Abstract:
:Conjugal tumors are rarely reported; but nevertheless, raise important questions of possible etiologic factors. In this report, the presentation of grade 2 gemistocytic astrocytomas in an unrelated married couple in their early thirties within 18 months of each other is described. In both cases the left frontal region of the brain was involved and histologically the tumors were very similar. Although there are no accurate figures on the true incidence of gliomas, an estimate can be derived from reliable epidemiologic studies of primary brain tumors as a whole. Using such data, it is calculated that the risk of two designated persons developing a grade 1 to 2 astrocytoma while in the fourth decade within the same year is approximately 1 in 30 billion (10(9)) and, for this couple, over a period of 15 years, at least 1 in 185 million. No specific causative environmental factors were identified in the patients, and results of conventional tests for viral and other infections were negative. It is postulated that apart from remote chance, such conjugal lesions implicate the action of an environmental agent. In the absence of other factors, involvement of a slow, unconventional virus is a possibility that must be strongly considered.
journal_name
Cancerjournal_title
Cancerauthors
Tupchong L,Levison DA,Jones AEdoi
10.1002/1097-0142(19850215)55:4<864::aid-cncr28205subject
Has Abstractpub_date
1985-02-15 00:00:00pages
864-9issue
4eissn
0008-543Xissn
1097-0142journal_volume
55pub_type
杂志文章相关文献
CANCER文献大全abstract::To assess the efficacy of performing both computed tomography (CT) of the thorax and upper abdomen and whole-body gallium scintigraphy for staging lung cancer, the results of each test were compared with those obtained by chest radiography and clinical examination in 100 patients. Clinical efficacy was defined in term...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891001)64:7<1404::aid-cncr2820
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to examine local definitive therapy for nonmetastatic breast cancer with the Patterns of Care Breast and Prostate Cancer (POCBP) study of the National Program of Cancer Registries (Centers for Disease Control and Prevention). METHODS:POCBP medical record data were re-abstracted...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29092
更新日期:2015-03-01 00:00:00
abstract::Over the years, there has been a continuous increase in clinically relevant driver mutations in patients with non-small cell lung cancer (NSCLC). Among these, dysregulated activation of the MET tyrosine kinase receptor has gained importance due to the recent development of quite effective treatments. MET dysregulation...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.33159
更新日期:2020-11-15 00:00:00
abstract:BACKGROUND:Standard therapy for advanced head and neck carcinoma is surgery and radiation, and the subsequent 5-year survival with this treatment has been less than 50%. New combined modality treatment strategies are being tested to improve survival. New chemotherapy combinations are being developed and administered si...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1997-05-15 00:00:00
abstract::This study is based on 38 patients, each of whom had a malignant lymphoma in which the gonad was the site of the main tumor mass at the time of diagnosis. Histiocytic lymphoma was the predominant type in the 27 male patients; in the 11 female patients, poorly differentiated lymphocytic lymphoma was the most frequent t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800201)45:3<561::aid-cncr28204
更新日期:1980-02-01 00:00:00
abstract::Carcinoembryonic antigen (CEA) was measured in extracts of cell suspensions from tumors of the colon, stomach, breast, lung and kidney. Cell suspensions were also obtained from normal tissue surrounding the primary tumors. The number of neoplastic cells in each cell suspension was determined by cytologic criteria. Hig...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197708)40:2<808::aid-cncr2820400
更新日期:1977-08-01 00:00:00
abstract:BACKGROUND:Interleukin-2 (IL-2) is used in the treatment of solid tumors and hematologic malignancies. Sudden death is a rare complication of IL-2 treatment. METHODS:A patient with lymphoma underwent chemoradiotherapy myeloablation and autologous stem cell transplantation. The stem cells were cultured in IL-2 (6000 IU...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980915)83:6<1231::aid-cn
更新日期:1998-09-15 00:00:00
abstract:BACKGROUND:Anemia in patients receiving chemotherapy can be ameliorated with recombinant human erythropoietin (rHuEPO), which is administered one to three times per week. Darbepoetin alpha, a new erythropoietic agent, has longer serum residence time, allowing it to be administered less frequently. METHODS:Patients (n ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/cncr.11186
