Abstract:
BACKGROUND:To the authors' knowledge, the long term follow-up of patients with carcinoma in situ of the urinary bladder is limited. METHODS:The authors studied 138 patients diagnosed with urothelial carcinoma in situ of the bladder at the Mayo Clinic between 1972-1979. All the histologic slides were reviewed and fulfilled the diagnostic criteria for carcinoma in situ according to the newly proposed World Health Organization and International Society of Urologic Pathology classification system. None of these patients had previous or coexisting invasive urothelial carcinoma at the time of diagnosis. Cox proportional hazards models were used to determine the prognostic significance of numerous clinical and pathologic findings using progression free, cancer specific, and all-cause survival as the endpoints for analysis. Progression was defined as the development of invasive carcinoma, distant metastases, or death from bladder carcinoma. RESULTS:The patients ages at the time of diagnosis ranged from 32-90 years (mean, 65.6 years). The male to female ratio was 7:1. Carcinoma in situ usually was multifocal (50%) with a predilection for the trigone, lateral wall, and dome. The mean follow-up after surgery was 11.0 years (range, 0.7-25 years). Actuarial progression free, cancer specific, and all-cause survival rates were 63%, 79%, and 55%, respectively, at 10 years, and 59%, 74%, and 40%, respectively, at 15 years. The mean interval from the time of diagnosis to cancer progression was 5 years. Patient age at diagnosis was significant in predicting progression free (P = 0.01) and all-cause survival (P = 0.002). Cystectomy performed within 3 months after the initial diagnosis was associated with improved all-cause survival (P = 0.03). After controlling for age, there was no difference in survival between patients who received immediate cystectomy and those did not (P = 0.16). CONCLUSIONS:Patients with carcinoma in situ of the bladder are at significant risk of cancer progression and death from bladder carcinoma. Cystectomy does not appear to offer a significant survival advantage in patients with carcinoma in situ of the bladder after adjusting for age.
journal_name
Cancerjournal_title
Cancerauthors
Cheng L,Cheville JC,Neumann RM,Leibovich BC,Egan KS,Spotts BE,Bostwick DGsubject
Has Abstractpub_date
1999-06-01 00:00:00pages
2469-74issue
11eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(19990601)85:11<2469::AID-Cjournal_volume
85pub_type
临床试验,杂志文章相关文献
CANCER文献大全abstract::There is currently no adequate staging system for cerebral astrocytomas. A scheme for acquiring data that can be used to stage cerebral hemisphere tumors is suggested. This data base, in conjunction with treatment and survival information, may be useful in the management of childhood hemispheric tumors. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851001)56:7+<1784::aid-cncr282
更新日期:1985-10-01 00:00:00
abstract:BACKGROUND:Image-directed biopsies may be collected as histologic or cytologic specimens. METHODS:In 34 patients, the results of aspiration cytologic examination were compared prospectively with core tissue biopsy findings obtained and diagnosed independently using the same image-guided procedure. RESULTS:Cytologic e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921015)70:8<2187::aid-cncr2820
更新日期:1992-10-15 00:00:00
abstract::CEA-like material was found in 51 of 62 primary human breast carcinomas and in only 2 of 12 fibroadenomas. Levels of carcinoma CEA-like material correlated weakly with cytoplasmic estradiol receptor levels, total cytosol estrogens, and cytosol progesterone. Levels of CEA-like material showed no significant correlation...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830101)51:1<121::aid-cncr28205
更新日期:1983-01-01 00:00:00
abstract::The authors present the case of a 40-year-old white man with an obstructing laryngeal mass. Despite considerable tumor size, results of repeated biopsies revealed widespread carcinoma in situ with chronic inflammation within the subcutaneous tissues, and only after extensive endoscopic "debulking" of the mass was a sm...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850801)56:3<490::aid-cncr28205
更新日期:1985-08-01 00:00:00
abstract::As part of epidemiologic studies of human T-lymphotropic virus (HTLV)-I-associated malignancies in Jamaica, the authors evaluated 26 patients with non-Hodgkin's lymphoma for the presence of integrated HTLV-I provirus in their malignant cells. Fifteen of 26 patients had integrated provirus. All 15 also were HTLV-I anti...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880401)61:7<1477::aid-cncr2820
更新日期:1988-04-01 00:00:00
abstract:BACKGROUND:Brain metastases from soft tissue sarcoma (STS) are uncommon. To the authors' knowledge limited information is available regarding the influence of the initial STS site, the significance of parenchymal versus leptomeningeal metastases, and the role of surgical resection. METHODS:STS patients evaluated betwe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10554
更新日期:2002-05-15 00:00:00
