Changes in guinea pig plasma cyclic nucleotide levels during the development of a transplantable leukemia.

Abstract:

:Plasma levels of cyclic AMP and cyclic GMP were determined in 35 guinea pigs for up to 9 days following subcutaneous passage of L2C leukemia cells. Twenty guinea pigs into which normal syngeneic guinea pig thymocytes were passaged served as controls. Cyclic AMP levels in plasma showed little change and were only elevated significantly in test animals on day 9 after passage. In contrast cyclic GMP levels reached a maximum on day 5 after passage of leukemia cells with two to threefold rises over day 1 levels. Increases in leukocyte counts were not observed until day 7 in test animals. Of the other tumour growth indices which were examined, the axillary (draining) node index gave the earliest indication of cell proliferation, with significant elevations on day 3 after passage. The authors conclude that plasma cyclic GMP increases precede increases in white cell counts by at least 2 days, and may reflect an early increase in axillary node growth.

journal_name

Cancer

journal_title

Cancer

authors

Wood PJ,Pao G,Cooper A

doi

10.1002/1097-0142(19840101)53:1<79::aid-cncr282053

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

79-82

issue

1

eissn

0008-543X

issn

1097-0142

journal_volume

53

pub_type

杂志文章

相关文献

CANCER文献大全
  • Cerebrospinal fluid-disseminated meningioma.

    abstract:BACKGROUND:Intracranial meningiomas are common and comprise 20% of all primary brain tumors. Meningiomas infrequently metastasize; however, to the authors' knowledge there are limited data regarding the spread of disease through cerebrospinal fluid (CSF). METHODS:Eight of 200 consecutive patients (4%) with meningiomas...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20926

    authors: Chamberlain MC,Glantz MJ

    更新日期:2005-04-01 00:00:00

  • DNA ploidy analysis of mucinous cystic tumors of the pancreas. Correlation of aneuploidy with malignancy and poor prognosis.

    abstract:BACKGROUND:Benign and malignant pancreatic mucinous tumors differ in proliferative activity, production of tumor markers, and expression of growth factors. DNA ploidy is a useful index of aggressiveness and poor survival in ductal adenocarcinoma, but has not been studied in pancreatic cystic tumors. METHODS:The DNA pl...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960101)77:1<58::AID-CNCR

    authors: Southern JF,Warshaw AL,Lewandrowski KB

    更新日期:1996-01-01 00:00:00

  • Osteosarcoma of the limbs. Report of the EORTC-SIOP 03 trial 20781 investigating the value of adjuvant treatment with chemotherapy and/or prophylactic lung irradiation.

    abstract::The European Organization for Research on Treatment of Cancer (EORTC) trial 20781, concerning osteosarcoma of the limbs is reported. After definitive treatment of the primary tumor with amputation or irradiation, adjuvant treatment was given, randomized into either 9 months of chemotherapy according to a modified Rose...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(19880301)61:5<1024::aid-cncr2820

    authors: Burgers JM,van Glabbeke M,Busson A,Cohen P,Mazabraud AR,Abbatucci JS,Kalifa C,Tubiana M,Lemerle JS,Voûte PA

    更新日期:1988-03-01 00:00:00

  • Fine-needle aspiration biopsy of Hurthle cell lesions of the thyroid gland: A cytomorphologic study of 139 cases with statistical analysis.

    abstract:BACKGROUND:Lesions of the thyroid gland composed of Hurthle cells encompass pathologic entities ranging from hyperplastic nodules with Hurthle cell metaplasia to Hurthle cell carcinomas. The cytologic distinction between these entities can be diagnostically challenging. Many cytologic features of Hurthle cell lesions t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21716

    authors: Elliott DD,Pitman MB,Bloom L,Faquin WC

    更新日期:2006-04-25 00:00:00

  • Pathogenetic implications of internuclear bridging in myelodysplastic syndrome. An Eastern Cooperative Oncology Group/Southwest Oncology Group Cooperative Study.

