Hypoxic regulation and prognostic value of LAMP3 expression in breast cancer.


BACKGROUND:LAMP3 is a newly described hypoxia regulated gene of potential interest in hypoxia-induced therapy resistance and metastasis. The prognostic value of LAMP3 in breast cancer was investigated. METHODS:Expression levels of LAMP3 in breast cancer cell lines and patient tissues were determined by real-time polymerase chain reaction and in a tissue microarray by immunohistochemistry. Immunofluorescent staining was used to evaluate the distribution of LAMP3 in tumor xenografts relative to pimonidazole. Kaplan-Meier analysis as well as multivariate Cox regression survival analyses were performed. RESULTS:LAMP3 was variably expressed in breast cancer cell lines and induced in an oxygen concentration-dependent manner. LAMP3 protein expression colocalized with hypoxic areas in breast cancer xenografts. LAMP3 mRNA was higher in breast tumors from patients with node-positive (P = .019) and/or steroid hormone receptor-negative tumors (P < .001). Breast cancer patients with high LAMP3 mRNA levels had more locoregional recurrences (P = .032 log-rank). This was limited to patients treated with lumpectomy and radiotherapy as primary treatment (n = 53, P = .009). No association with metastasis-free survival was found. In multivariate Cox regression analysis, LAMP3 remained as a statistically independent prognostic factor for locoregional recurrence (hazard ratio, 2.76; 95% confidence interval, 1.01-7.5; P = .048) after correction for menopausal status, histologic grade, tumor size, nodal status, therapy, and steroid hormone receptor status. LAMP3 protein in breast cancer tissue proved also to be of prognostic relevance. CONCLUSIONS:Evidence was provided for an association of LAMP3 with tumor cell hypoxia in breast cancer xenografts. In the current breast cancer cohorts, LAMP3 had independent prognostic value.






Nagelkerke A,Mujcic H,Bussink J,Wouters BG,van Laarhoven HW,Sweep FC,Span PN




Has Abstract


2011-08-15 00:00:00














  • Prophylactic intrathecal methotrexate and hydrocortisone reduces central nervous system recurrence and improves survival in aggressive non-hodgkin lymphoma.

    abstract:BACKGROUND:Central nervous system (CNS) recurrence is almost invariably fatal in patients with aggressive non-Hodgkin lymphoma (NHL). Although some protocols are intended to prevent CNS disease, the value of CNS prophylaxis in patients with aggressive NHL remains to be determined. METHODS:We retrospectively analyzed a...


    pub_type: 杂志文章


    authors: Tomita N,Kodama F,Kanamori H,Motomura S,Ishigatsubo Y

    更新日期:2002-08-01 00:00:00

  • Transcatheter arterial chemoembolization or chemoinfusion for unresectable intrahepatic cholangiocarcinoma: clinical efficacy and factors influencing outcomes.

    abstract:BACKGROUND:The role of transcatheter arterial chemoembolization (TACE) or transcatheter arterial chemoinfusion (TACI) for unresectable intrahepatic cholangiocarcinoma (ICC) has recently been questioned. The aim of the study was to evaluate the clinical efficacy of TACE or TACI in patients with unresectable ICC and to i...


    pub_type: 杂志文章


    authors: Kim JH,Yoon HK,Sung KB,Ko GY,Gwon DI,Shin JH,Song HY

    更新日期:2008-10-01 00:00:00

  • Predictive clinical outcome of the intratumoral CD66b-positive neutrophil-to-CD8-positive T-cell ratio in patients with resectable nonsmall cell lung cancer.

    abstract:BACKGROUND:The role of the interaction between tumor cells and inflammatory cells in nonsmall cell lung carcinoma (NSCLC) is unclear. In this study, the authors assessed the prognostic impact of intratumoral cluster of differentiation 66b (carcinoembryonic antigen-related cell adhesion molecule 8 [CD66b])-positive neut...


    pub_type: 杂志文章


    authors: Ilie M,Hofman V,Ortholan C,Bonnetaud C,Coëlle C,Mouroux J,Hofman P

    更新日期:2012-03-15 00:00:00

  • Epidermal Langerhans' cell densities influence survival in mycosis fungoides and Sézary syndrome.

