Reproductive history and prognosis in patients with operable breast cancer.

Abstract:

BACKGROUND:Late menarche, early menopause, high parity, and early first birth decrease the risk of development of breast cancer. The influence of these factors on the survival of breast cancer patients has not been explained. METHODS:A group of 1885 patients with operable breast cancer was studied retrospectively. A univariate analysis was used to calculate 10-year overall survival (OS) and disease free survival (DFS) in relation to age, menopausal status, age at menarche and menopause, and number of pregnancies and deliveries. A multivariate analysis (Cox model) was performed in which classic prognostic factors (tumor size and grade, lymph node involvement) were included in addition to reproductive factors. RESULTS:Univariate analysis demonstrated better prognosis in patients who had never been pregnant compared with those who had (OS, 62% vs. 54%, respectively; P = 0.01; DFS, 53% vs. 44%, respectively; P = 0.005) and in nulliparous compared with parous patients (OS, 62% vs. 53%, respectively; P = 0.006; DFS, 52% vs. 44%, respectively; P = 0.004). Survival rates decreased with the number of pregnancies and deliveries. Patients with late menarche had worse survival then those whose first menstruation occurred before the age of 16 years (DFS, 47% vs. 41%, respectively; P = 0.04). By multivariate analysis, parity remained an independent prognostic indicator in addition to classic highly significant prognostic factors (nodal involvement, tumor grade and size). CONCLUSIONS:Results suggest that reproductive factors known to decrease the risk of breast cancer development have an adverse effect on prognosis.

journal_name

Cancer

journal_title

Cancer

authors

Korzeniowski S,Dyba T

doi

10.1002/1097-0142(19940901)74:5<1591::aid-cncr2820

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

1591-4

issue

5

eissn

0008-543X

issn

1097-0142

journal_volume

74

pub_type

杂志文章

相关文献

CANCER文献大全
  • Familial cutaneous malignant melanoma and tumors of the nervous system. A hereditary cancer syndrome.

    abstract:BACKGROUND:Excessive risk of cutaneous melanoma as a second cancer has been associated with benign or malignant tumors of the nervous system. Cutaneous melanoma and nervous system tumors may independently aggregate in families. There are, however, no previous reports of increased likelihood of tumors of the nervous sys...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19951101)76:9<1571::aid-cncr2820

    authors: Azizi E,Friedman J,Pavlotsky F,Iscovich J,Bornstein A,Shafir R,Trau H,Brenner H,Nass D

    更新日期:1995-11-01 00:00:00

  • Fine-needle aspiration biopsy of granulocytic sarcoma: a clinicopathologic study of 27 cases.

    abstract:BACKGROUND:Because of morphologic similarities, the differential diagnosis of granulocytic sarcoma (GS) in fine-needle aspiration (FNA) specimens includes non-Hodgkin or Hodgkin lymphoma, extramedullary hematopoiesis, poorly differentiated carcinoma, and infection. METHODS:Twenty-six FNAs and 1 pleural effusion fluid ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Suh YK,Shin HJ

    更新日期:2000-12-25 00:00:00

  • Combination chemotherapy in abdominal Burkitt's lymphoma.

    abstract::In a clinical trial, 42 patients with abdominal Burkitt's lymphoma (BL) were treated with a combination regimen, code-named CVA, consisting of cyclophosphamide (CTX), vincristine, and cystosine arabinoside. In addition, intrathecal methotrexate (i.t. MTX) was administered as prophylaxis against subsequent central nerv...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197710)40:4<1410::aid-cncr282040

    authors: Nkrumah FK,Perkins IV,Biggar RJ

    更新日期:1977-10-01 00:00:00

  • A comparison of aztreonam plus vancomycin and imipenem plus vancomycin as initial therapy for febrile neutropenic cancer patients.

    abstract:BACKGROUND:The improved efficacy of imipenem over other beta-lactam antibiotics in the treatment of febrile neutropenic patients has been attributed to its broad spectrum of activity. METHODS:A prospective, randomized, clinical trial was performed comparing vancomycin 1 g every 12 hours plus imipenem/cilassatin 500 mg...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/(SICI)1097-0142(19960401)77:7<1386::AID-CN

    authors: Raad II,Whimbey EE,Rolston KV,Abi-Said D,Hachem RY,Pandya RG,Ghaddar HM,Karl CL,Bodey GP

