Abstract:
BACKGROUND:Lung carcinoma represents the most frequent cause of cancer death worldwide because of tumor metastases. The objective of the current study was to analyze the immunologic response during the progress of lung carcinoma metastasis. METHODS:The authors established two tumor cell lines that were derived from primary and metastatic lesions in a patient with lung carcinoma (Patient G603). One cell line (G603L) was established from the primary lesion, and the other cell line (G603AD) was established from a metastatic lesion in the right adrenal gland 7 months after the patient underwent surgery for the primary lesion. Autologous regional lymph node lymphocytes were stimulated with CD80-transfected G603L cells, then cytotoxic T lymphocytes (CTLs) were induced against both lung carcinoma cell lines. RESULTS:Both G603L cells and G603AD cells expressed Class I human leukocyte antigen, intracellular cell adhesion molecule 1, and lymphocyte-associated antigen type 3 (LFA-3), but not Fas or Fas ligand on their surfaces. By stimulation with CD80-transfected G603L cells, 2 CTL clones (H2/17 and H2/36) were established from the bulk CTLs. CTL clone H2/17 lysed G603L cells but not G603AD cells, suggesting that the antigen recognized by CTL clone H2/17 was abrogated during the process of metastasis. In contrast, CTL clone H2/36 lysed both G603L cells and G603AD cells, indicating that the antigen recognized by CTL clone H2/36 was maintained in the tumor cells throughout tumor progression. CONCLUSIONS:The results demonstrated the possibility that some tumor-associated antigens may be abrogated during the process of metastasis, although others are maintained. The identification of these antigens will lead to a better understanding of their immunologic role during disease progression in patients with lung carcinoma.
journal_name
Cancerjournal_title
Cancerauthors
So T,Takenoyama M,Ichiki Y,Mizukami M,So T,Hanagiri T,Sugio K,Yasumoto Kdoi
10.1002/cncr.20782subject
Has Abstractpub_date
2005-01-01 00:00:00pages
200-8issue
1eissn
0008-543Xissn
1097-0142journal_volume
103pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Polymorphic reticulosis, a type of lethal midline granuloma (LMG), has been referred to as nasal T-cell lymphoma (NTL) because of its proliferating cells' positive reactivity to anti-T-lymphocyte antibodies. Recently, several studies have suggested that proliferating cells in NTL may be natural killer (NK) i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950201)75:3<894::aid-cncr28207
更新日期:1995-02-01 00:00:00
abstract::In order to determine if there are morphologically identifiable characteristics between malignant cells obtained from a primary cancer and its metastasis the nuclear diameter was used as an indicator of the degree of malignancy, since there is good correlation between nuclear size, DNA content, and chromosome numbers....
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851001)56:7<1605::aid-cncr2820
更新日期:1985-10-01 00:00:00
abstract::Myelography was performed on 78 patients with breast cancer who had signs or symptoms compatible with spinal cord compression. Of 42 patients (54%) with extradural defects, 21 (50%) had a complete block. All patients with positive myelograms (M+) had a positive bone scan and 41 of 42 (97%) had positive skeletal x-rays...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850615)55:12<2839::aid-cncr282
更新日期:1985-06-15 00:00:00
abstract:BACKGROUND:The objective of the current study was to investigate the effects and the morbidities of single-fraction stereotactic radiation therapy (SRT) for lung tumors. METHODS:A Microtron device was modified to deliver stereotactic irradiation under respiratory gating. Between August 1998 and December 2004, 59 malig...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21747
更新日期:2006-03-15 00:00:00
abstract:BACKGROUND:Immunohistological markers specific for a single type of epithelium are rare. Recently, urothelium tissue-specific genes were cloned. The genes encoded a family of transmembrane proteins, uroplakins, that are expressed only in urothelial mucosa. Using uroplakin antibodies on paraffin-embedded tissue, a previ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.9032
更新日期:2001-06-25 00:00:00
abstract::Recent follow-up studies of patients with mammary carcinoma treated with breast-conserving primary radiotherapy identified a triad of pathologic features significantly associated with local treatment failure. These unfavorable characteristics of the primary tumor were: poor or undifferentiated nuclear grade; intraduct...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860401)57:7<1415::aid-cncr2820
更新日期:1986-04-01 00:00:00
abstract::In estrogen target tissues and hormone-dependent tumors, the steroid enters the cells and binds to a cytoplasmic protein called the estrogen receptor (ER). The steroid-receptor complex then migrates to the nuclei, where it initiates the biochemicial events characteristic of estrogen stimulation. Since ER is absent in ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197508)36:2+<638::aid-cncr282036