    abstract::Because Langerhans' cells (LC) (CD1a-positive epidermal cells) have been discussed to be involved in the pathogenesis of mycosis fungoides and Sézary syndrome, the authors examined the influence of densities of Langerhans' cells and, concurrently, of other phenotypes retrospectively on survival of 35 patients. Cell de...


    pub_type: 杂志文章


    authors: Meissner K,Michaelis K,Rehpenning W,Löning T

    更新日期:1990-05-01 00:00:00

  • Gender differences in the effect of grief reactions and burnout on emotional distress among clinical oncologists.

    abstract:BACKGROUND:The current study was conducted to examine gender differences in the effect of grief reactions and burnout on emotional distress among clinical oncologists. METHODS:The participants included a convenience sample of 178 oncologists from Israel (52 of whom were women) and Canada (48 of whom were women). Oncol...


    pub_type: 杂志文章


    authors: Granek L,Krzyzanowska MK,Nakash O,Cohen M,Ariad S,Barbera L,Levy R,Ben-David M

    更新日期:2016-12-01 00:00:00

  • BRCA1, TP53, and CHEK2 germline mutations in uterine serous carcinoma.

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    pub_type: 杂志文章


    authors: Pennington KP,Walsh T,Lee M,Pennil C,Novetsky AP,Agnew KJ,Thornton A,Garcia R,Mutch D,King MC,Goodfellow P,Swisher EM

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  • Treatment with bevacizumab and irinotecan for recurrent high-grade glial tumors.

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    pub_type: 杂志文章


    authors: Bokstein F,Shpigel S,Blumenthal DT

    更新日期:2008-05-15 00:00:00

  • Clinical and proteomic characterization of acute myeloid leukemia with mutated RAS.

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    pub_type: 杂志文章


    authors: Kadia TM,Kantarjian H,Kornblau S,Borthakur G,Faderl S,Freireich EJ,Luthra R,Garcia-Manero G,Pierce S,Cortes J,Ravandi F

    更新日期:2012-11-15 00:00:00

  • Immunologic and clinicopathologic features of common acute lymphoblastic leukemia antigen-positive childhood T-cell leukemia. A Pediatric Oncology Group Study.

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    pub_type: 杂志文章


    authors: Dowell BL,Borowitz MJ,Boyett JM,Pullen DJ,Crist WM,Quddus FF,Russell EC,Falletta JM,Metzgar RS

    更新日期:1987-06-15 00:00:00

  • Conservative treatment of distal rectal cancer by local excision.

    abstract::From 1954 through 1982, 57 patients with invasive, distal rectal cancer had a full-thickness local excision with curative intent. Prognostic criteria and need for further treatment were based on the histopathologic results of the operative specimen. The overall 5-year survival rate was 83.4%. The rectal cancer-specifi...


    pub_type: 杂志文章


    authors: DeCosse JJ,Wong RJ,Quan SH,Friedman NB,Sternberg SS

    更新日期:1989-01-15 00:00:00

  • Analysis of prognostic factors in patients with isolated chest wall recurrence of breast cancer.

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    pub_type: 杂志文章


    authors: Magno L,Bignardi M,Micheletti E,Bardelli D,Plebani F

    更新日期:1987-07-15 00:00:00

  • High-voltage irradiation and combination chemotherapy for malignant pheochromocytoma.

    abstract::A 29-year-old man with metastatic extraadrenal pheochromocytoma developed paraplegia which reversed completely after megavoltage irradiation of the dorsolumbar spine. Later, treated with cyclophosphamide, vincristine, and dacarbazine, he had a temporary decrease in plasma norepinephrine concentration, a partial recalc...


    pub_type: 杂志文章


    authors: Siddiqui MZ,Von Eyben FE,Spanos G

    更新日期:1988-08-15 00:00:00

  • Clinical observation on the association of gallstones and colorectal cancer.

