Abstract:
:The present overview of advanced prostate cancer required the identification of randomized clinical trials studying the question of maximal androgen blockade versus the classic castration therapy. The heterogeneity of the trials concerned the type of castration (surgical or chemical) and the type of antiandrogen (flutamide, Anandron, or cyproterone acetate) added to castration. This paper reviews the different types of heterogeneity that might exist among trials that are involved in the overview: study design, randomization procedure, treatment evaluation, statistical evaluation, and data maturity. In order to overcome these various types of heterogeneity and to compare like with like, the treatment comparison should be stratified a posteriori by question (i.e., type of castration or type of anti-androgen studied) and by study. In this way, one may draw valid conclusions. Of course, those trials with a larger number of patients and a longer follow-up will contribute more to the overview's results.
journal_name
Cancerjournal_title
Cancerauthors
Suciu S,Sylvester R,Iversen P,Christensen I,Denis Ldoi
10.1002/1097-0142(19931215)72:12+<3841::aid-cncr28subject
Has Abstractpub_date
1993-12-15 00:00:00pages
3841-6issue
12 Suppleissn
0008-543Xissn
1097-0142journal_volume
72pub_type
杂志文章,评审相关文献
CANCER文献大全abstract:BACKGROUND:Interferon is approved for adjuvant treatment of patients with stage IIB/III melanoma. The identification of predictive markers that would permit selection of patients would be beneficial. Specific human leukocyte antigen (HLA) class I and II antigens have previously shown an association with response to the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25211
更新日期:2010-09-15 00:00:00
abstract:BACKGROUND:Hypoxia inducible factor-1 (HIF-1) plays a critical role in angiogenesis during vascular development. The authors tested the hypothesis that HIF-1 expression correlates with progression and angiogenesis in brain tumors. METHODS:The authors investigated the expression of the HIF-1alpha and HIF-1beta subunits...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:The role of adjuvant therapy in the management of patients with malignant mixed Müllerian tumors (MMMT) of the uterus has not been defined. The outcome of planned multimodality therapy for patients with apparent early stage disease was assessed. METHODS:A pilot study was performed on 38 patients with clinic...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:2001-04-15 00:00:00
abstract::The metabolism of 5-fluorouracil (5-FU) was studied in biopsy specimens of primary colorectal cancer and healthy colonic mucosa obtained from previously untreated patients immediately after surgical removal. The conversion of 5-FU to anabolites was measured under saturating substrate (5-FU) and cosubstrate concentrati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19911101)68:9<1903::aid-cncr2820
更新日期:1991-11-01 00:00:00
abstract::In this study the authors applied flow cytometric DNA-ploidy analysis to multiple female genital tract malignant tumors in 43 patients, most of whom (n = 37) had bilateral ovarian cancer. An algorithm was developed for calculation of the likelihood ratio of the probabilities that measured DNA index differences between...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1990-10-15 00:00:00
abstract::This report documents, in seven infants younger than 2 years of age, a previously unrecognized association of a renal embryonal neoplasm (malignant rhabdoid tumor in six patients and a Wilms' tumor in one) with an embryonal primary tumor originating in the central nervous system. The neuroepithelial tumors included th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841115)54:10<2137::aid-cncr282
更新日期:1984-11-15 00:00:00
abstract::A 28-year-old man with evidence of feminization was demonstrated after 4 years of investigation to have a estrogen-secreting interstitial cell tumor. Such feminizing neoplasms are uncommon, only 37 having been described. They are usually benign and are characterized by gynecomastia, a testicular mass and, with lesser ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197504)35:4<1184::aid-cncr282035
更新日期:1975-04-01 00:00:00
abstract:BACKGROUND:Although acquired somatic mutations presumably are crucial in carcinogenesis, nothing is known about the chromosome aberrations of bilateral breast carcinomas. METHODS:Eighteen specimens from 16 bilateral carcinomas were analyzed cytogenetically. The banding analysis was supplemented with fluorescence in si...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950715)76:2<250::aid-cncr28207
更新日期:1995-07-15 00:00:00
