Abstract:
BACKGROUND:The purpose of this project was to develop the M. D. Anderson Symptom Inventory (MDASI), a brief measure of the severity and impact of cancer-related symptoms. METHODS:A list of symptoms was generated from symptom inventories and by panels of clinicians. Twenty-six symptoms and 6 interference items were rated by a validation sample of 527 outpatients, a sample of 30 inpatients from the blood and bone marrow transplantation service, and a cross-validation sample of 113 outpatients. Clinical judgment and statistical techniques were used to reduce the number of symptoms. Reliability, validity, and sensitivity of the MDASI were examined. RESULTS:Cluster analysis, best subset analysis, and clinical judgment reduced the number of symptoms to a "core" list of 13 that accounted for 64% of the variance in symptom distress. Factor analysis demonstrated a similar pattern in both outpatient samples, and two symptom factors and the interference scale were reliable. Expected differences in symptom pattern and severity were found between patients with "good" versus "poor" performance status and between patients in active therapy and patients who were seen for follow-up. Patients rated fatigue-related symptoms as the most severe. Groups of patients classified by disease or treatment had severe symptoms that were not on the "core" list. CONCLUSIONS:The core items of the MDASI accounted for the majority of symptom distress reported by cancer patients in active treatment and those who were followed after treatment. The MDASI should prove useful for symptom surveys, clinical trials, and patient monitoring, and its format should allow Internet or telephone administration.
journal_name
Cancerjournal_title
Cancerauthors
Cleeland CS,Mendoza TR,Wang XS,Chou C,Harle MT,Morrissey M,Engstrom MCdoi
10.1002/1097-0142(20001001)89:7<1634::aid-cncr29>3subject
Has Abstractpub_date
2000-10-01 00:00:00pages
1634-46issue
7eissn
0008-543Xissn
1097-0142pii
10.1002/1097-0142(20001001)89:7<1634::AID-CNCR29>3journal_volume
89pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Epidermal growth factor (EGF) and EGF-regulated processes play an important role in steroid signal transduction. Comparative analysis of EGF and steroid receptor expression and the sensitivity of early stages of proliferation induction, such as activation of phospholipid turnover to EGF and steroids, may pro...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19951215)76:12<2524::aid-cncr282
更新日期:1995-12-15 00:00:00
abstract:BACKGROUND:Population-based studies suggest that, because of inequalities in treatment, black women with localized endometrial cancer have shorter survival compared with white women. The objective of the current investigation was to determine whether there is a racial disparity in outcome between black patients and whi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23717
更新日期:2008-09-15 00:00:00
abstract::A young woman with a very extensive intramedullary hemangioblastoma of the spinal cord was treated with a moderately high dose of irradiation after biopsy only of the tumor. Now, five years following treatment, there have been no radiation sequelae and no evidence of progressive disease. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800101)45:1<49::aid-cncr282045
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:The objectives of this study were to investigate outcome prediction by measuring absolute tumor volume and regression ratios using serial magnetic resonance imaging (MRI) during radiation therapy (RT) for cervical cancer and to develop algorithms capable of identifying patients at risk of a poor therapeutic ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25260
更新日期:2010-11-01 00:00:00
abstract::Forty-one previously untreated patients with a diagnosis of acute myelogenous leukemia (AML) were entered on a study using early intensification followed by a short-term maintenance chemotherapy. Induction and early intensification consisted of three to four cycles of doxorubicin, vincristine, cytosine arabinoside (Ar...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861015)58:8<1603::aid-cncr2820
更新日期:1986-10-15 00:00:00
abstract:BACKGROUND:In this study, the authors evaluated the clinical presentation of patients with T4b breast carcinoma, analyzed the impact of noninflammatory skin involvement on long-term survival, and addressed the question whether the T4 tumor category still has any justification. METHODS:The clinical course of a study gr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21394
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:Extragonadal germ cell tumors (EGGCT) are uncommon, occur primarily in the mediastinum and retroperitoneum, and have been noted to have variable response rates to cisplatin-based chemotherapy regimens. METHODS:The Southwest Oncology Group (SWOG) has completed a prospective trial of combination chemotherapy ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19930415)71:8<2631::aid-cncr2820
