Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. A potentially more common pharmacogenetic syndrome.

Abstract:

:This study describes the inheritance of a defect in pyrimidine catabolism and its association with drug-induced toxicity in a patient receiving 5-fluorouracil (FUra) as adjuvant chemotherapy for breast carcinoma. The study population included the affected patient (proband), nine of her blood relatives, and seven healthy volunteers. The activity of dihydropyrimidine dehydrogenase (DPD), the initial enzyme of pyrimidine (and FUra) catabolism, in peripheral blood mononuclear cells was measured in each subject by a specific radiometric assay using FUra as the substrate. The proband had no detectable DPD activity. When enzyme levels in the proband and relatives were compared with that in controls, an autosomal recessive pattern of inheritance was demonstrated. This is the third patient with severe FUra toxicity secondary to an alteration in pyrimidine catabolism and the second from our clinic population suggesting that the frequency of this genetic defect may be greater than previously thought. Monitoring DPD activity may be important in the management of patients experiencing severe toxicity secondary to FUra chemotherapy.

journal_name

Cancer

journal_title

Cancer

authors

Harris BE,Carpenter JT,Diasio RB

doi

10.1002/1097-0142(19910801)68:3<499::aid-cncr28206

subject

Has Abstract

pub_date

1991-08-01 00:00:00

pages

499-501

issue

3

eissn

0008-543X

issn

1097-0142

journal_volume

68

pub_type

杂志文章

相关文献

CANCER文献大全
  • Evaluation of three cervical cancer detection programs in Japan with special reference to cost-benefit analysis.

    abstract::Three screening programs for early cervical cancer currently in use in Japan were evaluated according to the following criteria: (1) economic effectiveness; (2) screening efficiency; and (3) access to medical care. The mobile program has the highest benefit-cost ratio (BCR, 1.20) and is hence most cost-effective; its ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850515)55:10<2514::aid-cncr282

    authors: Takenaga N,Kai I,Ohi G

    更新日期:1985-05-15 00:00:00

  • Costs of cancer along the care continuum: What we can expect based on recent literature.

    abstract:BACKGROUND:Cancer costs should be discussed by patients and providers, but information is not readily available. Results from recently published studies (in the last 5 years) on direct and indirect cancer costs may help guide these discussions. METHODS:The authors reviewed studies published between 2013 and 2017 that ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.31643

    authors: Pisu M,Henrikson NB,Banegas MP,Yabroff KR

    更新日期:2018-11-01 00:00:00

  • Primary reticulum cell sarcoma of testis in a 12-year-old.

    abstract::A 12-year-old boy with primary reticulum cell sarcoma of the testis who is alive and free of tumor 32 months after orchiectomy, radiation therapy to inguinal, iliac and retroperitoneal lymph nodes and chemotherapy is reported. Seven previously documented cases of childhood primary testicular lymphoma are reviewed. The...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197602)37:2<935::aid-cncr2820370

    authors: Weitzner S,Gropp A

    更新日期:1976-02-01 00:00:00

  • Absence of c-KIT and members of the epidermal growth factor receptor family in refractory germ cell cancer.

    abstract:BACKGROUND:Germ cell tumors (GCTs) in adolescent and young males are very sensitive to cisplatin-based chemotherapy. However, 10-20% of the patients cannot be cured by currently available therapeutic options. Once a tumor does not respond to cisplatin, current therapeutic modalities offer only a chance for short pallia...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10671

    authors: Kollmannsberger C,Mayer F,Pressler H,Koch S,Kanz L,Oosterhuis JW,Looijenga LH,Bokemeyer C

    更新日期:2002-07-15 00:00:00

  • Pleuroperitoneal shunting for malignant pleural effusions.

    abstract::Traditional therapy for malignant pleural effusions includes thoracentesis or tube drainage with instillation of irritants to achieve pleurodesis. This can require a lengthy hospitalization, causes pain and discomfort, and has an appreciable failure rate. Because of these drawbacks, the authors used a shunting device ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19861215)58:12<2740::aid-cncr282

    authors: Little AG,Ferguson MK,Golomb HM,Hoffman PC,Vogelzang NJ,Skinner DB

    更新日期:1986-12-15 00:00:00

  • Lymphadenectomy for isolated lymph node metastasis from extremity soft-tissue sarcomas.

    abstract:BACKGROUND:Previous studies have suggested that the prognosis in patients with extremity soft-tissue sarcomas (ESTS) with isolated lymph node (LN) metastases (stage IV) is comparable to that of patients with high-risk ESTS without metastases (stage III). This study was performed to determine the outcomes of patients wh...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23363

    authors: Al-Refaie WB,Andtbacka RH,Ensor J,Pisters PW,Ellis TL,Shrout A,Hunt KK,Cormier JN,Pollock RE,Feig BW