    更新日期:1996-04-01 00:00:00

  • The Department of Veterans Affairs' unique clinical cancer research effort.

    abstract::Without organized clinical trials, we are doomed to repeat our mistakes endlessly. There are many genuine conflicts of interest intrinsic to clinical research. Some of these arise from the necessity of admitting that we as physicians do not know the best way to treat every disease or each patient and that all treatmen...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19941101)74:9+<2701::aid-cncr282

    authors: Hrushesky WJ

    更新日期:1994-11-01 00:00:00

  • Findings from NSABP Protocol No. B-04: comparison of radical mastectomy with alternative treatments. II. The clinical and biologic significance of medial-central breast cancers.

    abstract::Findings from 1665 women with primary breast cancer, treated at 34 NSABP institutions in Canada and the United States, have failed to demonstrate that patients with medial-central tumors had a greater probability of developing distant metastases or dying than did those with lateral tumors despite the greater incidence...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19811015)48:8<1863::aid-cncr2820

    authors: Fisher B,Wolmark N,Redmond C,Deutsch M,Fisher ER

    更新日期:1981-10-15 00:00:00

  • Fine-needle aspiration of cystic parotid glands lesions: an institutional review of 46 cases with histologic correlation.

    abstract:BACKGROUND:Many case reports describing various benign and malignant disease entities diagnosed in cystic parotid gland lesions by fine-needle aspiration (FNA) exist in the literature. Very few studies, however, discuss the efficacy and the diagnostic difficulties of FNA cytology in such lesions. The authors report a 5...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(20000425)90:2<111::aid-cnc

    authors: Nasuti JF,Yu GH,Gupta PK

    更新日期:2000-04-25 00:00:00

  • Role of 5-aminolevulinic acid in the detection of urothelial premalignant lesions.

    abstract:BACKGROUND:The authors evaluated the role of 5-aminolevulinic acid (5-ALA)-induced fluorescence endoscopy (AFE) in the detection of flat urothelial lesions in light of the suggestions made for flat neoplastic lesions within the 1999 World Health Organization (WHO) classification of urinary bladder tumors. METHODS:From...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10821

    authors: Zaak D,Hungerhuber E,Schneede P,Stepp H,Frimberger D,Corvin S,Schmeller N,Kriegmair M,Hofstetter A,Knuechel R

    更新日期:2002-09-15 00:00:00

  • Fatal hepatic vascular toxicity of DTIC. Is it really a rare event?

    abstract::A fatal massive hepatic necrosis with widespread thrombotic occlusion of the small hepatic veins developed in two of 68 patients treated with DTIC for advanced melanoma in a randomized study. Thirteen similar reactions, in patients treated with single-agent DTIC, are reported in the literature. Several clinical and pa...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880515)61:10<1988::aid-cncr282

    authors: Ceci G,Bella M,Melissari M,Gabrielli M,Bocchi P,Cocconi G

    更新日期:1988-05-15 00:00:00

  • Complements as new diagnostic tools of hepatocellular carcinoma in cirrhotic patients.

    abstract::Serum complements, C3, C4, and C3 proactivator (C3PA), were evaluated prospectively for their diagnostic power in detecting hepatocellular carcinoma (HCC) in patients with liver cirrhosis (LC). Sixty-three LC patients, including 36 LC with HCC patients, were recruited for this study during the period from March to Nov...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880715)62:2<227::aid-cncr28206

    authors: Chang WY,Chuang WL

    更新日期:1988-07-15 00:00:00

  • Prolactin cell carcinoma of the pituitary. Clinicopathologic, immunohistochemical, and ultrastructural study of a case with cranial and extracranial metastases.

