Abstract:
BACKGROUND:: Although patients with chronic pancreatitis (CP) have an increased risk of pancreatic cancer (PanCa), the timely detection of PanCa often is difficult, because the symptoms of CP and PanCa are very similar. Moreover, secondary inflammation may be identified in PanCa, further complicating diagnosis. To improve the survival of patients with PanCa, a reliable test to differentiate CP from PanCa is needed. In this article, the authors describe a methylation profile of cell-free plasma DNA that distinguished CP from PanCa with >90% accuracy. METHODS:: Methylation in cell-free, plasma DNA was compared among 30 samples from patients with CP, 30 samples from patients with PanCa, and 30 samples from healthy controls (N) using a microarray-mediated methylation analysis of 56 fragments in each sample (MethDet56). Statistical analysis was done by using the Fisher exact test, a naive Bayes algorithm, and 25 rounds of 5-fold cross-validation. RESULTS:: The MethDet56 methylation analysis technique identified 17 gene promoters as informative (8 for distinguishing N from CP and 14 for distinguishing CP from PanCa). It achieved 81.7% sensitivity and 78% specificity (P<.01) in the detection of CP (N vs CP) and 91.2% sensitivity and 90.8% specificity (P<.01) in the differential detection of PanCa (PanCa vs CP). CONCLUSIONS:: The current data suggested that, among patients with pancreatic disease, the methylation profiles of inflammatory disease and cancer are different and open a new venue for the development of biomarkers for differential diagnosis. Further investigation of diagnostic biomarkers for pancreatic cancer based on methylation in cell-free, circulating DNA appears to be warranted. Cancer 2010. (c) 2010 American Cancer Society.
journal_name
Cancerjournal_title
Cancerauthors
Liggett T,Melnikov A,Yi QL,Replogle C,Brand R,Kaul K,Talamonti M,Abrams RA,Levenson Vdoi
10.1002/cncr.24893subject
Has Abstractpub_date
2010-04-01 00:00:00pages
1674-80issue
7eissn
0008-543Xissn
1097-0142journal_volume
116pub_type
杂志文章相关文献
CANCER文献大全abstract:METHODS:Between 1983 and 1989, 42 patients with Stage II, III, and IV, node-negative, squamous cell head and neck cancer were treated with concurrent 5-fluorouracil, cisplatin, and radiation therapy. Two courses of chemotherapy with 30 Gy of concurrent radiation therapy were to be followed in all patients by definitive...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19921201)70:11<2685::aid-cncr282
更新日期:1992-12-01 00:00:00
abstract::A patient with a primary adenohypophyseal neoplasm who had a long course marked by multiple surgical resections, radiation therapy, and high-dose dopamine agonist therapy developed local invasion as well as cranial and extracranial osseous metastatic lesions. The serum prolactin levels were greatly elevated, and immun...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850201)55:3<598::aid-cncr28205
更新日期:1985-02-01 00:00:00
abstract::Granulocyte (PMN) directional locomotion (migration) in vitro and in vivo, resting nitroblue tetrazolium (NBT)-reduction and adherence to nylon wool of polymorphonuclear neutrophils (PMN) were assayed in 7 patients with Hodgkin's disease (HD) and in 11 patients with non-Hodgkin's lymphoma (NHL) prior to therapy. In mo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800201)45:3<469::aid-cncr28204
更新日期:1980-02-01 00:00:00
abstract::This report is to make the general scientific community aware of availability of human tissues through this network. During the short period of its existence, this network has developed useful procedures for distributing human tumor tissue in a rapid, scientifically useful, cost-effective manner to investigators to wh...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890401)63:7<1452::aid-cncr2820
更新日期:1989-04-01 00:00:00
abstract:BACKGROUND:Few previous articles have analyzed the relation between infection with Helicobacter pylori (H. pylori) and primary gastric lymphoma in a large number of patients. METHODS:Resected and biopsied specimens from 237 patients with primary gastric lymphoma were investigated for H. pylori using hematoxylin and eo...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::During the period from September, 1976 to June, 1979, 70 patients with locoregional or extensive epidermoid carcinoma of the esophagus were treated with the two-drug combination of cisplatin and bleomycin (DB). For the 43 patients with locoregional disease (LRD), DB was used prior to surgery and/or radiation therapy; ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19841201)54:11<2351::aid-cncr282
更新日期:1984-12-01 00:00:00
abstract::The effect of cyclophosphamide (CY) on ovarian function was studied in patients with breast cancer receiving prolonged daily administration of this agent (100 mg/day) after radical surgery. Out of 18 premenopausal patients that received 8.4-39.9 g CY, 15 developed permanent amenorrhea. The average dose given before th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197704)39:4<1403::aid-cncr282039
