Abstract:
:A pulmonary blastoma in a 52-year-old Japanese man was serially transplanted into athymic nude mice. This report emphasizes the characteristics of the neoplasm seen on light and electron microscopic examination. The original tumor consisted of branching tubular structures and primitive mesenchymal components with a few smooth-muscle cell bundles, and resembled fetal lung tissue. Electron microscopic examination revealed that the immature stromal cells resembled epithelial cells. After serial passages in nude mice, the stromal element of the tumor disappeared, and the epithelial element showed squamous metaplasia and occasional mucus production. Endocrine-type granules were observed in a few tumor cells. Histogenetic considerations, including a suggestion that the tumor was derived from entodermal cells, are presented.
journal_name
Cancerjournal_title
Cancerauthors
Tamai S,Kameya T,Shimosato Y,Tsumuraya M,Wada Tdoi
10.1002/1097-0142(19800915)46:6<1389::aid-cncr2820subject
Has Abstractpub_date
1980-09-15 00:00:00pages
1389-96issue
6eissn
0008-543Xissn
1097-0142journal_volume
46pub_type
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