更新日期:1975-08-01 00:00:00
abstract:BACKGROUND:The primary purpose of this study was to establish the maximum tolerated dose (MTD) of intravenous melphalan in combination with paclitaxel and cisplatin plus granulocyte-colony stimulating factor (G-CSF) in patients with suboptimal advanced epithelial ovarian carcinoma or primary peritoneal carcinoma. METH...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:The sensitivity of the intraoperative diagnosis of sentinel lymph node (SLN) micrometastases and the metastases of invasive lobular carcinoma (ILC) is low. The goal of the current study was to assess whether the use of intraoperative, rapid immunohistochistochemistry (IHC) enhances the intraoperative detecti...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.21133
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Endometrial carcinoma is generally diagnosed only after the onset of postmenopausal bleeding. Although most patients with Stage I disease can be cured, the prognosis worsens significantly when the tumor is no longer confined to the uterine corpus. Serum CA 125 is elevated in only 10-20% cases of Stage I and ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940401)73:7<1855::aid-cncr2820
更新日期:1994-04-01 00:00:00
abstract::Histologic, histochemical, immunocytochemical, and ultrastructural features of two cardiac myxomas containing glandular elements are reported. Glandular elements in both cases stained positively with both mucicarmine and periodic acid-Schiff reagent with diastase pretreatment (DPAS). Immunoperoxidase studies demonstra...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870515)59:10<1767::aid-cncr282
更新日期:1987-05-15 00:00:00
abstract::Gonadal dosimetry and spermatogenic activity was monitored in patients given radiation therapy (RT) after unilateral orchiectomy for seminoma. The RT given was, with minor variations, 3200 rad in 16 fractions in four weeks to the para-aortic and ipsilateral pelvic inguinal lymphatics in order to include the orchiectom...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820715)50:2<337::aid-cncr28205
更新日期:1982-07-15 00:00:00
abstract::The histologic findings of five patients with clinically typical Bowenoid dysplasia (BD) allowed the authors to classify the vulvar and perineal biopsies of 18 patients under 40 years as BD and the vulvar biopsies of six patients under 40 years as squamous cell carcinoma in situ (CIS). The two best criteria for BD are...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821215)50:12<2910::aid-cncr282
更新日期:1982-12-15 00:00:00
abstract:BACKGROUND:Synovial sarcoma usually arises in the extremities and in close proximity to large joints. Reported examples arising in the anterior abdominal wall are rare. Because most accounts from this location consist of case reports, neither clinical nor prognostic features have been well delineated. METHODS:Twenty-s...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930715)72:2<469::aid-cncr28207
更新日期:1993-07-15 00:00:00
abstract:BACKGROUND:Breast conservation is now established treatment for patients with small breast cancers. The authors reviewed a large series of patients with long term follow-up who underwent conservative treatment. Clinical and pathologic factors were analyzed to identify patients at an increased risk of relapse in the bre...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19951201)76:11<2260::aid-cncr282
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND:Although flow cytometric DNA analysis has been recognized to be a useful prognostic indicator for patients with squamous cell carcinoma of the esophagus, the biologic significance of DNA aneuploidy remains to be elucidated. METHODS:Twenty-five patients with squamous cell carcinoma of the esophagus who under...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:Patients affected by neurofibromatosis type 1 (NF1) are at higher risk of developing soft-tissue sarcomas (STS) than the general population. The clinical findings and outcome in 43 children and adolescents with NF1 treated for STS in the Italian protocols between 1988 and 2004 are reported. METHODS:The stud...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.22533
更新日期:2007-04-01 00:00:00
abstract::Disease that is known to have extended beyond the prostatic capsule is unlikely to be cured by radical surgical excision, although the primary tumor may be controlled by external irradiation. The development of progressive (metastatic) disease is common and may be retarded by hormonal therapy. The timing of such treat...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19930201)71:3+<1074::aid-cncr282
