Abstract:
:The altered expression of the human retinoblastoma (RB) gene has been demonstrated to play an important role in the pathogenesis of RB and other tumors. To determine whether the RB gene might be involved in the pathogenesis of human ovarian and endometrial cancer, DNA from 24 human ovarian tumors, 3 normal ovaries, 3 endometrial carcinomas, and 1 endometrial hyperplasia was examined with an RB complementary DNA probe. Evidence for homozygous deletion of the RB gene was observed in only one specimen. Interestingly, the specimen was an endometrioid tumor of the ovary of low malignant potential (LMP). This patient experienced rapid progression of the tumor and died 8 months after diagnosis. Abnormalities of the RB gene may be involved in the aggressive biologic behavior of certain forms of ovarian carcinoma, particularly those of LMP.
journal_name
Cancerjournal_title
Cancerauthors
Sasano H,Comerford J,Silverberg SG,Garrett CTdoi
10.1002/1097-0142(19901115)66:10<2150::aid-cncr282subject
Has Abstractpub_date
1990-11-15 00:00:00pages
2150-4issue
10eissn
0008-543Xissn
1097-0142journal_volume
66pub_type
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