Combination therapy of intraarterial 5-fluorouracil and systemic interferon-alpha for advanced hepatocellular carcinoma with portal venous invasion.

abstract：BACKGROUND:The effect of adjuvant chemotherapy after resection of nonsmall cell lung cancer (NSCLC) remains an unresolved question. METHODS:From October, 1982, to November, 1986, 267 patients with resected NSCLC were included in a randomized trial. The adjuvant allocated treatments were either postoperative radiothera...

journal_title：Cancer

authors： Dautzenberg B,Chastang C,Arriagada R,Le Chevalier T,Belpomme D,Hurdebourcq M,Lebeau B,Fabre C,Charvolin P,Guérin RA

更新日期：1995-09-01 00:00:00

abstract：:Rational treatment of pediatric malignancies requires a detailed knowledge of the clinical pharmacology of those antineoplastic agents used therapeutically. A number of different agents are administered by the oral route. Recently, the clinical pharmacology of 6-mercaptopurine (6-MP) and methotrexate (MTX), the two ag...

journal_title：Cancer

authors： Poplack DG,Balis FM,Zimm S

更新日期：1986-07-15 00:00:00

abstract：:A case of an extramedullary intrathoracic plasmacytoma causing superior vena cava syndrome is described. Review of the literature on intrathoracic plasmacytomas and superior vena cava syndrome revealed that no similar cases have been described to date. The initial presentation, management, and response to treatment ar...

journal_title：Cancer

authors： Davis SR,King HS,Le Roux I,Bolding E

更新日期：1991-09-15 00:00:00

abstract：:A leukocyte migration procedure was utilized to test cellular hypersensitivity of breast cancer patients' leukocytes to autologous and homologous breast cancer tissues and to murine milk containing murine mammary tumor virus (MuMTV). The in vitro responsiveness of the leukocytes and the antigenicity of breast cancer t...

journal_title：Cancer

authors： Black MM,Zachrau RE,Shore B,Moore DH,Leis HP Jr

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:Lobular neoplasia (LN), also known as lobular carcinoma in situ, is an incidental histologic finding in tissue removed at breast surgery. Patients with LN are known to be predisposed to develop invasive or intraductal carcinoma (CA). This study investigates factors that influence the cancer risk in LN patien...

journal_title：Cancer

authors： Bodian CA,Perzin KH,Lattes R

更新日期：1996-09-01 00:00:00

abstract：:Malignant lymphomas with multilobated nuclei are rare, recently recognized neoplasms of the immune system initially thought to be of T-cell type. Reported is a case of large cell lymphoma with multilobated nuclei in which immunologic marker studies demonstrated that the neoplastic cells had characteristics of B-lympho...

journal_title：Cancer

authors： Parfrey NA,Mann RB,Selonick SE,Beschorner WE

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND:The association of increasing radiotherapy (RT) dose with reduced biochemical failure (BF) is accepted widely. However, there is little direct evidence that dose escalation has an impact on distant metastasis (DM) or overall mortality (OM). These associations were examined in the current study. METHODS:The ...

journal_title：Cancer

authors： Jacob R,Hanlon AL,Horwitz EM,Movsas B,Uzzo RG,Pollack A

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Infection with oncogenic-type human papillomavirus (HPV) and consecutive cytologic abnormalities of the uterine cervix precede the evolution of carcinoma. However, the specificity of both changes is too low to predict the true malignant potential of the change in a given time point, because the majority of t...

journal_title：Cancer

authors： Bollmann R,Méhes G,Speich N,Schmitt C,Bollmann M

更新日期：2005-04-25 00:00:00

abstract：:The following case report describes a 22-year-old healthy man, non-smoker, non-drinker, who developed a squamous cell carcinoma of the buccal mucosa. The appearance of this unusual tumor in an unexpected clinical setting was unexplained until it was discovered that the patient had a lifetime habit of chewing plastic m...

journal_title：Cancer

authors： Casterline CL,Casterline PF,Jaques DA

更新日期：1977-04-01 00:00:00

abstract：:The purpose of this study was to determine whether the presence of more than 5% blasts in a differential count of cytocentrifuged cerebrospinal fluid (CSF) with less than 6 leukocytes/microliter was predictive of central nervous system (CNS) relapse in children with acute lymphoblastic leukemia (ALL). A double concent...

journal_title：Cancer

authors： Odom LF,Wilson H,Cullen J,Bank J,Blake M,Jamieson B

更新日期：1990-10-15 00:00:00

abstract：BACKGROUND:Programmed death 1 (PD-1) signaling in the tumor microenvironment dampens immune responses to cancer, and blocking this axis induces antitumor effects in several malignancies. Clinical studies of PD-1 blockade are only now being initiated in pediatric patients, and little is known regarding programmed death-...

