Environmental factors in cancer of the larynx: a second look.

Abstract:

:During a retrospective case-control study of recent laryngeal cancer patients, several associated factors were studied to determine possible changes in the epidemiology of laryngeal cancer between 1956 and 1974. The large sex difference noted in the early survey (male: female ratio of 14.9:1) diminished considerably in the present sample (4.6:1) because more women are cigarette smokers in the cancer age group today than was the case 20 years ago. Laryngeal cancer patients tended to be less educated than the controls and included a smaller proportion of Jews and more Catholics than the control group. The risk for developing laryngeal cnacer was considerably lower for exsmokers and long-term (10+ years) filter cigarette smokers as compared with non-filter smokers. At each level of alcohol consumption, the risk increased as exposure to tobacco increased. Occupations associated with wood exposure were found to affect the development of laryngeal cancer, independently of smoking status. Future studies should include an extensive study of nutritional deficiencies associated with alcoholism to determine if a correlation exists between such deficiencies, socioeconomic status, and an increased risk of laryngeal cnacer.

journal_name

Cancer

journal_title

Cancer

authors

Wynder EL,Covey LS,Mabuchi K,Mushinski M

doi

10.1002/1097-0142(197610)38:4<1591::aid-cncr282038

subject

Has Abstract

pub_date

1976-10-01 00:00:00

pages

1591-601

issue

4

eissn

0008-543X

issn

1097-0142

journal_volume

38

pub_type

杂志文章

相关文献

CANCER文献大全
  • Urinary chorionic gonadotropin subunits and beta-core in nonpregnant women. A study of benign and malignant gynecologic disorders.

    abstract:BACKGROUND:The presence of urinary excretion products of human chorionic gonadotropin (hCG) has been proposed as a tumor marker. To ascertain the clinical value in gynecologic cancers, the authors studied 612 nonpregnant women. METHODS:Three different assays in four clinical groups were compared: no disease, benign di...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930615)71:12<4124::aid-cncr282

    authors: Neven P,Iles RK,Lee CL,Hudson CN,Shepherd JH,Chard T

    更新日期:1993-06-15 00:00:00

  • Adenosarcoma of uterus and ovary: a clinicopathologic study of two cases.

    abstract::We report the clinical and pathologic features of two cases of adenosarcoma. Our first case occurred in the ovary of a 51-year-old woman with extensive pelvic involvement. She was treated vigorously with radiation and chemotherapy and at the present time almost 9 years later the patient is free of disease. This repres...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197904)43:4<1439::aid-cncr282043

    authors: Valdez VA,Planas AT,Lopez VF,Goldberg M,Herrera NE

    更新日期:1979-04-01 00:00:00

  • Chronic lymphocytic leukemia. Immunologic markers and functional properties of the leukemic cells.

    abstract::In 230 cases of chronic lymphocytic leukemia (CLL), marker analysis was performed with rosette techniques and a panel of xeno-antisera. A monoclonal B-cell proliferation was found in the majority of cases (94%). In most cases, the B-cells carried IgM, with or without IgD. Cytoplasmic immunoglobulin-inclusion bodies we...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19821215)50:12<2826::aid-cncr282

    authors: van der Reijden HJ,van der Gaag R,Pinkster J,Rümke HC,van't Veer MB,Melief CJ,von dem Borne AE

    更新日期:1982-12-15 00:00:00

  • Serum HER-2/neu and relative resistance to trastuzumab-based therapy in patients with metastatic breast cancer.

    abstract:BACKGROUND:Previous reports based on small patient numbers suggested that changes in serum HER-2/neu levels may predict response or lack of response to trastuzumab-based therapies in metastatic breast cancer (MBC). The objectives of this study were to pool data from 307 patients with MBC from 7 medical institutions to ...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.23689

    authors: Ali SM,Carney WP,Esteva FJ,Fornier M,Harris L,Köstler WJ,Lotz JP,Luftner D,Pichon MF,Lipton A,Serum HER-2\/neu Study Group.