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:The diagnostic accuracy of technetium-99m methoxyisobutylisonitrile (Tc-MIBI) single photon emission computed tomography (SPECT) and computed tomography (CT) of the head and neck for differentiating recurrent or residual nasopharyngeal carcinomas (NPC) from benign lesions after radiotherapy was compared with...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/cncr.10400
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND:Chemoradiotherapy has become the standard of care for head and neck squamous cell carcinoma; however, those patients often experience multiple treatment-related symptoms or symptom clusters. Two symptom clusters have been identified for this population. Little is known about the risk factors of these symptom...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.28500
更新日期:2014-03-15 00:00:00
abstract:BACKGROUND:Cisplatin and carboplatin are essential to management of advanced-stage epithelial ovarian carcinoma. No published data exist regarding carboplatin dose intensity importance in ovarian cancer, nor are there data for the effect of age on the ability to deliver dose-intensive carboplatin. METHODS:Retrospectiv...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.2820710225
更新日期:1993-01-15 00:00:00
abstract::A case report of a metastasizing basal cell carcinoma is presented, primary in the leg with regional inguinal lymph node metastasis, followed by extensive metastasis to skin and bone marrow with myelophthisic anemia and terminal splenohepatic and unilateral adrenal metastasis. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(196810)22:4<879::aid-cncr2820220
更新日期:1968-10-01 00:00:00
abstract:BACKGROUND:The National Pediatric Oncology Unit (UNOP) is the only pediatric hemato-oncology center in Guatemala. METHODS:Patients ages 1 to 17 years with acute lymphoblastic leukemia (ALL) were treated according to modified ALL Intercontinental Berlin-Frankfurt-Münster (IC-BFM) 2002 protocol. Risk classification was ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30257
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:The presence of urinary excretion products of human chorionic gonadotropin (hCG) has been proposed as a tumor marker. To ascertain the clinical value in gynecologic cancers, the authors studied 612 nonpregnant women. METHODS:Three different assays in four clinical groups were compared: no disease, benign di...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930615)71:12<4124::aid-cncr282
更新日期:1993-06-15 00:00:00
abstract:BACKGROUND:Fortunately, primary malignant mucosal melanoma of the head and neck is a rare entity. A paucity of data elucidating the predictive factors as well as the unpredictable and aggressive biologic behavior of mucosal melanoma compound the vexing clinical situation. This review summarizes what the literature reve...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19971015)80:8<1373::aid-cn
更新日期:1997-10-15 00:00:00
abstract:BACKGROUND:Ethnic disparities in colorectal cancer (CRC) mortality are observed in the United States. The authors studied this among minority New Yorkers with CRC. METHODS:In a study of CRC patients in a New York City teaching hospital, 5-year data on demographics and clinical features were reviewed. Adjusted cancer-r...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24614
更新日期:2009-12-01 00:00:00
abstract::One hundred thirty-five hepatocellular carcinomas were examined for the presence of antigenic tumor markers by the avidin-biotin-peroxidase complex method. Ninety-seven were from the US and 38 came from Argentina. The following markers were tested: alpha-fetoprotein (AFP), alpha-1-antitrypsin (AAT), hepatitis B surfac...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900101)65:1<84::aid-cncr282065
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:The quality of randomized radiotherapy studies investigating the palliation of painful bone metastases has been questioned, with some authors recognizing the potential impact of bias on result interpretation. However, there has been no published comprehensive evaluation of quality assessment. The goals of th...
journal_title:Cancer
pub_type: 杂志文章,meta分析
doi:10.1002/cncr.20993
更新日期:2005-05-01 00:00:00
abstract::Radiation therapy alone, surgery alone, or the combination of these two modalities, remain the accepted treatments in the management of epidermoid carcinomas of the mucosa of the head and neck. These modalities of therapy produce comparable results; but, radiotherapy alone has the advantage that it can conserve anatom...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850501)55:9+<2259::aid-cncr282
更新日期:1985-05-01 00:00:00
abstract::Nine children with acute promyelocytic leukemia (APL) are presented. This series of children represents 7% of all acute leukemias and 21% of acute myelogenous leukemias seen during the same period at the Red Cross War Memorial Children's Hospital. These figures are much higher than the incidence quoted in other series...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870301)59:5<933::aid-cncr28205
更新日期:1987-03-01 00:00:00