Oxaliplatin and capecitabine in the treatment of patients with recurrent or refractory carcinoma of unknown primary site: a phase 2 trial of the Sarah Cannon Oncology Research Consortium.

abstract：BACKGROUND:Hemangiopericytomas and malignant solitary fibrous tumors (HPC/SFT) are rare, closely related sarcomas with unpredictable behavior that respond infrequently to chemotherapy. An optimal systemic treatment strategy for advanced HPC/SFT has not yet been identified. METHODS:We retrospectively analyzed the recor...

journal_title：Cancer

authors： Park MS,Patel SR,Ludwig JA,Trent JC,Conrad CA,Lazar AJ,Wang WL,Boonsirikamchai P,Choi H,Wang X,Benjamin RS,Araujo DM

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:The presence of single-nucleotide polymorphisms (SNPs) within the 3'-untranslated regions of genes could affect the binding between a microRNA (miRNA) and its target, with consequences on gene expression regulation. Considering the important role of miRNAs in carcinogenesis, it is hypothesized here that thes...

journal_title：Cancer

authors： Landi D,Gemignani F,Pardini B,Naccarati A,Garritano S,Vodicka P,Vodickova L,Canzian F,Novotny J,Barale R,Landi S

更新日期：2012-10-01 00:00:00

abstract：:Nineteen patients with locally advanced bladder cancer were treated with irradiation and concomitant 5-fluorouracil intravenous infusion with or without bolus mitomycin. Eighteen of the 19 patients were evaluated for local response. Eleven of the 18 patients (61%) obtained a complete local response within 3 to 6 month...

journal_title：Cancer

authors： Rotman M,Macchia R,Silverstein M,Aziz H,Choi K,Rosenthal J,Braverman A,Laungani GB

更新日期：1987-02-15 00:00:00

abstract：:The presence of hepatitis B virus (HBV) has been evaluated in liver specimens from 11 children with primary liver tumors and negative results of serologic testing for HBV markers. HBV-DNA sequences were detected by the polymerase chain reaction procedure, using different sets of oligonucleotide primers from highly con...

journal_title：Cancer

authors： Pontisso P,Morsica G,Ruvoletto MG,Barzon M,Perilongo G,Basso G,Cecchetto G,Chemello L,Alberti A

更新日期：1992-06-01 00:00:00

abstract：:The myeloproliferative neoplasms (MPNs) essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (MF) are malignancies that frequently harbor the recurrent somatic point mutation JAK2(V617F). The discovery of this mutation has fueled the development of Janus kinase 2 (JAK2) inhibitors. Availab...

journal_title：Cancer

authors： Quintás-Cardama A,Verstovsek S

更新日期：2012-02-15 00:00:00

abstract：BACKGROUND:This report evaluated whether biochemical recurrence (BCR) as a time-dependent covariate (t) after radical prostatectomy (RP) for prostate cancer was associated with the risk of death and whether salvage therapy with radiotherapy (RT) and/or hormonal therapy (HT) can lessen this risk METHODS:This was a retr...

journal_title：Cancer

authors： Choueiri TK,Chen MH,D'Amico AV,Sun L,Nguyen PL,Hayes JH,Robertson CN,Walther PJ,Polascik TJ,Albala DM,Moul JW

更新日期：2010-04-15 00:00:00

abstract：BACKGROUND:Aggressive non-Hodgkin's lymphoma is now often curable with chemotherapy. The International Prognostic Index (IPI) was recently developed to predict patient survival on the basis of pretreatment clinical features. However, classical multivariate regression models such as the IPI fail to detect time-dependent...

journal_title：Cancer

authors： Mounier N,Morel P,Haioun C,Coiffier B,Tilly H,Chatelain C,Lederlin P,Thyss A,Herbrecht R,Gisselbrecht C,Lepage E

更新日期：1998-05-15 00:00:00

abstract：:Unexpected nephrotoxicity has been described in high-dose, bolus ifosfamide (IFF) therapy. Renal injury is not thought to occur in patients receiving fractionated schedules, although microscopic hematuria from bladder irritation is not uncommon. IFF is undergoing trials in patients with malignant lymphomas, gynecologi...

journal_title：Cancer

authors： Patterson WP,Khojasteh A

更新日期：1989-02-15 00:00:00

abstract：BACKGROUND:This study was performed to evaluate the effect of positive margins, Gleason grade, and capsular penetration on progression after radical prostatectomy. METHODS:The authors followed 507 men with totally embedded retropubic prostatectomy specimens performed for clinical Stages A and B prostate cancer for a m...

