Hypoxic regulation and prognostic value of LAMP3 expression in breast cancer.


BACKGROUND:LAMP3 is a newly described hypoxia regulated gene of potential interest in hypoxia-induced therapy resistance and metastasis. The prognostic value of LAMP3 in breast cancer was investigated. METHODS:Expression levels of LAMP3 in breast cancer cell lines and patient tissues were determined by real-time polymerase chain reaction and in a tissue microarray by immunohistochemistry. Immunofluorescent staining was used to evaluate the distribution of LAMP3 in tumor xenografts relative to pimonidazole. Kaplan-Meier analysis as well as multivariate Cox regression survival analyses were performed. RESULTS:LAMP3 was variably expressed in breast cancer cell lines and induced in an oxygen concentration-dependent manner. LAMP3 protein expression colocalized with hypoxic areas in breast cancer xenografts. LAMP3 mRNA was higher in breast tumors from patients with node-positive (P = .019) and/or steroid hormone receptor-negative tumors (P < .001). Breast cancer patients with high LAMP3 mRNA levels had more locoregional recurrences (P = .032 log-rank). This was limited to patients treated with lumpectomy and radiotherapy as primary treatment (n = 53, P = .009). No association with metastasis-free survival was found. In multivariate Cox regression analysis, LAMP3 remained as a statistically independent prognostic factor for locoregional recurrence (hazard ratio, 2.76; 95% confidence interval, 1.01-7.5; P = .048) after correction for menopausal status, histologic grade, tumor size, nodal status, therapy, and steroid hormone receptor status. LAMP3 protein in breast cancer tissue proved also to be of prognostic relevance. CONCLUSIONS:Evidence was provided for an association of LAMP3 with tumor cell hypoxia in breast cancer xenografts. In the current breast cancer cohorts, LAMP3 had independent prognostic value.






Nagelkerke A,Mujcic H,Bussink J,Wouters BG,van Laarhoven HW,Sweep FC,Span PN




Has Abstract


2011-08-15 00:00:00














  • Cognitive effects of hormone therapy in men with prostate cancer: a review.

    abstract:BACKGROUND:Men who receive androgen-deprivation therapy (ADT) for prostate cancer experience several side effects from this treatment. A few recent studies have examined the cognitive implications of ADT and how they impact a patient's treatment decision-making, occupational pursuits, and quality of life. For this repo...


    pub_type: 杂志文章,评审


    authors: Nelson CJ,Lee JS,Gamboa MC,Roth AJ

    更新日期:2008-09-01 00:00:00

  • Pituitary adenomas. Immunocytochemical study of 150 tumors with clinicopathologic correlation.

    abstract::Retrospective immunocytochemical study of prolactin, growth hormone, ACTH, TSH and gonadotropins was performed on 150 pituitary adenomas from 142 patients and the results were correlated with clinical manifestations. There were 60 prolactin-positive tumors, 13 growth hormone-positive tumors, nine ACTH-positive tumors ...


    pub_type: 杂志文章


    authors: Mukai K

    更新日期:1983-08-15 00:00:00

  • Immune thrombocytopenic purpura and intravenous immunoglobulin.

    abstract::The observation, in 1980, of a rapid increase in platelet counts as a result of administration of intravenous immunoglobulin (IVIG) in a patient with immune thrombocytopenic purpura (ITP) was followed by clinical studies confirming the efficacy of this new treatment alternative in ITP. Simultaneously, new sensitive as...


    pub_type: 杂志文章,评审


    authors: Imbach P

    更新日期:1991-09-15 00:00:00

  • Clinically ascertained health outcomes, quality of life, and social attainment among adult survivors of neuroblastoma: A report from the St. Jude Lifetime Cohort.

    abstract:BACKGROUND:The objective of this study was to characterize chronic disease, health-related quality of life (HRQOL), emotional distress, and social attainment among long-term survivors of neuroblastoma. METHODS:Chronic health conditions among 136 ≥10-year neuroblastoma survivors (median age, 31.9 years; range, 20.2-54....