更新日期:1977-04-01 00:00:00
abstract:BACKGROUND:In the United States, incidence rates for malignant tumors of the uterine corpus are lower among blacks than among whites, whereas mortality rates are higher among blacks. Reasons for the higher level of mortality among blacks have been debated. METHODS:Using data from the Surveillance, Epidemiology, and En...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11484
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Testicular cancer is curable in the majority of men, and persisting treatment toxicity is a concern. The authors report a cross-sectional study of the long-term effects of chemotherapy (C) on neurologic function and development of Raynaud phenomenon. METHODS:Seven hundred thirty-nine patients who were treat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24981
更新日期:2010-05-15 00:00:00
abstract:BACKGROUND:It is questionable whether enrollment on clinical trials offers any survival advantage at the population level over standard-of-care treatment. The objectives of this study were to describe the impact of trial enrollment on event-free survival and overall survival in pediatric acute myeloid leukemia (AML) us...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31728
更新日期:2018-10-15 00:00:00
abstract:BACKGROUND:The primary purpose of this study was to establish the maximum tolerated dose (MTD) of intravenous melphalan in combination with paclitaxel and cisplatin plus granulocyte-colony stimulating factor (G-CSF) in patients with suboptimal advanced epithelial ovarian carcinoma or primary peritoneal carcinoma. METH...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract::The long-term effect of cisplatin on renal function was studied in a follow-up investigation, 16 to 52 months after chemotherapy in 22 patients with disseminated nonseminomatous testicular cancer. The median cumulated cisplatin dose was 452 mg/m2 (range, 275-650 mg/m2). Prehydration with isotonic saline secured diures...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861115)58:10<2214::aid-cncr282
更新日期:1986-11-15 00:00:00
abstract::The correlation between clinicopathologic findings and point mutation in codon 12 of c-Ki-ras gene was examined in primary lung adenocarcinomas using polymerase chain reaction and oligonucleotide hybridization techniques. The mutation was detected in ten of 67 cases (15%). Microscopically, mutation-positive cases reve...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900715)66:2<289::aid-cncr28206
更新日期:1990-07-15 00:00:00
abstract:BACKGROUND:In a cohort including 5112 prostate cancer (pCa) patients, the authors investigated associations among triglycerides (TG), total cholesterol (TC), and pCa while taking into account glucose. METHODS:A cohort (n = 200,660) based on 4 groups of men, according to age at cohort entry, with TG, TC, and glucose me...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25758
更新日期:2011-05-15 00:00:00
abstract:BACKGROUND:The possible association between ovarian carcinoma and ovulation-inducing drugs has led to renewed interest in the potential carcinogenic risks of these drugs. In vitro fertilization (IVF) has been linked to multiple pregnancies and possibly congenital malformations. However, to the authors' knowledge the as...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20000615)88:12<2845::aid-cncr26>
更新日期:2000-06-15 00:00:00
abstract:BACKGROUND:The relationship between serum levels of matrix metalloproteinase-2 (MMP-2) and MMP-3 and recurrence in patients with urothelial carcinoma after complete resection was studied to determine whether the enzymes could be a new predictor of recurrence. METHODS:Serum levels of MMP-2 and MMP-3 in 146 healthy cont...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:Recent preclinical explorations strongly support the tumorigenic potential of bile on laryngopharyngeal mucosa. Herein, the authors describe, in bile-related human hypopharyngeal squamous cell carcinoma (HSCC), NF-κB-related messenger RNA (mRNA) and microRNA (miRNA) oncogenic phenotypes similar to those prev...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32369
更新日期:2019-10-15 00:00:00
abstract::Fifty-one cases of acinic cell carcinoma (ACC) arising in major and minor salivary glands are reported (primary sites: parotid 37, submandibular, six, and oral cavity, eight.) These lesions usually produced painless slowly growing masses. Of 49 patients with follow-up information, 17 (35%) developed local recurrences ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197910)44:4<1434::aid-cncr282044
更新日期:1979-10-01 00:00:00
abstract::The pathologic features, clinical presentation and natural history of hepatocellular carcinoma (HCC) developing in the noncirrhotic liver were studied in 61 patients against a background of 63 patients seen concurrently with HCC complicating cirrhosis. Noncirrhotic HCC had a bimodal age distribution, with females pred...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19881001)62:7<1414::aid-cncr2820
