Patterns of recurrence of rectal cancer after potentially curative surgery.

Abstract:

:The results of surgical treatment alone for 142 cases of carcinoma of the rectum and rectosigmoid from the Massachusetts General Hospital were reviewed. The incidence of local failure as any component of failure was found to be strongly dependent on the pathologic stage, and for Dukes' A was 8.0% (3/39); Dukes' B, 31% (18/59), and Dukes' C, 50% (22/44). The incidence of local failure for tumors without lymph node metastasis was 17% with only microscopic extension through the wall (modified Astler-Coller Stage MAC-B2m), but increased to 54% in tumors that were adherent to or invading adjacent organs and structures (MAC-B3). Similarly, in tumors with positive lymph nodes, there was a 36% incidence of local failure for tumors confined to the wall or with only microscopic extension through the wall (MAC-C1/C2m), compared to a 67% incidence for tumors with adherence or involvement of adjacent organs (MAC-C3). Other predictors of local recurrence were the tumor location, grade, number of lymph nodes, and blood vessel invasion. The pathologic factors predicting distant metastasis are also presented. Five-year survival for Dukes' A was 77% (30/39); Dukes' B, 44% (26/59); and Dukes' C, 23% (10/44). The implications for future adjuvant therapy based on the identification of patients with the highest risk for local and distant failure are discussed.

journal_name

Cancer

journal_title

Cancer

authors

Rich T,Gunderson LL,Lew R,Galdibini JJ,Cohen AM,Donaldson G

doi

10.1002/1097-0142(19831001)52:7<1317::aid-cncr2820

subject

Has Abstract

pub_date

1983-10-01 00:00:00

pages

1317-29

issue

7

eissn

0008-543X

issn

1097-0142

journal_volume

52

pub_type

杂志文章

相关文献

CANCER文献大全
  • Laboratory aids to diagnosis--enzymes.

    abstract::A summary is presented of those organ specific enzyme assays traditionally used in evaluation of the patient with cancer. In addition, the use of certain serum enzymes such as gamma-glutamyl transpeptidase, phosphohexose isomerase or 5'-nucleotidase as aids in following the course of the disease, particularly in patie...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197601)37:1+<542::aid-cncr282037

    authors: Schwartz MK

    更新日期:1976-01-01 00:00:00

  • Suicide risk among cancer survivors: Head and neck versus other cancers.

    abstract:BACKGROUND:Cancer survivors face psychosocial issues that increase their risk of suicide. This study examined the risk of suicide across cancer sites, with a focus on survivors of head and neck cancer (HNC). METHODS:The Surveillance, Epidemiology, and End Results 18-registry database (from 2000 to 2014) was queried fo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31675

    authors: Osazuwa-Peters N,Simpson MC,Zhao L,Boakye EA,Olomukoro SI,Deshields T,Loux TM,Varvares MA,Schootman M

    更新日期:2018-10-15 00:00:00

  • Changing trends. An overview of breast cancer incidence and mortality.

    abstract::The incidence of breast cancer rose about 1% per year between 1940 and 1980 according to data in the Connecticut Tumor Registry. A sharp increase of 32% was reported between 1980 and 1987 in the Surveillance, Epidemiology and End Results Program of the National Cancer Institute. Data from this program shows that the i...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.2820741304

    authors: Garfinkel L,Boring CC,Heath CW Jr

    更新日期:1994-07-01 00:00:00

  • Vascular endothelial growth factor-targeted therapy for the treatment of adult metastatic Xp11.2 translocation renal cell carcinoma.

    abstract:BACKGROUND:Adult "translocation" renal cell carcinoma (RCC), bearing transcription factor E3 (TFE3) gene fusions at Xp11.2, is a recently recognized, unique entity for which prognosis and therapy remain poorly understood. In the current study, the authors investigated the effect of vascular endothelial growth factor (V...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25512

    authors: Choueiri TK,Lim ZD,Hirsch MS,Tamboli P,Jonasch E,McDermott DF,Dal Cin P,Corn P,Vaishampayan U,Heng DY,Tannir NM

    更新日期:2010-11-15 00:00:00

  • Antifungal treatment by amphotericin B and 5-fluorocytosine delays the recovery of normal hematopoietic cells after intensive cytostatic therapy for acute myeloid leukemia.

    abstract::Systemic fungal infections are recognized at increasing frequency during the course of intensive therapy for acute leukemias and require parenteral antifungal treatment mostly by amphotericin B (ampho B) alone or in combination with 5-Fluorocytosine (5-FC). Because of the potential myelosuppressive side effects of 5-F...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19910701)68:1<9::aid-cncr2820680

    authors: Hiddemann W,Essink ME,Fegeler W,Zühlsdorf M,Sauerland C,Büchner T

    更新日期:1991-07-01 00:00:00

  • The value of complete lymphadenectomy in radical treatment of cancer of the cervix, Stage IB.

