The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer.

abstract：BACKGROUND:Endocrine therapy resistance is a major cause of distant recurrence (DR) in hormone receptor-positive breast cancer. This study evaluated differences in survival after DR in patients treated with different adjuvant endocrine therapy regimens in the Breast International Group (BIG) 1-98 trial. METHODS:BIG 1-...

journal_title：Cancer

authors： Leone JP,Cole BF,Regan MM,Thürlimann B,Coates AS,Rabaglio M,Giobbie-Hurder A,Gelber RD,Ejlertsen B,Harvey VJ,Neven P,Láng I,Bonnefoi H,Wardley A,Goldhirsch A,Di Leo A,Colleoni M,Vaz-Luis I,Lin NU

更新日期：2020-12-08 00:00:00

abstract：BACKGROUND:Childhood cancer survivors have been reported to be vulnerable to psychiatric morbidities and risky health behavior. Suicides, substance abuse, accidents, and violence as causes of death can be regarded as an extreme manifestation of risky health behavior. In the current study, the authors studied the risk o...

journal_title：Cancer

authors： Korhonen LM,Taskinen M,Rantanen M,Erdmann F,Winther JF,Bautz A,Feychting M,Mogensen H,Talbäck M,Malila N,Ryynänen H,Madanat-Harjuoja L

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:Attrition is common among supportive care/palliative oncology clinical trials. However, to the authors' knowledge, few studies to date have documented the reasons and predictors for dropout. In the current study, the authors' objective was to determine the rate, reasons, and factors associated with attrition...

journal_title：Cancer

authors： Hui D,Glitza I,Chisholm G,Yennu S,Bruera E

更新日期：2013-03-01 00:00:00

abstract：:In order to search for the histogenesis and progression of colorectal cancer, the background mucosas of 18 patients with a single colorectal cancer, apart from familial adenomatosis coli, were studied by a step sectioning method. Three early minute cancers (3-5 mm in diameter) were detected in the apparently normal mu...

journal_title：Cancer

authors： Kuramoto S,Oohara T

更新日期：1988-02-15 00:00:00

abstract：BACKGROUND:This year, the 7th edition of the AJCC staging manual has for the first time attributed a unique pTNM staging to intrahepatic cholangiocarcinoma (IHCC) that is intended to replace the 2 Western and ideally also the 2 Eastern systems currently in use. This proposal, which has not yet been validated, was teste...

journal_title：Cancer

authors： Farges O,Fuks D,Le Treut YP,Azoulay D,Laurent A,Bachellier P,Nuzzo G,Belghiti J,Pruvot FR,Regimbeau JM

更新日期：2011-05-15 00:00:00

abstract：:The serial technetium 99 (99Tc) bone scans of 76 patients with Stage D-2 prostate cancers were reviewed. Sites of metastases in skeletal areas in decreasing order were vertebrae, ribs, pelvis, long bones, and skull. Patients with one or two involved skeletal areas had a significantly longer progression-free interval a...

journal_title：Cancer

authors： Knudson G,Grinis G,Lopez-Majano V,Sansi P,Targonski P,Rubenstein M,Sharifi R,Guinan P

更新日期：1991-07-15 00:00:00

abstract：:To investigate the possible role of sex-hormone imbalance in hepatocellular carcinogenesis in male alcoholic cirrhotic patients, we determined plasma levels of testosterone (T), dihydrotestosterone (DHT), androstenedione (A), dehydroepiandrosterone (DHA), estrone (E1), estradiol (E2), and sex-hormone-binding globulin ...

journal_title：Cancer

authors： Guéchot J,Peigney N,Ballet F,Vaubourdolle M,Giboudeau J,Poupon R

更新日期：1988-08-15 00:00:00

abstract：:During a retrospective case-control study of recent laryngeal cancer patients, several associated factors were studied to determine possible changes in the epidemiology of laryngeal cancer between 1956 and 1974. The large sex difference noted in the early survey (male: female ratio of 14.9:1) diminished considerably i...

journal_title：Cancer

authors： Wynder EL,Covey LS,Mabuchi K,Mushinski M

更新日期：1976-10-01 00:00:00

abstract：:The administration of two chemoimmunotherapy programs to 103 consecutive patients with metastatic colorectal cancer resulted in improved survival for patients who achieved either objective tumor regressions or disease stabilization for more than 8 weeks. Objective tumor regression was observed in 47% of patients treat...

journal_title：Cancer

authors： Valdivieso M,Bedikian A,Burgess MA,Rodriguez V,Hersh EM,Bodey GP,Mavligit GM