abstract::Breast cancer is the most common malignant tumor among women in the world. In 2005, there were approximately 272,000 new cases diagnosed and more than 70,000 deaths from breast cancer in China. Of the patients who are newly diagnosed with breast cancer each year, approximately 3% to 10% have distant metastases at the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32832
更新日期:2020-08-15 00:00:00
abstract::A retrospective analysis of 12 patients with primary central nervous system non-Hodgkin's lymphoma seen from 1958 to 1980 was carried out with emphasis on diagnostic evaluation and treatment results. Computerized tomography (CT) scans were found to be the most valuable diagnostic tool both for initial evaluation as we...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19831201)52:11<1993::aid-cncr282
更新日期:1983-12-01 00:00:00
abstract:BACKGROUND:Commonly used chemotherapies can be toxic to the ovaries. To the authors' knowledge, the majority of studies evaluating receipt of fertility counseling for women in their reproductive years have been performed in specific settings, thereby limiting generalizability. METHODS:A nationwide sample of US women d...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32126
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:9-Aminocamptothecin (9AC) and its parent compound, camptothecin, have shown outstanding preclinical activity against colorectal carcinoma. Irinotecan (CPT-11), another camptothecin derivative, has demonstrated clinical activity in patients with 5-fluorouracil (5-FU)-refractory colorectal carcinoma. METHODS:...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0142(19971101)80:9<1727::aid-cn
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:This report evaluated whether biochemical recurrence (BCR) as a time-dependent covariate (t) after radical prostatectomy (RP) for prostate cancer was associated with the risk of death and whether salvage therapy with radiotherapy (RT) and/or hormonal therapy (HT) can lessen this risk METHODS:This was a retr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25013
更新日期:2010-04-15 00:00:00
abstract::To evaluate the incidence of thrombocytopenia and bleeding among patients with solid tumors treated intensively with chemotherapy, the records of 1274 patients treated between 1972 and 1980 on protocols known to produce significant myelosuppression were reviewed. Three hundred one patients with solid tumors (breast, l...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840201)53:3<557::aid-cncr28205
更新日期:1984-02-01 00:00:00
abstract:BACKGROUND:Selective neck dissection (SND) is a mainstay of head and neck cancer treatment. A common sequela is shoulder syndrome from spinal accessory nerve (SAN) trauma. Extensive dissection in neck levels 2 and 5 leads to SAN dysfunction. However, it is not known whether limited level 2 dissection reduces SAN injury...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.32681
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Surgery alone is the appropriate first-line treatment for patients with mesoblastic nephroma (MN). Nevertheless, there are reports of local recurrences and metastasis, especially in the cellular subtype. The authors evaluated the outcome of patients with MN who were enrolled in either the International Socie...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21836
更新日期:2006-05-15 00:00:00
abstract::The authors present a retrospective review of 90 cases of Stage III endometrial carcinoma seen over a 10-year period at the Princess Margaret Hospital, Toronto. Overall 5-year survival was 45.5% and disease-free survival was 36.0%. Prognostic factors identified within Stage III were tumor grade, geographic distributio...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851115)56:10<2519::aid-cncr282
更新日期:1985-11-15 00:00:00
abstract::The authors describe their experience with total body irradiation (TBI) with 8 MeV-x rays in the treatment of disseminated tumors. With a dose of 125 rad, given three times with 2-week intervals, some objective remissions (6/26) were obtained, especially in patients with lymphomas. For solid tumors only subjective imp...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197704)39:4<1435::aid-cncr282039
更新日期:1977-04-01 00:00:00
abstract:BACKGROUND:This study was conducted to investigate the influence of therapeutic parameters on local control (LC) in the sphincter-conserving treatment of T2-T3 anal carcinoma. METHODS:From 1976 to 1993, 137 patients with anal carcinoma classified as T2 (85 patients) or T3 (52 patients) were treated curatively by radio...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970615)79:12<2329::aid-c
更新日期:1997-06-15 00:00:00
abstract:BACKGROUND:Rural residence has been associated with increased risk of late stage cancer diagnosis, but it is unknown if this is related to lower socioeconomic status (SES) of rural residents or to other factors. This study examined the impacts of SES and urban/rural status on colorectal cancer (CRC) stage at diagnosis ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22016
更新日期:2006-09-01 00:00:00