    abstract::Two hundred ninety-three patients with Stage IB carcinoma of the uterine cervix were treated by intracavitary irradiation followed by radical hysterectomy and pelvic lymph node dissection in the 3-year period 1970 to 1972, inclusive. Preoperative lymphography was performed and intraoperative films were taken to obtain...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841115)54:10<2215::aid-cncr282

    authors: Kjorstad KE,Kolbenstvedt A,Strickert T

    更新日期:1984-11-15 00:00:00

  • Incidence of thrombocytopenia and serious hemorrhage among patients with solid tumors.

    abstract::To evaluate the incidence of thrombocytopenia and bleeding among patients with solid tumors treated intensively with chemotherapy, the records of 1274 patients treated between 1972 and 1980 on protocols known to produce significant myelosuppression were reviewed. Three hundred one patients with solid tumors (breast, l...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840201)53:3<557::aid-cncr28205

    authors: Dutcher JP,Schiffer CA,Aisner J,O'Connell BA,Levy C,Kendall JA,Wiernik PH

    更新日期:1984-02-01 00:00:00

  • Angiotropic (intravascular) large cell lymphoma. A clinicopathologic study of seven cases with unique clinical presentations.

    abstract::The authors recently reported the antigenic phenotypes of three cases of so-called "malignant angioendotheliomatosis" and suggested that angiotropic large cell lymphoma (ALCL) is a more appropriate designation for this disease. The authors now report an additional seven cases of ALCL with unique clinical presentations...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19901015)66:8<1781::aid-cncr2820

    authors: Stroup RM,Sheibani K,Moncada A,Purdy LJ,Battifora H

    更新日期:1990-10-15 00:00:00

  • Reproducibility of the diagnosis of atypical endometrial hyperplasia: a Gynecologic Oncology Group study.

    abstract:BACKGROUND:Most gynecologists determine therapy based on current International Society of Gynecologic Pathologists (ISGP)/World Health Organization classification of endometrial hyperplasia, the reproducibility of which has been questioned. The Gynecologic Oncology Group (GOG) initiated a protocol to assess the efficac...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.21649

    authors: Zaino RJ,Kauderer J,Trimble CL,Silverberg SG,Curtin JP,Lim PC,Gallup DG

    更新日期:2006-02-15 00:00:00

  • Primary lymphoma of bone: the relationship of morphologic diversity to clinical behavior.

    abstract::Since primary lymphoma of bone (PLB) exhibits morphologic diversity and variability in individual survival, we analyzed the relationship between histopathologic features and biological behavior in 33 patients treated at the Massachusetts General Hospital. Three major histologic subgroups were identified, based on a va...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820901)50:5<1009::aid-cncr2820

    authors: Dosoretz DE,Raymond AK,Murphy GF,Doppke KP,Schiller AL,Wang CC,Suit HD

    更新日期:1982-09-01 00:00:00

  • Management of locally advanced and disseminated breast cancer--chemotherapy.

    abstract::Breast cancer is one of the most responsive of the common solid tumors when systemic therapy is indicated in the treatment of locally advanced or disseminated cancer. Many single agents have been useful in inducing remission in mammary carcinoma, but in recent years various drug combinations have been developed that a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800815)46:4+<1079::aid-cncr282

    authors: Bisel HF

    更新日期:1980-08-15 00:00:00

  • Preoperative and postoperative immunological evaluation of patients with colorectal cancer.

    abstract::Twenty-two patients with cancer of the colon and rectum were studied: preoperative and postoperative cell-mediated and humoral immune factors were assessed, and local concentration of immunoglobulins in tumor tissue and in normal mucosa were measured. Lymphocyte function was found to be reduced in 50% of stage A and B...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800815)46:4<700::aid-cncr28204

    authors: Shafir M,Bekesi JG,Papatestas A,Slater G,Aufses AH Jr

    更新日期:1980-08-15 00:00:00

  • Incidence of the superficial fascia and its relevance in skin-sparing mastectomy.

    abstract:BACKGROUND:With the move away from classical radical mastectomy to ever more skin-sparing procedures, there has been an ongoing discussion about how much skin and subcutaneous tissue should be resected to perform an adequate mastectomy while leaving viable skin flaps. One of the common recommendations is to dissect jus...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10429

    authors: Beer GM,Varga Z,Budi S,Seifert B,Meyer VE

    更新日期:2002-03-15 00:00:00

  • Role of stromal-derived cytokines and growth factors in bone metastasis.

