Minute cancers arising de novo in the human large intestine.

Abstract:

:In order to search for the histogenesis and progression of colorectal cancer, the background mucosas of 18 patients with a single colorectal cancer, apart from familial adenomatosis coli, were studied by a step sectioning method. Three early minute cancers (3-5 mm in diameter) were detected in the apparently normal mucosa, and two cancers in the adenoma (focal cancer in adenomatous polyp). The three early cancers had no evidence of preexisting adenoma, so they were considered to be de novo cancers. In form they were depressed, flat, and slightly elevated. In humans, de novo cancer has an important significance in histogenesis and treatment of colorectal cancer. Clinically, it is also important to recognize the early phase of colorectal cancer in flat type as well as polypoid type.

journal_name

Cancer

journal_title

Cancer

authors

Kuramoto S,Oohara T

doi

10.1002/1097-0142(19880215)61:4<829::aid-cncr28206

subject

Has Abstract

pub_date

1988-02-15 00:00:00

pages

829-34

issue

4

eissn

0008-543X

issn

1097-0142

journal_volume

61

pub_type

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