for clinicians, researchers, and others who shape public health policy to understand the demographic correlates and psychologic factors that drive health behaviors, such as screening for early detection of cancer, particularly among individuals at high risk for developing the disease. METHOD...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20121

    authors: Beebe-Dimmer JL,Wood DP Jr,Gruber SB,Chilson DM,Zuhlke KA,Claeys GB,Cooney KA

    更新日期:2004-04-01 00:00:00

  • High-dose chemotherapy and unpurged autologous bone marrow transplantation for acute leukemia in second or subsequent remission.

    abstract::The authors administered high-dose chemotherapy with cyclophosphamide, BCNU (carmustine) and VP-16 (etoposide) plus autologous bone marrow transplantation (ABMT) to 22 adult patients with relapsed acute leukemia in second or subsequent remission. The marrow was not treated ex vivo. The long-term, disease-free survival...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900815)66:4<619::aid-cncr28206

    authors: Spinolo JA,Dicke KA,Horwitz LJ,Jagannath S,McCredie K,Estey E,Kantarjian H,Zander AR,Keating M,Spitzer G

    更新日期:1990-08-15 00:00:00

  • The combination of cisplatin, doxorubicin, and mitomycin (PAM) compared with the FAM regimen in treating advanced gastric carcinoma. A phase II randomized trial of the Italian Oncology Group for Clinical Research.

    abstract:BACKGROUND:In a randomized Phase II study, the authors evaluated the activity and toxicity of the new cisplatin, doxorubicin, and mitomycin C (PAM) combination, that includes cisplatin (P) instead of 5-fluorouracil as in the 5-fluorouracil, doxorubicin, and mitomycin C (FAM) combination, in patients with advanced gastr...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1002/(SICI)1097-0142(19960115)77:2<245::AID-CNC

    authors: De Lisi V,Cocconi G,Angelini F,Cavicchi F,Di Costanzo F,Gilli G,Rodinò C,Soldani M,Tonato M,Finardi C

    更新日期:1996-01-15 00:00:00

  • Metastatic hemangiopericytoma with prolonged survival.

    abstract::A case of a hemangiopericytoma tumor metastatic to the lung from a central nervous system primary tumor in the posterior fossa is reported. The tumor was not responsive to treatment with cyclophosphamide, Adriamycin (doxorubicin), vincristine, DTIC (CYVADIC), high-dose methotrexate with citrovorum factor rescue, aziri...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870815)60:4<916::aid-cncr28206

    authors: Hart LL,Weinberg JB

    更新日期:1987-08-15 00:00:00

  • Radiotherapy alone or combined with surgery for salivary gland carcinoma.

    abstract:BACKGROUND:The authors analyzed the outcomes of patients treated with radiotherapy (RT) alone or combined with surgery for carcinoma of the salivary glands. METHODS:Between October 1964 and June 2003, 224 previously untreated patients were treated with curative intent with RT alone (n = 64) or combined with surgery (n...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21083

    authors: Mendenhall WM,Morris CG,Amdur RJ,Werning JW,Villaret DB

    更新日期:2005-06-15 00:00:00

  • Small bore catheter drainage and sclerotherapy for malignant pleural effusions.

    abstract::The accumulation of large amounts of fluid in the pleural space is a common sequela of disseminated carcinomatosis. Traditional management has included therapeutic thoracentesis or the placement of a large bore chest tube for drainage with the subsequent installation of a sclerosing agent in an attempt to achieve pleu...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890915)64:6<1218::aid-cncr2820

    authors: Parker LA,Charnock GC,Delany DJ

    更新日期:1989-09-15 00:00:00

  • Comparability of prostate trials.

    abstract::The present overview of advanced prostate cancer required the identification of randomized clinical trials studying the question of maximal androgen blockade versus the classic castration therapy. The heterogeneity of the trials concerned the type of castration (surgical or chemical) and the type of antiandrogen (flut...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19931215)72:12+<3841::aid-cncr28

    authors: Suciu S,Sylvester R,Iversen P,Christensen I,Denis L

    更新日期:1993-12-15 00:00:00

  • Coordinate elevation of serum markers in ovarian cancer but not in benign disease.

    abstract::Effective screening for occult ovarian cancer will require a strategy that is both sensitive and specific. Preliminary data suggest that CA 125 is elevated at diagnosis in a majority of patients with ovarian cancer. Although CA 125 is sufficiently specific to prompt its evaluation as one component of a strategy to det...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19911015)68:8<1758::aid-cncr2820

    authors: Bast RC Jr,Knauf S,Epenetos A,Dhokia B,Daly L,Tanner M,Soper J,Creasman W,Gall S,Knapp RC

    更新日期:1991-10-15 00:00:00

  • DNA flow cytometry and pathologic grading as prognostic guides in axillary lymph node-negative breast cancer.

    abstract:BACKGROUND:The recurrence or mortality rate of axillary lymph node-negative invasive breast cancer has been associated with the tumor S-phase fraction, which is measured by DNA flow cytometry. Because many of the studies that established this association were performed using frozen, pulverized tumor specimens, this ass...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930915)72:6<1926::aid-cncr2820

    authors: Merkel DE,Winchester DJ,Goldschmidt RA,August CZ,Wruck DM,Rademaker AW

    更新日期:1993-09-15 00:00:00

  • The natural history of breast carcinoma in patients with > or = 10 metastatic axillary lymph nodes before and after the advent of adjuvant therapy: a multiinstitutional retrospective study.

    abstract:BACKGROUND:The majority of patients with breast carcinoma with > or = 10 metastatic axillary lymph nodes (ALNs) develop recurrent disease within 5 years from diagnosis. The purpose of the current study, performed retrospectively, was to characterize the natural history of this subset of patients, both before and after ...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.21182

    authors: Montero AJ,Rouzier R,Lluch A,Theriault RL,Buzdar AU,Delaloge S,Bermejo B,Le M,Kau SW,Dunant A,Arriagada R,Spielmann M,Garcia-Conde J,Sahin AA,Singletary SE,Hortobagyi GN,Valero V

    更新日期:2005-07-15 00:00:00

  • Primary intestinal lymphoma with paraproteinemia.

    abstract::Five cases of primary intestinal lymphoma are described. The main clinical features included abdominal pain, diarrhea, and marked weight loss, together with radiologic and some laboratory findings suggestive of malabsorption. Laparatomy perfomed in four cases revealed dilatation of the small intestine, with mesenteric...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197503)35:3<848::aid-cncr2820350

    authors: Shahid MJ,Alami SY,Nassar VH,Balikian JB,Salem AA

    更新日期:1975-03-01 00:00:00

  • Thalidomide in the treatment of patients with hepatocellular carcinoma: a phase II trial.

    abstract:BACKGROUND:The treatment of patients with hepatocellular carcinoma (HCC) presents a major challenge, because associated cirrhosis limits the choice of chemotherapeutic agents. However, the abundant vascularity of HCC presents an attractive target for antiangiogenic therapy that potentially may be tolerated by cirrhotic...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/cncr.20821

    authors: Patt YZ,Hassan MM,Lozano RD,Nooka AK,Schnirer II,Zeldis JB,Abbruzzese JL,Brown TD

    更新日期:2005-02-15 00:00:00