Clinical impact of molecular genetic diagnosis, genetic counseling, and management of hereditary cancer. Part I: Studies of cancer in families.

abstract：:Dr. Wendell G. Scott hailed mammography as the first significant contribution to the control of breast cancer since Halsted described the radical mastectomy in 1903. Mammography as engendered new approaches and has supplied new concepts of breast cancer. Through the tenacity of a few physicians convinced something cou...

journal_title：Cancer

authors： Egan RL

更新日期：1975-11-01 00:00:00

abstract：BACKGROUND:There is an increase in the incidence of cutaneous malignant melanoma (CMM) among white people throughout the world. In Sweden, a fivefold increase has been recorded since 1960, but the mortality is rising at a much lower rate. Tumor thickness is the single most important prognostic factor for primary melano...

journal_title：Cancer

authors： Måsbäck A,Westerdahl J,Ingvar C,Olsson H,Jonsson N

更新日期：1994-03-15 00:00:00

abstract：:The urinary neopterin excretion was measured by high-performance liquid chromatography in 417 healthy subjects and in 76 patients with clinically and pathohistologically verified neoplasias of the urinary tract (bladder tumor, carcinoma of the prostate, and renal cell carcinoma). The patients with early tumor stages b...

journal_title：Cancer

authors： Aulitzky W,Frick J,Fuchs D,Hausen A,Reibnegger G,Wachter H

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:Lymph node involvement is an important prognostic factor in gallbladder carcinoma (GBC). The lymph node involvement pattern, extent, and indications for systematic lymph node dissection for patients with advanced GBC were investigated. METHODS:Forty-one patients with GBC who underwent radical resection with...

journal_title：Cancer

authors： Shimada H,Endo I,Togo S,Nakano A,Izumi T,Nakagawara G

更新日期：1997-03-01 00:00:00

abstract：:Twenty-three leukemic children were studied prospectively to detect chronic effects of therapy. All patients received CNS prophylaxis, including 2400 R cranial irradiation, and intermittent maintenance therapy with intravenous methotrexate, cyclophosphamide and cytosine arabinoside. Neurologic symptoms were observed i...

journal_title：Cancer

authors： McIntosh S,Klatskin EH,O'Brien RT,Aspnes GT,Kammerer BL,Snead C,Kalavsky SM,Pearson HA

更新日期：1976-02-01 00:00:00

abstract：BACKGROUND:Adjuvant chemotherapy after surgical resection improves outcomes for patients with early-stage non-small cell lung cancer (NSCLC). To the authors' knowledge, there are no published prospective trials to date of adjuvant chemotherapy after surgical resection administered exclusively in older patients. In the ...

journal_title：Cancer

authors： Ganti AK,Williams CD,Gajra A,Kelley MJ

更新日期：2015-08-01 00:00:00

abstract：:Fifteen patients with acute nonlymphocytic leukemia (ANLL) who either had a relapse after a previous complete remission (nine patients) or progressive disease after initial induction attempts with combination chemotherapy (six patients) were treated with 5-azacytidine. Five patients (33%) achieved a complete remission...

journal_title：Cancer

authors： Larson RA,Sweet DL,Golomb HM,Testa JR,Rowley JD

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:EphA2 is overexpressed in the majority of ovarian cancers and predicts poor clinical outcome. Based on EphA2's emerging role in angiogenesis, we hypothesized that tumors overexpressing EphA2 demonstrate greater microvessel density (MVD) and matrix metalloproteinase (MMP) expression. METHODS:After Institutio...

journal_title：Cancer

authors： Lin YG,Han LY,Kamat AA,Merritt WM,Landen CN,Deavers MT,Fletcher MS,Urbauer DL,Kinch MS,Sood AK

更新日期：2007-01-15 00:00:00

abstract：:Multifocal osteosarcoma with unique patho-biological features in a 23-year old white male is reported. The natural history and classification of multiple osteosarcomas are reviewed. A proposal is presented for evaluation of the multicentric origin in future cases. ...

journal_title：Cancer

authors： Mahoney JP,Spanier SS,Morris JL

更新日期：1979-11-01 00:00:00

abstract：:Beta-glucuronidase activity was extracted from prostatic carcinomas and hyperplastic prostates. It was 3.6-fold higher (P less than 0.0001) in prostatic carcinoma than in prostatic hyperplasia. Analysis for isoenzymes of prostatic beta-glucuronidase by disc-gel electrophoresis in nondenaturing polyacrylamide gels demo...

journal_title：Cancer

authors： Pearson JP,Pretlow TP,Bradley EL Jr,McGinnis MC,Pretlow TG

更新日期：1989-08-15 00:00:00

abstract：BACKGROUND:Colorectal cancer patients undergoing chemotherapy (CT) are likely to experience multiple concurrent toxicities that, rather than appearing singularly, may be associated with one another. Graphic and tabular representations of distance matrices were used to identify associations between toxicities and to def...