abstract::We report the clinical and pathologic features of two cases of adenosarcoma. Our first case occurred in the ovary of a 51-year-old woman with extensive pelvic involvement. She was treated vigorously with radiation and chemotherapy and at the present time almost 9 years later the patient is free of disease. This repres...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197904)43:4<1439::aid-cncr282043
更新日期:1979-04-01 00:00:00
abstract::Almost all patients with prostatic cancer will eventually escape the control of the first-line endocrine therapy and relapse. This escape is attributed to selecting and/or cloning preexisting or de novo appearing hormone-independent or resistant cell lines and occurs in most patients after a median time of 12 to 18 mo...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19920701)70:1+<329::aid-cncr2820
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND:Nude mice with xenografted human tumors is the most exploited animal model used to elucidate the efficacy of experimental radioimmunolocalization and radioimmunotherapy. These animals accept transplants and are generally considered immunologically inert with regard to cell-mediated and humoral immune respons...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19971215)80:12+<2404::aid-
更新日期:1997-12-15 00:00:00
abstract:BACKGROUND:The objective of this study was to determine the potential economic implications resulting from using exemestane (EXE), a new steroidal, irreversible aromatase inactivator, compared with megestrol acetate (MA) in patients with advanced breast carcinoma. METHODS:The model used the clinical results from the m...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(20010201)91:3<484::aid-cncr1026>
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND:A diagnosis of cancer provides a teachable moment in which a physician can counsel or teach the patient. The Cancer and Leukemia Group B hypothesized that this teachable moment could also be used to encourage counseling of the patients' relatives who smoke. The authors' first study sought to determine the fe...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/(sici)1097-0142(19970101)79:1<152::aid-cnc
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Proton therapy has been a hotly contested issue in both scientific publications and lay media. Proponents cite the modality's ability to spare healthy tissue, but critics claim the benefit gained from its use does not validate its cost compared with photon therapy. The objective of this study was to evaluate...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28322
更新日期:2013-12-15 00:00:00
abstract:BACKGROUND:Lung carcinoma represents the most frequent cause of cancer death worldwide because of tumor metastases. The objective of the current study was to analyze the immunologic response during the progress of lung carcinoma metastasis. METHODS:The authors established two tumor cell lines that were derived from pr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20782
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:The use of complementary methods (CMs) is widespread and increasing in the United States. Most literature on CM use among cancer survivors focuses on the treatment period, whereas only a few studies address use further along the cancer continuum. METHODS:This study analyzed the prevalence and the medical an...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23659
更新日期:2008-09-01 00:00:00
abstract::Epidemiology and prognosis were analyzed in a consecutive, population-based series of 137 patients with malignant fibrous histiocytoma of soft tissue in the extremities and trunk wall, with a complete follow-up of minimum 3 years. All but one patient were treated by surgery in 28 cases combined with adjuvant radiother...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910115)67:2<499::aid-cncr28206
更新日期:1991-01-15 00:00:00
abstract::Of the remote effects of cancer on the neurologic system, paraneoplastic cerebellar degeneration (PCD), characterized by global cerebellar dysfunction, is second only to paraneoplastic neuropathies in frequency. Recent evidence, including the finding of anti-Purkinje cell (now termed anti-Yo) antibodies directed again...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19911015)68:8<1835::aid-cncr2820
更新日期:1991-10-15 00:00:00
abstract:BACKGROUND:The aims of this study were to compare human epidermal growth factor receptor 2 (HER2) results between immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), and to investigate the clinicopathological characteristics and outcomes according to their results. METHODS:Using consecutive tissu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26406
更新日期:2012-02-15 00:00:00
abstract::Correlations of c-erbB-2 protein expression with clinical outcomes of gastric carcinomas were studied in 189 gastric carcinomas. There were 23 (12.2%) carcinomas with evidence of c-erbB-2 protein in which the reaction was localized to the cell membrane. There was no significant association between c-erbB-2 staining an...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910601)67:11<2914::aid-cncr282
更新日期:1991-06-01 00:00:00