Significance of estrogen and progesterone receptors, disease-free interval, and site of first metastasis on survival of breast cancer patients.

Abstract:

:Estrogen and progesterone receptors (ER/PR) were measured in primary tumors and metastases of 397 breast cancer patients. Survival following mastectomy was significantly longer in patients with ER and PR positive tumors, as was survival after first recurrence. The prognostic value of ER and PR was compared with such clinical factors as disease-free interval (DFI) and the dominant site of first metastasis by Cox's regression analysis. With all the different therapy modalities long DFI was the best prognostic indicator. However, in the patient group treated with endocrine therapy, ER and PR positivity was the best prognostic indicator, suggesting that longer survival in receptor positive patients was related to the response to endocrine treatment.

journal_name

Cancer

journal_title

Cancer

authors

Alanko A,Heinonen E,Scheinin T,Tolppanen EM,Vihko R

doi

10.1002/1097-0142(19851001)56:7<1696::aid-cncr2820

subject

Has Abstract

pub_date

1985-10-01 00:00:00

pages

1696-700

issue

7

eissn

0008-543X

issn

1097-0142

journal_volume

56

pub_type

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