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:Research suggests that patients' end-of-life (EOL) care is determined primarily by the medical resources available, and not by patient preferences. The authors examined whether patients' desire for life-extending therapy was associated with their EOL care. METHODS:Coping with Cancer is a multisite, prospect...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.25217
更新日期:2010-10-01 00:00:00
abstract::From 1974 to 1983, simple and radical nephrectomies were performed at the Chaim Sheba Medical Center (Tel Hashomer, Israel) for renal cell carcinoma. The authors reviewed 109 cases that were followed for a period ranging from 5 to 14 years. Simple nephrectomy was performed in 55 patients, and 54 patients underwent rad...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910515)67:10<2506::aid-cncr282
更新日期:1991-05-15 00:00:00
abstract::Tissue specimens from 27 patients with mammary fibrocystic disease were assayed for estrogen (ER) and progestin (PR) receptors. Seventeen patients (63%) had ER-positive lesions (greater than 5 fmol/mg protein). A progression in ER presence was noted from fibrocystic disease (35%) and fibrosing adenosis (50%) to lobula...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820615)49:12<2534::aid-cncr282
更新日期:1982-06-15 00:00:00
abstract:BACKGROUND:The efficacy of the current 6th edition of the American Joint Committee on Cancer (AJCC) tumor staging criteria in improving outcome prediction for patients with oropharyngeal cancer was analyzed. METHODS:From the database of the Department of Radiation Oncology at the University of Texas M. D. Anderson Can...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21867
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:It is frequently difficult to establish histologically whether a parathyroid tumor is a parathyroid carcinoma, parathyromatosis, or an atypical adenoma. The authors asked whether these tumors have a distinctive molecular profile, whether benign tumors could be distinguished from malignant tumors, and whether...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24037
更新日期:2009-01-15 00:00:00
abstract:BACKGROUND:Recent evidence has identified pre-existing type 2 diabetes mellitus (T2DM) as a risk factor for the development of PAC, but relatively little is known about its effects on survival. Our aim was to determine the effect of varying durations of pre-existing T2DM on survival in patients with PAC. METHODS:We co...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27731
更新日期:2013-01-15 00:00:00
abstract::K-ras gene mutation in colorectal tumors from patients with familial polyposis coli were investigated using oligonucleotide probes specific for a mutation at codon 12, 13, or 61 of the K-ras gene. The authors examined 22 colorectal carcinomas and 51 colorectal adenomas from 41 familial polyposis coli patients and obse...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900601)65:11<2576::aid-cncr282
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:Heavy alcohol consumption, viral hepatitis, and diabetes are risk factors for hepatocellular carcinoma (HCC). However, to the authors' knowledge, the information concerning their interaction effect in patients with risk of HCC is sparse. METHODS:A population-based, case-control study of HCC was conducted du...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20427
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:To enhance the efficacy of chemotherapy for medullary thyroid carcinoma (MTC), we evaluated the effect of combining radioimmunotherapy (RAIT) with 90Y-anticarcinoembryonic antigen (CEA) monoclonal antibody MN-14 and chemotherapy in nude mice bearing human MTC xenografts. A preliminary study evaluated doxorub...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10157
更新日期:2002-01-01 00:00:00
abstract::Flow cytometry (FC) analysis including DNA index (ploidy status) and cell kinetics (%S and %S + G2/M) was done on frozen tissue of the primary lesions of 101 women with node negative (N-) breast cancer who were studied prospectively. Currently, 19% (19/101) of the patients have recurred. No significant relations have ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891101)64:9<1894::aid-cncr2820
更新日期:1989-11-01 00:00:00
abstract::Chemokines are chemoattractant cytokines that regulate the trafficking and activation of leukocytes and other cell types under a variety of inflammatory and noninflammatory conditions. Over the past few years, studies have increasingly shown that chemokines play an important role in several aspects of tumor progressio...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.22706