    abstract::A possible association between gallstones, colorectal cancer, and gastric cancer was investigated. The age distribution and mean age of the two cancer groups were identical. The incidence of gallstones in 378 colorectal cancer cases and 869 gastric cancer cases was 7.1% and 5.5%, respectively. Of colorectal cancer cas...


    pub_type: 杂志文章


    authors: Narisawa T,Yamazaki Y,Kusaka H,Takahashi M,Kotanagi H,Koyama K

    更新日期:1991-03-15 00:00:00

  • Malignant large cell lymphoma of B-cell type with multilobated nuclei. Report of a case and review of the literature.

    abstract::Malignant lymphomas with multilobated nuclei are rare, recently recognized neoplasms of the immune system initially thought to be of T-cell type. Reported is a case of large cell lymphoma with multilobated nuclei in which immunologic marker studies demonstrated that the neoplastic cells had characteristics of B-lympho...


    pub_type: 杂志文章


    authors: Parfrey NA,Mann RB,Selonick SE,Beschorner WE

    更新日期:1985-05-01 00:00:00

  • Metaanalysis of the accuracy of rapid prescreening relative to full screening of pap smears.

    abstract:BACKGROUND:Efficient quality assurance and improvement measures are essential ingredients in a well organized cytology-based program for cervical carcinoma screening. Various pap smear review procedures, aiming for optimization of accuracy, are described throughout the literature. Evaluation and synthesis of those meth...


    pub_type: 杂志文章,meta分析


    authors: Arbyn M,Schenck U,Ellison E,Hanselaar A

    更新日期:2003-02-25 00:00:00

  • Time for reappraisal of extracranial treatment options? Synchronous brain metastases from nonsmall cell lung cancer.

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    pub_type: 杂志文章


    authors: Lind JS,Lagerwaard FJ,Smit EF,Postmus PE,Slotman BJ,Senan S

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  • Clinical relevance of Ki-67 expression in bone tumors.

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    pub_type: 杂志文章


    authors: Scotlandi K,Serra M,Manara MC,Maurici D,Benini S,Nini G,Campanacci M,Baldini N

    更新日期:1995-02-01 00:00:00

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    abstract::The purpose of this study was to determine whether the presence of more than 5% blasts in a differential count of cytocentrifuged cerebrospinal fluid (CSF) with less than 6 leukocytes/microliter was predictive of central nervous system (CNS) relapse in children with acute lymphoblastic leukemia (ALL). A double concent...


    pub_type: 杂志文章


    authors: Odom LF,Wilson H,Cullen J,Bank J,Blake M,Jamieson B

    更新日期:1990-10-15 00:00:00

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    abstract:BACKGROUND:The optimal use of radiation therapy for cancer treatment is hampered by the application of tolerance limits of normal tissues derived empirically from population averages. Such limits do not reflect the considerable differences from patient to patient in susceptibility to late radiation sequelae. Assays tha...


    pub_type: 杂志文章,评审


    authors: Peters LJ

    更新日期:1996-06-01 00:00:00

  • Active immunotherapy of human solid tumor with autologous cells treated with cholesteryl hemisuccinate. A Phase I study.

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    pub_type: 临床试验,杂志文章


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  • Evaluation of ovarian findings in asymptomatic postmenopausal women with color Doppler ultrasound.

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    pub_type: 临床试验,杂志文章


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  • Applied cancer prevention in practice.

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    pub_type: 杂志文章


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  • Perceived discrimination, trust in physicians, and prolonged symptom duration before ovarian cancer diagnosis in the African American Cancer Epidemiology Study.

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  • Mucin core protein expression in extrahepatic bile duct carcinoma is associated with metastases to the liver and poor prognosis.

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    pub_type: 杂志文章


    authors: Takao S,Uchikura K,Yonezawa S,Shinchi H,Aikou T

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Burish TG

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    pub_type: 杂志文章


    authors: Bonnin JM,Rubinstein LJ,Palmer NF,Beckwith JB

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    更新日期:1997-07-15 00:00:00

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Deyashiki Y,Nishioka Y,Takahashi K,Kosaka Y,Suzuki K

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