    更新日期:2008-09-15 00:00:00

  • Urinary pepsinogen I as a tumor marker of stomach cancer after total gastrectomy.

    abstract::The possibility that urinary pepsinogen I is a tumor marker of stomach cancer after total gastrectomy was examined. To decide the cutoff level of urinary pepsinogen I after total gastrectomy, urine samples from 15 patients who had undergone total gastrectomy for stomach cancer in the early or advanced stages and had b...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910815)68:4<906::aid-cncr28206

    authors: Yamaguchi T,Takahashi T,Yokota T,Kitamura K,Noguchi A,Kamiguchi M,Doi M,Ahn T,Sawai K,Yamane T

    更新日期:1991-08-15 00:00:00

  • Endodermal sinus tumor of the mediastinum.

    abstract::Endodermal sinus tumor (EST) of the mediastinum is a rare germ-cell neoplasm affecting mainly young adult males. Ten patients with EST were treated with a multimodality approach that included surgery, chemotherapy, and radiotherapy. All patients had relapses after achieving a transient response except one who is still...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820815)50:4<766::aid-cncr28205

    authors: Kuzur ME,Cobleigh MA,Greco FA,Einhorn LH,Oldham RK

    更新日期:1982-08-15 00:00:00

  • Indolent diffuse histiocytic lymphoma with sclerosis and chylous effusions.

    abstract::A case of diffuse histiocytic lymphoma with sclerosis and chylous pleural and peritoneal effusions spanning four years from onset to diagnosis is presented. Treatment with combination chemotherapy and consolidative radiotherapy resulted in clinical improvement and the patient remains free of disease 14 months after st...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830601)51:11<2144::aid-cncr282

    authors: Hansen RM,Komaki R,Hanson GA,Schlueter DP,Anderson T

    更新日期:1983-06-01 00:00:00

  • Carcinoma cuniculatum (verrucous carcinoma of the skin): a clinicopathologic study of 46 cases with ultrastructural observations.

    abstract::Forty-six examples of carcinoma cuniculatum, a rare variant of squamous cell carcinoma of the skin, were studied by means of light and electron microscopy and immunoperoxidase techniques. The tumors usually presented as ulcerated, fungating, and polypoid masses with openings of sinus tracts onto the skin surface that ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820601)49:11<2395::aid-cncr282

    authors: Kao GF,Graham JH,Helwig EB

    更新日期:1982-06-01 00:00:00

  • Effectiveness of high-dose MCNU therapy and hematopoietic stem cell autografts treatment of childhood acute leukemia/lymphoma with high-risk features.

    abstract::Clinical and pharmacokinetic studies were performed regarding the toxicity of methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside (MCNU) with other drugs, in conjunction with a peripheral blood stem cell autograft (PBSCT), for treating 26 children with acute leukemia or lymphoma associated wit...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19910401)67:7<1830::aid-cncr2820

    authors: Takaue Y,Watanabe T,Hoshi Y,Abe T,Matsunaga K,Saito S,Hirao A,Kawano Y,Ninomiya T,Kuroda Y

    更新日期:1991-04-01 00:00:00

  • Nasopharyngeal carcinoma in childhood and adolescence: a single-institution experience with combined therapy.

    abstract:BACKGROUND:A high cure rate may be attained for locally advanced, undifferentiated nasopharyngeal carcinoma (NPC) in children, provided that a combined modality of treatment is employed. Both local and systemic therapies are necessary. Results at a single pediatric institution were analyzed. METHODS:From November 1988...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Zubizarreta PA,D'Antonio G,Raslawski E,Gallo G,Preciado MV,Casak SJ,Scopinaro M,Morales G,Sackmann-Muriel F

    更新日期:2000-08-01 00:00:00

  • Treatment of recurrent epithelial ovarian cancer.

