Changing prognosis of metastatic colorectal adenocarcinoma: Differential improvement by age and tumor location.

abstract：BACKGROUND:Aberrant methylation is a known cause of cancer initiation and/or progression. There are scant data on the genome-wide methylation pattern of nonfunctioning pancreatic neuroendocrine tumors (NFPanNETs) and sporadic and hereditary NFPanNETs. METHODS:Thirty-three tissue samples were analyzed: they included sa...

journal_title：Cancer

authors： Tirosh A,Mukherjee S,Lack J,Gara SK,Wang S,Quezado MM,Keutgen XM,Wu X,Cam M,Kumar S,Patel D,Nilubol N,Tyagi MV,Kebebew E

更新日期：2019-04-15 00:00:00

abstract：BACKGROUND:Previous Phase II trials evaluating paclitaxel as a single agent have produced objective response rates of 38-40%. However, in these studies patients had recurrent disease and had received previous treatment with chemotherapy, radiation, surgery, or some combination of the same. To the authors' knowledge, th...

journal_title：Cancer

authors： Grecula JC,Smith RE,Rhoades CA,Sharma P,Agrawal A,Zhang H,Allen J,Goldman FP,Young D,Schuller DE

更新日期：2000-12-15 00:00:00

abstract：:A retrospective analysis of 12 patients with primary central nervous system non-Hodgkin's lymphoma seen from 1958 to 1980 was carried out with emphasis on diagnostic evaluation and treatment results. Computerized tomography (CT) scans were found to be the most valuable diagnostic tool both for initial evaluation as we...

journal_title：Cancer

authors： Mendenhall NP,Thar TL,Agee OF,Harty-Golder B,Ballinger WE Jr,Million RR

更新日期：1983-12-01 00:00:00

abstract：BACKGROUND:This retrospective analysis examines the frequency, distribution, and the pattern of disease progression of bone metastasis in patients treated for cervical cancer and the use and results of palliative intent radiation therapy. METHODS:Charts, films, and other available records were reviewed for the 41 pati...

journal_title：Cancer

authors： Ratanatharathorn V,Powers WE,Steverson N,Han I,Ahmad K,Grimm J

更新日期：1994-05-01 00:00:00

abstract：:The glucose consumption rate of 9L rat brain tumor cells was determined as a function of concentration. Glucose uptake followed Michaelis-Menten kinetics with a Km of 0.58 mM and a Vmax of 1.6 pg/cell-min. The glucose diffusion coefficient in spheroids of 9L tumor cells was determined to be 1.5 x 10(-6) cm2/s at 37 de...

journal_title：Cancer

authors： Li CK

更新日期：1982-11-15 00:00:00

abstract：:Eleven patients with advanced soft tissue sarcoma were treated with whole body hyperthermia (41.8 degrees C-43.0 degrees C) for 2 hours, doxorubicin (45 mg/m2) at the beginning of peak temperature and cyclophosphamide (1000 mg/m2) 6 hours after doxorubicin. Warming was accomplished with a nylon and vinyl mesh water pe...

journal_title：Cancer

authors： Gerad H,van Echo DA,Whitacre M,Ashman M,Helrich M,Foy J,Ostrow S,Wiernik PH,Aisner J

更新日期：1984-06-15 00:00:00

abstract：BACKGROUND:Many experienced oncologists have encountered patients with proven non-small cell lung cancer (NCLC) who received modest doses of palliative radiotherapy (RT) and who unexpectedly survived for > 5 years; some were apparently cured. We used a very large prospective database to estimate the frequency of this p...

journal_title：Cancer

authors： Mac Manus MP,Matthews JP,Wada M,Wirth A,Worotniuk V,Ball DL

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Capecitabine with oxaliplatin (CAPOX) has previously demonstrated clinical activity in patients with small bowel adenocarcinoma (SBA) and ampullary adenocarcinoma (AAC). Herein, the authors conducted a phase 2 trial to evaluate the benefit of adding bevacizumab to CAPOX. METHODS:In this phase 2, single-arm,...

journal_title：Cancer

authors： Gulhati P,Raghav K,Shroff RT,Varadhachary GR,Kopetz S,Javle M,Qiao W,Wang H,Morris J,Wolff RA,Overman MJ

更新日期：2017-05-15 00:00:00

abstract：BACKGROUND:Well differentiated (WD) and dedifferentiated (DD) retroperitoneal liposarcoma (RPLS) have distinct biologic behaviors. Consequently, the therapeutic approaches for these tumors differ and mandate an accurate preoperative diagnosis. The authors of this report evaluated whether computed tomography (CT) can be...

journal_title：Cancer

authors： Lahat G,Madewell JE,Anaya DA,Qiao W,Tuvin D,Benjamin RS,Lev DC,Pollock RE