journal_title：Cancer

authors： Epstein JI,Pizov G,Walsh PC

更新日期：1993-06-01 00:00:00

abstract：:Intraoperative radiotherapy (IOR) or "direct view" irradiation permits the delivery of a single exposure of high-energy electrons to a surgically exposed tumor. Surgical exposure permits physical retraction of normal uninvolved tissues away from the IOR beam as well as the accurate assessment of the target volume. IOR...

journal_title：Cancer

authors： Goldson AL,Streeter OE Jr,Ashayeri E,Collier-Manning J,Barber JB,Fan KJ

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:Many patients with stage III colon adenocarcinoma do not receive adjuvant chemotherapy despite the proven survival advantage it offers. To enhance the provision of optimal cancer care, patient characteristics associated with not receiving guideline-adherent treatment must be identified among patients with op...

journal_title：Cancer

authors： Winget M,Hossain S,Yasui Y,Scarfe A

更新日期：2010-10-15 00:00:00

abstract：:Without organized clinical trials, we are doomed to repeat our mistakes endlessly. There are many genuine conflicts of interest intrinsic to clinical research. Some of these arise from the necessity of admitting that we as physicians do not know the best way to treat every disease or each patient and that all treatmen...

journal_title：Cancer

authors： Hrushesky WJ

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:The therapeutic impact of tumor resection is poorly defined. Therefore the current study was conducted. METHODS:A retrospective, 2-institutional study was conducted (1991-1994) to compare the treatment results of stereotactic biopsy plus radiation therapy (99 patients; tumor dose: 60 gray [Gy]) with those o...

journal_title：Cancer

authors： Kreth FW,Berlis A,Spiropoulou V,Faist M,Scheremet R,Rossner R,Volk B,Ostertag CB

更新日期：1999-11-15 00:00:00

abstract：:The unique case of a 60-year-old patient with a non-Hodgkin's B-cell lymphoma of the lymphoplasmacytic type and three associated monoclonal proteins, is described. The patient also exhibited various autoimmune phenomena that were consistent with the diagnoses of Sjögren's syndrome and autoimmune thyroiditis. The evolu...

journal_title：Cancer

authors： Berg AR,Weisenburger DD,Linder J,Armitage JO

更新日期：1986-05-01 00:00:00

abstract：BACKGROUND:Hypercalcemia of malignancy (HM) is one of the commonest metabolic complications associated with cancer. Plasma parathyroid hormone-related peptide (PTH-rp) is known to cause hypercalcemia in the vast majority of patients with HM. METHODS:Fifty-two patients with HM were treated with a single infusion of 60 ...

journal_title：Cancer

authors： Wimalawansa SJ

更新日期：1994-04-15 00:00:00

abstract：:To investigate the possible role of sex-hormone imbalance in hepatocellular carcinogenesis in male alcoholic cirrhotic patients, we determined plasma levels of testosterone (T), dihydrotestosterone (DHT), androstenedione (A), dehydroepiandrosterone (DHA), estrone (E1), estradiol (E2), and sex-hormone-binding globulin ...

journal_title：Cancer

authors： Guéchot J,Peigney N,Ballet F,Vaubourdolle M,Giboudeau J,Poupon R

更新日期：1988-08-15 00:00:00

abstract：BACKGROUND:It is challenging for clinicians to foster coping and allow hope when discussing prognosis and end-of-life (EOL) issues with terminally ill cancer patients and their caregivers. To the authors' knowledge, little research evidence is currently available to guide clinical practice. METHODS:The authors conduct...

journal_title：Cancer

authors： Clayton JM,Butow PN,Arnold RM,Tattersall MH

更新日期：2005-05-01 00:00:00

abstract：:The entire colonic mucosa of 51 cases of colorectal carcinoma was examined histologically. Mucosal lesions including goblet cell hyperplasia, crypt dilatation, ulceration with regeneration, basal cell hyperplasia, metaplastic lesions, and adenomas were encountered. Goblet cell hyperplasia (80.4%) was most prominent ad...

journal_title：Cancer

authors： Lee YS

更新日期：1988-04-15 00:00:00

abstract：BACKGROUND:For certain types of cancer, resection alone rarely achieves a cure, but patients nevertheless tend to have a prolonged survival before they die of the tumor. For other types of cancer, the opposite scenario prevails, suggesting that those biologic mechanisms that allow a curative resection are not identical...

journal_title：Cancer

authors： Gamel JW,McLean IW,McCurdy JB

更新日期：1993-04-01 00:00:00

abstract：:Survivors of pediatric and young adult cancers remain at risk for subsequent diseases, including those related to human papillomavirus (HPV) infection. Prevention of HPV acquisition through vaccination has become possible over the last decade. HPV vaccines have been shown to be safe and effective, yet rates of vaccina...