    abstract::Numerous morphologic features have been described in bone marrow and peripheral blood in myelodysplastic syndrome (MDS). We draw attention to a high incidence of a subtle morphologic feature, internuclear bridging (INB), not previously recognized as a morphologic feature in MDS. The occurrence of INB in MDS suggests a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19891201)64:11<2199::aid-cncr282

    authors: Head DR,Kopecky K,Bennett JM,Grenier K,Morrison FS,Miller KB,Grever MR

    更新日期:1989-12-01 00:00:00

  • A meta-analytic review of religious or spiritual involvement and social health among cancer patients.

    abstract::Religion and spirituality (R/S) play an important role in the daily lives of many cancer patients. There has been great interest in determining whether R/S factors are related to clinically relevant health outcomes. In this meta-analytic review, the authors examined associations between dimensions of R/S and social he...

    journal_title:Cancer

    pub_type: 杂志文章,meta分析

    doi:10.1002/cncr.29352

    authors: Sherman AC,Merluzzi TV,Pustejovsky JE,Park CL,George L,Fitchett G,Jim HS,Munoz AR,Danhauer SC,Snyder MA,Salsman JM

    更新日期:2015-11-01 00:00:00

  • Thyroid medullary carcinoma with thyroglobulin immunoreactivity in sporadic multiple endocrine neoplasia type 2-B.

    abstract:BACKGROUND:Thyroid carcinomas historically have been divided into two groups according to their presumedly separate embryonic origins: those of neuroectodermal derivation (parafollicular or medullary carcinoma [MCT]) and those of foregut endodermal origin (follicular and papillary carcinomas). The validity of this conc...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940801)74:3<928::aid-cncr28207

    authors: Kovacs CS,Masé RM,Kovacs K,Nguyen GK,Chik CL

    更新日期:1994-08-01 00:00:00

  • Analysis of racial differences in incidence, survival, and mortality for malignant tumors of the uterine corpus.

    abstract:BACKGROUND:In the United States, incidence rates for malignant tumors of the uterine corpus are lower among blacks than among whites, whereas mortality rates are higher among blacks. Reasons for the higher level of mortality among blacks have been debated. METHODS:Using data from the Surveillance, Epidemiology, and En...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11484

    authors: Sherman ME,Devesa SS

    更新日期:2003-07-01 00:00:00

  • A three-step strategy of induction chemotherapy then chemoradiation followed by surgery in patients with potentially resectable carcinoma of the esophagus or gastroesophageal junction.

    abstract:BACKGROUND:Patients with locoregional carcinoma of the esophagus or gastroesophageal junction have a poor survival rate after surgery. Preoperative chemotherapy or chemoradiotherapy has not improved the outcome for these patients. Our study was designed to assess the feasibility of preoperative induction combination ch...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(20010715)92:2<279::aid-cncr1320>

    authors: Ajani JA,Komaki R,Putnam JB,Walsh G,Nesbitt J,Pisters PW,Lynch PM,Vaporciyan A,Smythe R,Lahoti S,Raijman I,Swisher S,Martin FD,Roth JA

    更新日期:2001-07-15 00:00:00

  • Laboratory aids to diagnosis--enzymes.

    abstract::A summary is presented of those organ specific enzyme assays traditionally used in evaluation of the patient with cancer. In addition, the use of certain serum enzymes such as gamma-glutamyl transpeptidase, phosphohexose isomerase or 5'-nucleotidase as aids in following the course of the disease, particularly in patie...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197601)37:1+<542::aid-cncr282037

    authors: Schwartz MK

    更新日期:1976-01-01 00:00:00

  • The Save our Sisters Project. A social network strategy for reaching rural black women.

    abstract::Why are older black women screened less for breast cancer? What can be done to narrow the racial gap in mammography screening? These are the questions addressed by the Save Our Sisters (SOS) Project, a pilot demonstration study funded by the National Cancer Institute in a rural county of North Carolina. The target pop...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19930801)72:3+<1071::aid-cncr282

    authors: Eng E

    更新日期:1993-08-01 00:00:00

  • Carcinoid tumor of the gallbladder associated with adenocarcinoma.

