Disposition of high-dose methotrexate in an obese cancer patient.

abstract：BACKGROUND:Fine-needle aspiration biopsy (FNAB) has been used with variable success as a diagnostic test for benign and malignant breast lesions. The goal of this study was to examine the effects of training physicians in the fine-needle aspiration sampling-technique on the diagnostic accuracy of FNAB of palpable breas...

journal_title：Cancer

authors： Ljung BM,Drejet A,Chiampi N,Jeffrey J,Goodson WH 3rd,Chew K,Moore DH 2nd,Miller TR

更新日期：2001-08-25 00:00:00

abstract：:Seventeen patients with carcinoma confined to the pancreas and the peripancreatic area received preoperative radiation therapy in an attempt to increase the resectability rate and to reduce the incidence of recurrence. The tumors were considered either unresectable or of borderline resectability. The radiation dose ra...

journal_title：Cancer

authors： Pilepich MV,Miller HH

更新日期：1980-11-01 00:00:00

abstract：BACKGROUND:Granulocyte-macrophage-colony stimulating factor (GM-CSF) administration stimulates the proliferation of hemopoietic progenitors. Shortly (48-96 hours) after its discontinuation, feedback phenomena occur and the progenitor proliferation rate drops below baseline levels. As the quiescence of hyperplastic bone...

journal_title：Cancer

authors： Aglietta M,Montemurro F,Fagioli F,Volta C,Botto B,Cantonetti M,Racanelli V,Teofili L,Ferrara R,Amadori S,Castoldi GL,Dammacco F,Levis A

更新日期：2000-01-15 00:00:00

abstract：BACKGROUND:A positive influence of anticoagulant treatment in small cell lung cancer (SCLC) has been suggested by experimental and clinical data. METHODS:In a multicenter clinical trial, 277 patients with SCLC were randomized either to receive or not to receive subcutaneous heparin injections for 5 weeks at effective ...

journal_title：Cancer

authors： Lebeau B,Chastang C,Brechot JM,Capron F,Dautzenberg B,Delaisements C,Mornet M,Brun J,Hurdebourcq JP,Lemarie E

更新日期：1994-07-01 00:00:00

abstract：:The combination of conservation surgery and radiation therapy for early breast cancer is gaining acceptance as an alternative to radical mastectomy. This article reviews the results of randomized trials showing that there is no advantage to a radical mastectomy in patients with early breast cancer. In addition, the ar...

journal_title：Cancer

authors： Montague ED,Ames FC,Schell SR,Romsdahl MM

更新日期：1984-12-01 00:00:00

abstract：:The poor postsurgical prognosis in patients with colorectal cancer of the Dukes' C classification has prompted a clinical trial of adjuvant immunotherapy versus chemoimmunotherapy intended to prolong either the disease-free interval or the overall survival or both. One hundred and twenty-one patients have been entered...

journal_title：Cancer

authors： Mavligit GM,Gutterman JU,Malahy MA,Burgess MA,McBride CM,Jubert A,Hersh EM

更新日期：1977-11-01 00:00:00

abstract：:Amyloid as defined by positive Congo red green birefringence and STB red birefringence was observed in the stroma of a tubular carcinoma of minor salivary gland origin. The amyloid exhibited additional histochemical characteristics of immunamyloid, viz., positive DMAB-nitrate and DC-reactions and spontaneous autofluor...

journal_title：Cancer

authors： David R,Buchner A

更新日期：1978-05-01 00:00:00

abstract：:Thirty-eight patients with metastatic colorecal carcinoma were treated with 5-fluorouracil (5-FU), and 38 patients were treated with the combination of 5-FU, cyclophosphamide, and methotrexate. In terms of percent response, response duration, and survival there was no apparent difference between the two regimens. Comb...

journal_title：Cancer

authors： Richards F 2nd,Pajak TL,Cooper MR,Spurr CL

更新日期：1975-11-01 00:00:00

abstract：:Antibodies to herpes simplex viral-induced antigens (HSVIA) were assayed by an indirect immunofluorescent technique in 93 regular cigarette smokers, 75 of whom also imbibed alcoholic beverages. Controls were 94 nonsmoking, nondrinking volunteers matched with the smoker for age and sex. IgA antibodies to HSVIA were det...

journal_title：Cancer

authors： Smith HG,Horowitz N,Silverman NA,Henson DE,Chretien PB

更新日期：1976-09-01 00:00:00

abstract：:A case of a glomus tumor arising in an unusual site, the trachea, is described. The tumor was composed of a mixture of glomus cells and mast cells. At the ultrastructural level, the glomus cells exhibited features of modified smooth-muscle cells. ...

