Correlation between clinical outcome and growth factor pathway expression in osteogenic sarcoma.

Abstract:

BACKGROUND:Multiple cell-signaling ligands and receptors-including vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), endothelial growth factor (EGF), v-akt murine thymoma viral oncogene homolog (AKT), platelet-derived growth factor (PDGF), mitogen-activated protein kinase (MAPK), and 70-kilodalton (kD) protein S6 kinase (p70S6 kinase)-reportedly are variably expressed in osteogenic sarcoma. Expression of these proteins may have future implications for prognostication and targeted therapy. The objective of the current study was to determine the relation between clinical outcome and the expression of these proteins. METHODS:A paraffin-embedded microarray of 48 human osteogenic sarcoma tissue specimens was stained with the antibodies against VEGF, IGF, EGF, AKT, PDGF, MAPK, and p70S6 kinase. Staining for each protein included the total protein and, when applicable, the phosphorylated version of the protein. Immunohistochemical staining was then correlated with patient survival (overall survival [OS] and event-free survival [EFS]), histologic response to chemotherapy, and serum markers. RESULTS:There was a negative correlation between VEGF receptor 3 (VEGF-R3) and both OS and EFS. VEGF-B was correlated with a poor histologic response to chemotherapy. Serum markers were not correlated with any specific proteins. When using a P value of .05, multiple correlations were observed between proteins of various pathways. CONCLUSIONS:The current results suggested that the VEGF pathway is a critical signaling pathway in osteogenic sarcoma. These data have identified specific proteins within these pathways toward which future investigations should be directed to further clarify their prognostic potential.

journal_name

Cancer

journal_title

Cancer

authors

Abdeen A,Chou AJ,Healey JH,Khanna C,Osborne TS,Hewitt SM,Kim M,Wang D,Moody K,Gorlick R

doi

10.1002/cncr.24562

subject

Has Abstract

pub_date

2009-11-15 00:00:00

pages

5243-50

issue

22

eissn

0008-543X

issn

1097-0142

journal_volume

115

pub_type

杂志文章

相关文献

CANCER文献大全
  • The value of breast self-examination.

    abstract::In this study of 2092 women with cancer of the breast, those who had practiced breast self-examination (BSE) had earlier cancer than did those who had not practiced BSE. This was true for both black and white races, all educational and economic levels, each age group, and within each period of delay between first symp...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810301)47:5<989::aid-cncr28204

    authors: Huguley CM Jr,Brown RL

    更新日期:1981-03-01 00:00:00

  • Cancer in the families of children with soft tissue sarcoma.

    abstract::The cancer experience among 754 first-degree relatives (mothers, fathers, and siblings) of a population-based series of 177 children with soft tissue sarcoma is reported. The current study represents an extension of our earlier work in which the authors found an excess of breast cancer in the mothers of 143 of these c...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19901115)66:10<2239::aid-cncr282

    authors: Birch JM,Hartley AL,Blair V,Kelsey AM,Harris M,Teare MD,Jones PH

    更新日期:1990-11-15 00:00:00

  • A phase I trial of 5-fluorouracil, folinic acid, and alpha-2a-interferon in patients with metastatic colorectal carcinoma.

    abstract::The mechanisms of biochemical modulation of 5-fluorouracil (5-FU) cytotoxicity by folinic acid (FA) have been elucidated, and the clinical use of this combination has improved response rates and survival in patients with metastatic colorectal cancer. Recently, Phase II trials also showed potential synergism between al...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19920215)69:4<889::aid-cncr28206

    authors: Bukowski RM,Inoshita G,Yalavarthi P,Murthy S,Gibson V,Budd GT,Sergi JS,Bauer L,Prestifilippo J

    更新日期:1992-02-15 00:00:00

  • Impact of access to NCI- and NCCN-designated cancer centers on outcomes for multiple myeloma patients: A SEER registry analysis.

    abstract:BACKGROUND:National Cancer Institute (NCI)/National Comprehensive Cancer Network (NCCN)-designated cancer centers (CCs) offer patients state-of-the-art treatment, but their impact on multiple myeloma (MM) patient outcomes has not been evaluated. METHODS:Adult MM patients diagnosed between 1973 and 2011 were identified...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29771

    authors: Ailawadhi S,Advani P,Yang D,Ghosh R,Swaika A,Roy V,Foran J,Colon-Otero G,Chanan-Khan A

    更新日期:2016-02-15 00:00:00

  • Predictors of survival in patients with carcinoma of the gallbladder.

    abstract:BACKGROUND:The role of resectional surgery in patients with advanced stages of gallbladder carcinoma has not been fully defined. It is generally believed that the survival depends on the stage of the disease, rather than on the treatment option. METHODS:Seventeen selected risk factors were analyzed using univariate an...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19951001)76:7<1145::aid-cncr2820

    authors: Pradeep R,Kaushik SP,Sikora SS,Bhattacharya BN,Pandey CM,Kapoor VK

    更新日期:1995-10-01 00:00:00

  • Deceptive bizarre stromal cells in polyps and ulcers of the gastrointestinal tract.

