Intracerebral delayed hypersensitivity reactions in glioblastoma multiforme patients.

Abstract:

:Patients with malignant gliomas who had undergone BCG inoculation were injected intratumorally with PPD to induce an intratumoral delayed hypersensitivity reaction. Histopathological examination of the tumor before and after PPD injections revealed that chronic inflammatory responses were increased after injection in four of the five patients. In no case, however, was the response more than moderate, and in no case did the inflammatory response encompass the tumor at its peripheral margins. Intracerebral delayed hypersensitivity reactions were evoked in humans with acceptable morbidity. The mild reactions evoked did not cause detectable tumor regression.

journal_name

Cancer

journal_title

Cancer

authors

Albright L,Seab JA,Ommaya AK

doi

10.1002/1097-0142(197703)39:3<1331::aid-cncr282039

subject

Has Abstract

pub_date

1977-03-01 00:00:00

pages

1331-6

issue

3

eissn

0008-543X

issn

1097-0142

journal_volume

39

pub_type

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