journal_title：Cancer

authors： Majzner RG,Simon JS,Grosso JF,Martinez D,Pawel BR,Santi M,Merchant MS,Geoerger B,Hezam I,Marty V,Vielh P,Daugaard M,Sorensen PH,Mackall CL,Maris JM

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Current salvage therapy for recurrent high-risk neuroblastoma is rarely curative. Assessment of the effectiveness of new, primarily cytostatic agents requires the redefinition of study endpoints to reflect disease stabilization rather than tumor response or regression. The intervals of disease control in the...

journal_title：Cancer

authors： Santana VM,Furman WL,McGregor LM,Billups CA

更新日期：2008-06-15 00:00:00

abstract：BACKGROUND:Insulin receptor (IR), a member of the receptor tyrosine kinase family, is expressed in normal thyroid cells and affects thyroid cell proliferation and differentiation. METHODS:The authors measured IR content in benign and malignant thyroid tumors by three independent methods: a specific radioimmunoassay, 1...

journal_title：Cancer

authors： Frittitta L,Sciacca L,Catalfamo R,Ippolito A,Gangemi P,Pezzino V,Filetti S,Vigneri R

更新日期：1999-01-15 00:00:00

abstract：:Between January 1988 and June 1990, seven previously untreated patients with histologically confirmed and clinically staged IIIa invasive thymoma (IT) were enrolled in a prospective, single treatment arm study of neoadjuvant chemotherapy (NC) followed by surgery and postoperative radiation therapy (4600 to 6000 cGy). ...

journal_title：Cancer

authors： Macchiarini P,Chella A,Ducci F,Rossi B,Testi C,Bevilacqua G,Angeletti CA

更新日期：1991-08-15 00:00:00

abstract：BACKGROUND:: Invasive aspergillosis (IA) is a common complication in patients with hematologic malignancies. Patients with solid tumors also are at risk for IA because they may develop neutropenia as a result of chemotherapy and radiotherapy. However, studies of IA in patients with solid tumors are rare. In this study,...

journal_title：Cancer

authors： Yan X,Li M,Jiang M,Zou LQ,Luo F,Jiang Y

更新日期：2009-11-01 00:00:00

abstract：:POEMS syndrome is a rare multisystem affliction known for its signs, from which it also takes its acronym name "peripheral neuropathy, organomegaly, endocrinopathy, monoclonal (M) protein, and skin lesions." Our study chronicles the course of this syndrome in a young woman with Castleman's disease (angiofollicular lym...

journal_title：Cancer

authors： Mandler RN,Kerrigan DP,Smart J,Kuis W,Villiger P,Lotz M

更新日期：1992-06-01 00:00:00

abstract：:Fifty-eight patients with Dukes' C classification of carcinoma of the large bowel were placed on adjuvant immuno- or chemoimmunotherapy with Bacillus calmette guerin (BCG) or combination of 5-fluorouracil (5-FU) plus BCG following primary and definitive surgery, and were followed for up to 21 months. Of twenty-six pat...

journal_title：Cancer

authors： Mavligit GM,Gutterman JU,Burgess MA,Khankhanian N,Seibert GB,Speer JF,Reed RC,Jubert AV,Martin RC,McBride CM,Copeland EM,Gehan EA,Hersh EM

更新日期：1975-12-01 00:00:00

abstract：:A tumor colony assay (TCA) was evaluated for its ability to predict anticancer drug responses in an N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT)-induced murine bladder tumor (MBT) model. Ten anticancer drugs were evaluated in vivo and in vitro using four MBT cell lines (40 drug responses). Using the optimum c...

journal_title：Cancer

authors： Niell HB,Soloway MS,Wood CA,McCallum LW,Webster K

更新日期：1983-08-15 00:00:00

abstract：BACKGROUND:Local recurrence is the most frequent site of failure after resection for pancreatic cancer. Tolerance, local control, and survival obtained by the association of resection and intraoperative radiation therapy (IORT) were reported. METHODS:Between June 1985 and March 1993, 90 resections for pancreatic cance...

journal_title：Cancer

authors： Zerbi A,Fossati V,Parolini D,Carlucci M,Balzano G,Bordogna G,Staudacher C,Di Carlo V

更新日期：1994-06-15 00:00:00

abstract：:A comprehensive immunologic and serologic analysis was performed on 31 untreated patients with Hodgkin's disease. Immune evaluations stressed T-cell functional activity and included traditional parameters (PHA responsiveness and delayed hypersensitivity skin reactivity), as well as newer functional assays (T-cell colo...