更新日期:2007-06-15 00:00:00
abstract:BACKGROUND:The objective of this study was to determine whether standardized treatment of germ cell tumors (GCTs) could overcome sociodemographic factors limiting patient care. METHODS:The records of all patients undergoing primary treatment for GCTs at both a public safety net hospital and an academic tertiary care c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33076
更新日期:2020-10-01 00:00:00
abstract::Hodgkin's disease (HD) was diagnosed in 24 patients who were either seropositive for human immunodeficiency virus (HIV) (21) or members of a high-risk group (three), but had not developed acquired immune deficiency syndrome (AIDS). Clinical presentation of the disease was characterized by constitutional symptoms in al...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910315)67:6<1614::aid-cncr2820
更新日期:1991-03-15 00:00:00
abstract::Multiple endocrine neoplasia, type 2b (MEN 2b) is a disorder characterized by C-cell disease of the thyroid gland (medullary carcinoma or C-cell hyperplasia, or both), pheochromocytoma, ganglioneuromatosis, and skeletal and connective tissue abnormalities. The medullary thyroid carcinoma (MTC) is bilateral and multice...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197912)44:6<2173::aid-cncr282044
更新日期:1979-12-01 00:00:00
abstract::Two children with metastatic extragonadal endodermal sinus tumor who had failed VAC chemotherapy were treated with combination chemotherapy consisting of cis-platinum, vinblastine, doxorubicin HCl (Adriamycin) and bleomycin (cis-VAB). There was a complete response in both patients with one child remaining tumor-free 3...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19811201)48:11<2371::aid-cncr282
更新日期:1981-12-01 00:00:00
abstract::Quantitative counts of ferruginous bodies were performed on digests of lungs from 100 control and 30 lung cancer patients. It was found that the lung cancer group had significantly higher levels, although only 1 patient was known to be occupationally exposed to asbestos. It is suggested that even extremely low levels ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197504)35:4<1236::aid-cncr282035
更新日期:1975-04-01 00:00:00
abstract:BACKGROUND:Because patients with germ cell tumors expect an additional life span of around 50 years after successful treatment, attention is now focused on potential long term toxicity. Limited data are available on Leydig cell function in long term survivors. METHODS:The authors measured testosterone, sex hormone bin...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010401)91:7<1297::aid-cncr1132
更新日期:2001-04-01 00:00:00
abstract::A patient developed widely metastatic adenoid cystic carcinoma of the parotid gland after several local recurrences. A complete regression of pleural, pulmonary parenchymal, cutaneous, and bone metastases was seen following therapy with 5-fluorouracil, Adriamycin, and mitomycin C. This is the second complete response ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830215)51:4<589::aid-cncr28205
更新日期:1983-02-15 00:00:00
abstract::Two-hundred-four patients with previously untreated adenocarcinoma of rectum, rectosigmoid, and sigmoid colon were retrospectively evaluated to determine patterns of recurrence following curative resection. Seventy-eight (38%) subsequently developed recurrent disease. Of these, 40% (31/78) presented with local recurre...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810915)48:6<1492::aid-cncr2820
更新日期:1981-09-15 00:00:00
abstract:BACKGROUND:Meticulous selection of patients for esophageal cancer surgery is critical, because major surgical intervention can cause considerable consequences. For this study, the authors explored their institution's large surgical experience to examine the impact of age on long-term patient survival and surgical compl...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24488
更新日期:2009-10-01 00:00:00
abstract::Nine children with acute promyelocytic leukemia (APL) are presented. This series of children represents 7% of all acute leukemias and 21% of acute myelogenous leukemias seen during the same period at the Red Cross War Memorial Children's Hospital. These figures are much higher than the incidence quoted in other series...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870301)59:5<933::aid-cncr28205
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND:Glembatumumab vedotin is an antibody-drug conjugate that produced preliminary clinical activity against advanced melanoma in a phase 1 dose-escalation trial. The objective of the current study was to investigate further the antitumor activity of glembatumumab vedotin at the recommended phase 2 dose in heavil...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31892
更新日期:2019-04-01 00:00:00