更新日期：2009-03-01 00:00:00

abstract：:The combination of conservation surgery and radiation therapy for early breast cancer is gaining acceptance as an alternative to radical mastectomy. This article reviews the results of randomized trials showing that there is no advantage to a radical mastectomy in patients with early breast cancer. In addition, the ar...

journal_title：Cancer

authors： Montague ED,Ames FC,Schell SR,Romsdahl MM

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:This article reviews the salient pathologic and clinical features of 171 patients with Stage III-IV disease who were 60 years of age or older who were treated on four Hodgkin disease (HD) protocols from 1969 to 1988. METHODS:Pretherapy sections were reviewed centrally for correlation of the histologic class...

journal_title：Cancer

authors： Mir R,Anderson J,Strauchen J,Nissen NI,Cooper MR,Rafla S,Canellos GP,Bloomfield CD,Gottlieb AJ,Peterson B

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:The authors evaluated the effects of taxol, a microtubular inhibitor, as a possible radiation sensitizer on the human leukemic cell line (HL-60). Taxol acts as a mitotic inhibitor, blocking cells in the G2M-phase of the cell cycle. The differential radiation sensitivity of cells in various phases of the cell...

journal_title：Cancer

authors： Choy H,Rodriguez FF,Koester S,Hilsenbeck S,Von Hoff DD

更新日期：1993-06-01 00:00:00

abstract：:Aziridinylbenzoquinone (AZQ) was studied in a Phase II protocol for persons with glioma of the central nervous system (CNS) recurrent or progressive after surgery and radiotherapy. Patients received AZQ, 30 mg/m2 intravenously every 3 weeks if previously untreated or 27.5 mg/m2 if previously exposed to cytotoxic drugs...

journal_title：Cancer

authors： Haid M,Khandekar JD,Christ M,Johnson CM,Miller SJ,Locker GY,Merrill JM,Reisel H,Hatfield A,Lanzotti V

更新日期：1985-09-15 00:00:00

abstract：:Biologicals and biological response modifiers (BRMs) represent a new class of agents for cancer therapy. Historically, there have been many attempts to stimulate the immune response with nonspecific immunomodulators in the form of bacterial extracts, viruses, and chemicals. Although these approaches have occasionally ...

journal_title：Cancer

authors： Oldham RK,Thurman GB,Talmadge JE,Stevenson HC,Foon KA

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:Cervical cancer mortality rates have declined in the United States, primarily because of Papanicolaou testing. However, limited information is available about the incidence of the disease in the US-Mexico border region, where some of the poorest counties in the United States are located. This study was under...

journal_title：Cancer

authors： Coughlin SS,Richards TB,Nasseri K,Weiss NS,Wiggins CL,Saraiya M,Stinchcomb DG,Vensor VM,Nielson CM

更新日期：2008-11-15 00:00:00

abstract：:The authors measured the serial serum carcinoembryonic antigen (CEA) levels in patients with recurrent gastric or colorectal carcinoma. Among the 45 patients with recurrent gastric carcinomas, those with lung metastases showed the most prolonged CEA doubling time (CEA-DT), followed by those with liver and peritoneal m...

journal_title：Cancer

authors： Umehara Y,Kimura T,Yoshida M,Oba N,Harada Y

更新日期：1993-06-15 00:00:00

abstract：BACKGROUND:The objective of this article was to report the results from a randomized clinical trial comparing intensity-modulated radiotherapy (IMRT) with 3-dimensonal conformal radiotherapy (3DCRT) for the treatment of prostate cancer on a hypofractionated schedule. METHODS:The authors randomly assigned 215 men who h...

journal_title：Cancer

authors： Viani GA,Viana BS,Martin JE,Rossi BT,Zuliani G,Stefano EJ

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to compare outcomes in patients with anal canal squamous cell carcinoma (SCCA) who were treated with definitive chemoradiotherapy by either intensity-modulated radiation therapy (IMRT) or conventional radiotherapy (CRT). METHODS:Forty-six patients who received definitive chemor...

journal_title：Cancer

authors： Bazan JG,Hara W,Hsu A,Kunz PA,Ford J,Fisher GA,Welton ML,Shelton A,Kapp DS,Koong AC,Goodman KA,Chang DT

更新日期：2011-08-01 00:00:00

abstract：:Major findings are presented from a workshop on Quality of Life Assessment in Cancer Symptom Management Trials, sponsored by the National Cancer Institute. Data-driven research reports focused on 3 topics, 1) the rationale and utility of health-related quality of life (HRQOL) assessment, 2) conceptual models, and 3) m...

journal_title：Cancer

authors： Buchanan DR,O'Mara AM,Kelaghan JW,Sgambati M,McCaskill-Stevens W,Minasian L

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Small areas unstained with Lugol's iodine are often observed in the mucosa surrounding esophageal carcinomas. METHODS:For light microscopic evaluation, the histologic features of 131 small areas unstained by Lugol's iodine in 12 selected cases were investigated. For clinicopathologic evaluation, the numbers...

