Abstract:
:Fifty-eight patients with Dukes' C classification of carcinoma of the large bowel were placed on adjuvant immuno- or chemoimmunotherapy with Bacillus calmette guerin (BCG) or combination of 5-fluorouracil (5-FU) plus BCG following primary and definitive surgery, and were followed for up to 21 months. Of twenty-six patients receiving BCG alone by scarification, five have relapsed with 75% of freedom from disease estimated at 15.1 months compared with 10.1 months in a group of carefully selected historical controls who had surgery alone (p = 0.12). The survival of all patients receiving BCG alone has not reached the 75 percentile yet, and the difference from controls is currently estimated at the 18% level. The combination of 5-FU plus BCG (studied in 32 patients) may be superior to BCG alone at this time, in that it appears to more effectively protect against tumor recurrence (75 percentile not yet reached compared to control, (p = 0.08). The survival of patients on 5-FU plus BCG also appears to be improved (p = 0.09). No patients have expired compared to a 75 percentile survival of 16.6 months in the control. Serial determination of plasma CEA was crucial in the clinical follow-up of these patients. Frequent CEA detetminations have led to early detection of clinical relapse. In the elevation of CEA suggests tumor recurrence with a high degree of probability in patients with past history of cancer of the large bowel.
journal_name
Cancerjournal_title
Cancerauthors
Mavligit GM,Gutterman JU,Burgess MA,Khankhanian N,Seibert GB,Speer JF,Reed RC,Jubert AV,Martin RC,McBride CM,Copeland EM,Gehan EA,Hersh EMdoi
10.1002/1097-0142(197512)36:6<2421::aid-cncr282036subject
Has Abstractpub_date
1975-12-01 00:00:00pages
2421-7issue
6 Suppleissn
0008-543Xissn
1097-0142journal_volume
36pub_type
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