更新日期：1977-11-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate the results of thyroid fine-needle aspiration (FNA) and to determine the reasons for the discrepancies between the cytologic and histologic diagnoses. METHODS:The authors evaluated the cytologic and histologic results of 133 FNAs obtained from 92 patients who underw...

journal_title：Cancer

authors： Sidawy MK,Del Vecchio DM,Knoll SM

更新日期：1997-08-25 00:00:00

abstract：:The endocrine action of medroxyprogesterone acetate (MPA) has been claimed to be of a glucocorticoid-like nature. Upon clinical observation, MPA has been shown to improve life quality and overall well-being in patients with advanced breast cancer, renal carcinoma, prostatic carcinoma, and uterine adenocarcinoma. The a...

journal_title：Cancer

authors： Lang I,Zielinski CC,Templ H,Spona J,Geyer G

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Factors contributing to the lower likelihood of urologist follow-up among African American (AA) men diagnosed with prostate cancer may not be strictly related to patient factors. The authors investigated the relationship between crime, poverty, and poor housing, among others, and postdiagnosis urologist visi...

journal_title：Cancer

authors： Onukwugha E,Osteen P,Jayasekera J,Mullins CD,Mair CA,Hussain A

更新日期：2014-11-01 00:00:00

abstract：:Forty-nine patients with regionally confined recurrent malignancy were treated with intra-arterial cis-diamminedichloro platinum II in a Phase I-II trial. A safe starting dose of 120 mg/m2 was established. An overall response rate of 45% was noted with significant responses observed among patients with melanoma, sarco...

journal_title：Cancer

authors： Calvo DB 3rd,Patt YZ,Wallace S,Chuang VP,Benjamin RS,Pritchard JD,Hersh EM,Bodey GP Sr,Mavligit GM

更新日期：1980-03-15 00:00:00

abstract：:Six hundred fifty-eight cases of previously untreated non-Hodgkin's lymphoma seen between 1970 and 1979 at the Medical Department, the Finsen Institute, were the basis for a comparative study of the prognostic value of the Rappaport, Kiel, and Lukes & Collins classifications and the new translation system, the Working...

journal_title：Cancer

authors： Ersbøll J,Schultz HB,Hougaard P,Nissen NI,Hou-Jensen K

更新日期：1985-05-15 00:00:00

abstract：:A classification for childhood brain tumors based upon revision of nomenclature of all brain tumors published by the World Health Organization (WHO) in 1979 is proposed. Applicability of the WHO classification scheme was tested in a combined study of the clinical and pathologic features of approximately 3300 brain tum...

journal_title：Cancer

authors： Rorke LB,Gilles FH,Davis RL,Becker LE

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Alpha-interferon and dexamethasone are each effective in patients with multiple myeloma and have a combined inhibitory effect on the in vitro growth of myeloma colonies. The effect of combined therapy in newly diagnosed patients is unknown. METHODS:Fifty-one consecutive patients with previously untreated mu...

journal_title：Cancer

authors： Dimopoulos MA,Weber D,Delasalle KB,Alexanian R

更新日期：1993-11-01 00:00:00

abstract：:Disease that is known to have extended beyond the prostatic capsule is unlikely to be cured by radical surgical excision, although the primary tumor may be controlled by external irradiation. The development of progressive (metastatic) disease is common and may be retarded by hormonal therapy. The timing of such treat...

journal_title：Cancer

authors： Smith PH

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Insular thyroid cancer (ITC) is an uncommon, poorly differentiated thyroid malignancy. To date, there have been no population-level studies of the characteristics and outcomes of patients with ITC. METHODS:The authors used the Surveillance, Epidemiology, and End Results (SEER) database from 1999 to 2007 to ...

journal_title：Cancer

authors： Kazaure HS,Roman SA,Sosa JA

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that the levels of 15-lipoxygenase 1 (15-LOX-1) and 15-LOX-2 as well as their metabolites 13-S-hydroxyoctadecadienoic acid (13(S)-HODE) and 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) are significantly reduced in smokers with non-small cell lung carcinoma (NSCLC). Furthermore,...

journal_title：Cancer

authors： Li MY,Yuan HL,Ko FW,Wu B,Long X,Du J,Wu J,Ng CS,Wan IY,Mok TS,Hui DS,Underwood MJ,Chen GG

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Recently, adenomatous hyperplasia (AH) of the liver, a sizable parenchymal nodule in the cirrhotic liver, has been considered a preneoplastic lesion in human hepatocarcinogenesis. METHODS:The authors evaluated cell proliferative activity by immunostaining for proliferating cell nuclear antigen (PCNA) in AH ...

