Abstract:
:DNA-aneuploid primary melanomas are said to show a greater propensity to metastasize than those without an aneuploid profile. A higher aneuploid rate has also been reported in metastatic melanomas than in primary lesions. The ploidy profile was determined of 26 primary melanomas and their first subsequent secondaries on Feulgen-stained sections from routinely processed material using a computerized video image-analysis system. In 18 of 26 cases, both primary and secondary tumor showed similar corresponding DNA patterns. These were aneuploid in 13 of 18 of the cases. A hyperdiploid pattern was present in one case in both the primary and its metastasis, and a diploid pattern was seen in four cases. There were only eight cases in which a disparity between the nuclear ploidy profile in the primary and secondary tumor was evident. Although the results suggest that ploidy studies are not useful for predicting the metastatic potential of a primary melanoma, the maintenance of similar DNA profiles in the metastases in most of these cases was interesting in regard to tumor biology.
journal_name
Cancerjournal_title
Cancerauthors
Rode J,Williams RA,Charlton IG,Dhillon AP,Moss Edoi
10.1002/1097-0142(19910501)67:9<2333::aid-cncr2820subject
Has Abstractpub_date
1991-05-01 00:00:00pages
2333-6issue
9eissn
0008-543Xissn
1097-0142journal_volume
67pub_type
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