Abstract：
BACKGROUND:Adjuvant radiation has been proposed for the treatment of patients with desmoplastic melanoma, who reportedly have local recurrence rates as high as 40-60%. The authors investigated local recurrence rates at a tertiary referral center to determine the success of wide excision alone for patients with desmoplastic melanoma. METHODS:A review of a prospectively maintained melanoma clinical data base identified 65 patients between March 1997 and March 2004 with pure cutaneous desmoplastic melanoma. Complete surgical, histopathologic, and staging information was collected along with data on outcome, including local, regional, and distant recurrence and survival. RESULTS:Similar to previous reports, patients with desmoplastic melanoma had a male-to-female ratio of 2 to 1, a mean age of 65.0 years (range, 31-92 yrs), and the majority of their tumors (55%) were located on the head and neck. The mean Breslow depth at diagnosis was 4.21 mm, with 38% of tumors thicker than 4.0 mm. All patients in this series underwent wide excision without radiation therapy. Surgical margins < or = 2 cm were obtained for all trunk and extremity lesions and for 63% of head and neck lesions that measured > 1 mm in depth (63%). Margins of 1-2 cm were obtained for the remaining patients. Among 49 patients who had a minimum of 2 years of follow-up (mean, 3.7 yrs), the local recurrence rate was 4% (2 of 49 patients). Seventy-eight percent of the patients studied remained alive with no evidence of disease. CONCLUSIONS:Local recurrence rates in the current series were considerably lower than the historically reported rates. This finding suggests that, for patients with desmoplastic melanoma, wide local excision with careful attention to appropriate margins produces excellent local control rates without the need for adjuvant radiation.
journal_name
Cancerjournal_title
Cancerauthors
Arora A,Lowe L,Su L,Rees R,Bradford C,Cimmino VC,Chang AE,Johnson TM,Sabel MSdoi
10.1002/cncr.21311subject
Has Abstractpub_date
2005-10-01 00:00:00pages
1462-7issue
7eissn
0008-543Xissn
1097-0142journal_volume
104pub_type
杂志文章相关文献
CANCER文献大全abstract：:A case of acute renal failure secondary to bilateral renal vein occlusion by a retroperitoneal plasmacytoma is described. The use of low-risk radiographic techniques including radionuclide venography and a computerized axial tomography (CAT) scan made a rapid and accurate diagnosis possible. Fatal hemorrhage occurred ...
journal_title：Cancer
pub_type： 杂志文章
doi：10.1002/1097-0142(19840301)53:5<1228::aid-cncr2820
更新日期：1984-03-01 00:00:00
abstract：BACKGROUND:For most cancers, information on treatment tolerance and results for elderly patients is quite limited. This study was conducted to investigate the feasibility and results of curative nonsurgical treatment of patients age 75 years or older with anal carcinoma. METHODS:From January 1976 through June 1996, in...
journal_title：Cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0142(19990101)85:1<26::aid-cncr
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:In 1991, the Italian Association for Pediatric Hematology-Oncology and the National Council of Research (CNR) initiated an Italian Cooperative Study (SE 91-CNR Protocol) with the main objective of improving the overall survival (SUR) and the event free survival (EFS) of children and young adults with localiz...
journal_title：Cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1002/(sici)1097-0142(19990801)86:3<421::aid-cnc
更新日期：1999-08-01 00:00:00
abstract：:Various dose-time treatment plans have been used to obtain long duration pain relief in patients with metastatic bone disease. Very little has appeared in the literature evaluating the relationship of dose and fractionation to initial, delayed and permanent bone pain relief. At the Swedish Hospital Tumor Institute, 15...
journal_title：Cancer
pub_type： 杂志文章
doi：10.1002/1097-0142(197602)37:2<984::aid-cncr2820370
更新日期：1976-02-01 00:00:00
abstract：BACKGROUND:The combination of paclitaxel with cisplatin or carboplatin has become the preferred chemotherapy regimen in the treatment of epithelial ovarian carcinoma. Anthracyclines also have activity in this disease. We conducted a Phase II study by using the combination of paclitaxel, cisplatin, and epirubicin for th...