journal_title：Cancer

authors： Aprile G,Ramoni M,Keefe D,Sonis S

更新日期：2008-01-15 00:00:00

abstract：:The dose of adjuvant chemotherapy for breast cancer may be an important factor in the success of the treatment program. In a retrospective analysis, the authors determined whether patients who were irradiated either postoperatively (N = 29) or as part of primary treatment (N = 13) received a lower dose of adjuvant cyc...

journal_title：Cancer

authors： Levine JF,Coleman CN,Cox RS,Ray GR,Rogoway WM,Martinez A,Stockdale FE

更新日期：1984-01-15 00:00:00

abstract：BACKGROUND:Childhood cancer is a highly curable disease when timely diagnosis and appropriate therapy are provided. A negative impact of the coronavirus disease 2019 (COVID-19) pandemic on access to care for children with cancer is likely but has not been evaluated. METHODS:A 34-item survey focusing on barriers to ped...

journal_title：Cancer

authors： Saab R,Obeid A,Gachi F,Boudiaf H,Sargsyan L,Al-Saad K,Javakhadze T,Mehrvar A,Abbas SS,Abed Al-Agele YS,Al-Haddad S,Al Ani MH,Al-Sweedan S,Al Kofide A,Jastaniah W,Khalifa N,Bechara E,Baassiri M,Noun P,El-Houdzi J,K

更新日期：2020-09-15 00:00:00

abstract：BACKGROUND:It remains controversial whether modified radical neck dissection (MRND) for patients with papillary thyroid carcinoma improves prognosis. However, it is highly probable that the incidence of local recurrence is reduced by lymph node dissection. Sentinel lymph node (SLN) biopsy (SLNB) for patients with melan...

journal_title：Cancer

authors： Fukui Y,Yamakawa T,Taniki T,Numoto S,Miki H,Monden Y

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:The effects of relaxin (RLX) on the human breast adenocarcinoma cell line MCF-7 have been evaluated. METHODS:The cells were maintained in culture with Dulbecco's modified Eagle's medium with 1% and 10% fetal calf serum. Highly purified porcine RLX was added at concentrations ranging between 10(-11) and 10(-...

journal_title：Cancer

authors： Bigazzi M,Brandi ML,Bani G,Sacchi TB

更新日期：1992-08-01 00:00:00

abstract：:"Bowen's disease" is a clinical and histologic diagnosis describing the lesions (single or multiple) of cutaneous in situ squamous cell carcinoma. The case of a 54-year-old man with 60 such intra-epidermal carcinomas, and a history of arsenic ingestion, is presented. The patient was sensitized to dinitrochlorobenzene ...

journal_title：Cancer

authors： Raaf JH,Krown SE,Pinsky CM,Cunningham-Rundles W,Safai B,Oettgen HF

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND:An open-label Phase II study of oxaliplatin was conducted to evaluate its safety and efficacy in children with recurrent or refractory medulloblastoma (MB), supratentorial primitive neuroectodermal tumors (SPNET), and atypical teratoid rhabdoid tumor (ATRT). METHODS:Patients were stratified as follows: stra...

journal_title：Cancer

authors： Fouladi M,Blaney SM,Poussaint TY,Freeman BB 3rd,McLendon R,Fuller C,Adesina AM,Hancock ML,Danks MK,Stewart C,Boyett JM,Gajjar A

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Early stage lung cancer has a variable prognosis, and there are currently no markers that predict which patients will recur. This study examined the relation between tumor-regulatory T (Treg) cells and total tumor-infiltrating T-cell lymphocytes (TIL) to determine whether they correlated with recurrence. ME...

journal_title：Cancer

authors： Petersen RP,Campa MJ,Sperlazza J,Conlon D,Joshi MB,Harpole DH Jr,Patz EF Jr

更新日期：2006-12-15 00:00:00

abstract：BACKGROUND:The growing diversity of the population of the United States and the high burden of cancer-related symptoms reflect the need for caregiver research within underserved groups. In this longitudinal study, the authors assessed changes in symptom severity in caregivers and underserved minority patients diagnosed...

journal_title：Cancer

authors： Palos GR,Mendoza TR,Liao KP,Anderson KO,Garcia-Gonzalez A,Hahn K,Nazario A,Ramondetta LM,Valero V,Lynch GR,Jibaja-Weiss ML,Cleeland CS

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Posttransplant lymphoproliferative disorder (PTLD) is a life-threatening complication of solid organ transplantation. Histologic heterogeneity and a lack of treatment standards have made evaluating clinical outcomes in specific patient populations difficult. This systematic literature review investigated the...

journal_title：Cancer

authors： Koff JL,Li JX,Zhang X,Switchenko JM,Flowers CR,Waller EK

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Most commercial fecal occult blood tests (FOBT) used for colorectal carcinoma screening of Western populations are guaiac-based, manually developed, subjective, and sensitive to dietary components. Preliminary studies demonstrated the unsuitability of these tests for screening a Chinese population. The goal ...