    pub_type: 杂志文章


    authors: Wilson CL,Brinkman TM,Cook C,Huang S,Hyun G,Green DM,Furman WL,Bhakta N,Ehrhardt MJ,Krasin MJ,Robison LL,Ness KK,Hudson MM

    更新日期:2020-03-15 00:00:00

  • Comparative tumor localization of whole immunoglobulin G anticarcinoembryonic antigen monoclonal antibodies IMMU-4 and IMMU-4 F(ab')2 in colorectal cancer patients.

    abstract:BACKGROUND:Previous studies in the literature have suggested that radiolabeled F(ab')2 fragments might be superior to whole immunoglobulin G (IgG) for imaging and therapy of cancer because of their greater penetration in tumors. To test this hypothesis, the authors compared tumor and normal tissue uptake along with pla...


    pub_type: 临床试验,杂志文章


    authors: Murray JL,Rosenblum MG,Zhang HZ,Podoloff DA,Kasi LP,Curley SA,Chan JC,Roh M,Hohn DC,Brewer H

    更新日期:1994-02-01 00:00:00

  • Adenosquamous carcinoma of the gallbladder warrants resection only if curative resection is feasible.

    abstract:BACKGROUND:Adenosquamous/squamous cell carcinoma of the gallbladder generally has been considered a lethal disease. The objective of this study was to clarify the effectiveness of resection for patients with adenosquamous/squamous cell carcinoma of the gallbladder. METHODS:Twenty-nine patients who underwent resection ...


    pub_type: 杂志文章


    authors: Oohashi Y,Shirai Y,Wakai T,Nagakura S,Watanabe H,Hatakeyama K

    更新日期:2002-06-01 00:00:00

  • Expression of autocrine motility factor receptor in colorectal cancer as a predictor for disease recurrence.

    abstract:BACKGROUND:New biologic prognostic factors are needed to guide the treatment of patients with colorectal cancer. The prognostic value of the altered expression of the cell surface glycoprotein gp78, which has been implicated in tumor-cell invasion and metastasis as an autocrine motility factor (AMF) receptor, was evalu...


    pub_type: 杂志文章


    authors: Nakamori S,Watanabe H,Kameyama M,Imaoka S,Furukawa H,Ishikawa O,Sasaki Y,Kabuto T,Raz A

    更新日期:1994-10-01 00:00:00

  • Breast cancer.

    abstract:BACKGROUND:Breast cancer is the most common cancer and the second leading cause of cancer death among women in the United States; annual breast cancer deaths are exceeded only by those for lung cancer. METHODS:Data from the Surveillance, Epidemiology, and End Results (SEER) program registry of the National Cancer Inst...


    pub_type: 杂志文章


    authors: Berg JW,Hutter RV

    更新日期:1995-01-01 00:00:00

  • Are patients of low socioeconomic status receiving suboptimal management for pancreatic adenocarcinoma?

    abstract:BACKGROUND:The objective of this study was to define the effects of socioeconomic status (SES) and other demographic variables on outcomes for patients with pancreatic adenocarcinoma. METHODS:Florida cancer registry and inpatient hospital data were queried for pancreatic adenocarcinoma diagnosed from 1998 to 2002. RE...


    pub_type: 杂志文章


    authors: Cheung MC,Yang R,Byrne MM,Solorzano CC,Nakeeb A,Koniaris LG

    更新日期:2010-02-01 00:00:00

  • Nonsurgical management of recurrent colorectal cancer.

    abstract::Most patients with colorectal carcinoma undergo attempts at curative surgery. However, some present with metastatic disease and many others ultimately relapse. Most recurrences of colorectal cancer are not resectable and require nonsurgical approaches such as chemotherapy and radiation therapy directed against local r...


    pub_type: 杂志文章,评审


    authors: Vaughn DJ,Haller DG

    更新日期:1993-06-15 00:00:00

  • Elevated perioperative serum vascular endothelial growth factor levels in patients with colon carcinoma.

    abstract:BACKGROUND:To the authors' knowledge, little is known to date regarding the prognostic relevance of measuring serum levels of vascular endothelial growth factor (VEGF), a potent stimulator of angiogenesis, in patients with colon carcinoma who undergo surgery. METHODS:Preoperative and postoperative VEGF serum levels we...


