Abstract:
:While investigating the cause of mild polycythemia in a young man, a testicular seminoma was discovered with unusual and tumor-dependent features: an absolute polycythemia with high plasma erythropoietin (EPO) levels, an overproduction of estradiol and testosterone, and a dramatic Leydig cell hyperplasia surrounding the tumor tissue. The authors attempted to gain insight into the relationship between this testicular tumor and the hormonal overproduction, i.e., of EPO, estradiol, and testosterone. Their results favored the conclusion that the high EPO levels and the polycythemia were an indirect effect secondary to the steroid overproduction rather than a direct EPO-producing activity. Moreover, the steroid overproduction by the testis could be caused by a paracrine mechanism through human chorionic gonadotropin activity on the Leydig cells.
journal_name
Cancerjournal_title
Cancerauthors
Reman O,Reznik Y,Casadevall N,Lacombe C,Troussard X,Mandard JC,Leporrier M,Mahoudeau Jdoi
10.1002/1097-0142(19911115)68:10<2224::aid-cncr282subject
Has Abstractpub_date
1991-11-15 00:00:00pages
2224-9issue
10eissn
0008-543Xissn
1097-0142journal_volume
68pub_type
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