更新日期:1988-10-01 00:00:00
abstract:BACKGROUND:There is significant need for quality follow-up care to optimize long-term outcomes for the growing population of lower gastrointestinal (GI) cancer survivors. Patient-reported outcomes (PROs) provide valuable information regarding late and long-term effects (LLTEs). METHODS:A convenience sample from 1129 c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30527
更新日期:2017-05-15 00:00:00
abstract::With the improved survival of children with cancer, increased attention is being focused on the health status of survivors. The ultimate objective of this research is to use the results to design and test rational intervention strategies directed toward reduction of morbidity and mortality associated with the diagnosi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930515)71:10+<3406::aid-cncr28
更新日期:1993-05-15 00:00:00
abstract:BACKGROUND:Metastases to the breast from extramammary primary tumors are uncommon. Malignant melanoma is one of the most common neoplasms to secondarily involve the mammary parenchyma. METHODS:Seven cases of malignant melanoma metastatic to the breast diagnosed by fine-needle aspiration biopsy are presented. RESULTS:...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980625)84:3<160::aid-cnc
更新日期:1998-06-25 00:00:00
abstract::A retrospective analysis of 12 patients with primary central nervous system non-Hodgkin's lymphoma seen from 1958 to 1980 was carried out with emphasis on diagnostic evaluation and treatment results. Computerized tomography (CT) scans were found to be the most valuable diagnostic tool both for initial evaluation as we...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19831201)52:11<1993::aid-cncr282
更新日期:1983-12-01 00:00:00
abstract::Currently attention is focused on the testicle as a site of leukemic relapse. Leukemic involvement of the ovary has been described in several autopsy series with an incidence of 11-50% in patients with bone marrow relapse, but has rarely been reported during the clinical course of leukemia. In this report, four girls ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820801)50:3<587::aid-cncr28205
更新日期:1982-08-01 00:00:00
abstract:BACKGROUND:Gastric carcinoma with lymphoid stroma (GCLS) has been reported to have a more favorable prognosis than ordinary gastric carcinoma, however, the precise mechanism of the pathogenesis for GCLS remains unclear. METHODS:The authors analyzed 99 GCLS in 94 patients for Epstein-Barr virus (EBV) sequences using po...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940501)73:9<2239::aid-cncr2820
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:Little is known about the size and characteristics of the decision-support networks of women newly diagnosed with breast cancer and whether their involvement improves breast cancer treatment decisions. METHODS:A population-based sample of patients newly diagnosed with breast cancer in 2014 and 2015, as repo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30848
更新日期:2017-10-15 00:00:00
abstract::Higher serum iron and ferritin levels noted in hepatitis B antigen (HBAg) carriers than in noncarriers suggests that virus might actively replicate in hepatocytes, stimulate ferritin synthesis, and result in increased liver iron stores. A comparative semiquantitative study of immunohistochemical ferritin (0-12) and he...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851101)56:9<2201::aid-cncr2820
更新日期:1985-11-01 00:00:00
abstract::Balloon-mesh cytologic screening for esophageal cancer done in 255 asymptomatic high-risk United States veterans (age greater than 40 years, ethanol abuse for greater than 20 years, and cigarette smoking greater than 20 pack years) identified 37 patients with squamous cell dysplasia. Of the 37 patients with dysplasia,...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900615)65:12<2731::aid-cncr282
更新日期:1990-06-15 00:00:00
abstract::The records were reviewed for all patients hospitalized at a pediatric oncology center for complications of leukemia (n = 822) or lymphoma (n = 290) during an 8-year period. The results of surveillance cultures (throat, rectal, and urine) and blood cultures were analyzed to identify cases of Candida tropicalis and C. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910801)68:3<594::aid-cncr28206
更新日期:1991-08-01 00:00:00
abstract::A patient is described in whom the first recurrence of a cloacogenic carcinoma of the rectum was an intrahepatic metastasis associated with an hepatic abscess caused by the anaerobic bacterium Peptococcus prevotii. Three previously reported cases of infection associated with hepatic tumor nodules have been found in wh...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197802)41:2<682::aid-cncr2820410
更新日期:1978-02-01 00:00:00