journal_title：Cancer

authors： Terada T,Nakanuma Y

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Despite advances in first-line therapy, there are few data on treatment of glioblastoma multiforme (GBM) at recurrence. Temozolomide (TMZ) is well tolerated and may have activity despite prior TMZ exposure if novel dose schedules are used. METHODS:The authors reviewed their experience with a continuous TMZ ...

journal_title：Cancer

authors： Perry JR,Rizek P,Cashman R,Morrison M,Morrison T

更新日期：2008-10-15 00:00:00

abstract：:The myeloproliferative neoplasms (MPNs) essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (MF) are malignancies that frequently harbor the recurrent somatic point mutation JAK2(V617F). The discovery of this mutation has fueled the development of Janus kinase 2 (JAK2) inhibitors. Availab...

journal_title：Cancer

authors： Quintás-Cardama A,Verstovsek S

更新日期：2012-02-15 00:00:00

abstract：BACKGROUND:National and international bodies acknowledge the benefit of exercise for people with cancer, yet limited accessibility to related programing remains. Given their involvement in managing the disease, cancer centers can play a central role in delivering exercise-oncology services. The authors developed and im...

journal_title：Cancer

authors： Santa Mina D,Au D,Auger LE,Alibhai SMH,Matthew AG,Sabiston CM,Oh P,Ritvo PG,Chang EB,Jones JM

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:The goal of this study was to examine the clinical significance of ZNF217 amplification and assess whether ZNF217 could be a potential therapeutic target in ovarian clear cell carcinoma (OCCC). METHODS:ZNF217 expression and amplification in OCCC was assessed by immunohistochemistry, fluorescence in situ hyb...

journal_title：Cancer

authors： Rahman MT,Nakayama K,Rahman M,Nakayama N,Ishikawa M,Katagiri A,Iida K,Nakayama S,Otsuki Y,Shih IeM,Miyazaki K

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND AND METHODS:Specimens obtained from 192 patients with Stage III squamous cell carcinoma of the cervix treated by radiation therapy alone were investigated with an immunohistochemical method for the expression of p53CM1, a monoclonal antibody that recognizes wild and mutant type p53 gene products in histologi...

journal_title：Cancer

authors： Oka K,Nakano T,Arai T

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:A single-institution, prospective, randomized open trial was performed to compare ondansetron and granisetron in the prevention of chemotherapy-related nausea and vomiting. The effect of antemetic drugs was analyzed indipendently for patients treated with highly emetogenic chemotherapy (Study 1), and those t...

journal_title：Cancer

authors： Gebbia V,Cannata G,Testa A,Curto G,Valenza R,Cipolla C,Latteri MA,Gebbia N

更新日期：1994-10-01 00:00:00

abstract：:Epidemiology and prognosis were analyzed in a consecutive, population-based series of 137 patients with malignant fibrous histiocytoma of soft tissue in the extremities and trunk wall, with a complete follow-up of minimum 3 years. All but one patient were treated by surgery in 28 cases combined with adjuvant radiother...

journal_title：Cancer

authors： Rööser B,Willén H,Gustafson P,Alvegård TA,Rydholm A

更新日期：1991-01-15 00:00:00

abstract：:A tumor colony assay (TCA) was evaluated for its ability to predict anticancer drug responses in an N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT)-induced murine bladder tumor (MBT) model. Ten anticancer drugs were evaluated in vivo and in vitro using four MBT cell lines (40 drug responses). Using the optimum c...

journal_title：Cancer

authors： Niell HB,Soloway MS,Wood CA,McCallum LW,Webster K

更新日期：1983-08-15 00:00:00

abstract：:Serum immunoglobulin levels IgA, IgG, and IgM have been estimated in 92 patients with breast cancer and 50 control patients, 40 of whom had benign disease of the breast. In patients with breast cancer, IgA was significantly raised at all stages and IgG was significantly reduced, but the two abnormalities were not nece...

journal_title：Cancer

authors： Roberts MM,Bathgate EM,Stevenson A

更新日期：1975-07-01 00:00:00

abstract：:In 147 cases of mammary carcinoma, 388 serial mammographies were performed before final treatment. The average retrospective observation time was 27 months with a range of two months to 11 years. The number of serial mammographies per case ranged between two and 11. The tumor volume doubling times (TV); obtained by me...

journal_title：Cancer

authors： von Fournier D,Weber E,Hoeffken W,Bauer M,Kubli F,Barth V

更新日期：1980-04-15 00:00:00