    abstract::The majority of patients with advanced ovarian cancer progress after first-line therapy and require further treatment. Tumor biology, prior chemotherapy, responses to previous therapy, performance status, and toxicity are the characteristics that influence treatment choice. These criteria have been linked to the time ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.32500

    authors: Pignata S,Pisano C,Di Napoli M,Cecere SC,Tambaro R,Attademo L

    更新日期:2019-12-15 00:00:00

  • Management of adult acute leukemia. A Southwest Oncology Group study.

    abstract::Five hundred forty three adult patients with acute leukemia were entered on the study designed to: (1) test efficacy of vincristine and prednisone used as primary drug therapy in patients with good prognosis as judged by a circulating blast cell count less than 30,000 cm2; (2) investigate the use of either simultaneou...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830915)52:6<958::aid-cncr28205

    authors: McCredie KB,Gehan EA,Freireich EJ,Hewlett JS,Coltman CA Jr,Hussein KK,Balcerzak SP,Chen TT

    更新日期:1983-09-15 00:00:00

  • Distinct cytogenetic and clinicopathologic features in acute myeloid leukemia after occupational exposure to pesticides and organic solvents.

    abstract:BACKGROUND:To study the correlation of environmental exposure to potentially mutagenic agents and the clinicopathologic picture in acute myeloid leukemia (AML), clinical features, morphologic characteristics, immunophenotype, and cytogenetics were studied in 59 patients with newly diagnosed AML. METHODS:Based on inter...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920701)70:1<77::aid-cncr282070

    authors: Fagioli F,Cuneo A,Piva N,Carli MG,Previati R,Balboni M,Tomasi P,Cariani D,Scapoli G,Castoldi G

    更新日期:1992-07-01 00:00:00

  • Low-dose continuous infusion 5-fluorouracil. Evaluation in advanced breast carcinoma.

    abstract::Low-dose continuous infusion 5-fluorouracil (LDCI-FU) was administered to 28 women with advanced breast carcinoma. Daily doses ranged from 175 to 250 mg/m2. The LDCI-FU was delivered continuously until the appearance of toxicity and was reinstituted at a 20% dose reduction after toxicity completely resolved. Patients ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890201)63:3<419::aid-cncr28206

    authors: Huan S,Pazdur R,Singhakowinta A,Samal B,Vaitkevicius VK

    更新日期:1989-02-01 00:00:00

  • Beta-benzene hexachloride in breast adipose tissue and risk of breast carcinoma.

    abstract:BACKGROUND:Epidemiologic studies have recently related benzene hexachloride (BHC) to breast carcinoma risk. Experimental studies have also shown that beta-BHC is weakly estrogenic, hence supporting the alleged association. By directly comparing beta-BHC levels in breast adipose tissue from incident breast carcinoma cas...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19990515)85:10<2212::aid-c

    authors: Zheng T,Holford TR,Mayne ST,Owens PH,Ward B,Carter D,Dubrow R,Zahm SH,Boyle P,Tessari J

    更新日期:1999-05-15 00:00:00

  • Health-related quality of life among breast cancer survivors and noncancer controls over 10 years: Pink SWAN.

    abstract:BACKGROUND:The goal of this study was to compare health-related quality of life (HRQL) from diagnosis to 10 years postdiagnosis among breast cancer survivors (BCS) and women without cancer over the same period and to identify BCS subgroups exhibiting different HRQL trajectories. METHODS:Our analysis included 141 BCS a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32757

    authors: Avis NE,Levine B,Goyal N,Crawford SL,Hess R,Colvin A,Bromberger JT,Greendale GA

    更新日期:2020-05-15 00:00:00

  • Evaluation of p16INK4a expression in ThinPrep cervical specimens with the CINtec p16INK4a assay: correlation with biopsy follow-up results.