journal_title：Cancer

authors： Fabich DR,Hafez GR

更新日期：1980-05-01 00:00:00

abstract：BACKGROUND:In animal models carbogen (normobaric 95% oxygen, 5% carbon dioxide) provides significant enhancement of local tumor control with fractionated radiotherapy. This approach to radiosensitization has been evaluated in the treatment of patients with bladder carcinoma using radical radiotherapy. METHODS:Sixty-on...

journal_title：Cancer

authors： Hoskin PJ,Saunders MI,Dische S

更新日期：1999-10-01 00:00:00

abstract：:A case of endometrial adenoacanthoma is reported in which two histologically distinct populations of cells were identified in the primary tumor. The two cell types differed in that one had phagocytosed large numbers of polymorphonuclear leucocytes. A subsequent skin metastasis was composed entirely of cells capable of...

journal_title：Cancer

authors： Chandrasoma P

更新日期：1980-05-01 00:00:00

abstract：BACKGROUND:Both genetic and epigenetic changes in nonsmall cell lung cancer (NSCLC) are known to be a common event. METHODS:Mutations in the epidermal growth factor receptor gene (EGFR), HER-2, and KRAS and the methylation profile of 9 genes for NSCLC were analyzed and correlated with clinical and histologic data. RE...

journal_title：Cancer

authors： Suzuki M,Shigematsu H,Iizasa T,Hiroshima K,Nakatani Y,Minna JD,Gazdar AF,Fujisawa T

更新日期：2006-05-15 00:00:00

abstract：BACKGROUND:Adjuvant radiation has been proposed for the treatment of patients with desmoplastic melanoma, who reportedly have local recurrence rates as high as 40-60%. The authors investigated local recurrence rates at a tertiary referral center to determine the success of wide excision alone for patients with desmopla...

journal_title：Cancer

authors： Arora A,Lowe L,Su L,Rees R,Bradford C,Cimmino VC,Chang AE,Johnson TM,Sabel MS

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:The reported frequency of gastrointestinal (GI) tract involvement in patients with mantle cell lymphoma (MCL) is 15-30%. However, this figure most likely is an underestimate because most patients with MCL involving the GI tract previously reported were examined endoscopically only if they had GI tract sympto...

journal_title：Cancer

authors： Romaguera JE,Medeiros LJ,Hagemeister FB,Fayad LE,Rodriguez MA,Pro B,Younes A,McLaughlin P,Goy A,Sarris AH,Dang NH,Samaniego F,Brown HM,Gagneja HK,Cabanillas F

更新日期：2003-02-01 00:00:00

abstract：:The records of all 27 adult patients (age, greater than or equal to 16 years) diagnosed with cerebellar medulloblastoma between 1968 and 1986 were reviewed. Twenty-four patients (89%) were treated with postoperative megavoltage irradiation. Twenty of these patients underwent craniospinal irradiation. Sixteen patients ...

journal_title：Cancer

authors： Hazuka MB,DeBiose DA,Henderson RH,Kinzie JJ

更新日期：1992-04-15 00:00:00

abstract：BACKGROUND:The Akt/mammalian target of rapamycin (mTOR) pathway mediates cell survival and proliferation and contributes to tumor progression. Soft tissue leiomyosarcoma continues to show poor prognosis, and little is known about its mechanisms of tumor progression. Here the authors investigated the significance of act...

journal_title：Cancer

authors： Setsu N,Yamamoto H,Kohashi K,Endo M,Matsuda S,Yokoyama R,Nishiyama K,Iwamoto Y,Dobashi Y,Oda Y

更新日期：2012-03-15 00:00:00

abstract：BACKGROUND:Ordinary craniopharyngiomas affecting sellar regions of children and preadolescents are composed of ameloblastomatous and/or squamous constituents. The authors encountered an autopsy case of a stillborn infant with a large craniopharyngioma with unusual manifestations. METHODS:The craniopharyngioma was anal...

journal_title：Cancer

authors： Yamada H,Haratake J,Narasaki T,Oda T

更新日期：1995-06-15 00:00:00

abstract：BACKGROUND:Total body irradiation (TBI) is commonly used with autologous bone marrow transplantation (BMT) for treatment of hematologic malignancies. Pulmonary complications of TBI can cause long-term morbidity and mortality. The authors have compared the pulmonary toxicity and efficacy of two different TBI fractionati...

journal_title：Cancer

authors： Gopal R,Ha CS,Tucker SL,Khouri IF,Giralt SA,Gajewski JL,Andersson BS,Cox JD,Champlin RE

更新日期：2001-10-01 00:00:00

abstract：:One hundred eighty-three patients with malignant skeletal (83) or soft tissue sarcoma (100) were entered into the multimodality preoperative limb salvage protocol. Local recurrences were observed in 5 of 183 (2.7%). Six patients required amputation because of complications, and 13 patients died within 1 year from meta...

