Abstract:
:A series of 27 patients with intramedullary osteogenic sarcomas that were so well-differentiated histologically as to be confused with benign lesions was studied. Of the 27 patients, 14 were females and 13 were males, and most were adults. The tibia and femur were involved commonly. Roentgenographically, the tumors showed a mixture of sclerosis and lysis with poor margination. However, they lacked the highly destructive appearance of high-grade osteosarcomas. Histologically, spindle cells with minimal cytologic atypia were arranged in interlacing bundles. Mitotic figures were scarce. The amount of osteoid was variable, commonly being abundant. With recurrence, three tumors became highly anaplastic. Excision of tumor almost invariably led to recurrences. Resection or amputation has led to good results in seven patients. Only three of the 27 patients died with metastatic tumor; one patient is alive with metastasis. Central low-grade osteosarcomas have been misdiagnosed frequently and hence treated inadequately. Careful roentgenographic and histologic correlation is required to make the diagnosis.
journal_name
Cancerjournal_title
Cancerauthors
Unni KK,Dahlin DC,McLeod RA,Pritchard DJdoi
10.1002/1097-0142(197709)40:3<1337::aid-cncr282040subject
Has Abstractpub_date
1977-09-01 00:00:00pages
1337-47issue
3eissn
0008-543Xissn
1097-0142journal_volume
40pub_type
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