journal_title：Cancer

authors： Temkin SM,Seibel NL

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Systemic, high-dose interferon-alpha treatment given three times per week subcutaneously induces tumor regression in approximately 30% of patients with inoperable hepatocellular carcinoma (HCC). The objective of the current study was to determine the efficacy and safety of transcatheter arterial interferon e...

journal_title：Cancer

authors： Yuen MF,Ooi CG,Hui CK,Wong WM,Wong BC,Chan AO,Lai CL

更新日期：2003-06-01 00:00:00

abstract：:Twenty-two cases of breast tumor with infiltrating lobular carcinoma were studied. Thirteen showed the classic single-file pattern as a sole component, and 6 as a predominant pattern; the less common confluent pattern was found in 3 instances as a predominant component. Mucin secretion was evidenced in 59% of the prim...

journal_title：Cancer

authors： Van Bogaert LJ,Maldague P

更新日期：1980-03-01 00:00:00

abstract：BACKGROUND:Knowledge of the expression of the galectins in human colon carcinomas is mainly restricted to galectin-3 and, to a lesser extent, galectin-1. The current study analyzed the prognostic values contributed by galectin-1, galectin-3, galectin-4, and galectin-8 in cases of colon carcinoma. METHODS:The authors s...

journal_title：Cancer

authors： Nagy N,Legendre H,Engels O,André S,Kaltner H,Wasano K,Zick Y,Pector JC,Decaestecker C,Gabius HJ,Salmon I,Kiss R

更新日期：2003-04-15 00:00:00

abstract：:Previous studies have shown that magnetic resonance imaging (MRI) is sensitive to white matter changes in children receiving cranial radiation of 3000 cGy or greater. The current study used MRI to investigate the integrity of white matter in children receiving 1800 to 2400 cGy of cranial radiation. Ten survivors of ac...

journal_title：Cancer

authors： Kramer JH,Norman D,Brant-Zawadzki M,Ablin A,Moore IM

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:The current study was performed to evaluate prognostic factors for overall survival (OS), distant metastasis (DM), and local failure (LF) in patients with Stage II/III esophageal carcinoma. METHODS:The following potential prognostic factors were retrospectively investigated in 124 patients treated with radi...

journal_title：Cancer

authors： Rades D,Schild SE,Bahrehmand R,Zschenker O,Alberti WA,Rudat VR

更新日期：2005-04-15 00:00:00

abstract：:New approaches are needed in the treatment of advanced breast cancer. In vitro studies have shown that recombinant tumor necrosis factor (TNF) is a growth inhibitor for the MCF-7, ZR-75-1, and BT-20 human breast cancer cell lines. Based on these considerations, the Southwest Oncology Group performed a Phase II trial o...

journal_title：Cancer

authors： Budd GT,Green S,Baker LH,Hersh EP,Weick JK,Osborne CK

更新日期：1991-10-15 00:00:00

abstract：BACKGROUND:A diagnosis of cancer provides a teachable moment in which a physician can counsel or teach the patient. The Cancer and Leukemia Group B hypothesized that this teachable moment could also be used to encourage counseling of the patients' relatives who smoke. The authors' first study sought to determine the fe...

journal_title：Cancer

authors： Schilling A,Conaway MR,Wingate PJ,Atkins JN,Berkowitz IM,Clamon GH,DiFino SM,Vinciguerra V

更新日期：1997-01-01 00:00:00

abstract：:Histologic groups in 231 cases of malignant lymphoma were correlated with survival data at 100 months from the time of initiation of the study. Patients in the first two decades of life fared comparably with adults, but those over 60 years of age showed a poorer survival trend. Seven favorable and four unfavorable his...

journal_title：Cancer

authors： Barcos M,Herrmann R,Pickren JW,Naeher C,Han T,Stutzman L,Henderson ES

更新日期：1981-06-15 00:00:00

abstract：:Common myths about nutrition education and care of cancer patients are debunked and realities are discussed. First, frequently held misconceptions of nonspecialized health professionals are considered. These include the myths that diet change in the population will be rapid now that dietary guidelines to prevent cance...

journal_title：Cancer

authors： Dwyer J

更新日期：1986-10-15 00:00:00

abstract：BACKGROUND:Although national guidelines do not recommend extent of disease imaging for patients with newly diagnosed early stage breast cancer given that the harm outweighs the benefits, high rates of testing have been documented. The 2012 Choosing Wisely guidelines specifically addressed this issue. We examined the ch...

journal_title：Cancer

authors： Henry NL,Braun TM,Breslin TM,Gorski DH,Silver SM,Griggs JJ

更新日期：2017-08-01 00:00:00