    abstract::The clinical and pathologic features of 33 pseudomalignant lesions of the gastrointestinal tract with bizarre stromal cells are reported. Deceptive histologic changes were identified in ulcers of seven patients and in inflammatory polyps of 26. A misdiagnosis of malignant neoplasm was made in six of the 33 patients (t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910415)67:8<2111::aid-cncr2820

    authors: Shekitka KM,Helwig EB

    更新日期:1991-04-15 00:00:00

  • High-risk patients with hematuria are not evaluated according to guideline recommendations.

    abstract:BACKGROUND:To determine whether high-risk patients with hematuria receive evaluation according to guideline recommendations. METHODS:We recently performed a screening study for bladder cancer using a urine-based tumor marker in 1502 subjects at high risk based on aged > or = 50 years, > or = 10-year smoking history, a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25048

    authors: Elias K,Svatek RS,Gupta S,Ho R,Lotan Y

    更新日期:2010-06-15 00:00:00

  • Analysis of factors related to the occurrence of chronic disseminated candidiasis in patients with acute leukemia in a non-bone marrow transplant setting: a follow-up study.

    abstract:BACKGROUND:Chronic disseminated candidiasis (CDC) is a serious complication of treatment in patients with acute leukemia. Although some general risk factors are known to predispose to systemic fungal infections, few studies have addressed the relevance of certain clinical and laboratory features in patients with CDC. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20010915)92:6<1349::aid-cncr1457

    authors: Sallah S,Wan JY,Nguyen NP,Vos P,Sigounas G

    更新日期:2001-09-15 00:00:00

  • The clinicopathologic significance of small areas unstained by Lugol's iodine in the mucosa surrounding resected esophageal carcinoma: an analysis of 147 cases.

    abstract:BACKGROUND:Small areas unstained with Lugol's iodine are often observed in the mucosa surrounding esophageal carcinomas. METHODS:For light microscopic evaluation, the histologic features of 131 small areas unstained by Lugol's iodine in 12 selected cases were investigated. For clinicopathologic evaluation, the numbers...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Nakanishi Y,Ochiai A,Yoshimura K,Kato H,Shimoda T,Yamaguchi H,Tachimori Y,Watanabe H,Hirohashi S

    更新日期:1998-04-15 00:00:00

  • Radiation therapy tolerance limits. For one or for all?--Janeway Lecture.

    abstract:BACKGROUND:The optimal use of radiation therapy for cancer treatment is hampered by the application of tolerance limits of normal tissues derived empirically from population averages. Such limits do not reflect the considerable differences from patient to patient in susceptibility to late radiation sequelae. Assays tha...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/(SICI)1097-0142(19960601)77:11<2379::AID-C

    authors: Peters LJ

    更新日期:1996-06-01 00:00:00

  • The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer.

    abstract:BACKGROUND:Transforming growth factor beta (TGFbeta) is important in colorectal cancer (CRC) progression. Bone morphogenetic proteins (BMPs), a subgroup within the TGFbeta superfamily, recently also have been implicated in CRC, but their precise role in CRC has yet to be investigated. METHODS:The authors used a tissue...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23160

    authors: Kodach LL,Bleuming SA,Musler AR,Peppelenbosch MP,Hommes DW,van den Brink GR,van Noesel CJ,Offerhaus GJ,Hardwick JC

    更新日期:2008-01-15 00:00:00

  • Radiotherapy alone or combined with surgery for salivary gland carcinoma.

    abstract:BACKGROUND:The authors analyzed the outcomes of patients treated with radiotherapy (RT) alone or combined with surgery for carcinoma of the salivary glands. METHODS:Between October 1964 and June 2003, 224 previously untreated patients were treated with curative intent with RT alone (n = 64) or combined with surgery (n...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21083

    authors: Mendenhall WM,Morris CG,Amdur RJ,Werning JW,Villaret DB

    更新日期:2005-06-15 00:00:00

  • Bleomycin-induced pulmonary fibrosis mimicking recurrent metastatic disease in a patient with testicular carcinoma: case report of the CT scan appearance.

    abstract::Pulmonary fibrosis is a well-recognized complication of bleomycin therapy. Detection of bleomycin-induced pulmonary fibrosis by computed axial tomographic scanning (CT) has not been reported. We report on a patient in whom the development of lesions on chest CT scan following cessation of chemotherapy (including bleom...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810115)47:2<236::aid-cncr28204

    authors: Nachman JB,Baum ES,White H,Cruissi FG

    更新日期:1981-01-15 00:00:00

  • Clostridial septicemia complicating the course of leukemia.