    pub_type: 杂志文章


    authors: De Vita F,Orditura M,Lieto E,Infusino S,Morgillo F,Martinelli E,Castellano P,Romano C,Ciardiello F,Catalano G,Pignatelli C,Galizia G

    更新日期:2004-01-15 00:00:00

  • Vulvar and vaginal melanoma: A unique subclass of mucosal melanoma based on a comprehensive molecular analysis of 51 cases compared with 2253 cases of nongynecologic melanoma.

    abstract:BACKGROUND:Optimal treatments for vulvar and vaginal melanomas (VVMs) have not been identified. Herein, the authors compare molecular profiles between VVM and nongynecologic melanoma (NGM) subtypes with the objective of identifying novel, targetable biomarkers. METHODS:In total, 2304 samples of malignant melanoma that...


    pub_type: 杂志文章


    authors: Hou JY,Baptiste C,Hombalegowda RB,Tergas AI,Feldman R,Jones NL,Chatterjee-Paer S,Bus-Kwolfski A,Wright JD,Burke WM

    更新日期:2017-04-15 00:00:00

  • Cytogenetics and comorbidity predict outcomes in older myelodysplastic syndrome patients after allogeneic stem cell transplantation using reduced intensity conditioning.

    abstract:BACKGROUND:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only treatment with a curative potential for myelodysplastic syndrome (MDS) patients. Allo-HSCT has substantial risks, particularly in the elderly, and its role for older MDS patients has yet to be defined. METHODS:We analyzed 88 MDS pati...


    pub_type: 杂志文章


    authors: Yucel OK,Saliba RM,Rondon G,Ahmed S,Alousi A,Bashir Q,Ciurea SO,Popat U,Khouri I,Marin D,Rezvani K,Kebriaei P,Shpall EJ,Champlin RE,Oran B

    更新日期:2017-07-15 00:00:00

  • Prostaglandin-E-producing hepatocellular carcinoma with hypercalcemia.

    abstract::An autopsy case of prostaglandin E-producing hepatocellular carcinoma with hypercalcemia is presented in this article. A 72-year-old man showed high serum calcium levels (14.2 to 17.3 mg/100 ml) and hypophosphatemia. The plasma level of immunoreactive parathyroid hormone was below the normal range. Administration of o...


    pub_type: 杂志文章


    authors: Ikeda T,Tozuka S,Hasumura Y,Takeuchi J

    更新日期:1988-05-01 00:00:00

  • Increased expression of matrix metalloproteinase 7 and 9 and membrane type 1-matrix metalloproteinase in esophageal squamous cell carcinomas.

    abstract:BACKGROUND:The 5-year survival rate of patients with submucosal (sm) esophageal carcinoma continues to be much worse than that with intramucosal (m) lesions. The reasons are unclear, but matrix metalloproteinases (MMPs) and membrane type matrix metalloproteinases (MT-MMPs) are known to be involved in degradation of ext...


    pub_type: 杂志文章


    authors: Ohashi K,Nemoto T,Nakamura K,Nemori R

    更新日期:2000-05-15 00:00:00

  • Impact of radiographic findings on prognosis for skin carcinoma with clinical perineural invasion.

    abstract:BACKGROUND:The objective of the current study was to correlate pretreatment computed tomography and magnetic resonance imaging studies with outcomes for patients with squamous or basal cell carcinoma of the skin and clinical perineural invasion. METHODS:Between 1986 and 2002, 45 patients were treated with radiotherapy...


    pub_type: 杂志文章


    authors: Galloway TJ,Morris CG,Mancuso AA,Amdur RJ,Mendenhall WM

    更新日期:2005-03-15 00:00:00

  • A clinical and pathological staging system for soft tissue sarcomas.

    abstract::A system for staging the clinical status of patients with soft tissue sarcomas is presented, based on the clinical characteristics of the primary tumor (size, extension), the involvement of lymph nodes, the presence of metastases, and the grade of the tumor. This represents the TNM system with grade of tumor (G) added...


