Abstract:
:From November 1973 to May 1986, 50 patients with Stage I epithelial ovarian cancer were treated at the University of Kentucky Medical Center (Lexington, KY) with oral Alkeran (melphalan) chemotherapy after primary surgery. Twenty-two patients had Grade 1 tumors, 23 patients had Grade 2 tumors, and five patients had Grade 3 tumors. Patients with ovarian tumors of borderline malignancy were excluded from this study. Twenty-eight patients received from six to 11 courses of chemotherapy and 22 patients completed 12 courses of chemotherapy. Chemotherapy was well tolerated and no patient died of chemotherapy-related complications. Thirty-eight patients underwent second-look laparotomy died of disease 41 months after diagnosis and one patient died with no evidence of disease 6 months after treatment. The actuarial survival of the total group of patients was 98% at 2 years and 94% at 5 years. Fewer than 12 months of chemotherapy may be necessary to obtain long-term survival in these patients.
journal_name
Cancerjournal_title
Cancerauthors
Gallion HH,van Nagell JR,Donaldson ES,Higgins RV,Powell DE,Kryscio RJdoi
10.1002/1097-0142(19890315)63:6<1070::aid-cncr2820subject
Has Abstractpub_date
1989-03-15 00:00:00pages
1070-3issue
6eissn
0008-543Xissn
1097-0142journal_volume
63pub_type
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