    abstract:BACKGROUND:The aim of this study was to examine p16(INK4a) protein expression in ThinPrep (Cytyc Corporation, Marlborough, Mass) cervical specimens by using the CINtec p16(INK4a) Cytology Kit (Dako, Glostrup, Denmark). The ability of this assay to accurately identify underlying high-grade lesions was assessed by using ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22580

    authors: Meyer JL,Hanlon DW,Andersen BT,Rasmussen OF,Bisgaard K

    更新日期:2007-04-25 00:00:00

  • Hepatic involvement in Hodgkin's disease. Clues to histologic diagnosis.

    abstract::The hepatic histopathology was studied in 125 patients with Hodgkin's disease to determine whether there are any features other than Reed-Sternberg (RS) cells that might aid in the diagnosis of hepatic involvement by the neoplastic process. Liver biopsy specimens from 41 patients with Hodgkin's disease in the liver we...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19891115)64:10<2121::aid-cncr282

    authors: Dich NH,Goodman ZD,Klein MA

    更新日期:1989-11-15 00:00:00

  • High mobility group AT-hook 1 (HMGA1) is an independent prognostic factor and novel therapeutic target in pancreatic adenocarcinoma.

    abstract:BACKGROUND:High mobility group AT-hook 1 (HMGA1) proteins are architectural transcription factors that are overexpressed by pancreatic adenocarcinomas. The authors hypothesized that tumor HMGA1 status represents a novel prognostic marker in pancreatic adenocarcinoma. They also tested the hypothesis that HMGA1 promotes ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23560

    authors: Liau SS,Rocha F,Matros E,Redston M,Whang E

    更新日期:2008-07-15 00:00:00

  • Racial disparities in the use of and indications for colorectal procedures in Medicare beneficiaries.

    abstract:BACKGROUND:African Americans are diagnosed more frequently with colorectal carcinoma at a later stage compared with Caucasians. One potential reason for the disparity is a lower rate of screening examinations. METHODS:Using Outpatient and Physician-Supplier claims for all Medicare beneficiaries age > or = 65 years in ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20014

    authors: Cooper GS,Koroukian SM

    更新日期:2004-01-15 00:00:00

  • Characteristics of patients with stage III colon adenocarcinoma who fail to receive guideline-recommended treatment.

    abstract:BACKGROUND:Many patients with stage III colon adenocarcinoma do not receive adjuvant chemotherapy despite the proven survival advantage it offers. To enhance the provision of optimal cancer care, patient characteristics associated with not receiving guideline-adherent treatment must be identified among patients with op...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25250

    authors: Winget M,Hossain S,Yasui Y,Scarfe A

    更新日期:2010-10-15 00:00:00

  • The value of splenectomy in chronic lymphocytic leukemia.

    abstract::Between January 1, 1980, and July 31, 1985, 168 patients were treated at our institution for chronic lymphocytic leukemia (CLL). Splenectomy was performed on 32 (23 men and 9 women). The mean age of these surgical patients was 59.4 years (range, 43-75). Twenty-four patients had received chemotherapy and/or corticother...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870115)59:2<340::aid-cncr28205

    authors: Delpero JR,Gastaut JA,Letreut YP,Caamano A,Mathieu-Tubiana N,Maraninchi D,Simon-Lejeune C,Mascret B,Blanc AP,Sebahoun G

    更新日期:1987-01-15 00:00:00

  • Methotrexate and asparaginase combination chemotherapy in refractory acute lymphoblastic leukemia of childhood.

    abstract::Two groups of children with refractory acute lymphoblastic leukemia were treated with a regimen of methotrexate (MTX) and asparaginase (Asn'ase) based on studies of the effect of MTX in vitro on human lymphoblasts exposed to Asn'ase. Induction therapy in 12 children produced 4 complete remissions, 3 partial remissions...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197903)43:3<1089::aid-cncr282043

    authors: Lobel JS,O'Brien RT,McIntosh S,Aspnes GT,Capizzi RL

    更新日期:1979-03-01 00:00:00

  • The changing landscape of phase II/III metastatic NSCLC clinical trials and the importance of biomarker selection criteria.