    abstract::The authors report an analysis of 47 leukemia patients (including 9 from our own medical center) whose courses were complicated by 48 episodes of clostridial septicemia. There were 36 adults and 11 children; acute myelogenous leukemia and acute lymphoblastic leukemia accounted for 61.7% and 14.9% of cases, respectivel...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860515)57:10<2045::aid-cncr282

    authors: Caya JG,Farmer SG,Ritch PS,Wollenberg NJ,Tieu TM,Oechler HW,Spivey M

    更新日期:1986-05-15 00:00:00

  • Blood vessel invasion and axillary lymph node involvement as prognostic indicators for human breast cancer.

    abstract::Blood vessel invasion and axillary lymph node involvement were examined in 175 breast cancer patients. The incidence of blood vessel invasion was 35%. The presence of blood vessel invasion was highly associated with early disease recurrence. The association of poor prognosis with blood vessel invasion was independent ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820901)50:5<962::aid-cncr28205

    authors: Weigand RA,Isenberg WM,Russo J,Brennan MJ,Rich MA

    更新日期:1982-09-01 00:00:00

  • Breast sarcoma. A clinicopathologic review of 25 cases.

    abstract::Sarcoma of the breast represents less than 1% of primary mammary malignancies; this study reports 25 such cases. The largest group had malignant fibrous histiocytoma (44%), followed by liposarcoma (24%) and fibrosarcoma (16%). Also represented were clear cell sarcoma, neurogenic sarcoma, leiomyosarcoma, and alveolar s...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900901)66:5<941::aid-cncr28206

    authors: Pollard SG,Marks PV,Temple LN,Thompson HH

    更新日期:1990-09-01 00:00:00

  • Survivin expression is associated with bladder cancer presence, stage, progression, and mortality.

    abstract:BACKGROUND:The purpose was to compare the differential expression of Survivin in normal bladder tissue, bladder transitional cell carcinoma (TCC) of different stages, and to determine whether expression of Survivin is associated with TCC clinical outcomes. METHODS:Immunohistochemical staining for Survivin was carried ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22521

    authors: Shariat SF,Ashfaq R,Karakiewicz PI,Saeedi O,Sagalowsky AI,Lotan Y

    更新日期:2007-03-15 00:00:00

  • Axillary lymph nodes and breast cancer: a review.

    abstract:BACKGROUND:The value of surgical staging and treatment of the axillary lymph nodes with either surgery or radiotherapy in the initial management of patients with Stage I or II invasive breast cancer is controversial. METHODS:A review of retrospective and prospective clinical studies was performed to assess the risks o...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19951101)76:9<1491::aid-cncr2820

    authors: Recht A,Houlihan MJ

    更新日期:1995-11-01 00:00:00

  • Central nervous system metastases of choriocarcinoma. 23 years' experience at Charing Cross Hospital.

    abstract::Between 1957 and February 1981, 782 patients received cytotoxic chemotherapy for gestational trophoblastic tumors (GTT) in the Department of Medical Oncology, Charing Cross Hospital (London, England). Sixty-nine (8.8%) patients had central nervous system (CNS) metastases. Thirty-three of them (48%) presented with CNS ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19831101)52:9<1728::aid-cncr2820

    authors: Athanassiou A,Begent RH,Newlands ES,Parker D,Rustin GJ,Bagshawe KD

    更新日期:1983-11-01 00:00:00

  • Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. A potentially more common pharmacogenetic syndrome.

    abstract::This study describes the inheritance of a defect in pyrimidine catabolism and its association with drug-induced toxicity in a patient receiving 5-fluorouracil (FUra) as adjuvant chemotherapy for breast carcinoma. The study population included the affected patient (proband), nine of her blood relatives, and seven healt...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910801)68:3<499::aid-cncr28206

    authors: Harris BE,Carpenter JT,Diasio RB

    更新日期:1991-08-01 00:00:00

  • Angiotropic (intravascular) large cell lymphoma. A clinicopathologic study of seven cases with unique clinical presentations.

    abstract::The authors recently reported the antigenic phenotypes of three cases of so-called "malignant angioendotheliomatosis" and suggested that angiotropic large cell lymphoma (ALCL) is a more appropriate designation for this disease. The authors now report an additional seven cases of ALCL with unique clinical presentations...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19901015)66:8<1781::aid-cncr2820

    authors: Stroup RM,Sheibani K,Moncada A,Purdy LJ,Battifora H

    更新日期:1990-10-15 00:00:00

  • Oncoproteins and tumor progression in papillary thyroid carcinoma: presence of epidermal growth factor receptor, c-erbB-2 protein, estrogen receptor related protein, p21-ras protein, and proliferation indicators in relation to tumor recurrences and patien

    abstract:BACKGROUND:The prognostic relevance of activated oncogenes and oncoproteins has not been well studied in papillary thyroid cancer, which is slow-growing, with only regional spread in most cases. Therefore, the influence of some protein markers and tumor cell proliferation on disease progress in a series of patients wit...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19951101)76:9<1643::aid-cncr2820

    authors: Akslen LA,Varhaug JE

    更新日期:1995-11-01 00:00:00

  • Developing epidemic of melanoma in the Hispanic population of California.