    abstract::A case of carcinoid tumor of the gallbladder associated with adenocarcinoma in a 56-year-old man is reported and a review of the literature is made. The tumor was a polypoid mass with a size of 5.5 X 4.0 X 2.8 cm. Histologically, the tumor showed carcinoid and adenocarcinoma with areas of mucous change. Tumor cells co...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830515)51:10<1911::aid-cncr282

    authors: Wada A,Ishiguro S,Tateishi R,Ishikawa O,Matsui Y

    更新日期:1983-05-15 00:00:00

  • Erectile function, incontinence, and other quality of life outcomes following proton therapy for prostate cancer in men 60 years old and younger.

    abstract:BACKGROUND:This study sought to evaluate patient-reported health-related quality of life following proton therapy for prostate cancer in men ≤ 60 years old. METHODS:Between August 2006 and January 2010, 262 hormone-naive men ≤ 60 years old were treated with definitive proton therapy for prostate cancer. Before treatme...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27398

    authors: Hoppe BS,Nichols RC,Henderson RH,Morris CG,Williams CR,Costa J,Marcus RB Jr,Mendenhall WM,Li Z,Mendenhall NP

    更新日期:2012-09-15 00:00:00

  • Amsacrine is safe and effective therapy for patients with myocardial dysfunction and acute leukemia.

    abstract::The role of amsacrine in inducing remission in patients with cardiac disease and acute leukemia was evaluated. There were 17 patients with acute myelogenous leukemia (AML), six with acute lymphocytic leukemia (ALL), and one with biphenotypic leukemia. In this series of 24 patients whose disease had relapsed and who ha...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910915)68:6<1198::aid-cncr2820

    authors: Arlin ZA,Feldman EJ,Mittelman A,Ahmed T,Puccio C,Chun HG,Cook P,Baskind P,Marboe C,Mehta R

    更新日期:1991-09-15 00:00:00

  • Malignant mixed tumor of salivary origin: a clinicopathologic study of 146 cases.

    abstract::A 30-year Memorial Hospital experience with 146 patients with malignant mixed tumor is reviewed. These comprised 5% of 2,743 patients who were treated for salivary neoplasms from 1939 through 1968. The tumors arose in the parotid gland in 108 patients, submaxillary gland in 23 patients, mucus or so-called minor saliva...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197702)39:2<388::aid-cncr2820390

    authors: Spiro RH,Huvos AG,Strong EW

    更新日期:1977-02-01 00:00:00

  • Polycythemia and steroid overproduction in a gonadotropin-secreting seminoma of the testis.

    abstract::While investigating the cause of mild polycythemia in a young man, a testicular seminoma was discovered with unusual and tumor-dependent features: an absolute polycythemia with high plasma erythropoietin (EPO) levels, an overproduction of estradiol and testosterone, and a dramatic Leydig cell hyperplasia surrounding t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19911115)68:10<2224::aid-cncr282

    authors: Reman O,Reznik Y,Casadevall N,Lacombe C,Troussard X,Mandard JC,Leporrier M,Mahoudeau J

    更新日期:1991-11-15 00:00:00

  • Adjuvant chemotherapy for advanced nasopharyngeal carcinoma in childhood.

    abstract::Seven children with advanced nasopharyngeal carcinoma younger than 20 years of age diagnosed between 1975 and 1986 (inclusive) were treated with a uniform adjuvant chemotherapy regimen, which consisted of vincristine (1.5 mg/m2; day 1), doxorubicin (45 mg/m2; day 1), 5-fluorouracil (8 mg/kg; days 1 through 5), and cyc...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19890515)63:10<1922::aid-cncr282

    authors: Kim TH,McLaren J,Alvarado CS,Wyly JB,Crocker I,Winn K,Singhapakdi S,Ragab A

    更新日期:1989-05-15 00:00:00

  • Sinus histiocytosis with massive lymphadenopathy and paraparesis: remission with chemotherapy. A case report.