    abstract:BACKGROUND:Interactions between bone marrow-derived cytokines, growth factors, and tumors play a critical role in both the homing of tumors to the bone and the development of bone metastasis. Bone is a storehouse of latent growth factors produced by stromal cells and osteoblasts that, when activated during osteoclastic...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.11148

    authors: David Roodman G

    更新日期:2003-02-01 00:00:00

  • Image and flow DNA cytometry of small cell carcinoma of the lung.

    abstract::Both image and flow DNA cytometry were performed in isolated nuclei from paraffin-embedded tumor tissue of patients with small cell carcinoma of the lung (SCCL). In 14 patients tissue was obtained by surgery from the primary tumor. From 14 patients tissue was taken by autopsy. From two patients tissue obtained by both...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890915)64:6<1304::aid-cncr2820

    authors: Oud PS,Pahlplatz MM,Beck JL,Wiersma-Van Tilburg A,Wagenaar SJ,Vooijs GP

    更新日期:1989-09-15 00:00:00

  • Intrahepatic cholangiocarcinoma with sarcomatous change. Clinicopathologic and immunohistochemical evaluation of seven cases.

    abstract:BACKGROUND:Although there have been a few reports dealing with the sarcomatous changes of intrahepatic cholangiocarcinoma, its clinicopathologic features as well as immunohistochemical nature remain obscure. METHODS:Among 155 cases of intrahepatic cholangiocarcinoma, 7 cases of sarcomatous cholangiocarcinoma were chos...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930915)72:6<1872::aid-cncr2820

    authors: Nakajima T,Tajima Y,Sugano I,Nagao K,Kondo Y,Wada K

    更新日期:1993-09-15 00:00:00

  • Familial polyposis.

    abstract::Familial polyposis is a genetically-transmitted disease characterized by multiple adenomatous colorectal polyps and a high risk for development of adenocarcinoma. Familial polyposis and Gardner's syndrome should be differentiated from other penetically-linked polyposis syndromes lacking a predisposition for cancer. To...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197701)39:1<267::aid-cncr2820390

    authors: DeCosse JJ,Adams MB,Condon RE

    更新日期:1977-01-01 00:00:00

  • Effects of first-dose doxorubicin on cardiac rhythm as evaluated by continuous 24-hour monitoring.

    abstract::Doxorubicin has been reported to cause ventricular arrhythmias and sudden death in the first 24 hours after administration. The authors placed continuous electrocardiographic recording devices on 30 patients 24 hours before, during, and 24 hours after doxorubicin administration. Nine patients experienced arrhythmias b...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851215)56:12<2762::aid-cncr282

    authors: Friess GG,Boyd JF,Geer MR,Garcia JC

    更新日期:1985-12-15 00:00:00

  • Expression of autocrine motility factor receptor in colorectal cancer as a predictor for disease recurrence.

    abstract:BACKGROUND:New biologic prognostic factors are needed to guide the treatment of patients with colorectal cancer. The prognostic value of the altered expression of the cell surface glycoprotein gp78, which has been implicated in tumor-cell invasion and metastasis as an autocrine motility factor (AMF) receptor, was evalu...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19941001)74:7<1855::aid-cncr2820

    authors: Nakamori S,Watanabe H,Kameyama M,Imaoka S,Furukawa H,Ishikawa O,Sasaki Y,Kabuto T,Raz A

    更新日期:1994-10-01 00:00:00

  • Tumor vaccine for ovarian carcinoma targeting sperm protein 17.

    abstract:BACKGROUND:The authors previously identified sperm protein 17 (Sp17) as being expressed in patients with multiple myeloma. The restricted expression of Sp17 in normal tissue makes it an ideal target for tumor vaccine. In the current study, the authors extended their research to include ovarian carcinoma. METHODS:A pai...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10506

    authors: Chiriva-Internati M,Wang Z,Salati E,Timmins P,Lim SH

    更新日期:2002-05-01 00:00:00

  • Oncology clinic attendance at an inner city hospital.

    abstract::Compliance in oncology clinic attendance was prospectively evaluated over a 12-month period at Harlem Hospital Center, an inner city municipal facility serving a predominantly black population. One hundred patients were followed (97 blacks, 2 Hispanics, 1 white) with an average age of 60 years. There were 41 men and 5...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860801)58:3<793::aid-cncr28205

    authors: Garrett TJ,Ashford A,Savage DG

    更新日期:1986-08-01 00:00:00

  • The significance of microsatellite instability in predicting the development of metachronous multiple colorectal carcinomas in patients with nonfamilial colorectal carcinoma.

    abstract:BACKGROUND:Patients with metachronous multiple colorectal carcinomas have been reported to have a higher frequency of a family history of colorectal carcinoma, associated colorectal adenomas, and extracolonic malignancies. These clinicopathologic factors also are considered to be related to the development of metachron...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:

    authors: Masubuchi S,Konishi F,Togashi K,Okamoto T,Senba S,Shitoh K,Kashiwagi H,Kanazawa K,Tsukamoto T