    abstract::A patient with a primary adenohypophyseal neoplasm who had a long course marked by multiple surgical resections, radiation therapy, and high-dose dopamine agonist therapy developed local invasion as well as cranial and extracranial osseous metastatic lesions. The serum prolactin levels were greatly elevated, and immun...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850201)55:3<598::aid-cncr28205

    authors: Scheithauer BW,Randall RV,Laws ER Jr,Kovacs KT,Horvath E,Whitaker MD

    更新日期:1985-02-01 00:00:00

  • Acral erythema secondary to high-dose cytosine arabinoside with pain worsened by cyclosporine infusions.

    abstract::Acral erythema after high-dose cytosine arabinoside (Ara-C) has been described as a painful, sharply demarcated, and intense erythema of the palms and soles. This phenomenon occurred and is described in three out of three allogeneic bone marrow transplant (BMT) recipients who received high-dose Ara-C and total-body ir...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890615)63:12<2482::aid-cncr282

    authors: Kampmann KK,Graves T,Rogers SD

    更新日期:1989-06-15 00:00:00

  • A comparative study of a BCNU containing 4-drug program versus MOPP versus 3-drug combinations in advanced Hodgkin's disease: a cooperative study by the Cancer and Leukemia Group B.

    abstract::A prospective randomized trial by CALGB examined the relative value of four chemotherapy regimens in 537 patients with stage III B and IV Hodgkin's disease. A new combination BOPP, derived by substitution of BCNU for nitrogen mustard in the MOPP regimen, was compared to MOPP and to two 3-drug regimens, derived by remo...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(197901)43:1<31::aid-cncr28204301

    authors: Nissen NI,Pajak TF,Glidewell O,Pedersen-Bjergaard J,Stutzman L,Falkson G,Cuttner J,Blom J,Leone L,Sawitsky A,Coleman M,Haurani F,Spurr CL,Harley JB,Seligman B,Cornell C Jr,Henry P,Senn HJ,Brunner K,Martz G,Maurice

    更新日期:1979-01-01 00:00:00

  • Randomized controlled study of chemoimmunotherapy of acute myelogenous leukemia (AML) in adults with Nocardia rubra cell-wall skeleton and irradiated allogeneic AML cells.

    abstract::The effect of immunotherapy with Nocardia rubra cell-wall skeleton (N-CWS) on remission duration and survival of adults with acute myelogenous leukemia (AML) was studied in a prospective randomized controlled study. After having been induced into complete remission and having been consolidated, 73 patients were random...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(19860415)57:8<1483::aid-cncr2820

    authors: Ohno R,Nakamura H,Kodera Y,Ezaki K,Yokomaku S,Oguma S,Kubota Y,Shibata H,Ogawa N,Masaoka T

    更新日期:1986-04-15 00:00:00

  • Evaluation and radiotherapy implications of chest relapse patterns in small cell lung carcinoma treated with radiotherapy-chemotherapy: study of 34 cases and review of the literature.

    abstract::Evaluation and radiotherapy implications of chest relapse patterns in small cell lung carcinoma treated with chemotherapy and radiotherapy to the chest and brain. Emphasis was placed on analysis of patterns of chest disease relapse, chest complications, and sites of initial chest disease relapse in relation to volume ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19801215)46:12<2557::aid-cncr282

    authors: Mira JG,Livingston RB

    更新日期:1980-12-15 00:00:00

  • Flow cytometric DNA analysis of cirrhotic liver cells in patients with hepatocellular carcinoma can provide a new prognostic factor.

    abstract:BACKGROUND:DNA flow cytometry of hepatocellular carcinoma (HCC) cells has been investigated in many studies, but, to the best of our knowledge, there are no data on DNA analysis of cirrhotic parenchyma around the HCC. In this study, cell kinetics and ploidy of parenchymal cells around HCC were performed to ascertain if...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960915)78:6<1195::AID-CN

    authors: Ruà S,Comino A,Fruttero A,Torchio P,Bouzari H,Taraglio S,Torchio B,Capussotti L

    更新日期:1996-09-15 00:00:00

  • Cervical adenocarcinoma and squamous cell carcinoma incidence trends among white women and black women in the United States for 1976-2000.