journal_title：Cancer

authors： Eilber FR,Morton DL,Eckardt J,Grant T,Weisenburger T

更新日期：1984-06-15 00:00:00

abstract：METHODS:The prognostic significance of flow cytometric analysis in patients with node-negative invasive breast carcinoma was evaluated in a retrospective series of 158 patients with a minimum follow-up study of 9 years. RESULTS:The ploidy status could be assessed in 147 specimens (93%), and the proliferative phase or ...

journal_title：Cancer

authors： Bosari S,Lee AK,Tahan SR,Figoni MA,Wiley BD,Heatley GJ,Silverman ML

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:Central nervous system (CNS) recurrence is almost invariably fatal in patients with aggressive non-Hodgkin lymphoma (NHL). Although some protocols are intended to prevent CNS disease, the value of CNS prophylaxis in patients with aggressive NHL remains to be determined. METHODS:We retrospectively analyzed a...

journal_title：Cancer

authors： Tomita N,Kodama F,Kanamori H,Motomura S,Ishigatsubo Y

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Thyroid carcinomas historically have been divided into two groups according to their presumedly separate embryonic origins: those of neuroectodermal derivation (parafollicular or medullary carcinoma [MCT]) and those of foregut endodermal origin (follicular and papillary carcinomas). The validity of this conc...

journal_title：Cancer

authors： Kovacs CS,Masé RM,Kovacs K,Nguyen GK,Chik CL

更新日期：1994-08-01 00:00:00

abstract：:The authors retrospectively reviewed 50 episodes of spinal epidural tumor that occurred in 42 patients with metastatic prostate cancer and were treated with external-beam radiation. Treatment response was evaluated in terms of symptoms, neurologic status, and, in most cases, reduction of tumor on repeat myelography. A...

journal_title：Cancer

authors： Zelefsky MJ,Scher HI,Krol G,Portenoy RK,Leibel SA,Fuks ZY

更新日期：1992-11-01 00:00:00

abstract：:The current report describes a secondary malignancy developing in a retroperitoneal mature residual lesion 6 years after chemotherapeutic treatment of a disseminated nonseminomatous testicular tumor. The histologically malignant component was not present in the primary tumor and consisted of polygonal and fusiform cel...

journal_title：Cancer

authors： Molenaar WM,Oosterhuis JW,Meiring A,Sleyfer DT,Schraffordt Koops H,Cornelisse CJ

更新日期：1986-07-15 00:00:00

abstract：:A specimen from the small intestine with multiple (three) classic carcinoid tumors and one appendiceal carcinoid tumor displaying argentaffinity, argyrophilia (Grimelius stain), and serotonin and neuron specific enolase immunoreactivity was examined by light microscopy with regard to the tumor cell histopathogenesis. ...

journal_title：Cancer

authors： Lundqvist M,Wilander E

更新日期：1987-07-15 00:00:00

abstract：:Knowledge of tumor antigenic expression is crucial to the design of therapeutic strategy. A murine monoclonal antibody (BE4) against a human melanoma membrane antigen, was used to study the in vitro expression of this antigen. By membrane immunofluorescence, BE4 reacted against 5 of 8 melanoma lines as compared to zer...

journal_title：Cancer

authors： Leong SP,Bolen JL,Chee DO,Smith VR,Taylor JC,Benfield JR,Klevecz RR

更新日期：1985-03-15 00:00:00

abstract：BACKGROUND:The activation of the clotting-fibrinolytic system in cancer patients is common and represents an unfavorable clinical sign. D-dimer (DD) is a sensitive marker of fibrinolysis. METHODS:The current study comprised 826 new lung carcinoma patients seen consecutively in a single institution over a 10-year perio...

journal_title：Cancer

authors： Buccheri G,Torchio P,Ferrigno D

更新日期：2003-06-15 00:00:00

abstract：:This paper discusses the imaging methods available for the detection and diagnosis of colon cancer, concentrating on endoscopy and barium radiology. Effective utilization of these two methods may be facilitated by using flexible sigmoidoscopy to direct further investigation. There is a need for educational efforts to ...

journal_title：Cancer

authors： Stevenson GW

更新日期：1993-06-15 00:00:00

abstract：:The clinical and laboratory features of nine patients with chronic myelomonocytic leukemia are described. Hepatic or splenic enlargement accompanied by an absolute monocytosis in an older patient with an elevated serum or urine lysozyme and serum vitamin B12 levels were characteristic of the majority of patients in th...

journal_title：Cancer

authors： Gingrich RD,Burns CP

更新日期：1979-12-01 00:00:00