    更新日期:2008-04-15 00:00:00

  • Flow cytometric analysis of nuclear DNA from adrenocortical neoplasms. A retrospective study using paraffin-embedded tissue.

    abstract::Nuclear DNA content of paraffin-embedded tissue from 48 adrenocortical neoplasms, 18 histologically normal control adrenal glands, and five hyperplastic adrenal glands was analyzed retrospectively using flow cytometry. Aneuploidy was compared with morphologic criteria as a predictor of recurrence. All 18 controls, fiv...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870615)59:12<2091::aid-cncr282

    authors: Amberson JB,Vaughan ED Jr,Gray GF,Naus GJ

    更新日期:1987-06-15 00:00:00

  • Clinical outcome of patients with Ewing sarcoma family of tumors of bone in Japan: the Japanese Musculoskeletal Oncology Group cooperative study.

    abstract:BACKGROUND:Ewing sarcoma family of tumors (ESFT) of bone is extremely rare in Japan. The objectives of the current study were to assess the clinical outcome and prognostic factors of patients with ESFT of bone in Japan and to compare them between Euro-American and Japanese populations. METHODS:The authors conducted a ...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.22481

    authors: Obata H,Ueda T,Kawai A,Ishii T,Ozaki T,Abe S,Tanaka K,Tsuchiya H,Matsumine A,Yabe H,Japanese Musculoskeletal Oncology Group.

    更新日期:2007-02-15 00:00:00

  • The treatment of Wilms' tumor: results of the Second National Wilms' Tumor Study.

    abstract::One-hundred-eighty-eight children up to 16 years of age were randomized in the second National Wilms' Tumor Study (NWTS) with tumors that were confined to the kidney and that had been totally excised (Group I). Most fared well whether treated for six or for 15 months with both actinomycin D (AMD) and vincristine (VCR)...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(19810501)47:9<2302::aid-cncr2820

    authors: D'Angio GJ,Evans A,Breslow N,Beckwith B,Bishop H,Farewell V,Goodwin W,Leape L,Palmer N,Sinks L,Sutow W,Tefft M,Wolff J

    更新日期:1981-05-01 00:00:00

  • Socioeconomic status and the risk of cervical intraepithelial neoplasia grade 3 among oncogenic human papillomavirus DNA-positive women with equivocal or mildly abnormal cytology.

    abstract:BACKGROUND:Low socioeconomic status (SES) is a reported risk factor for cervical carcinoma, but few studies have taken into account adequately the possibly confounding effects of oncogenic human papillomavirus (HPV) infection as well as access to screening and subsequent treatment. METHODS:Women (n = 5060 women) with ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21129

    authors: Khan MJ,Partridge EE,Wang SS,Schiffman M

    更新日期:2005-07-01 00:00:00

  • Mixed germ cell-sex cord stroma tumor of the testis. A report with ultrastructural findings.

    abstract::The case of a 41-year-old man with testicular mixed germ cell-sex cord stroma tumor is reported. The patient noticed a gradual, painless, right-sided testicular enlargement 4 years before being treated by radical orchiectomy. The testis contained a centrally located tumor. There was no evidence of metastases. An histo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19891115)64:10<2146::aid-cncr282

    authors: Matoŝka J,Talerman A

    更新日期:1989-11-15 00:00:00

  • Sequential development of peripheral T-cell lymphoma in the course of chronic myelogenous leukemia.

    abstract::A patient is described with chronic myelogenous leukemia (CML) and an unusual karyotype 46XY,t(Y;12) (q11;p12), whose clinical course was complicated by T-cell lymphoma 5 years later. At that time bone marrow cells showed an additional karyotypic abnormality 46XY,t(Y;12) (q11;p12) del(7) (pter-p21), which remained unc...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900915)66:6<1198::aid-cncr2820

    authors: Blonk MC,van der Valk P,Beverstock GC,Ossenkoppele GJ

    更新日期:1990-09-15 00:00:00

  • Basosquamous (transitional cloacogenic) carcinoma of the sigmoid colon.

    abstract::A case of basosquamous or so-called transitional cloacogenic carcinoma of the sigmoid colon, which arose above the pelvic brim at the peritoneal reflection, is reported. We were not able to find a report of this histologic type of tumor arising this far from the pectinate line of the anus, which is the most common pri...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197709)40:3<1234::aid-cncr282040

    authors: Strate RW,Richardson JD,Bannayan GA

    更新日期:1977-09-01 00:00:00

  • Incidence of multiple myeloma in Olmsted County, Minnesota: Trend over 6 decades.

    abstract:BACKGROUND:Previous studies have indicated that the incidence and mortality rates for multiple myeloma have increased in the United States. The authors reported on the incidence of multiple myeloma in Olmsted County, Minnesota, between 1991 and 2001 and on trends in multiple myeloma incidence over the last 56 years. M...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20652

    authors: Kyle RA,Therneau TM,Rajkumar SV,Larson DR,Plevak MF,Melton LJ 3rd

    更新日期:2004-12-01 00:00:00

  • Malignant epithelial tumors in the minor salivary glands, the submandibular gland, and the sublingual gland. Prognostic factors and treatment results.