    abstract:BACKGROUND:Although cervical carcinoma incidence and mortality rates have declined in the U.S. greatly since the introduction of the Papanicolaou smear, this decline has not been uniform for all histologic subtypes. Therefore, the authors assessed the differential incidence rates of squamous cell carcinoma (SCC) and ad...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20064

    authors: Wang SS,Sherman ME,Hildesheim A,Lacey JV Jr,Devesa S

    更新日期:2004-03-01 00:00:00

  • Acute lymphoblastic leukemia in adults and children. Differences in response with similar therapeutic regimens.

    abstract::Twenty-three adult patients (ages greater than 15 years) and 75 children with acute lymphoblastic leukemia were treated with similar intensive, sequential cytotoxic protocols (L-2). The adult patients have lower remission rate (78%) than the children (98%). The duration of remission and the length of survival are also...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197603)37:3<1256::aid-cncr282037

    authors: Gee TS,Haghbin M,Dowling MD,Cunningham I,Middleman MP,Clarkson BD

    更新日期:1976-03-01 00:00:00

  • The treatment of bilateral ulcerated lymph node metastases from carcinoma of the penis. A case report.

    abstract::A 44-year-old patient with histologically proven bilateral ulcerated lymph node metastases from a carcinoma of the penis was treated by sequenced combined chemotherapy and radical irradiation. Methotrexate and bleomycin were administered at weekly intervals for 5 weeks, followed by radiation with a split-course coning...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841015)54:8<1720::aid-cncr2820

    authors: Abratt RP

    更新日期:1984-10-15 00:00:00

  • Secondary sarcomas after radiotherapy for breast cancer: sustained risk and poor survival.

    abstract:BACKGROUND:Radiotherapy (RT) has been a risk factor for development of soft tissue sarcomas (STS). The objective of the current study was to quantify the risk of STS after RT and surgery for breast cancer (BCa), assess time trends, and compare long-term survival of patients with RT-associated and non-RT-associated angi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24462

    authors: Mery CM,George S,Bertagnolli MM,Raut CP

    更新日期:2009-09-15 00:00:00

  • Erratum: Borderud SP, Li Y, Burkhalter JE, Sheffer CE and Ostroff JS. Electronic cigarette use among patients with cancer: Characteristics of electronic cigarette users and their smoking cessation outcomes. Cancer. doi: 10.1002/ cncr.28811.

    abstract::The authors discovered some errors regarding reference group labels in Table 2. The corrected table is attached. The authors regret these errors. ...

    journal_title:Cancer

    pub_type: 已发布勘误

    doi:10.1002/cncr.29118

    authors:

    更新日期:2015-03-01 00:00:00

  • Variation in the use of advanced imaging at the time of breast cancer diagnosis in a statewide registry.

    abstract:BACKGROUND:Although national guidelines do not recommend extent of disease imaging for patients with newly diagnosed early stage breast cancer given that the harm outweighs the benefits, high rates of testing have been documented. The 2012 Choosing Wisely guidelines specifically addressed this issue. We examined the ch...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30674

    authors: Henry NL,Braun TM,Breslin TM,Gorski DH,Silver SM,Griggs JJ

    更新日期:2017-08-01 00:00:00

  • Cytodifferentiation of a Wilms' tumor pulmonary metastasis: theoretic and clinical implications.

    abstract:BACKGROUND:Complete maturation (cytodifferentiation) of treated metastatic Wilms' tumor is an infrequent occurrence. In a large series of reports, Wilms' metastases have generally contained malignant blastemic elements admixed with lesser amounts of cytodifferentiated mesenchyme. The authors describe a patient in whom ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1097-0142(19970415)79:8<1629::aid-cn

    authors: Seemayer TA,Harper JL,Shickell D,Gross TG

    更新日期:1997-04-15 00:00:00

  • Locally advanced melanoma: results of postoperative hypofractionated radiation therapy.

