Concomitant conjugal gliomas with similar histologic features.

Abstract:

:Conjugal tumors are rarely reported; but nevertheless, raise important questions of possible etiologic factors. In this report, the presentation of grade 2 gemistocytic astrocytomas in an unrelated married couple in their early thirties within 18 months of each other is described. In both cases the left frontal region of the brain was involved and histologically the tumors were very similar. Although there are no accurate figures on the true incidence of gliomas, an estimate can be derived from reliable epidemiologic studies of primary brain tumors as a whole. Using such data, it is calculated that the risk of two designated persons developing a grade 1 to 2 astrocytoma while in the fourth decade within the same year is approximately 1 in 30 billion (10(9)) and, for this couple, over a period of 15 years, at least 1 in 185 million. No specific causative environmental factors were identified in the patients, and results of conventional tests for viral and other infections were negative. It is postulated that apart from remote chance, such conjugal lesions implicate the action of an environmental agent. In the absence of other factors, involvement of a slow, unconventional virus is a possibility that must be strongly considered.

journal_name

Cancer

journal_title

Cancer

authors

Tupchong L,Levison DA,Jones AE

doi

10.1002/1097-0142(19850215)55:4<864::aid-cncr28205

subject

Has Abstract

pub_date

1985-02-15 00:00:00

pages

864-9

issue

4

eissn

0008-543X

issn

1097-0142

journal_volume

55

pub_type

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