更新日期:1993-04-15 00:00:00
abstract:BACKGROUND:To retrospectively evaluate the significance of morphologic examination and ancillary studies performed on bilateral bone marrow biopsy specimens, 1864 bone marrow samples were studied. METHODS:Bilateral bone marrow biopsy specimens included 883 specimens that were evaluated for involvement by non-Hodgkin l...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10364
更新日期:2002-03-01 00:00:00
abstract::Seventeen patients with carcinoma confined to the pancreas and the peripancreatic area received preoperative radiation therapy in an attempt to increase the resectability rate and to reduce the incidence of recurrence. The tumors were considered either unresectable or of borderline resectability. The radiation dose ra...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801101)46:9<1945::aid-cncr2820
更新日期:1980-11-01 00:00:00
abstract::Various attempts have been made to improve the effectiveness of radiation in the treatment of cerebral malignant astrocytomas. A trend favoring multiple daily fractionated (MDF) radiation therapy over conventional single daily fractionated (CF) radiation therapy was identified in our previous study. In order to assess...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19850815)56:4<758::aid-cncr28205
更新日期:1985-08-15 00:00:00
abstract::A lifetime history of analgesics and tobacco consumption was obtained by a questionnaire completed at interview from 67 patients with carcinoma of the renal pelvis (40 women, 27 men) and 180 control subjects drawn from two sources, friends of patients and persons attending a health screening clinic. Regular consumptio...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820615)49:12<2617::aid-cncr282
更新日期:1982-06-15 00:00:00
abstract:BACKGROUND:The role of adjuvant therapy in the management of patients with malignant mixed Müllerian tumors (MMMT) of the uterus has not been defined. The outcome of planned multimodality therapy for patients with apparent early stage disease was assessed. METHODS:A pilot study was performed on 38 patients with clinic...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:2001-04-15 00:00:00
abstract::This article reviews the clinicopathologic features and the biological behavior of 24 cases of synovial sarcoma that took origin from the cervical prevertebral connective tissue space and manifested as a retropharyngeal tumor or as a palpable mass in the anterior or posterior cervical triangle. The age of the 24 patie...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197504)35:4<1243::aid-cncr282035
更新日期:1975-04-01 00:00:00
abstract::The antitumor effect of human leukocyte interferon was investigated on ten patients with malignant brain tumor. In eight cases of primary tumor, IFN alone was administered when their recurrent sign was evident. A dose of 3 X 10(6) IU or 1 X 10(6) IU of IFN was injected intramuscularly two or three times a week in high...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830601)51:11<1976::aid-cncr282
更新日期:1983-06-01 00:00:00
abstract::The histologic features of a malignant clear cell acrospiroma were those of infiltrative local growth, frequent mitoses and angiolymphatic invasion. The histochemical and ultrastructural findings were similar to those reported for benign clear cell acrospriomas. Amputation of the leg and regional node dissection were ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197802)41:2<641::aid-cncr2820410
更新日期:1978-02-01 00:00:00
abstract::Cutaneous atypical fibroxanthoma (AFX) occurs in elderly persons as a small nodule or ulcernodule in actinically damaged skin of the head and neck area. The vast majority of AFX behave in a benign manner, and metastasis is rare. Eight examples of metastasizing AFX are reported. Factors that portend aggressive behavior...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860115)57:2<368::aid-cncr28205
更新日期:1986-01-15 00:00:00
abstract::One hundred fifteen patients underwent surgical treatment of renal cell carcinoma. Survival time was analyzed by statistical regression methods in order to determine the joint significance of stage, using both the Robson and TNM classifications, histologic grade, cell type, and demographic features of the patient samp...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830901)52:5<899::aid-cncr28205
更新日期:1983-09-01 00:00:00
abstract::If radical surgery is the only rational policy for most cases of rectal cancer, the problem of local treatment in poor surgical risk patients should be discussed in selected cases. Only limited, fairly-well-differentiated tumors, still confined to the rectal wall may have a sufficiently low probability of lymphatic sp...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197508)36:2+<696::aid-cncr282036
更新日期:1975-08-01 00:00:00
abstract::Head and neck cancer (H&N CA) patients have known depression of cell-mediated immunity. There is suggestive evidence that prostaglandin (PGE2)-secreting cells may be a major factor. The authors have sought to determine the role of PGE2-releasing monocytes-macrophages in this immune depression by determining the effect...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880201)61:3<462::aid-cncr28206