    abstract::Ninety-five malignant tumors in the submandibular gland, the sublingual gland, and the minor salivary glands seen in a 25-year period were reviewed. The patients were retrospectively staged using the Union Internationale Contre le Cancer (UICC) classification. The most frequent tumor was adenoid cystic carcinoma, foll...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19911201)68:11<2431::aid-cncr282

    authors: Andersen LJ,Therkildsen MH,Ockelmann HH,Bentzen JD,Schiødt T,Hansen HS

    更新日期:1991-12-01 00:00:00

  • Phase I dose and sequencing study of pegylated liposomal doxorubicin and docetaxel in patients with advanced malignancies.

    abstract:BACKGROUND:Pegylated liposomal doxorubicin (PEG-LD) and docetaxel have single-agent activity in several malignancies. The authors conducted a Phase I trial to evaluate the maximum tolerated dose (MTD), toxicities, and effect of dose sequencing of this combination in patients with advanced malignancies. METHODS:Twenty-...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/cncr.11547

    authors: Fracasso PM,Rodriguez LC,Herzog TJ,Fears CL,Goodner SA,Govindan R,Picus J,Rader JS,Tan BR,Arquette MA

    更新日期:2003-08-01 00:00:00

  • Biliary cystadenocarcinoma: Case report of hepatic malignancy originating in benign cystadenoma.

    abstract::A case of biliary cystadenoma undergoing malignant dedifferentiation is presented. Biliary cystadenocarcinoma is an infrequently occurring neoplasm; fewer than 20 cases have been reported in the literature. This case is the first in which there is documentation of cystadenocarcinoma arising from a previously diagnosed...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810615)47:12<2936::aid-cncr282

    authors: Woods GL

    更新日期:1981-06-15 00:00:00

  • Acute myelomonocytic leukemia associated with paraproteinemia.

    abstract::A 49-year-old white woman with refractory anemia subsequently developed acute myelomonocytic leukemia with paraproteinemia 12 months later. The paraprotein was characterized as immunoglobulin G, type kappa, and the Bence Jones protein as free kappa chains. Further studies, including electron microscopy, cytochemistry,...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197603)37:3<1359::aid-cncr282037

    authors: Law IP,Koch FJ,Cannon GB,Herberman RB,Oldham RK

    更新日期:1976-03-01 00:00:00

  • The radiographic diagnosis and treatment of paraneoplastic central nervous system disease.

    abstract::Paraneoplastic nervous system syndromes are being identified with increasing frequency because of greater physician awareness and the availability of serodiagnostic tests for some syndromes. Frequently, paraneoplastic syndromes develop in the setting of an indolent, limited stage, or otherwise occult malignancy. As a ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19940101)73:1<168::aid-cncr28207

    authors: Glantz MJ,Biran H,Myers ME,Gockerman JP,Friedberg MH

    更新日期:1994-01-01 00:00:00

  • Neuroendocrine tumors of the sinonasal tract. Results of a prospective study incorporating chemotherapy, surgery, and combined proton-photon radiotherapy.

    abstract:BACKGROUND:The authors report the results of a prospective study of patients with malignant neuroendocrine tumors of the sinonasal tract who received multimodality treatment incorporating high-dose proton-photon radiotherapy. METHODS:Nineteen patients with olfactory neuroblastoma (ONB) or neuroendocrine carcinoma (NEC...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10537

    authors: Fitzek MM,Thornton AF,Varvares M,Ancukiewicz M,Mcintyre J,Adams J,Rosenthal S,Joseph M,Amrein P

    更新日期:2002-05-15 00:00:00

  • Transgenic mice as models of hemopoiesis.

    abstract::A useful approach to establishing the biologic actions, in vivo, of granulocyte-macrophage colony-stimulating factor (GM-CSF) is to assess the consequences of long-term elevation of the factor in transgenic mice. Two lines of transgenic GM-CSF mice were analyzed. The major abnormality exhibited was an elevation in the...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910515)67:10+<2695::aid-cncr28

    authors: Metcalf D

    更新日期:1991-05-15 00:00:00

  • A prospective pilot study to evaluate a new dental assessment and treatment paradigm for patients scheduled to undergo intensive chemotherapy for cancer.

    abstract:BACKGROUND:Patients scheduled to receive chemotherapy frequently undergo pretherapy dental treatment to eliminate potential sources of odontogenic infection. A prospective study was conducted to assess a new protocol emphasizing minimal pretherapy dental treatment. METHODS:Forty-eight consecutive patients diagnosed wi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Toljanic JA,Bedard JF,Larson RA,Fox JP