journal_title：Cancer

authors： Wong WM,Lam SK,Cheung KL,Tong TS,Rozen P,Young GP,Chu KW,Ho J,Law WL,Tung HM,Choi HK,Lee YM,Lai KC,Hu WH,Chan CK,Yuen MF,Wong BC

更新日期：2003-05-15 00:00:00

abstract：:Proviral DNA of adult T-cell leukemia virus (HTLV-I) was examined by the standard Southern blotting method in lymph nodes of 45 patients with anti-HTLV-I antibody (ATLA)-positive adult T-cell leukemia/lymphoma (ATLL). Six of these patients revealed no monoclonal proviral HTLV-I DNA in tumor cells. These six patients s...

journal_title：Cancer

authors： Yoshida T,Kikuchi M,Ooshima K,Takeshita M,Kimura N,Kozuru M,Satoh H

更新日期：1989-12-15 00:00:00

abstract：:The histories of 121 Stage II melanoma patients were reviewed to determine the value of monitoring serum LDH in postoperative follow-up examinations. Charts of 58 Stage III patients who had autopsies at UCLA also were reviewed to define the relationship between an elevated LDH and liver metastases. The sensitivity and...

journal_title：Cancer

authors： Finck SJ,Giuliano AE,Morton DL

更新日期：1983-03-01 00:00:00

abstract：:Carcinoembryonic antigen (CEA) was measured in extracts of cell suspensions from tumors of the colon, stomach, breast, lung and kidney. Cell suspensions were also obtained from normal tissue surrounding the primary tumors. The number of neoplastic cells in each cell suspension was determined by cytologic criteria. Hig...

journal_title：Cancer

authors： MacSween JM,Anderson GH

更新日期：1977-08-01 00:00:00

abstract：BACKGROUND:Human breast cancers frequently show loss of heterozygosity (LOH) and/or amplification at specific chromosomal regions. METHODS:To investigate the roles of these genetic alterations during tumor development and/or progression, 457 cases of primary breast cancer were examined for LOH at chromosomal regions 1...

journal_title：Cancer

authors： Harada Y,Katagiri T,Ito I,Akiyama F,Sakamoto G,Kasumi F,Nakamura Y,Emi M

更新日期：1994-10-15 00:00:00

abstract：:This trial was conducted to determine if the reported superiority of tamoxifen (TAM) plus prednisolone (PRDLN) over TAM alone in postmenopausal women with metastatic breast cancer could be corroborated. A total of 326 patients were randomized on a double-blind trial to TAM (10 mg twice daily) plus placebo or TAM plus ...

journal_title：Cancer

authors： Ingle JN,Mailliard JA,Schaid DJ,Krook JE,Gesme DH Jr,Windschitl HE,Pfeifle DM,Etzell PS,Gerstner JG,Long HJ

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Nonsmall cell lung carcinomas (NSCLCs) are associated with very dismal prognoses, and adjuvant chemotherapy, including irinotecan, taxanes, platin, and vinca alkaloid derivatives, offer patients only slight clinical benefits. Part of the chemoresistance of NSCLC results from the expression in NSCLC cells of ...

journal_title：Cancer

authors： Mathieu A,Remmelink M,D'Haene N,Penant S,Gaussin JF,Van Ginckel R,Darro F,Kiss R,Salmon I

更新日期：2004-10-15 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine risk factors that affect locoregional control of nasopharyngeal carcinoma (NPC) after radiotherapy. Computed tomography (CT) is utilized for radiotherapy planning and for identifying high risk anatomic areas. METHODS:Between April 1990 and December 1993, 40 consecu...

journal_title：Cancer

authors： Jian JJ,Cheng SH,Prosnitz LR,Tsai SY,Tsai MJ,Huang AT

更新日期：1998-01-15 00:00:00

abstract：BACKGROUND:Breast carcinoma is one of the leading causes of excess mortality rates in Harlem, an inner-city neighborhood with the highest mortality rates and worst life expectancy in New York City. This study reports the results of a breast carcinoma screening and diagnostic program in Harlem. METHODS:Retrospective re...

journal_title：Cancer

authors： Liberman L,Freeman HP,Chandra S,Stein AL,McCord C,Godfrey D,Dershaw DD

更新日期：2002-07-01 00:00:00

abstract：:Long-term vocational achievements of 40 survivors of cancer diagnosed during adolescence were examined and compared with 40 healthy sex-matched and age-matched controls. Patients' ages at diagnosis ranged from 13 to 19 years (mean, 16.15). Study subjects had survived cancer for over 5 years and were on no cancer thera...

journal_title：Cancer

authors： Tebbi CK,Bromberg C,Piedmonte M

更新日期：1989-01-01 00:00:00