abstract::A prospective randomized trial by CALGB examined the relative value of four chemotherapy regimens in 537 patients with stage III B and IV Hodgkin's disease. A new combination BOPP, derived by substitution of BCNU for nitrogen mustard in the MOPP regimen, was compared to MOPP and to two 3-drug regimens, derived by remo...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(197901)43:1<31::aid-cncr28204301
更新日期:1979-01-01 00:00:00
abstract::The authors retrospectively reviewed 50 episodes of spinal epidural tumor that occurred in 42 patients with metastatic prostate cancer and were treated with external-beam radiation. Treatment response was evaluated in terms of symptoms, neurologic status, and, in most cases, reduction of tumor on repeat myelography. A...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921101)70:9<2319::aid-cncr2820
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:The optimal use of radiation therapy for cancer treatment is hampered by the application of tolerance limits of normal tissues derived empirically from population averages. Such limits do not reflect the considerable differences from patient to patient in susceptibility to late radiation sequelae. Assays tha...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1097-0142(19960601)77:11<2379::AID-C
更新日期:1996-06-01 00:00:00
abstract::Ultrastructural examination of an alveolar rhabdomyosarcoma revealed that the bulk of the tumor was composed of small polygonal cells containing polyribosomes, short strands of rough endoplasmic reticulum, and variable amounts of glycogen; the cells were joined by small desmosome-like structures. Similar cells, as wel...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197804)41:4<1355::aid-cncr282041
更新日期:1978-04-01 00:00:00
abstract::A tumor colony assay (TCA) was evaluated for its ability to predict anticancer drug responses in an N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT)-induced murine bladder tumor (MBT) model. Ten anticancer drugs were evaluated in vivo and in vitro using four MBT cell lines (40 drug responses). Using the optimum c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830815)52:4<619::aid-cncr28205
更新日期:1983-08-15 00:00:00
abstract:BACKGROUND:Despite extensive investigation, the role of MDR of human cancer remains unclear. Canine lymphoma is a spontaneously arising correlate of human non-Hodgkin's lymphoma that may complement other in vivo models for investigation of issues related to MDR. METHODS:Immunoreactivity of primary antibodies to the hu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960501)77:9<1892::AID-CN
更新日期:1996-05-01 00:00:00
abstract::One hundred and sixty-two cases of Stage IA microinvasive carcinoma of the cervix are presented. These patients represent the combined experience at the University of Miami School of Medicine, Miami, Florida, and Downstate Medical Center, Brooklyn, New York. The criteria used in both institutions are 1) penetration of...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197607)38:1<414::aid-cncr2820380
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND:Social needs may affect cancer survivors' health-related quality of life (HRQOL) above and beyond sociodemographic and cancer-related factors. The purpose of this study was to estimate associations between social needs and HRQOL. METHODS:Results included data from 1754 participants in the Detroit Research o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33286
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Current adjuvant hormone therapy in postmenopausal women with breast cancer is debatable between upfront aromatase inhibitors (AIs) and sequential treatment with tamoxifen. A major concern is the higher rate of early recurrences observed with sequential treatment. The authors conducted a retrospective analys...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22667
更新日期:2007-06-01 00:00:00
abstract::Since 1969, 29 previously untreated patients with Stage III nodular malignant lymphoreticular (MLT) have received total central lymphatic (TCL) irradiation. The volume irradiated included the entire abdomen, Waldeyer's ring, and preauricular nodes in addition to the usual regions encompassed by total nodal irradiation...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810501)47:9<2247::aid-cncr2820
更新日期:1981-05-01 00:00:00
abstract::Univariate and multivariate regression methods were used to analyze 17 potential clinical prognostic factors among 138 patients with advanced breast cancer who received Adriamycin-cyclophosphamide combination chemotherapy between 1973 and 1977 at the University of Arizona. Follow-up of patients was through September 1...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801201)46:11<2380::aid-cncr282
更新日期:1980-12-01 00:00:00