    更新日期:1999-04-15 00:00:00

  • Public education projects in skin cancer. The evolution of skin cancer prevention education for children at a comprehensive cancer center.

    abstract:BACKGROUND:Skin cancer affects more Americans than any other type of cancer. Children are prime targets for prevention education, because sun overexposure in early childhood may affect the development of skin cancer later in life. Preventive behaviors adopted early in life may be less resistant to change than those acq...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(19950115)75:2+<651::aid-cncr2820

    authors: Loescher LJ,Buller MK,Buller DB,Emerson J,Taylor AM

    更新日期:1995-01-15 00:00:00

  • Multiple myeloma associated with immune thrombocytopenic purpura.

    abstract::Thrombocytopenia in patients with multiple myeloma is usually due to chemotherapy or marrow replacement with myeloma cells. Two patients with multiple myeloma who fulfilled criteria for the diagnosis of immune thrombocytopenic purpura are presented. The etiologic and therapeutic implications of this unusual associatio...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850901)56:5<1199::aid-cncr2820

    authors: Verdirame JD,Feagler JR,Commers JR

    更新日期:1985-09-01 00:00:00

  • Malignant metastatic disease of the eye: management of an uncommon complication.

    abstract::Twenty-four patients with metastatic cancer of the choroid were seen in the Department of Therapeutic Radiology, Rush-Presbyterian--St. Luke's Medical Center, Chicago, between 1964 and 1975. One fourth of the patients had involvement in both eyes, for a total of 30 eyes involved with metastatic cancer. The most common...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Reddy S,Saxena VS,Hendrickson F,Deutsch W

    更新日期:1981-02-15 00:00:00

  • Gender and other survival predictors in patients with metastatic melanoma on Southwest Oncology Group trials.

    abstract:BACKGROUND:Some studies have suggested that women with metastatic malignant melanoma have a better survival rate than men. However, little is known about the effect of gender on survival in combination with other clinical variables and treatment variables. Thus, an analysis of 813 eligible patients from 15 consecutive ...

    journal_title:Cancer

    pub_type: 杂志文章,meta分析,多中心研究

    doi:10.1002/1097-0142(20010315)91:6<1148::aid-cncr1111

    authors: Unger JM,Flaherty LE,Liu PY,Albain KS,Sondak VK

    更新日期:2001-03-15 00:00:00

  • What do transplant physicians think about palliative care? A national survey study.

    abstract:BACKGROUND:Despite its established benefits, palliative care (PC) is rarely utilized for hematopoietic stem cell transplant (HSCT) patients. We sought to examine transplant physicians' perceptions of PC. METHODS:We conducted a cross-sectional survey of transplant physicians recruited from the American-Society-for-Bloo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31709

    authors: El-Jawahri A,LeBlanc TW,Burns LJ,Denzen E,Meyer C,Mau LW,Roeland EJ,Wood WA,Petersdorf E

    更新日期:2018-12-01 00:00:00

  • A descriptive study of BRCA1 testing and reactions to disclosure of test results.

    abstract:BACKGROUND:The identification of the BRCA1 gene is a powerful tool for predicting a patient's lifetime risk for carcinoma of the breast and ovary when she has hereditary breast/ovarian carcinoma (HBOC) syndrome. The process of BRCA1 testing and genetic counseling and participants' reactions to test results, are describ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19970601)79:11<2219::aid-c

    authors: Lynch HT,Lemon SJ,Durham C,Tinley ST,Connolly C,Lynch JF,Surdam J,Orinion E,Slominski-Caster S,Watson P,Lerman C,Tonin P,Lenoir G,Serova O,Narod S

    更新日期:1997-06-01 00:00:00

  • The dynamics of prostate specific antigen during watchful waiting of prostate carcinoma: a study of 94 Japanese men.

    abstract:BACKGROUND:For the moment, there is uncertainty about the usefulness of early treatment of localized prostate carcinoma, uncertainty about whether some patients with early cancer can be managed expectantly, and uncertainty about how such patients might be recognized. METHODS:The authors studied serial values of prosta...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10443

    authors: Vollmer RT,Egawa S,Kuwao S,Baba S

    更新日期:2002-03-15 00:00:00

  • Clear cell carcinoma has an expression pattern of cell cycle regulatory molecules that is unique among ovarian adenocarcinomas.

    abstract:BACKGROUND:The purpose of this study was to identify biologic differences between ovarian clear cell carcinoma and other ovarian adenocarcinomas by comparing the expression of cell cycle regulatory molecules and by analyzing the survival of the patients. METHODS:In 51 cases of epithelial ovarian carcinoma, the express...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19990201)85:3<669::aid-cnc

    authors: Shimizu M,Nikaido T,Toki T,Shiozawa T,Fujii S

    更新日期:1999-02-01 00:00:00