    pub_type: 杂志文章


    authors: Russell WO,Cohen J,Enzinger F,Hajdu SI,Heise H,Martin RG,Meissner W,Miller WT,Schmitz RL,Suit HD

    更新日期:1977-10-01 00:00:00

  • A front-line window of opportunity phase 2 study of sorafenib in patients with advanced nonsmall cell lung cancer: North Central Cancer Treatment Group Study N0326.

    abstract:BACKGROUND:The current study was conducted to assess the efficacy and toxicity of sorafenib as front-line therapy in patients with stage IIIB (pleural effusion) or IV nonsmall cell lung cancer (NSCLC). METHODS:Patients received sorafenib 400 mg twice daily by mouth continuously, and were evaluated every 2 weeks during...


    pub_type: 杂志文章


    authors: Dy GK,Hillman SL,Rowland KM Jr,Molina JR,Steen PD,Wender DB,Nair S,Mandrekar S,Schild SE,Adjei AA,North Central Cancer Treatment Group Study N0326.

    更新日期:2010-12-15 00:00:00

  • Elevation of serum levels of matrix metalloproteinase-2 and -3 as new predictors of recurrence in patients with urothelial carcinoma.

    abstract:BACKGROUND:The relationship between serum levels of matrix metalloproteinase-2 (MMP-2) and MMP-3 and recurrence in patients with urothelial carcinoma after complete resection was studied to determine whether the enzymes could be a new predictor of recurrence. METHODS:Serum levels of MMP-2 and MMP-3 in 146 healthy cont...


    pub_type: 杂志文章


    authors: Gohji K,Fujimoto N,Komiyama T,Fujii A,Ohkawa J,Kamidono S,Nakajima M

    更新日期:1996-12-01 00:00:00

  • Treatment of intrahepatic malignancy with radiofrequency ablation: radiologic-pathologic correlation.

    abstract:BACKGROUND:Radiofrequency (RF)-induced tissue coagulation represents a new approach for the thermal destruction of tumors within the liver. The purpose of the current study was to 1) assess technique safety; 2) determine the extent and evolution of induced cellular damage; and 3) correlate the observed pathologic effec...


    pub_type: 杂志文章


    authors: Goldberg SN,Gazelle GS,Compton CC,Mueller PR,Tanabe KK

    更新日期:2000-06-01 00:00:00

  • Correlation between expression of MUC1 core protein and outcome after surgery in mass-forming intrahepatic cholangiocarcinoma.

    abstract:BACKGROUND:It has been reported that MUC1 is an important prognostic factor in several cancers. This study investigated the importance of MUC1 as a prognostic factor in mass-forming intrahepatic cholangiocarcinoma (m-ICC). METHODS:In 50 patients with m-ICC who had undergone hepatectomy, expression of MUC1 was investig...


    pub_type: 杂志文章


    authors: Matsumura N,Yamamoto M,Aruga A,Takasaki K,Nakano M

    更新日期:2002-03-15 00:00:00

  • The equivalence and difference between the English and Chinese versions of two major, cancer-specific, health-related quality-of-life questionnaires.

    abstract:BACKGROUND:English and Chinese are two of the most widely used primary languages in the world. Patients in many cancer centers have a variety of ethnic backgrounds and primary languages. The comparability of version 4 of the English and Chinese versions of the Functional Assessment of Cancer Therapy-General (FACT-G) an...


    pub_type: 杂志文章


    authors: Cheung YB,Thumboo J,Goh C,Khoo KS,Che W,Wee J

    更新日期:2004-12-15 00:00:00

  • Local recurrence of resectable non-oat cell carcinoma of the lung. A warning against conservative treatment for N0 and N1 disease.

    abstract::Ninety-five patients with non-oat cell lung cancer underwent resection of all apparent disease and were followed for a minimum of 36 months. Incidence of recurrence was 34% in 47 patients with N0 disease, 65% in 32 patients with N1 disease, and 81.3% in 16 patients with N2 disease (P less than 0.02 and P less than 0.0...