journal_title：Cancer
pub_type： 临床试验,杂志文章
doi：10.1002/1097-0142(20001001)89:7<1547::aid-cncr19>3
更新日期：2000-10-01 00:00:00
abstract：:The serum lactase dehydrogenase (LDH) of 56 patients with Ewing's sarcoma was examined to determine the use of LDH as a tumor marker. The initial LDH level was used to determine its ability to predict survival. The follow-up LDH level also was examined, as an indicator of recurrent disease. The initial LDH level was f...
journal_title：Cancer
pub_type： 杂志文章
doi：10.1002/1097-0142(19870401)59:7<1245::aid-cncr2820
更新日期：1987-04-01 00:00:00
abstract：BACKGROUND:Pediatric renal cell carcinoma (RCC) is clinically distinct from adult RCC. Characterization of the unique biological and clinical features of pediatric RCC are required. METHODS:A retrospective review and biological analysis of all RCC cases presenting to Cincinnati Children's Hospital Medical Center (CCHM...
journal_title：Cancer
pub_type： 杂志文章
doi：10.1002/cncr.23331
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:Crizotinib is a tyrosine kinase inhibitor active against ALK, MET, and ROS1. We previously reported that crizotinib decreases testosterone in male patients. The detailed etiology of the effect, its symptomatic significance, and the effectiveness of subsequent testosterone replacement have not been previously...
journal_title：Cancer
pub_type： 杂志文章,多中心研究
doi：10.1002/cncr.28089
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:A residual mediastinal mass after treatment represents a common diagnostic problem in the management of patients with Hodgkin lymphoma (HD). Conventional diagnostic radiology, computed tomography (CT), or ultrasonography (US) do not adequately reflect changes as fibrosis or necrosis. Gallium-67 (67Ga) imagin...
journal_title：Cancer
pub_type： 杂志文章
doi：10.1002/1097-0142(19930715)72:2<577::aid-cncr28207
更新日期：1993-07-15 00:00:00
abstract：:Sixty patients with advanced prostatic carcinoma were treated with monthly subcutaneous injections of a depot formulation of goserelin, a luteinizing hormone-releasing hormone (LHRH) analogue (Zoladex, ICI Pharma, Destelbergen, Belgium). All patients were regularly evaluated with measurements of luteinizing hormone (L...
journal_title：Cancer
pub_type： 杂志文章
doi：10.1002/1097-0142(19910201)67:3<557::aid-cncr28206
更新日期：1991-02-01 00:00:00
abstract：:Fifteen oncocytic (oxyphilic granular cell) neoplasms of the salivary glands collected from three large university medical centers are presented. The histologic and ultrastructural criteria that characterize oncocytes are presented and electron micrographs of two of our cases are discussed. Included in the series are ...
journal_title：Cancer
pub_type： 杂志文章
doi：10.1002/1097-0142(197609)38:3<1306::aid-cncr282038
更新日期：1976-09-01 00:00:00
abstract：:Laparoscopy is highly effective in diagnosing malignant liver disease, with overall accuracy in the 90% range. Up to 80% of the liver surface can be inspected, and biopsies can be directed with precision. A major advantage over scan guided percutaneous techniques is the ability to detect and biopsy lesions only a few ...
journal_title：Cancer
pub_type： 杂志文章
doi：
更新日期：1982-12-01 00:00:00
abstract：:Immunoblastic sarcoma is a malignancy of transformed lymphocytes with a high association of occurrence in patients with immune disorders. The youngest previously reported case occurred in a 6-year-old child with immunoblastic lymphadenopathy. The authors report the finding of immunoblastic sarcoma of B-cells in a prev...
journal_title：Cancer
pub_type： 杂志文章
doi：10.1002/1097-0142(19841101)54:9<2032::aid-cncr2820
更新日期：1984-11-01 00:00:00
abstract：BACKGROUND:Previous studies have shown that matrix metalloproteinase-2 (MMP-2) (a 72-kilodalton Type IV collagenase/gelatinase A) is associated with breast carcinoma, but to the authors' knowledge there are no reports showing that it is prognostic for overall survival. METHODS:Expression of the immunoreactive protein ...
