Abstract:
:The clinical and pathologic features of eight infants with monocytic leukemia are reviewed. The children were all aged 12 months or less at diagnosis and had a high incidence of extramedullary features, skin infiltration being particularly common. The diagnosis was established by conventional morphologic and cytochemical techniques. Using the French-American-British (FAB) classification, five infants had FAB 5a disease, and three had FAB 5b. The difficulties in making the diagnosis from extramedullary sites and the overlap that exists at this age between monocytic leukemia, true histiocytic lymphoma, and malignant histiocytosis are discussed. The treatments given to the group and their response are reviewed. Five of the patients received VP-16-213 and cyclophosphamide as primary induction chemotherapy, a combination that merits further evaluation in leukemia with monocytic features.
journal_name
Cancerjournal_title
Cancerauthors
Darbyshire PJ,Smith JH,Oakhill A,Mott MGdoi
10.1002/1097-0142(19851001)56:7<1584::aid-cncr2820subject
Has Abstractpub_date
1985-10-01 00:00:00pages
1584-9issue
7eissn
0008-543Xissn
1097-0142journal_volume
56pub_type
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