    abstract::A case of sinus histiocytosis with massive lymphadenopathy (SHML) in which cranial nerve function was impaired is described. Severe paraparesis due to an epidural block at the C2 and C5-T2 levels was also present. Treatment with cytotoxic agents resulted in a dramatic decrease in the size of the involved lymph nodes a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197807)42:1<77::aid-cncr28204201

    authors: Haas RJ,Helmig MS,Prechtel K

    更新日期:1978-07-01 00:00:00

  • Simultaneous gastric cancer in monozygotic twins.

    abstract::Monozygotic twins developed gastric cancers that were found almost simultaneously. A 47-year-old man complained of nausea and vomiting; an upper gastrointestinal series and endoscopy revealed advanced gastric cancer invading the serosa. Palliative subtotal gastrectomy was performed. In his asymptomatic twin a gastric ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19881201)62:11<2430::aid-cncr282

    authors: Matsukura N,Onda M,Tokunaga A,Yoshiyuki T,Shimizu Y,Nishi K,Furukawa K,Yoshiyasu M,Kiyama T,Tanaka N

    更新日期:1988-12-01 00:00:00

  • Cytologic examination of pancreatic juice for differential diagnosis of benign and malignant mucin-producing tumors of the pancreas.

    abstract:BACKGROUND:A new clinical type of pancreatic tumor, the mucin-producing tumor, has been recognized recently. However, it is not always easy to distinguish benign from malignant tumors preoperatively. In this study, three different methods of differentiating mucin-producing tumors of the pancreas were compared. METHODS...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940801)74:3<826::aid-cncr28207

    authors: Uehara H,Nakaizumi A,Iishi H,Tatsuta M,Kitamra T,Okuda S,Ohigashi H,Ishikawa O,Takenaka A,Ishiguro S

    更新日期:1994-08-01 00:00:00

  • Guideline implementation for breast healthcare in low- and middle-income countries: breast healthcare program resource allocation.

    abstract::Breast cancer is serious public health problem in countries of all resource levels. Although major advances in the detection and treatment of the disease have occurred in higher income settings, similar progress has been slow or scarce in most low- and middle-income countries (LMCs). The poorer outcomes in LMCs may re...

    journal_title:Cancer

    pub_type: 共识发展会议,杂志文章,实务指引

    doi:10.1002/cncr.23841

    authors: Harford J,Azavedo E,Fischietto M,Breast Health Global Initiative Healthcare Systems Panel.

    更新日期:2008-10-15 00:00:00

  • Molecular epidemiology of HTLV-I-associated non-Hodgkin's lymphomas in Jamaica.

    abstract::As part of epidemiologic studies of human T-lymphotropic virus (HTLV)-I-associated malignancies in Jamaica, the authors evaluated 26 patients with non-Hodgkin's lymphoma for the presence of integrated HTLV-I provirus in their malignant cells. Fifteen of 26 patients had integrated provirus. All 15 also were HTLV-I anti...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880401)61:7<1477::aid-cncr2820

    authors: Clark JW,Gurgo C,Franchini G,Gibbs WN,Lofters W,Neuland C,Mann D,Saxinger C,Gallo RC,Blattner WA

    更新日期:1988-04-01 00:00:00

  • Primary combined malignant melanoma and ductal carcinoma of the breast. A report of two cases.

    abstract:BACKGROUND:Tumors consisting of a combination of malignant melanoma and carcinoma are very rare. The authors report two such cases occurring as primary breast tumors. METHODS:The breast tumors were analyzed by histologic, immunohistochemical, and ultrastructural techniques. RESULTS:Histologically, the tumors were com...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Padmore RF,Lara JF,Ackerman DJ,Gales T,Sigurdson ER,Ehya H,Cooper HS,Patchefsky AS

    更新日期:1996-12-15 00:00:00

  • The diagnostic value of the hemoccult as a screening test in patients taking anticoagulants.