journal_title：Cancer

authors： Nakanishi Y,Ochiai A,Yoshimura K,Kato H,Shimoda T,Yamaguchi H,Tachimori Y,Watanabe H,Hirohashi S

更新日期：1998-04-15 00:00:00

abstract：:Indomethacin (prostaglandin synthetase inhibitor) was found to be capable of enhancing the mitogen-induced lymphocyte proliferative responses of healthy subjects and patients with lung cancer. A whole-blood culture technique was used. Indomethacin had no mitogenic activity. We observed a greater enhancement of lymphoc...

journal_title：Cancer

authors： Han T,Takita H

更新日期：1980-12-01 00:00:00

abstract：BACKGROUND:Nipple duct lavage (NDL) may be useful for breast cancer risk stratification. Published guidelines recommend that women with a 5-year Gail risk >/=1.7% should consider undergoing lavage for any fluid-yielding ducts, but it is not known whether increased breast cancer risk or nipple fluid production predict l...

journal_title：Cancer

authors： Bushnaq ZI,Ashfaq R,Leitch AM,Euhus D

更新日期：2007-04-01 00:00:00

abstract：:To examine the relationship between smoking and stage of colorectal cancer at diagnosis, data on 2788 current smokers and 6313 nonsmokers with known stage at diagnosis were obtained from the Massachusetts Cancer Registry. The stage at diagnosis was treated as a polytomous response variable in a logit-type, log-linear ...

journal_title：Cancer

authors： Longnecker MP,Clapp RW,Sheahan K

更新日期：1989-09-15 00:00:00

abstract：BACKGROUND:Conflicting results have been obtained regarding blood flow distribution to liver tumors. The emphasis on portal vein perfusion has had a great impact on the design of treatment protocols. METHODS:Double microsphere technique with reference organ sampling was used for the measurement of hepatic artery and p...

journal_title：Cancer

authors： Wang LQ,Persson BG,Bergqvist L,Bengmark S

更新日期：1994-11-01 00:00:00

abstract：:An 11-year-old female with a large embryonal carcinoma of the left ovary was treated by unilateral salpingo-oophorectomy combined with a systemic chemotherapy of a total dose of 1.9 mg of dactinomycin. The preoperative serum alpha-fetoprotein (AFP) level of 70,350 ng/ml decreased to 270 ng/ml 5 weeks after the operati...

journal_title：Cancer

authors： Nakakuma K,Tashiro S,Uemura K,Takayama K

更新日期：1983-10-15 00:00:00

abstract：:A squamous cell carcinoma arising in intralobar bronchopulmonary sequestration of the right lower lobe is described in a 69-year-old man. One other reported case was found. Other complications of bronchopulmonary sequestration include nonspecific infections and tuberculosis. ...

journal_title：Cancer

authors： Bell-Thomson J,Missier P,Sommers SC

更新日期：1979-07-01 00:00:00

abstract：BACKGROUND:The authors examined whether survivors from the Childhood Cancer Survivor Study were less likely to be in higher-skill occupations than a sibling comparison and whether certain survivors were at higher risk for lower-skill jobs. METHODS:The authors created 3 mutually exclusive occupational categories for pa...

journal_title：Cancer

authors： Kirchhoff AC,Krull KR,Ness KK,Park ER,Oeffinger KC,Hudson MM,Stovall M,Robison LL,Wickizer T,Leisenring W

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:: Although patients with chronic pancreatitis (CP) have an increased risk of pancreatic cancer (PanCa), the timely detection of PanCa often is difficult, because the symptoms of CP and PanCa are very similar. Moreover, secondary inflammation may be identified in PanCa, further complicating diagnosis. To impr...

journal_title：Cancer

authors： Liggett T,Melnikov A,Yi QL,Replogle C,Brand R,Kaul K,Talamonti M,Abrams RA,Levenson V

更新日期：2010-04-01 00:00:00

abstract：:From 1959 to 1986, 24 patients with primary malignant tumors of the trachea received radiotherapy as all or part of treatment. Common presentations included respiratory symptoms in 20 patients and hemoptysis in 15. Thirteen patients had squamous carcinomas with undifferentiated and adenoid cystic cancers in five and f...

journal_title：Cancer

authors： Fields JN,Rigaud G,Emami BN

更新日期：1989-06-15 00:00:00

abstract：:Nine human hybridoma cell lines were established from a fusion of axillary lymph node lymphocytes of a patient with breast ductal carcinoma with a human lymphoblastoid cell line. The human hybridoma nature of the fusion products was confirmed by chromosomal analysis and HLA typing. The hybridomas are stable over a yea...

journal_title：Cancer

authors： Shoenfeld Y,Hizi A,Tal R,Smorodinsky NI,Lavie G,Mor C,Schteren S,Mammon Z,Pinkhas J,Keydar T

更新日期：1987-01-01 00:00:00