Abstract:
:Glucocorticoid and progesterone receptors, tyrosine aminotransferase, gamma-glutamyltransferase and alpha-fetoprotein levels were determined in human hepatocellular carcinoma (HCC) and adjacent liver tissues. Glucocorticoid receptor was present in seven of ten HCC samples, values ranged from 1.9 to 66.8 fmol/mg protein. Progesterone receptor was present in two of ten HCC samples with values of 1.7 and 7.2 fmol/mg protein, respectively. In the adjacent liver tissues, no measurable progesterone receptor was found and only one sample had glucocorticoid receptor with a value of 3.0 fmol/mg protein. The increase of glucocorticoid receptor in HCC samples was coincident with a decreased level of tyrosine aminotransferase and an increased level of gamma-glutamyltransferase. No correlation was found among glucocorticoid receptor level, serum or tissue alpha-fetoprotein levels. The presence of glucocorticoid receptors in HCC suggest that hormones may play an important role in the formation of hepatoma, and hormonal therapy may be useful for patients with HCC.
journal_name
Cancerjournal_title
Cancerauthors
P'eng FK,Lui WY,Chang TJ,Kao HL,Wu LH,Liu TY,Chi CWdoi
10.1002/1097-0142(19881115)62:10<2134::aid-cncr282subject
Has Abstractpub_date
1988-11-15 00:00:00pages
2134-8issue
10eissn
0008-543Xissn
1097-0142journal_volume
62pub_type
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