Intraosseous well-differentiated osteosarcoma.

Abstract:

:A series of 27 patients with intramedullary osteogenic sarcomas that were so well-differentiated histologically as to be confused with benign lesions was studied. Of the 27 patients, 14 were females and 13 were males, and most were adults. The tibia and femur were involved commonly. Roentgenographically, the tumors showed a mixture of sclerosis and lysis with poor margination. However, they lacked the highly destructive appearance of high-grade osteosarcomas. Histologically, spindle cells with minimal cytologic atypia were arranged in interlacing bundles. Mitotic figures were scarce. The amount of osteoid was variable, commonly being abundant. With recurrence, three tumors became highly anaplastic. Excision of tumor almost invariably led to recurrences. Resection or amputation has led to good results in seven patients. Only three of the 27 patients died with metastatic tumor; one patient is alive with metastasis. Central low-grade osteosarcomas have been misdiagnosed frequently and hence treated inadequately. Careful roentgenographic and histologic correlation is required to make the diagnosis.

journal_name

Cancer

journal_title

Cancer

authors

Unni KK,Dahlin DC,McLeod RA,Pritchard DJ

doi

10.1002/1097-0142(197709)40:3<1337::aid-cncr282040

subject

Has Abstract

pub_date

1977-09-01 00:00:00

pages

1337-47

issue

3

eissn

0008-543X

issn

1097-0142

journal_volume

40

pub_type

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