journal_title：Cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0142(19980915)83:6<1153::aid-cn
更新日期：1998-09-15 00:00:00
abstract：:Three cases of peritoneal papillary serous carcinoma with a complete response to chemotherapy and long-term disease free survival are reported. All three patients presented with multifocal or diffuse peritoneal involvement. Microscopic ovarian serosal surface involvement was demonstrated in two cases. The ovaries were...
journal_title：Cancer
pub_type： 杂志文章
doi：10.1002/1097-0142(19860915)58:6<1371::aid-cncr2820
更新日期：1986-09-15 00:00:00
abstract：BACKGROUND:The AKT inhibitor MK-2206 at a dose of 60 mg every other day was evaluated in gastric/gastroesophageal junction cancers. METHODS:Patients who had progressed after first-line treatment were eligible. Pertinent eligibility criteria included adequate organ function, a fasting serum glucose level ≤ 150 mg/dL, a...
journal_title：Cancer
pub_type： 杂志文章,多中心研究
doi：10.1002/cncr.29363
更新日期：2015-07-01 00:00:00
abstract：:Late side effects of chemotherapy were studied in 51 women who had received at least 300 mg of melphalan for ovarian cancer and had survived for at least three years. Hematologic, statistical, and cytogenetic methods were employed. Six cases of iatrogenic leukemia were found. They appeared to represent a hematologic e...
journal_title：Cancer
pub_type： 杂志文章
doi：10.1002/1097-0142(19820601)49:11<2234::aid-cncr282
更新日期：1982-06-01 00:00:00
abstract：BACKGROUND:Although flow cytometry (FCM) has become a widely used technique for the measurement of DNA content in solid tumors, the correlation of ploidy analysis by FCM with cytogenetic analysis (CGA) is not well described. The sensitivities of G-banded CGA and FCM were compared to determine the accuracy of the DNA in...
journal_title：Cancer
pub_type： 杂志文章
doi：10.1002/1097-0142(19930915)72:6<2033::aid-cncr2820
更新日期：1993-09-15 00:00:00
abstract：BACKGROUND:Despite an increasing interest in the clinical application of positron emission tomography (PET) in tumors of the adult patient as a diagnostic and prognostic tool, only a few studies have been concerned with the usefulness of PET with [18F]2-deoxy-2-fluoro-D-glucose (FDG) in childhood tumors. METHODS:Fifte...
journal_title：Cancer
pub_type： 杂志文章
doi：10.1002/1097-0142(19930815)72:4<1394::aid-cncr2820
更新日期：1993-08-15 00:00:00
abstract：:Disulfiram (tetraethylthiuram disulfide, Antabuse) and sodium diethyldithiocarbamate, when added to the diet, inhibit 1,2-dimethylhydrazine (DMH)-induced neoplasia of the large bowel in female CF1 mice. Ethylene bis(dithiocarbamato)manganese (Maneb) and bis(ethylxanthogen), two pesticides with structural similarities ...
journal_title：Cancer
pub_type： 杂志文章
doi：10.1002/1097-0142(197711)40:5+<2432::aid-cncr28204
更新日期：1977-11-01 00:00:00
abstract：:Immunoproliferative small intestinal diseases (IPSID), previously known as Mediterranean Lymphomas, constitute more than 60% of the non-Burkitt's small intestinal lymphomas in Tunisia. A multidisciplinary study of IPSID was undertaken by the Tunisian/French Lymphoma Study Group in 1980 to reach a better understanding ...
journal_title：Cancer
pub_type： 杂志文章
doi：10.1002/1097-0142(19880415)61:8<1699::aid-cncr2820
更新日期：1988-04-15 00:00:00
abstract：:Combined teletherapy and interstitial iridium 192 implantation can control locally advanced breast cancer in a consistent fashion without causing significant morbidity. Moreover, in the absence of clinically evident distant metastases, patients who undergo this treatment can survive comfortably for long periods of tim...