    abstract::The value of a 3-day Hemoccult II test in the diagnosis of colorectal disease in patients receiving anticoagulant therapy was studied. The influence of rehydration and nonrehydration of the slide was investigated, as well as the reproducibility of positive tests. Eight hundred forty-nine patients on anticoagulant ther...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841215)54:12<3054::aid-cncr282

    authors: Kewenter J,Svanvik J,Svensson C,Wållgren K

    更新日期:1984-12-15 00:00:00

  • Occupational outcomes of adult childhood cancer survivors: A report from the childhood cancer survivor study.

    abstract:BACKGROUND:The authors examined whether survivors from the Childhood Cancer Survivor Study were less likely to be in higher-skill occupations than a sibling comparison and whether certain survivors were at higher risk for lower-skill jobs. METHODS:The authors created 3 mutually exclusive occupational categories for pa...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25867

    authors: Kirchhoff AC,Krull KR,Ness KK,Park ER,Oeffinger KC,Hudson MM,Stovall M,Robison LL,Wickizer T,Leisenring W

    更新日期:2011-07-01 00:00:00

  • Prophylactic cranial irradiation in limited-stage small cell lung cancer.

    abstract:BACKGROUND:The role of prophylactic cranial irradiation (PCI) for patients with limited-stage small cell lung cancer (LSSCLC) remains a controversial issue. This study evaluated PCI in patients with LSSCLC who achieved a complete response to initial chemotherapy. METHODS:A retrospective case study of all nonprotocol p...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950315)75:6<1302::aid-cncr2820

    authors: Liengswangwong V,Bonner JA,Shaw EG,Foote RL,Frytak S,Richardson RL,Creagan ET,Eagan RT,Su JQ

    更新日期:1995-03-15 00:00:00

  • Antimullerian hormone and inhibin B are hormone measures of ovarian function in late reproductive-aged breast cancer survivors.

    abstract:BACKGROUND:In late reproductive-aged breast cancer survivors, there is a need for real-time biomarkers of postchemotherapy ovarian function. The objective was to determine whether antimullerian hormone (AMH) and inhibin B are such biomarkers. The authors tested whether AMH and inhibin B were impacted by breast cancer t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24746

    authors: Su HI,Sammel MD,Green J,Velders L,Stankiewicz C,Matro J,Freeman EW,Gracia CR,DeMichele A

    更新日期:2010-02-01 00:00:00

  • p53CM1 expression is not associated with prognosis in uterine cervical carcinoma.

    abstract:BACKGROUND AND METHODS:Specimens obtained from 192 patients with Stage III squamous cell carcinoma of the cervix treated by radiation therapy alone were investigated with an immunohistochemical method for the expression of p53CM1, a monoclonal antibody that recognizes wild and mutant type p53 gene products in histologi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930701)72:1<160::aid-cncr28207

    authors: Oka K,Nakano T,Arai T

    更新日期:1993-07-01 00:00:00

  • Multiple primary esophageal and concurrent upper aerodigestive tract cancer and the aldehyde dehydrogenase-2 genotype of Japanese alcoholics.

    abstract:BACKGROUND:Multiple intraesophageal primary cancer and upper aerodigestive tract (UADT) cancer associated with esophageal cancer are common diseases, especially in heavy drinkers. They are often explained by the concept of field cancerization, which suggests a similar etiology. However, little is known about the nature...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960515)77:10<1986::AID-C

    authors: Yokoyama A,Muramatsu T,Ohmori T,Makuuchi H,Higuchi S,Matsushita S,Yoshino K,Maruyama K,Nakano M,Ishii H

    更新日期:1996-05-15 00:00:00

  • The current state of brachytherapy nomograms for patients with clinically localized prostate cancer.

    abstract::For men diagnosed with clinically localized prostate cancer, definitive therapy with radical prostatectomy, external beam radiation therapy, or brachytherapy offers a high chance of cure. Currently, there are insufficient data to recommend 1 treatment approach over another, leaving physicians and patients to decide ba...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.24344

    authors: Nguyen CT,Zelefsky MJ,Kattan MW

    更新日期:2009-07-01 00:00:00