    更新日期:1999-05-01 00:00:00

  • Aggressive cutaneous malignancies following cardiothoracic transplantation: the Australian experience.

    abstract:BACKGROUND:The development of malignancies in recipients of a cardiothoracic transplant (CTT)--that is, heart, lung, or heart and lung recipients-is of concern. Cutaneous and lymphoproliferative malignancies comprise the two major groups of malignancies encountered. A small subgroup of patients will develop potentially...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Veness MJ,Quinn DI,Ong CS,Keogh AM,Macdonald PS,Cooper SG,Morgan GW

    更新日期:1999-04-15 00:00:00

  • Prostate cancer risk in the Swedish AMORIS study: the interplay among triglycerides, total cholesterol, and glucose.

    abstract:BACKGROUND:In a cohort including 5112 prostate cancer (pCa) patients, the authors investigated associations among triglycerides (TG), total cholesterol (TC), and pCa while taking into account glucose. METHODS:A cohort (n = 200,660) based on 4 groups of men, according to age at cohort entry, with TG, TC, and glucose me...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25758

    authors: Van Hemelrijck M,Garmo H,Holmberg L,Walldius G,Jungner I,Hammar N,Lambe M

    更新日期:2011-05-15 00:00:00

  • The prognostic value of histologic subtypes in primary extremity liposarcoma.

    abstract::Patients with a localized primary liposarcoma of the extremity who were treated in Memorial Sloan-Kettering Cancer Center between 1968 and 1978 were studied. The prognosis of patients with extremity liposarcoma was analyzed according to histopathologic subtypes. A system of five subtypes was used; well-differentiated,...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19891001)64:7<1514::aid-cncr2820

    authors: Chang HR,Hajdu SI,Collin C,Brennan MF

    更新日期:1989-10-01 00:00:00

  • Adenoid cystic carcinoma of the salivary gland. Sustained complete response to chemotherapy.

    abstract::A patient developed widely metastatic adenoid cystic carcinoma of the parotid gland after several local recurrences. A complete regression of pleural, pulmonary parenchymal, cutaneous, and bone metastases was seen following therapy with 5-fluorouracil, Adriamycin, and mitomycin C. This is the second complete response ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830215)51:4<589::aid-cncr28205

    authors: Budd GT,Groppe CW

    更新日期:1983-02-15 00:00:00

  • Mitoxantrone for refractory and relapsed acute leukemia.

    abstract::Seventy-seven patients with relapsed or refractory acute leukemia and three with acute blastic chronic myeloid leukemia (CML) were treated in an open Phase II study using mitoxantrone 12 mg/m2 intravenously daily X 5 days. Complete remission (CR) was achieved in 32 of 80 (40%), including 23/45 (52%) with relapsed acut...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/1097-0142(19900801)66:3<418::aid-cncr28206

    authors: Bezwoda WR,Bernasconi C,Hutchinson RM,Winfield DA,de Bock R,Mandelli F

    更新日期:1990-08-01 00:00:00

  • Evolution of the team approach in breast cancer.

    abstract::Dr. Wendell G. Scott hailed mammography as the first significant contribution to the control of breast cancer since Halsted described the radical mastectomy in 1903. Mammography as engendered new approaches and has supplied new concepts of breast cancer. Through the tenacity of a few physicians convinced something cou...

    journal_title:Cancer

    pub_type: 历史文章,杂志文章

    doi:10.1002/1097-0142(197511)36:5<1815::aid-cncr282036

    authors: Egan RL

    更新日期:1975-11-01 00:00:00

  • Detection of human papillomavirus DNA in esophageal carcinoma in Japan by polymerase chain reaction.

    abstract:BACKGROUND:Human papillomaviruses (HPV) have been implicated strongly in the pathogenesis of human squamous cell carcinomas, especially of anogenital carcinomas. Some pathologic changes of the esophagus may be one of the candidates for HPV etiology, but the role of HPV infections in the carcinogenesis of the esophagus ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19921101)70:9<2234::aid-cncr2820

    authors: Toh Y,Kuwano H,Tanaka S,Baba K,Matsuda H,Sugimachi K,Mori R

    更新日期:1992-11-01 00:00:00

  • The prevalence of variant alkaline phosphatase in hepatocellular carcinoma in southern African blacks.

    abstract::The prevalence of variant alkaline phosphatase in the serum of 335 southern African blacks with hepatocellular carcinoma was determined using polyacrylamide gel electrophoresis. The isoenzyme was detected in 2% (seven of 335) of the patients: it could not be found in the serum of 300 matched, healthy individuals or in...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880901)62:5<978::aid-cncr28206

    authors: Bukofzer S,Kew MC,Rowe P

    更新日期:1988-09-01 00:00:00