journal_title：Cancer
pub_type： 杂志文章
doi：10.1002/1097-0142(197611)38:5<1936::aid-cncr282038
更新日期：1976-11-01 00:00:00
abstract：BACKGROUND:Based on previous data demonstrating a potentially synergistic interaction between tamoxifen and cisplatin in metastatic melanoma therapy, a Phase II study was performed to assess the activity of tamoxifen, etoposide, mitoxantrone, and cisplatin (TEMP) in patients with metastatic breast carcinoma. METHODS:F...
journal_title：Cancer
pub_type： 临床试验,杂志文章
doi：10.1002/(sici)1097-0142(19961101)78:9<1906::aid-cn
更新日期：1996-11-01 00:00:00
abstract：BACKGROUND:Over the past 2 decades, significant progress has been made in the field of metastatic colorectal cancer (mCRC) regarding new imaging techniques, surgical interventions, and systemic therapy. It is not known whether the benefit from these interventions has extended overall survival (OS) within the general mC...
journal_title：Cancer
pub_type： 杂志文章
doi：10.1002/cncr.28143
更新日期：2013-08-15 00:00:00
abstract：:Combined modality therapy consisting of CHOP-Bleo (cyclophosphamide, Adriamycin [doxorubicin], vincristine (Oncovin), prednisone, and bleomycin) and limited-field radiotherapy was given to 47 patients with Stage III and IIIE diffuse large cell lymphomas. Overall 5-year survival and disease-free survival figures are 64...
journal_title：Cancer
pub_type： 杂志文章
doi：10.1002/1097-0142(19840401)53:7<1478::aid-cncr2820
更新日期：1984-04-01 00:00:00
abstract：:Multiple endocrine neoplasia, type 2b (MEN 2b) is a disorder characterized by C-cell disease of the thyroid gland (medullary carcinoma or C-cell hyperplasia, or both), pheochromocytoma, ganglioneuromatosis, and skeletal and connective tissue abnormalities. The medullary thyroid carcinoma (MTC) is bilateral and multice...
journal_title：Cancer
pub_type： 杂志文章,评审
doi：10.1002/1097-0142(197912)44:6<2173::aid-cncr282044
更新日期：1979-12-01 00:00:00
abstract：BACKGROUND:Cisplatin has been reported to enhance the cell-killing effect of radiation. The current study was conducted to evaluate the efficacy and toxicity of radiotherapy combined with cisplatin in patients with locally advanced pancreatic carcinoma. METHODS:Forty-one patients with pancreatic carcinoma that was unr...
journal_title：Cancer
pub_type： 临床试验,杂志文章
doi：10.1002/1097-0142(20010401)91:7<1384::aid-cncr1142
更新日期：2001-04-01 00:00:00
abstract：:This study sought to replicate and expand findings reported by the National Surgical Adjuvant Breast and Bowel Project (NSABP) on prognostic factors in resectable colon cancer. Mantel-Haenszel tests and the Cox model were used to analyze prognostic significance and effect of primary disease symptoms and tumor location...
journal_title：Cancer
pub_type： 杂志文章
doi：10.1002/1097-0142(19860501)57:9<1866::aid-cncr2820
更新日期：1986-05-01 00:00:00
abstract：:Chondrosarcoma of the temporal bone is a rare lesion. Clinically it has been confused with multiple sclerosis, glomus jugulare tumors, meningioma, and chordomas. The cranial nerve palsies frequently observed with the tumors are related to the anatomic locations of the tumors. Thirteen patients with this entity are pre...
journal_title：Cancer
pub_type： 杂志文章
doi：10.1002/1097-0142(19861215)58:12<2689::aid-cncr282
更新日期：1986-12-15 00:00:00
abstract：:Platelet kinetics were studied in 70 patients with testicular cancer to elicit the agent responsible for chemotherapy-induced transient early-onset thrombocytopenia; 204 treatment courses were analyzed using three different therapy protocols, which contained vinblastine and bleomycin either alone or in combination wit...
journal_title：Cancer
pub_type： 杂志文章
doi：10.1002/1097-0142(19890101)63:1<51::aid-cncr282063
更新日期：1989-01-01 00:00:00