journal_title：Cancer

authors： Schulof RS,Bockman RS,Garofalo JA,Cirrincione C,Cunningham-Rundles S,Fernandes G,Day NK,Pinsky CM,Incefy GS,Thaler HT,Good RA,Gupta S

更新日期：1981-08-15 00:00:00

abstract：:The authors describe the results of multimodality therapy in 27 patients with biopsy-proven primary central nervous system (CNS) lymphoma treated between 1976 and 1986. Treatment included surgical resection (15 patients), radiotherapy (27 patients), and chemotherapy (nine patients). Actuarial survival rates for the 27...

journal_title：Cancer

authors： Pollack IF,Lunsford LD,Flickinger JC,Dameshek HL

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:This study was undertaken to determine whether the use of intermediate dose methotrexate in combination with vinblastine, doxorubicin, and cisplatin as first-line therapy increases the proportion of major responders and overall survival in patients with unresectable or metastatic transitional cell carcinoma ...

journal_title：Cancer

authors： Dodd PM,McCaffrey JA,Mazumdar M,Scher H,Vlamis V,Higgins G,Herr H,Bajorin DF

更新日期：1999-03-01 00:00:00

abstract：:In a clinical trial, 42 patients with abdominal Burkitt's lymphoma (BL) were treated with a combination regimen, code-named CVA, consisting of cyclophosphamide (CTX), vincristine, and cystosine arabinoside. In addition, intrathecal methotrexate (i.t. MTX) was administered as prophylaxis against subsequent central nerv...

journal_title：Cancer

authors： Nkrumah FK,Perkins IV,Biggar RJ

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND:The purpose of this project was to develop the M. D. Anderson Symptom Inventory (MDASI), a brief measure of the severity and impact of cancer-related symptoms. METHODS:A list of symptoms was generated from symptom inventories and by panels of clinicians. Twenty-six symptoms and 6 interference items were rat...

journal_title：Cancer

authors： Cleeland CS,Mendoza TR,Wang XS,Chou C,Harle MT,Morrissey M,Engstrom MC

更新日期：2000-10-01 00:00:00

abstract：:Bone marrow trephine biopsies were performed on 107 previously untreated patients with Hodgkin's disease (HD). Fifteen patients (14%) exhibited bone marrow involvement. These consisted of two of three patients (67%) with lymphocyte depletion, six of 27 patients (22%) with mixed cellularity, five of 64 patients (8%) wi...

journal_title：Cancer

authors： O'Carroll DI,McKenna RW,Brunning RD

更新日期：1976-10-01 00:00:00

abstract：:Eighteen patients with unresectable ductal adenocarcinoma of the pancreas received definitive, high-dose, small-volume radiation therapy. All patients had at least one laparotomy, at which time a biopsy was obtained, radio-opaque clips were placed to define the extent of the gross tumor, and usually some form of bypas...

journal_title：Cancer

authors： Dobelbower RR Jr,Borgelt BB,Suntharalingam N,Strubler KA

更新日期：1978-03-01 00:00:00

abstract：:Poor drug compliance may cause a decreased survival of children with malignancies. Children who fail to take their medications are not receiving optimum amounts of chemotherapy and suboptimal therapy causes a shortened survival in children with cancer. This is a study of prednisone compliance in 52 children with cance...

journal_title：Cancer

authors： Smith SD,Rosen D,Trueworthy RC,Lowman JT

更新日期：1979-01-01 00:00:00

abstract：:The authors report an analysis of 47 leukemia patients (including 9 from our own medical center) whose courses were complicated by 48 episodes of clostridial septicemia. There were 36 adults and 11 children; acute myelogenous leukemia and acute lymphoblastic leukemia accounted for 61.7% and 14.9% of cases, respectivel...

journal_title：Cancer

authors： Caya JG,Farmer SG,Ritch PS,Wollenberg NJ,Tieu TM,Oechler HW,Spivey M

更新日期：1986-05-15 00:00:00

abstract：:In order to determine if there are morphologically identifiable characteristics between malignant cells obtained from a primary cancer and its metastasis the nuclear diameter was used as an indicator of the degree of malignancy, since there is good correlation between nuclear size, DNA content, and chromosome numbers....

journal_title：Cancer

authors： Zajdela A,Asselain B,Ghossein NA

更新日期：1985-10-01 00:00:00

abstract：:The use of molecular techniques in cytopathology has become an accepted and billable practice for certain applications. Other applications still are in the developmental or experimental stages but may soon be clinically useful. The current study provides a review of these techniques including molecular detection of cl...

journal_title：Cancer

authors： Rimm DL

更新日期：2000-02-25 00:00:00