    abstract:BACKGROUND:High rates of locoregional recurrence have been reported from surgical series of locally advanced melanoma. In this study, the outcomes of patients treated with surgery and postoperative hypofractionated radiation therapy were reviewed to assess local recurrence and survival. METHODS:From 1989 to 1998, 174 ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(20000101)88:1<88::aid-cncr

    authors: Stevens G,Thompson JF,Firth I,O'Brien CJ,McCarthy WH,Quinn MJ

    更新日期:2000-01-01 00:00:00

  • Basosquamous (transitional cloacogenic) carcinoma of the sigmoid colon.

    abstract::A case of basosquamous or so-called transitional cloacogenic carcinoma of the sigmoid colon, which arose above the pelvic brim at the peritoneal reflection, is reported. We were not able to find a report of this histologic type of tumor arising this far from the pectinate line of the anus, which is the most common pri...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197709)40:3<1234::aid-cncr282040

    authors: Strate RW,Richardson JD,Bannayan GA

    更新日期:1977-09-01 00:00:00

  • Immune complexes, serum proteins, cell-mediated immunity, and immune regulation in patients with squamous cell carcinoma of the head and neck.

    abstract::A collaborative study of the humoral and cellular immune status of patients with carcinoma of the Head and Neck (H&N) was conducted at the West Virginia University (WVU) hospital. In addition, blind-coded serum panels were supplied on H&N cancer patients being treated at the National Cancer Institute (NCI). Serum prot...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860615)57:12<2295::aid-cncr282

    authors: Veltri RW,Rodman SM,Maxim PE,Baseler MW,Sprinkle PM

    更新日期:1986-06-15 00:00:00

  • High-dose combination chemotherapy with autologous bone marrow transplantation in adult solid tumors.

    abstract::In order to determine whether high-dose combination chemotherapy was active in chemotherapy resistant patients, 19 patients, (9 with small cell bronchogenic carcinoma, 6 with embryonal cell carcinoma, 2 with diffuse histiocytic lymphoma, 1 with Hodgkin's disease and 1 with chondrosarcoma), 18 of whom had had extensive...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800615)45:12<3075::aid-cncr282

    authors: Spitzer G,Dicke KA,Litam J,Verma DS,Zander A,Lanzotti V,Valdivieso M,McCredie KB,Samuels ML

    更新日期:1980-06-15 00:00:00

  • Perspectives on research in gynecologic oncology.

    abstract::Gynecologic cancers present unusual opportunities to explore the fruits of well-designed clinical trials to assess the value of existing treatment using a combined modality approach soon after diagnosis. Cancers of the ovary and uterus have well-defined, familiar natural histories. Pathways of spread are clear and rea...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,评审

    doi:10.1002/1097-0142(197607)38:1<509::aid-cncr2820380

    authors: DeVita VT Jr,Wasserman TH,Young RC,Carter SK

    更新日期:1976-07-01 00:00:00

  • Toxicity of high-dose cytosine arabinoside in the treatment of advanced childhood tumors resistant to conventional therapy. A Pediatric Oncology Group study.

    abstract::Experience with high-dose cytosine arabinoside (HDAC) in pediatric solid tumors is limited. Sixteen children with solid tumors resistant to conventional therapies were registered in a pilot Pediatric Oncology Group (POG) study that required the administration of HDAC at 3 g/m2 every 12 hours for four doses. There were...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19901115)66:10<2064::aid-cncr282

    authors: Tebbi CK,Krischer J,Fernbach DJ,Mahoney DH,Alvarado C,Camitta B

    更新日期:1990-11-15 00:00:00

  • The reliability of fine-needle aspiration biopsy as the initial diagnostic procedure for palpable masses: a 4-year experience of 730 patients from a community hospital-based outpatient aspiration biopsy clinic.

    abstract:BACKGROUND:Fine-needle aspiration biopsy (FNAB) is a reliable, rapid, minimally invasive alternative to surgical biopsy when it is performed by physician specialists for the diagnosis of palpable masses. FNAB may be under-utilized in community hospitals in the U.S. because physicians without specialty training commonly...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21976

    authors: Florentine BD,Staymates B,Rabadi M,Barstis J,Black A,Cancer Committee of the Henry Mayo Newhall Memorial Hospital.

    更新日期:2006-07-15 00:00:00