Abstract:
:Increasing scientific attention is focused on the gut-brain axis, including the ability of the gastrointestinal (GI) tract to modulate central nervous system function. Changes in the intestinal microbiome can influence affective-like behavior, cognitive performance, fatigue, and sleep in rodents and humans. Patients with cancer who are receiving chemotherapy experience similar negative behavioral changes and concurrent GI symptoms. These chemotherapy comorbidities can be long-lasting and may reduce patients' quality of life and motivation to comply with treatment. This review summarizes the clinical and preclinical evidence supporting a role for the intestinal microbiome in mediating behavioral comorbidities through peripheral immune activation in patients with cancer who are receiving chemotherapy. In addition, evidence suggesting that targeted modification of the intestinal microbiome during cancer treatment could ameliorate associated behavioral comorbidities is reviewed.
journal_name
Cancerjournal_title
Cancerauthors
Jordan KR,Loman BR,Bailey MT,Pyter LMdoi
10.1002/cncr.31584subject
Has Abstractpub_date
2018-10-15 00:00:00pages
3990-3999issue
20eissn
0008-543Xissn
1097-0142journal_volume
124pub_type
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