    abstract::Over the last decade, new cytotoxic treatments and targeted therapies have altered treatment paradigms for patients with metastatic non-small cell lung cancer (NSCLC). We sought to analyze the impact of histology and biomarker selection criteria on outcomes of clinical trials in metastatic NSCLC reported over the last...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28956

    authors: Gentzler RD,Yentz SE,Johnson ML,Rademaker AW,Patel JD

    更新日期:2014-12-15 00:00:00

  • Correlation between genetic alteration and long-term clinical outcome of patients with oligodendroglial tumors, with identification of a consistent region of deletion on chromosome arm 1p.

    abstract:BACKGROUND:In oligodendroglial tumors, allelic losses on chromosome arms 1p and 19q are not only diagnostic molecular markers but also statistically significant predictors of both chemosensitivity and longer recurrence-free survival. In the current study, the authors attempted to analyze 21 patients genetically and cli...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11322

    authors: Hashimoto N,Murakami M,Takahashi Y,Fujimoto M,Inazawa J,Mineura K

    更新日期:2003-05-01 00:00:00

  • The association of embryonal tumors originating in the kidney and in the brain. A report of seven cases.

    abstract::This report documents, in seven infants younger than 2 years of age, a previously unrecognized association of a renal embryonal neoplasm (malignant rhabdoid tumor in six patients and a Wilms' tumor in one) with an embryonal primary tumor originating in the central nervous system. The neuroepithelial tumors included th...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841115)54:10<2137::aid-cncr282

    authors: Bonnin JM,Rubinstein LJ,Palmer NF,Beckwith JB

    更新日期:1984-11-15 00:00:00

  • Benign breast lesions at risk of developing cancer--a challenging problem in breast cancer screening programs: five years' experience of the Breast Cancer Screening Program in Verona (1999-2004).

    abstract:BACKGROUND:Cytology and core-needle biopsies are not always sufficient to exclude malignancy in benign breast lesions (BBL) that are at risk of developing cancer, and open biopsy often is mandatory. In screening programs, open biopsies performed for lesions that are at risk of developing malignancy are considered benig...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24038

    authors: Manfrin E,Mariotto R,Remo A,Reghellin D,Falsirollo F,Dalfior D,Bricolo P,Piazzola E,Bonetti F

    更新日期:2009-02-01 00:00:00

  • Issues in the consideration of intervention strategies in long-term survivors of childhood cancer.

    abstract::With the improved survival of children with cancer, increased attention is being focused on the health status of survivors. The ultimate objective of this research is to use the results to design and test rational intervention strategies directed toward reduction of morbidity and mortality associated with the diagnosi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930515)71:10+<3406::aid-cncr28

    authors: Robison LL

    更新日期:1993-05-15 00:00:00

  • Thyroid medullary carcinoma with thyroglobulin immunoreactivity in sporadic multiple endocrine neoplasia type 2-B.

    abstract:BACKGROUND:Thyroid carcinomas historically have been divided into two groups according to their presumedly separate embryonic origins: those of neuroectodermal derivation (parafollicular or medullary carcinoma [MCT]) and those of foregut endodermal origin (follicular and papillary carcinomas). The validity of this conc...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940801)74:3<928::aid-cncr28207

    authors: Kovacs CS,Masé RM,Kovacs K,Nguyen GK,Chik CL

    更新日期:1994-08-01 00:00:00

  • The use of molecular assays to establish definitively the clonality of ipsilateral breast tumor recurrences and patterns of in-breast failure in patients with early-stage breast cancer treated with breast-conserving therapy.

    abstract:BACKGROUND:Results from numerous trials have indicated that breast-conserving therapy (BCT) produces outcomes equivalent to those produced by mastectomy in terms of both locoregional control and survival. However, conservative treatment has resulted in the dilemma of how best to address recurrences when they appear in ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22529

    authors: Vicini FA,Antonucci JV,Goldstein N,Wallace M,Kestin L,Krauss D,Kunzmann J,Gilbert S,Schell S

    更新日期:2007-04-01 00:00:00