DNA content and other prognostic features in childhood medulloblastoma. Proposal of a scoring system.

Abstract:

:The authors reviewed clinical features, surgical extent of resection, histologic parameters, and DNA content in 55 children with medulloblastomas and found that complete or near total resection, absence of tumor dissemination, tumor DNA aneuploidy, and low proliferative index correlated with a favorable clinical outcome. A scoring system was developed based upon these features to identify patients who, in the future, may benefit from more aggressive or novel therapeutic regimens. Patient age and sex and adjuvant chemotherapy did not significantly correlate with long-term survival. The data also suggest that tumors that have been designated as cerebellar neuroblastomas may be a distinct group of posterior fossa tumors, which may have a better prognosis.

journal_name

Cancer

journal_title

Cancer

authors

Schofield DE,Yunis EJ,Geyer JR,Albright AL,Berger MS,Taylor SR

doi

10.1002/cncr.2820690539

subject

Has Abstract

pub_date

1992-03-01 00:00:00

pages

1307-14

issue

5

eissn

0008-543X

issn

1097-0142

journal_volume

69

pub_type

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