    abstract:BACKGROUND:Hispanics comprise almost one-third of the population of California, are the most rapidly increasing racial/ethnic group in the state, and represent almost one-third of all Hispanics in the U.S. California has among the highest rates of melanoma in the world, yet little is known about trends in melanoma in i...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21654

    authors: Cockburn MG,Zadnick J,Deapen D

    更新日期:2006-03-01 00:00:00

  • Value of integrated positron emission tomography revised using a phantom study to evaluate malignancy grade of lung adenocarcinoma: a multicenter study.

    abstract:BACKGROUND:The malignant biological behavior of small-sized lung adenocarcinomas remains obscure, although understanding this feature is important for selecting appropriate treatment. In the current study, the authors evaluated malignancy grades of small adenocarcinomas using fluorodeoxyglucose-positron emission tomogr...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/cncr.25244

    authors: Nakayama H,Okumura S,Daisaki H,Kato Y,Uehara H,Adachi S,Yoshimura M,Okada M

    更新日期:2010-07-01 00:00:00

  • Correlation between increased granulocyte elastase release and activation of blood coagulation in patients with lung cancer.

    abstract:BACKGROUND:Coagulopathies often are associated with malignant tumors. The pathogenesis of these complications in cancer is not clear. Host inflammatory (monocyte/macrophage) cell-mediated triggering of clotting activation has been suggested. METHODS:The objective of this study was to evaluate the role of neutrophil-de...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19931001)72:7<2134::aid-cncr2820

    authors: Gabazza E,Taguchi O,Yamakami T,Machishi M,Ibata H,Suzuki S

    更新日期:1993-10-01 00:00:00

  • Ovarian dysplasia: nuclear texture analysis.

    abstract:BACKGROUND:Ovarian dysplasia has been defined by histologic and morphometric studies focusing on architectural and nuclear profile changes. A new technique is used to enhance the accuracy of this diagnosis by a quantitative evaluation of the nuclear texture that represents the nuclear chromatin pattern on which convent...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19931201)72:11<3253::aid-cncr282

    authors: Deligdisch L,Miranda C,Barba J,Gil J

    更新日期:1993-12-01 00:00:00

  • Diet-related cancer in Native Hawaiians.

    abstract:BACKGROUND:Since contact with Westerners in 1778, the native people of the Hawaiian Islands have experienced multiple health and social problems. Among these are the debilitating effects of high rates of cancer incidence and mortality. METHODS:The method used in this article was a review and integration of the literat...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Hughes CK,Tsark JA,Mokuau NK

    更新日期:1996-10-01 00:00:00

  • Loss of efficacy and cost-effectiveness when screening colonoscopy is performed by nongastroenterologists.

    abstract:BACKGROUND:Specialty of the endoscopist has been related to the postcolonoscopy interval risk of colorectal cancer (CRC). However, the impact of such a difference on the long-term CRC prevention rate by screening colonoscopy is largely unknown. METHODS:A Markov model was constructed to simulate the efficacy and cost o...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27664

    authors: Hassan C,Rex DK,Zullo A,Cooper GS

    更新日期:2012-09-15 00:00:00

  • Cost-effectiveness of human papillomavirus vaccination for adolescent girls in Punjab state: Implications for India's universal immunization program.

    abstract:BACKGROUND:Introduction of human papillomavirus (HPV) vaccination for adolescent girls is being considered in the Punjab state of India. However, evidence regarding cost-effectiveness is sought by policy makers when making this decision. The current study was undertaken to evaluate the incremental cost per quality-adju...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30734

    authors: Prinja S,Bahuguna P,Faujdar DS,Jyani G,Srinivasan R,Ghoshal S,Suri V,Singh MP,Kumar R

    更新日期:2017-09-01 00:00:00

  • Androgen and estrogen receptors in hepatocellular carcinoma and the surrounding liver in women.

    abstract::Androgen receptors (AR) and estrogen receptors (ER) were consecutively assayed for hepatocellular carcinoma (HCC) and the surrounding liver was removed surgically from 19 female patients. Patient age ranged from 43 to 79 years, with an average of 61 +/- 9 years. All patients had underlying liver disease (liver cirrhos...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890101)63:1<112::aid-cncr28206

    authors: Nagasue N,Kohno H,Chang YC,Hayashi T,Utsumi Y,Nakamura T,Yukaya H

    更新日期:1989-01-01 00:00:00