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND:The prognosis of patients with clinically staged hilar nodal involvement (Stage N1) or clinical Stage II non-small cell lung cancer (NSCLC, Stage T1-2N1M0) treated with radiation therapy (RT) alone is not well established. METHODS:Records of 758 patients with clinical Stage I-III NSCLC treated with RT were ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921115)70:10<2410::aid-cncr282
更新日期:1992-11-15 00:00:00
abstract::A routine admission chest radiograph (CXR) in pediatric patients with cancer who are admitted to the hospital for fever and neutropenia has been advised because the signs and symptoms of pneumonia may be absent. The authors studied 131 consecutive patient admissions for fever and neutropenia to evaluate the diagnostic...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19910901)68:5<940::aid-cncr28206
更新日期:1991-09-01 00:00:00
abstract::A case report is presented, believed to be the first documented example of pleomorphic rhabdomyosarcoma developing in the larynx of a child. A review of the literature then follows, with evaluation of the epidemiology, treatment options, and survival of patients with this disease. Cure of this malignancy is more likel...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870301)59:5<1012::aid-cncr2820
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND:Cetuximab in combination with docetaxel was examined in chemotherapy-refractory/resistant patients with advanced nonsmall-cell lung cancer (NSCLC) to determine response rate, survival, safety, and pharmacokinetics (PK). METHODS:Patients had evidence of epidermal growth factor receptor (EGFR) expression (> o...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.24148
更新日期:2009-04-15 00:00:00
abstract::Eighteen patients with isolated vaginal recurrence of their previously treated endometrial carcinoma were treated with radiation therapy at North Carolina Baptist Hospital, Winston-Salem between 1971 and 1982. Most patients received external beam irradiation which were followed by boost treatments that were delivered ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870801)60:3<419::aid-cncr28206
更新日期:1987-08-01 00:00:00
abstract:BACKGROUND:A phase II prospective trial was carried out to study the concept of 5-fluorouracil (5-FU) dose-intensity in patients with advanced colorectal cancer. Forty patients were treated with 5-FU plus leucovorin (LV), with individually increasing doses of 5-FU. A 5-FU pharmacokinetic follow up was performed and a r...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(SICI)1097-0142(19960201)77:3<441::AID-CNC
更新日期:1996-02-01 00:00:00
abstract::The case of a European patient with a malignant lymphoepithelial lesion of epithelial type is presented. This type of tumor has an exceptionally high incidence among Eskimos. To the authors' knowledge this is the first case reported with an ultrastructural study that demonstrates the squamous nature of the tumor cells...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810715)48:2<289::aid-cncr28204
更新日期:1981-07-15 00:00:00
abstract::Twenty-three adult patients (ages greater than 15 years) and 75 children with acute lymphoblastic leukemia were treated with similar intensive, sequential cytotoxic protocols (L-2). The adult patients have lower remission rate (78%) than the children (98%). The duration of remission and the length of survival are also...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197603)37:3<1256::aid-cncr282037
更新日期:1976-03-01 00:00:00
abstract::A total of 289 cases with malignant pleuroperitoneal effusions were reviewed, and their prognosis were analyzed in relation to the following factors: (1) chronologically divided series; (2) previous tumorectomy of the primary lesion; (3) presence or absence of other metastases; (4) site of effusion; (5) site of the pr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830101)51:1<136::aid-cncr28205
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:The recommended phase 2 dose (RP2D) of anticancer agents is determined traditionally by dose-limiting toxicities. Nontoxicity or biological endpoints such as pharmacokinetics, pharmacodynamics, and efficacy can also be used to identify RP2D, which may be relevant to molecularly targeted agents (MTAs). METHO...
journal_title:Cancer
pub_type: 杂志文章,meta分析
doi:10.1002/cncr.30579
更新日期:2017-04-15 00:00:00
abstract:BACKGROUND:Insulin receptor (IR), a member of the receptor tyrosine kinase family, is expressed in normal thyroid cells and affects thyroid cell proliferation and differentiation. METHODS:The authors measured IR content in benign and malignant thyroid tumors by three independent methods: a specific radioimmunoassay, 1...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990115)85:2<492::aid-cnc
更新日期:1999-01-15 00:00:00