abstract::The distribution of synchronous neoplasms was retrospectively analyzed in 220 patients undergoing initial colonoscopic evaluation for colorectal neoplasms. In 159 of the 220 patients, an index neoplasm was present in the rectosigmoid region. Of these 159 patients, 32 had an index rectosigmoid adenoma less than 5 mm in...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19871001)60:7<1599::aid-cncr2820
更新日期:1987-10-01 00:00:00
abstract::Cancer of the penis is infrequent in the United States because of good genital hygiene and circumcision of male babies at birth. In other countries, it represents 11-12% of all cancer in males. Tumors of the penis consist mainly of squamous cell carcinoma. Mesenchymal tumors are rare. The treatment is based on the sur...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.1980.45.s7.1973
更新日期:1980-04-01 00:00:00
abstract::A solitary hepatic tumor in a 50-year-old woman, which was observed as a hemangioma, ultimately was resected because it increased in size. The tumor volume doubling time was 28.8 months over the observed period of 30 months. The histologic diagnosis was carcinoid tumor. Immunohistochemical staining showed strong focal...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19930901)72:5<1547::aid-cncr2820
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:Timely delivery of care has been identified by the Institute of Medicine as an indicator for quality health care, and treatment delay is a potentially modifiable obstacle that can contribute to the disparities among African American (AA) and Caucasian patients in prostate cancer recurrence and mortality. Usi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27975
更新日期:2013-07-01 00:00:00
abstract::The value of the serum level of carcinoembryonic antigen (CEA) as an indicator of recurrent colorectal carcinoma has been accepted, and the use of serial CEA levels to monitor postoperative chemotherapy has been suggested, However, elevated CEA levels may be associated with nonneoplastic conditions, of which the most ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810201)47:3<481::aid-cncr28204
更新日期:1981-02-01 00:00:00
abstract::Reported are six cases of meningocerebral astrocytomas attached to dura, involving the superficial cortex, in infants under 1 year of age. They represent 1.25% of 483 intracranial tumors in infancy studied at the Children's Hospital in the last 12 years. Five were located in the frontal lobes, with variable extension ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841201)54:11<2505::aid-cncr282
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:An association between fats and colorectal carcinoma has been suggested, but the epidemiologic evidence by type of dietary fat is far less clear. Colorectal carcinoma rates have been relatively low in Mediterranean countries compared with most other Western countries, but the components of the Mediterranean ...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/(sici)1097-0142(19980201)82:3<448::aid-cnc
更新日期:1998-02-01 00:00:00
abstract:BACKGROUND:Prior studies raise concern about gender bias in cancer research, including insufficient inclusion of women or men, or studying women and men differently. The 1993 National Institutes of Health Revitalization Act aimed to eliminate gender bias in medicine. To examine changes in medical and psychological lite...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27432
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Aggressive treatment of early stage prostate carcinoma (PC) is limited primarily to two modalities: radical prostatectomy (RP) and external beam radiation therapy (RT). The authors conducted a population-based study of Detroit area men with localized PC to determine the outcome of bowel, urinary, and sexual ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10650
更新日期:2002-07-01 00:00:00
abstract::Although improvements in the management of adults with acute leukemia have lagged behind those seen in the treatment of children, there are clear reasons for optimism. Combination chemotherapy for acute myeloblastic leukemia (AML) and acute lymphoblastic leukemia (ALL) in adults results in complete remissions in 50-85...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830615)51:12+<2460::aid-cncr28
更新日期:1983-06-15 00:00:00
abstract::The Chicago Consensus Working Group provides multidisciplinary recommendations for the management of colorectal cancer specifically as it relates to the management of peritoneal surface malignancy. These guidelines are developed with input from leading experts, including surgical oncologists, medical oncologists, path...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32874
更新日期:2020-06-01 00:00:00