Glucocorticoid receptors in hepatocellular carcinoma and adjacent liver tissue.

Abstract:

:Glucocorticoid and progesterone receptors, tyrosine aminotransferase, gamma-glutamyltransferase and alpha-fetoprotein levels were determined in human hepatocellular carcinoma (HCC) and adjacent liver tissues. Glucocorticoid receptor was present in seven of ten HCC samples, values ranged from 1.9 to 66.8 fmol/mg protein. Progesterone receptor was present in two of ten HCC samples with values of 1.7 and 7.2 fmol/mg protein, respectively. In the adjacent liver tissues, no measurable progesterone receptor was found and only one sample had glucocorticoid receptor with a value of 3.0 fmol/mg protein. The increase of glucocorticoid receptor in HCC samples was coincident with a decreased level of tyrosine aminotransferase and an increased level of gamma-glutamyltransferase. No correlation was found among glucocorticoid receptor level, serum or tissue alpha-fetoprotein levels. The presence of glucocorticoid receptors in HCC suggest that hormones may play an important role in the formation of hepatoma, and hormonal therapy may be useful for patients with HCC.

journal_name

Cancer

journal_title

Cancer

authors

P'eng FK,Lui WY,Chang TJ,Kao HL,Wu LH,Liu TY,Chi CW

doi

10.1002/1097-0142(19881115)62:10<2134::aid-cncr282

subject

Has Abstract

pub_date

1988-11-15 00:00:00

pages

2134-8

issue

10

eissn

0008-543X

issn

1097-0142

journal_volume

62

pub_type

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