An unusual presentation of a large tumor coexisting with an unusually high nonspecific immune responsiveness. A case report.

Abstract:

:The authors present the case of a 40-year-old white man with an obstructing laryngeal mass. Despite considerable tumor size, results of repeated biopsies revealed widespread carcinoma in situ with chronic inflammation within the subcutaneous tissues, and only after extensive endoscopic "debulking" of the mass was a small focus of invasive carcinoma identified. Just as surprising was the patient's unusual degree of immune competence as estimated to be at least in the upper normal range and definitely much higher than that observed in the other patients with head and neck cancer routinely examined in our department. The immune responsiveness of the patient was evaluated by total lymphocyte count, in vivo skin testing, in vitro blastogenesis, interleukin-2 and interferon-gamma production. The authors postulate that these observations may constitute a rare demonstration of the ability of the immune surveillance system to contain malignancy under physiologic conditions.

journal_name

Cancer

journal_title

Cancer

authors

Eskinazi DP,Mihail R,Dichtel WG

doi

10.1002/1097-0142(19850801)56:3<490::aid-cncr28205

subject

Has Abstract

pub_date

1985-08-01 00:00:00

pages

490-4

issue

3

eissn

0008-543X

issn

1097-0142

journal_volume

56

pub_type

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