    pub_type: 杂志文章


    authors: Iascone C,DeMeester TR,Albertucci M,Little AG,Golomb HM

    更新日期:1986-02-01 00:00:00

  • Pretreatment cognitive performance predicts survival in patients with leptomeningeal disease.

    abstract:BACKGROUND:Leptomeningeal disease (LMD) involves the spread of malignant cells from solid tumors to the cerebrospinal fluid or to the leptomeninges. LMD has a very poor prognosis and it is difficult to diagnose and follow with traditional diagnostic tools. The purposes of this study were to characterize cognitive funct...


    pub_type: 杂志文章


    authors: Sherman AM,Jaeckle K,Meyers CA

    更新日期:2002-09-15 00:00:00

  • Soft tissue fibrosarcoma. A clinicopathologic study of 132 cases.

    abstract::Over the last 20 to 30 years, a recognition and general acceptance of the entity of malignant fibrous histiocytoma and monophasic synovial sarcoma has occurred. The introduction of these diagnostic categories among the generic group of spindle cell sarcomas now requires a reevaluation of the more traditional and histo...


    pub_type: 杂志文章,评审


    authors: Scott SM,Reiman HM,Pritchard DJ,Ilstrup DM

    更新日期:1989-08-15 00:00:00

  • Efficacy of ondansetron against nausea and vomiting caused by dacarbazine-containing chemotherapy.

    abstract:BACKGROUND AND METHODS:The antiemetic activity of ondansetron (Zofran, Glaxo Pharmaceuticals, Research Triangle Park, NC) was evaluated in 25 patients with recurrent melanoma who were treated sequentially with dacarbazine (DTIC), vinblastine, and cisplatin. The antiemetic regimen included ondansetron alone in 11 patien...


    pub_type: 杂志文章


    authors: Legha SS,Hodges C,Ring S

    更新日期:1992-10-01 00:00:00

  • Extended-field radiation therapy for carcinoma of the cervix.

    abstract::The survival of cervical carcinoma patients with paraaortic/high common iliac nodal metastases was evaluated by retrospective chart review during a 13-year interval. Thirty-three patients with cervical carcinoma and surgically documented nodal metastases received primary, extended-field radiation therapy. Overall 2-ye...


    pub_type: 杂志文章


    authors: Podczaski E,Stryker JA,Kaminski P,Ndubisi B,Larson J,DeGeest K,Sorosky J,Mortel R

    更新日期:1990-07-15 00:00:00

  • Malignant large cell lymphoma of B-cell type with multilobated nuclei. Report of a case and review of the literature.

    abstract::Malignant lymphomas with multilobated nuclei are rare, recently recognized neoplasms of the immune system initially thought to be of T-cell type. Reported is a case of large cell lymphoma with multilobated nuclei in which immunologic marker studies demonstrated that the neoplastic cells had characteristics of B-lympho...


    pub_type: 杂志文章


    authors: Parfrey NA,Mann RB,Selonick SE,Beschorner WE

    更新日期:1985-05-01 00:00:00

  • Ductal carcinoma in situ of the male breast.

    abstract:BACKGROUND:Ductal carcinoma in situ (DCIS) of the male breast is an uncommon disease, accounting for approximately 7% of all male breast carcinomas. Compared with invasive carcinomas of the breast, the prognosis associated with DCIS in men is excellent; however, clinical features, pathology, and treatment of this disea...


    pub_type: 杂志文章


    authors: Camus MG,Joshi MG,Mackarem G,Lee AK,Rossi RL,Munson JL,Buyske J,Barbarisi LJ,Sanders LE,Hughes KS

    更新日期:1994-08-15 00:00:00

  • Spontaneously regressing adrenocortical carcinoma in a newborn. A case report with DNA ploidy analysis.

    abstract::Adrenal cortical carcinoma is an uncommon neoplasm in children. Only a handful of congenital adrenal cortical carcinoma cases have been described. A newborn who had metastatic adrenal cortical carcinoma (skin metastases and cerebral lesions) is described. This patient underwent surgical resection of the right adrenal ...


    pub_type: 杂志文章


    authors: Saracco S,Abramowsky C,Taylor S,Silverman RA,Berman BW

    更新日期:1988-08-01 00:00:00